Home-Based Pulmonary Rehab for Patients With Pulmonary Fibrosis (EXPLORE-IPF)
Outpatient (phase 2) pulmonary rehab is an important, but mostly underutilized intervention to improve physical function in patients with idiopathic pulmonary fibrosis (IPF). Of those individuals who complete phase 2 pulmonary rehab, only a small cohort continues with any type of maintenance exercise therapy (phase 3). This is largely due to personal factors, such as access to transportation, weather, scheduling difficulties, and cost.
Little is known about how to enhance physical activity among patients with IPF. In addition, no studies have investigated the long-term maintenance strategies of physical training in patients with IPF. Thus, the purpose of this study is to test the feasibility and effectiveness of a home-based, pulmonary rehab program for patients with IPF. A randomized, blinded, clinical trial (RCT) design with two arms -- Wii Fit Plus exergame program and cognitive video gaming, with no active whole body movement involved - will be used to investigate the benefits of a home-based exergame program on improving pulmonary-related function and symptoms in patients with IPF.
調査の概要
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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-
Alabama
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Birmingham、Alabama、アメリカ、35294-1212
- University of Alabama at Birmingham
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-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- confirmed diagnosis of IPF based on the criteria of the American Thoracic Society/European Respiratory Society 2011 guidelines;
- ≥ 40 years-of-age;
- ambulatory without the use of an assistive device;
- stable clinical condition (i.e., no pulmonary exacerbation for at least 6 weeks);
- no changes in medication for at least 4 weeks before enrollment;
- currently sedentary (i.e., exercise or participate in sports less than 3 times per week for 20 min in the past 6 months) and do not play any exergames;
- report dyspnea on exertion leading to a limitation in performing daily activities (i.e., Medical Research Council (MRC) dyspnea grade >1);
- able to read and follow exercise directions in English on the television screen;
- have permission from their treating physician to participate in moderate-intensity exercise;
- able to provide informed consent by understanding the nature of study participation.
Exclusion Criteria:
- contraindication for moderate-intensity exercise (e.g., unstable cardiac disease),
- severe musculoskeletal, vestibular, or neurological disorders limiting exercise performance, or inability to perform the 6-min walk test or 15-step test,
- requires > 6 lpm supplemental oxygen therapy via nasal cannula during exercise to maintain SpO2 >88%;
- MRC dyspnea grade 4 or 5; IPF patients with MRC dyspnea grade 4 or 5 have been reported to show little or no improvement, or deteriorated following pulmonary rehab;
- stage 2 hypertension,
- anemia (hemoglobin < 8 g/dL);
- collagen vascular disease;
- obstructive lung disease,
- non-parenchymal restrictive lung disease,
- occupational lung disease (pneumoconiosis, hypersensitivity pneumonitis),
- sarcoidosis,
- other idiopathic interstitial pneumonia;
- currently participating or have participated (in the past 30 days) in another clinical trial which can affect the outcomes of the proposed study; or
- planning to move out of Alabama within the next 6 months.
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：トリプル
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Physical exercise training
Combined aerobic and resistance exercise for 30 or more minutes at least 3 times per week for 12 weeks using the Wii Fit Plus
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|
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アクティブコンパレータ：Cognitive exercise training
Cognitive, brain-training, video gaming ~30 minutes per session, 3 times per week for 12 weeks
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Functional performance
時間枠：12 weeks
|
6-min walk distance (m)
|
12 weeks
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Exercise dyspnea
時間枠：12 weeks
|
Dyspnea level (Borg CR10) after completing the 15-step test oximetry test
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12 weeks
|
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15-Step Test: Time
時間枠：12 weeks
|
time (sec) to complete 15-step test
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12 weeks
|
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15-Step Test: Exercise desaturation
時間枠：12 weeks
|
Level of desaturation (%) during 15-step test
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12 weeks
|
|
15-Step Test: Recovery
時間枠：12 weeks
|
Time to recovery to baseline oxygen saturation following 15-step test
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12 weeks
|
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Physical activity level
時間枠：12 weeks
|
Time (min) spent per week in moderate-vigorous physical activity (assessed via an accelerometer)
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12 weeks
|
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Health-related quality of life
時間枠：12 weeks
|
St George's Respiratory Questionnaire
|
12 weeks
|
協力者と研究者
捜査官
- 主任研究者：Hon K Yuen, PhD、University of Alabama at Birmingham
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。