The Impact of Reward-induced Dopamine Release on Functional Connectivity: a Combined PET/fMRI Study
調査の概要
状態
条件
詳細な説明
Aim 1. To test the relationship between reward-induced dopamine (DA) release on changes in resting state functional connectivity (RSFC) in healthy subjects. In 20 healthy adults, the investigators will examine DA release (measured using positron emission tomography, PET) in the ventral striatum, thalamus, and prefrontal cortex, as previously described. Before and after the task the investigators will examine RSFC (measured using functional magnetic resonance imaging, fMRI) between these structures, which have been shown to form functional pathways serving motivation and emotion regulation in rodents and nonhuman primates. The investigators hypothesize that DA release will impact the functional relationship between these and other structures as determined by changes in RSFC.
Aim 2. To examine the relationship between dopamine release and the Reward Positivity (RewP) potential. Subjects will be presented with the option to participate in an event-related potential (ERP) study. The investigators will correlate the amount of DA release with the amplitude of the RewP potential, an ERP that is enhanced in reward versus non-reward circumstances. Based on previous studies, the investigators hypothesize that RewP amplitude will positively correlate with dopamine release in the nucleus accumbens.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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New York
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Stony Brook、New York、アメリカ、11794
- Health Sciences Center
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Healthy men and women age 18-45 who have the capacity to consent to the protocol.
- Ability to understand and follow instructions and oriented to name, time, and place.
- A negative urine pregnancy and toxicology screen
- Willingness to abstain from using aspirin, NSAIDs, or anticoagulants during the study
Exclusion Criteria:
- Left-handed or ambidextrous
- History of seizures
- History of strokes
- Clinically significant, uncontrolled liver, kidney, cardiac, or pulmonary disease
- Terminal medical diagnosis consistent with survival < 1 year
- Serious mental impairment. Mini mental state exam of < 23/30
- Current or past DSM-IV Axis I or neurologic disorders
- Actively abusing substances, including alcohol (regular alcohol use during the past 6 months equal to or greater than 16 cans of beer per week or equivalent; use of street drugs or regular tobacco use during the past 6 months)
- Unstable medical condition (≥ 3 months), or serious medical illnesses during the past three months (e.g., serious infections)
- Unexplained loss of consciousness; history of traumatic brain injury involving loss of consciousness greater than 2 minutes
- Currently pregnant or breastfeeding, sexually active and of child-bearing potential and not using adequate contraceptive methods
- Childbirth or miscarriage during past 6 months, breastfeeding within 6 months of recruitment
- Allergic to latex and/or study pharmaceuticals
- Diabetes and/or unable to fast for up to 7 hours
- Unable to lie comfortably in the scanner for up to 4 consecutive hours
- Would receive a total of over 5 rems to a radiosensitive organ (bone marrow, gonads, lens of the eye) or 15 rems to any other organ or to the body as a whole during a 12 month period
- Contraindications for MRI including neurostimulators, implanted medical devices, metal in the body, claustrophobia, weight over 440 pounds, and girth size incompatible for scanner bore.
- Participation in a similar Social Feedback Task within 2 months of the start of the study.
研究計画
研究はどのように設計されていますか？
デザインの詳細
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Dopamine receptor binding potential
時間枠：1-3 weeks
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changes in dopamine receptor binding potential will be measured during and after a reward task or social stimulus task
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1-3 weeks
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Resting state fMRI
時間枠：1-3 weeks
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Resting state functional connectivity will be measured using fMRI
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1-3 weeks
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Event-related potential (ERP) during reward
時間枠：1-3 weeks
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ERP during a reward task is measured
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1-3 weeks
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協力者と研究者
スポンサー
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。