Comparison of Serum Trefoil Factor 3 in Patients With Gingivitis and Periodontitis After Scaling and Root Planing (CSTF3PGPSR)
Comparison of Serum Levels of Trefoil Factor 3 in Patients With Gingivitis and Periodontitis Following Non Surgical Periodontal Therapy
調査の概要
詳細な説明
A goal of periodontal diagnostic procedure is to provide useful information to the clinician regarding the present periodontal disease type and severity. Advances in diagnostic research are moving towards methods where periodontal risk can be identified and quantified by objective measures such as Biomarkers.
Trefoil factors (TFFs) are one such secreted molecules derived from mucin producing epithelial cells of the gastro intestinal tracts and other tissues such as Salivary glands, Parotid ducts and oral mucosa. Among three Trefoil factors reported, Trefoil Factor 3 (TFF3) is the modifying factor for signalling pathway involved in cell survival, cell proliferation and cell migration of oral keratinocytes. Hence assessing the marker levels would achieve beneficial effects on diagnosing the disease severity.
研究の種類
入学 (実際)
段階
- 適用できない
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
For Gingivitis:
- Gingival Index: 1.1 to 2.
- Modifies Plaque Index: 1.0 to 1.9
For Periodontitis:
- Gingival Index: 1.1 to 2.
- Modifies Plaque Index: 1.0 to 1.9
- Probing depth > 4mm
- Clinical attachment loss > 2mm
Exclusion Criteria:
For Gingivitis:
- Presence of gingival recession.
- Presence of clinical attachment loss.
- Presence of furcation.
- Presence of systemic infections like diabetes, infections.
- Smokers.
- Antibiotic therapy received preceding 3 months.
- Patients who underwent periodontal therapy within 3 months.
- Pregnant and Lactating women.
For Periodontitis:
- Presence of any systemic conditions like diabetes, infections.
- Smokers.
- Antibiotic therapy received preceding 3 months.
- Patients who underwent periodontal therapy within 3 months.
- Pregnant and Lactating women.
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：独身
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
実験的：Experimental: Interventional
Group A patients consists of Gingivitis patients whose serum is collected at base line and treated with Scaling and root planing and after three months serum is collected for assessment of Trefoil factor 3.
|
After the serum collection is done from the patient for the assessment of trefoil factor 3, Non surgical periodontal therapy is carried out.
|
|
実験的：Experimental Interventional
Group B patients consists of Periodontitis patients whose serum is collected at base line and treated with Scaling and Root Planing and after three months serum is collected for assessment of Trefoil factor 3.
|
After the serum collection is done from the patient for the assessment of trefoil factor 3, Non surgical periodontal therapy is carried out.
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Trefoil factor 3
時間枠：3 months.
|
Blood samples were collected by venepuncture of anti-cubital vein.
2ml of blood was collected in each test tube.
10 minutes after collection, the test tube containing 2ml blood was subjected to centrifugation at 3000rpm for 10 min.
The supernatant straw colored fluid (serum) was separated into storage vials (Eppendorf tubes) for serum Trefoil Factor 3.
|
3 months.
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Change in the Gingival Index.
時間枠：3 months
|
The severity of gingivitis is scored on all surfaces of selected teeth using Williams Periodontal probe. Index teeth- 16, 12, 24, 36, 32, 44. Score around each tooth is totalled and divided by 4-score of tooth. 0.1-1.0: Mild gingivitis. 1.1-2.0:Moderate gingivitis 2.1-3.0:Severe gingivitis |
3 months
|
|
Change in Modified Plaque Index
時間枠：3 months
|
Examination of all the surfaces of the teeth are done using an explorer. The scores for individual teeth may be grouped and totalled and divided by the number of teeth. Excellent:0 Good:0.1-0.9 Fair:1.0-1.9 Poor:2-3 |
3 months
|
|
Change in Probing depth
時間枠：3 months
|
The distance from the gingival margin to the depth of the pocket is measured using Williams periodontal probe.
|
3 months
|
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Change in Clinical Attachment loss
時間枠：3 months
|
The distance from the cementoenamel junction to the tip of the alveolar crest is measures using Williams periodontal probe.
|
3 months
|
協力者と研究者
出版物と役立つリンク
一般刊行物
- Chaiyarit P, Chayasadom A, Wara-Aswapati N, Hormdee D, Sittisomwong S, Nakaresisoon S, Samson MH, Pitiphat W, Giraud AS. Trefoil factors in saliva and gingival tissues of patients with chronic periodontitis. J Periodontol. 2012 Sep;83(9):1129-38. doi: 10.1902/jop.2011.110431. Epub 2011 Dec 19.
- Storesund T, Schreurs O, Messelt EB, Kolltveit KM, Schenck K. Trefoil factor family 3 expression in the oral cavity. Eur J Oral Sci. 2009 Dec;117(6):636-43. doi: 10.1111/j.1600-0722.2009.00679.x.
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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