Immediate Implant Placement in Aggressive Periodontitis (implant)
Evaluation of the Health of Peri-implant Tissues Around Immediately Placed Dental Implants in Aggressive Periodontitis Patients Versus Periodontally Healthy Individuals in Maxillary Esthetic Zone
調査の概要
詳細な説明
Aggressive periodontitis is an enigmatic periodontal disease that characterized by massive and undeterminable periods of tissue destruction. It gets along well to young individuals with successive periods of disease activity. Aggressive bone destruction with limited plaque and calculus deposits usually detected. According to microbial theory, Aggregatibacter actinomycetemcomitans (A.a) and P. gingivalis (P. G) were claimed for such a disease. Patients of aggressive periodontitis have disturbed esthetic and masticatory function problems.
After wards, microbial theory was modified to enroll the genetic background that can be the cause behind the developed body resistance. Although the importance of the genetic treatment to improve the body response, it was totally dismissed during the routine periodontal work attributable to high cost effectiveness of the needed genetic analysis especially in developing countries.
Further researches tried to explain the cause behind the impaired body response. Impaired functions of the immune cells and the massive amounts of catabolic cytokines such as IL-1, IL-6, Il-17, TNF- α and prostaglan¬din E2 (PGE2) are usually released during the active periods of the disease. On the other hand, matrix-metalloproteinases are destructive enzymes that released in an uncontrollable manner. Host modulators were suggested to control the released of the destructive agents.
Immediate implant placement provides an efficient modality that shortens the dental management period. The aim behind immediate implant placement is the proper implant positioning to counteract the advanced bone resorption following extraction.
Periodontitis is considered an important risk factor for peri-implantitis. The pre-existing periodontitis must be treated prior to implant placement in order to avoid the bacterial accumulation in the periodontal lesions regardless the type of periodontitis. Local and systemic supportive therapy is strongly recommended in order to reduce the microbial colonies and post-operative bone loss.
Higher rate of implant failure (peri-implantitis) has been reported in immediately placed implants when compared with the delayed conventional technique. The failure rate markedly increased with the immediate placement of implants in patients with history of periodontitis especially the aggressive form.
研究の種類
入学 (予想される)
段階
- 適用できない
連絡先と場所
研究連絡先
- 名前:nermin M yussif, TA
- 電話番号:01118271929
- メール:dr_nermin_yussif@yahoo.com
研究連絡先のバックアップ
- 名前:ahmed reda, T
- 電話番号:01006608568
- メール:dr.a.reda@gmail.com
研究場所
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Giza、エジプト
- 募集
- Octobar University of Modern Sciences and Arts
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コンタクト:
- nermin yussif, TA
- 電話番号:01118271929
- メール:dr_nermin_yusuf@yahoo.com
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コンタクト:
- rasha attia, TA
- 電話番号:01009032255
- メール:periorasha1@gmail.com
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
• Subjects aged above 18 years old.
- Patients should be free from any systemic disease.
- patients with good oral hygiene
- completely or partially edenthulus patients
Exclusion Criteria:
Current and former smokers.
- Pregnant females.
- Patients with systemic diseases that may interfere with periodontal condition
- Uncooperative patients
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 主な目的:ヘルスサービス研究
- 割り当て:非ランダム化
- 介入モデル:並列代入
- マスキング:なし(オープンラベル)
武器と介入
参加者グループ / アーム |
介入・治療 |
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プラセボコンパレーター:implants in healthy individuals
immediate placement of dental implants in individuals with healthy periodontium.
the device is dental implants, radiographs, william's periodontal probe
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it targets immediate implant placement in patients suffering from aggressive periodontitis
他の名前:
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実験的:implants in periodontitis patients
immediate implantation in patients suffering from aggressive periodontitis. the device is the dental implants, radiographs, william's periodontal probe
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it targets immediate implant placement in patients suffering from aggressive periodontitis
他の名前:
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
implant and peri-implant tissues health
時間枠:12 months following implant placement
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it includes evaluation of the health of the placed implant in aggressive periodontitis patients and the surrounding alveolar bone and soft tissue.
in other wards it evaluate the survival rate of the dental implants placed in aggressive periodontitis patients.
the health condition of the placed implants are evaluated according to scale called health scale which include 5 categories in which probing depth, alveolar bone ressorption, mobility, pain and other items are measured).
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12 months following implant placement
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
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midfacial peri-implant mucosal level
時間枠:12 months following implant placement
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evaluattion of the mucosal level at the midfacial site of the immediately placed dental implants
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12 months following implant placement
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協力者と研究者
スポンサー
捜査官
- スタディディレクター:mona darhous, Prof、Faculty of Oral and Dental Medicine Cairo University
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
implants in periodontitisの臨床試験
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Symatese Aesthetics募集
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Establishment LabsNAMSA募集
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BlueWillow BiologicsPorton Biopharma Ltd.完了
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HK inno.N Corporationまだ募集していません