The Impact of Reward-induced Dopamine Release on Functional Connectivity: a Combined PET/fMRI Study

Inclusion Criteria:

1. Healthy men and women age 18-45 who have the capacity to consent to the protocol.
2. Ability to understand and follow instructions and oriented to name, time, and place.
3. A negative urine pregnancy and toxicology screen
4. Willingness to abstain from using aspirin, NSAIDs, or anticoagulants during the study

Exclusion Criteria:

1. Left-handed or ambidextrous
2. History of seizures
3. History of strokes
4. Clinically significant, uncontrolled liver, kidney, cardiac, or pulmonary disease
5. Terminal medical diagnosis consistent with survival < 1 year
6. Serious mental impairment. Mini mental state exam of < 23/30
7. Current or past DSM-IV Axis I or neurologic disorders
8. Actively abusing substances, including alcohol (regular alcohol use during the past 6 months equal to or greater than 16 cans of beer per week or equivalent; use of street drugs or regular tobacco use during the past 6 months)
9. Unstable medical condition (≥ 3 months), or serious medical illnesses during the past three months (e.g., serious infections)
10. Unexplained loss of consciousness; history of traumatic brain injury involving loss of consciousness greater than 2 minutes
11. Currently pregnant or breastfeeding, sexually active and of child-bearing potential and not using adequate contraceptive methods
12. Childbirth or miscarriage during past 6 months, breastfeeding within 6 months of recruitment
13. Allergic to latex and/or study pharmaceuticals
14. Diabetes and/or unable to fast for up to 7 hours
15. Unable to lie comfortably in the scanner for up to 4 consecutive hours
16. Would receive a total of over 5 rems to a radiosensitive organ (bone marrow, gonads, lens of the eye) or 15 rems to any other organ or to the body as a whole during a 12 month period
17. Contraindications for MRI including neurostimulators, implanted medical devices, metal in the body, claustrophobia, weight over 440 pounds, and girth size incompatible for scanner bore.
18. Participation in a similar Social Feedback Task within 2 months of the start of the study.