Intra-epidermal Stimulation (IES) of Small Nerve Fibers (A-delta Fibers) (IES)
調査の概要
詳細な説明
The epidermis is the outermost layer of the skin that includes skin cells and small nerve fibers called A-delta fibers. A-delta fibers send signals to the brain about pin-prick type of pain and temperature. The investigators want to study whether the investigators can stimulate A-delta fibers and document this by recording electrical potentials from the nerves in subjects' limbs.
Study Procedures:
A small piece of plastic will be applied to your foot and your hand. A tiny sharp tip protrudes from this piece of plastic. You will be barely able to feel this sharp tip when touching the piece of plastic. This is the electrode for intra-epidermal stimulation.
With stimulation, you will feel a pin-prick type of sensation. The stimulus will be adjusted so that you barely feel the pin-prick type of sensation. The investigators will record responses of stimulation from nerves in your skin.
研究の種類
段階
- 適用できない
連絡先と場所
研究場所
-
-
Minnesota
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Minneapolis、Minnesota、アメリカ、55455
- University of Minnesota
-
-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Individuals aged 21 through 60 years with no history or clinical signs of neuropathy.
Exclusion Criteria:
- History of peripheral nerve disease or disease of somatosensory pathways.
- Abnormalities on neurologic examination.
- Prior or current exposure to known neurotoxins, such as excessive alcohol use or chemotherapy.
- Neurologic or psychiatric conditions that would prevent the subject from being able to cooperate with testing.
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：他の
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
他の：Intra-epidermal stimulation
A small piece of plastic with a tiny sharp protruding tip (the intra-epidermal stimulation electrode) will be applied to the foot and hand.
Small "sticker" electrodes will be placed over nerves on the forearm or ankle.
A stimulus will be applied to the electrode for intra-epidermal stimulation.
The stimulus will be gradually increased from no stimulus to a stimulus that is barely felt as a pin-prick type of sensation.
Thereafter, the stimulus will be applied 5-15 times per second for 10 periods of 40-60 seconds.
|
A small piece of plastic with a tiny sharp protruding tip (the intra-epidermal stimulation electrode) will be applied to the foot and hand.
Small "sticker" electrodes will be placed over nerves on the forearm or ankle.
A stimulus will be applied to the electrode for intra-epidermal stimulation.
The stimulus will be gradually increased from no stimulus to a stimulus that is barely felt as a pin-prick type of sensation.
Thereafter, the stimulus will be applied 5-15 times per second for 10 periods of 40-60 seconds.
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Feasibility to selectively stimulate and record from A-delta nerve fibers using the intra-epidermal stimulation electrode as measured by electromyography (EMG)
時間枠：one year
|
Stimulate and record from A-delta nerve fibers in normal individual using intra-epidermal stimulation electrode.
|
one year
|
協力者と研究者
スポンサー
捜査官
- 主任研究者：David Walk, MD、University of Minnesota
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- 140103
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