- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03218228
Immediate Implant Placement in Aggressive Periodontitis (implant)
Evaluation of the Health of Peri-implant Tissues Around Immediately Placed Dental Implants in Aggressive Periodontitis Patients Versus Periodontally Healthy Individuals in Maxillary Esthetic Zone
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Aggressive periodontitis is an enigmatic periodontal disease that characterized by massive and undeterminable periods of tissue destruction. It gets along well to young individuals with successive periods of disease activity. Aggressive bone destruction with limited plaque and calculus deposits usually detected. According to microbial theory, Aggregatibacter actinomycetemcomitans (A.a) and P. gingivalis (P. G) were claimed for such a disease. Patients of aggressive periodontitis have disturbed esthetic and masticatory function problems.
After wards, microbial theory was modified to enroll the genetic background that can be the cause behind the developed body resistance. Although the importance of the genetic treatment to improve the body response, it was totally dismissed during the routine periodontal work attributable to high cost effectiveness of the needed genetic analysis especially in developing countries.
Further researches tried to explain the cause behind the impaired body response. Impaired functions of the immune cells and the massive amounts of catabolic cytokines such as IL-1, IL-6, Il-17, TNF- α and prostaglan¬din E2 (PGE2) are usually released during the active periods of the disease. On the other hand, matrix-metalloproteinases are destructive enzymes that released in an uncontrollable manner. Host modulators were suggested to control the released of the destructive agents.
Immediate implant placement provides an efficient modality that shortens the dental management period. The aim behind immediate implant placement is the proper implant positioning to counteract the advanced bone resorption following extraction.
Periodontitis is considered an important risk factor for peri-implantitis. The pre-existing periodontitis must be treated prior to implant placement in order to avoid the bacterial accumulation in the periodontal lesions regardless the type of periodontitis. Local and systemic supportive therapy is strongly recommended in order to reduce the microbial colonies and post-operative bone loss.
Higher rate of implant failure (peri-implantitis) has been reported in immediately placed implants when compared with the delayed conventional technique. The failure rate markedly increased with the immediate placement of implants in patients with history of periodontitis especially the aggressive form.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: nermin M yussif, TA
- Phone Number: 01118271929
- Email: dr_nermin_yussif@yahoo.com
Study Contact Backup
- Name: ahmed reda, T
- Phone Number: 01006608568
- Email: dr.a.reda@gmail.com
Study Locations
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-
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Giza, Egypt
- Recruiting
- Octobar University of Modern Sciences and Arts
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Contact:
- nermin yussif, TA
- Phone Number: 01118271929
- Email: dr_nermin_yusuf@yahoo.com
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Contact:
- rasha attia, TA
- Phone Number: 01009032255
- Email: periorasha1@gmail.com
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
• Subjects aged above 18 years old.
- Patients should be free from any systemic disease.
- patients with good oral hygiene
- completely or partially edenthulus patients
Exclusion Criteria:
Current and former smokers.
- Pregnant females.
- Patients with systemic diseases that may interfere with periodontal condition
- Uncooperative patients
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Health Services Research
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: implants in healthy individuals
immediate placement of dental implants in individuals with healthy periodontium.
the device is dental implants, radiographs, william's periodontal probe
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it targets immediate implant placement in patients suffering from aggressive periodontitis
Other Names:
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Experimental: implants in periodontitis patients
immediate implantation in patients suffering from aggressive periodontitis. the device is the dental implants, radiographs, william's periodontal probe
|
it targets immediate implant placement in patients suffering from aggressive periodontitis
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
implant and peri-implant tissues health
Time Frame: 12 months following implant placement
|
it includes evaluation of the health of the placed implant in aggressive periodontitis patients and the surrounding alveolar bone and soft tissue.
in other wards it evaluate the survival rate of the dental implants placed in aggressive periodontitis patients.
the health condition of the placed implants are evaluated according to scale called health scale which include 5 categories in which probing depth, alveolar bone ressorption, mobility, pain and other items are measured).
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12 months following implant placement
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
midfacial peri-implant mucosal level
Time Frame: 12 months following implant placement
|
evaluattion of the mucosal level at the midfacial site of the immediately placed dental implants
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12 months following implant placement
|
Collaborators and Investigators
Sponsor
Investigators
- Study Director: mona darhous, Prof, Faculty of Oral and Dental Medicine Cairo University
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- immediate implant
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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