Dysfunctional Adiposity and Glucose Impairment (DICAMANO)
Discovering Carbohydrate Metabolism Alterations in Normoglycemic Obese Patients Study
調査の概要
詳細な説明
研究の種類
入学 (実際)
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Fasting glucose level ≤ 5.5 mmol l-1
- BMI ≥ 25
Exclusion Criteria:
- Type 2 diabetes mellitus
- Severe renal, liver or thyroid dysfunction
研究計画
研究はどのように設計されていますか?
デザインの詳細
この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Body fat percentage and carbohydrate intolerance
時間枠:Baseline
|
Investigate whether body fat percentage estimated by air-displacement plethysmography (Bod-Pod®, Life Measurements, Concord, CA, USA) predicts postprandial carbohydrate intolerance early on in the metabolic dysregulation process. Body fat percentage (BF%) is calculated from body density by means of the Siri equation. |
Baseline
|
Neck circumference as screening tool
時間枠:Baseline
|
Examine the predictive value of neck circumference as screening tool for the selection of patients who are most likely to benefit from an oral glucose tolerance test (OGTT)
|
Baseline
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Waist-to-hip ratio as screening tool
時間枠:Baseline
|
Examine the predictive value of waist-to-hip ratio as screening tool for the selection of patients who are most likely to benefit from an oral glucose tolerance test (OGTT).
Waist-to-hip ratio was calculated as waist circumference divided by hip circumference.
Waist circumference was measured at the midpoint between the iliac crest and the rib cage on the mid-axillary line, and hip circumference at the level of the greater trochanters was measured to the nearest millimetre using a flexible tape.
|
Baseline
|
Waist-to-height ratio as screening tool
時間枠:Baseline
|
Examine the predictive value of waist-to-height ratio as screening tool for the selection of patients who are most likely to benefit from an oral glucose tolerance test (OGTT).
Waist-to-height ratio was calculated as waist circumference divided by height.
|
Baseline
|
BMI as screening tool
時間枠:Baseline
|
Examine the predictive value of body adiposity index (BMI) as screening tool for the selection of patients who are most likely to benefit from an oral glucose tolerance test (OGTT).
BMI was calculated as weight in kilograms divided by height in meters squared.
|
Baseline
|
Body adiposity index as screening tool
時間枠:Baseline
|
Examine the predictive value of body adiposity index (BAI) ([hip circumference/height1.5]-18)
as screening tool for the selection of patients who are most likely to benefit from an oral glucose tolerance test (OGTT).
|
Baseline
|
Central fat depot and carbohydrate intolerance
時間枠:Baseline
|
Investigate whether central fat depot predicts postprandial carbohydrate intolerance early on in the metabolic dysregulation process.
Visceral and abdominal adiposity was quantified by the use of the abdominal bioelectrical impedance analysis device ViScan (Tanita AB-140, Tanita Corp., Tokyo, Japan).
|
Baseline
|
Central fat depot and cardiometabolic risk
時間枠:Baseline
|
Investigate whether a higher central fat depot is able to identify those individuals with higher inflammatory parameters (c-reactive protein, homocysteine and uric acid) and cardiovascular risk (higher rate of hypercholesterolemia, hypertension and/or obstructive sleep apnea). Body fat percentage (BF%) is calculated from body density by means of the Siri equation. |
Baseline
|
Body fat percentage and cardiometabolic risk
時間枠:Baseline
|
Investigate whether a higher body fat percentage is able to identify those individuals with higher inflammatory parameters (c-reactive protein, homocysteine and uric acid) and cardiovascular risk (higher rate of hypercholesterolemia, hypertension and/or obstructive sleep apnea). Body fat percentage (BF%) is calculated from body density by means of the Siri equation. |
Baseline
|
Prevalence of postprandial carbohydrate intolerance
時間枠:Baseline
|
Assess the prevalence of postprandial carbohydrate intolerance in individuals with normal fasting glycaemia
|
Baseline
|
Oral glucose tolerance test parameters and cardiometabolic profile
時間枠:Baseline
|
Verification of the utility of the two-hour OGTT glucose value to select those individuals with higher cardiometabolic risk (higher rate of hypercholesterolemia, hypertension and/or obstructive sleep apnea).
|
Baseline
|
Non-alcoholic fatty liver disease (NAFLD) and glucose dysregulation
時間枠:Baseline
|
Analyse the association between NAFLD and OGTT-based ß-cell function and insulin resistance in non-diabetic subjects.
|
Baseline
|
OGTT-based indices as screening tool of NAFLD
時間枠:Baseline
|
Examine whether OGTT-based ß-cell function and insulin resistance indices could be used as screening tools for the selection of patients who are most likely to benefit from a NAFLD-study.
|
Baseline
|
OGTT-derived glucose curve as screening tool of NAFLD
時間枠:Baseline
|
Examine whether the glucose response curve could be used as screening tool for the selection of patients who are most likely to benefit from a NAFLD-study.
|
Baseline
|
協力者と研究者
捜査官
- スタディチェア:Gema Frühbeck, PhD、Clinica Universidad de Navarra
- 主任研究者:Belén Pérez Pevida, MD、Clinica Universidad de Navarra
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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