Resistance Training in Patients With Morbid Obesity (ExinMO)
Preventing Metabolic Syndrome in Patients With Morbid Obesity by Resistance Training: Reporting Non-responder Prevalence
調査の概要
詳細な説明
The prevalence of metabolic syndrome (MetS) and cardiovascular disease is expected to rise along with the global obesity epidemic. MetS is a cluster of clinical risk factors, including abdominal (visceral) obesity, hypertension, elevated serum triglycerides, low serum high-density lipoprotein (HDL) and hyperglycaemia.The MetS for example, significantly decreases the life expectancy of individuals with morbid obesity and increases the disease burden and economic costs associated with healthcare. In this sense, more recently, there was reported that body mass index (BMI) and fat distribution showed higher associations with inflammation, fat indices, and more prevalence of MetS in morbidly obese subjects, claiming for an early prevention of the MetS in the morbid obese state.
Exercise training has proven to be effective in inducing a clinically significant weight loss and reducing cardiovascular risk. Exercise have reported to be associated with increased muscle mass, decreased body fat, and improved metabolic profile (i.e., improved glucose control and lipid levels). In addition, supervised RT improved muscle strength and functional capacity in patients with obesity undergoing bariatric surgery. However, although RT has been widely studied in obesity, there is little information in the morbid obesity. On the other hand, there is poor knowledge similarly, about the interindividual variability to exercise training in terms of responders and non-responders (NR). Thus, considering the poor knowledge about the MetS prevention in morbid obese patients, as well as the little information about Responders and Non-Responders for improving MetS outcomes, the aim of this study will be determine the effects of a RT program on cardio-metabolic outcomes of MetS in patients with morbid obesity. A second aim will be report the prevalence of non-responders in terms of the effects of resistance training on MetS markers and other health-related variables.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
-
-
Llanquihue
-
Osorno、Llanquihue、チリ、5290000
- Cristian ALvarez
-
-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
Inclusion Criteria:
- Older than 18 and younger and ≤65 years of age.
- With risk factors to Metabolic syndrome
- With obesity and morbid obesity condition
- Medical authorization by a physician.
Exclusion Criteria:
- Physical limitations (e.g., restricting injuries of the musculoskeletal system, or dependent of a third person).
- Exercise-related dyspnoea or respiratory alterations.
- Chronic heart disease with any worsening in the last month.
- Adherence rate of less than 80% of the total interventions.
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：防止
- 割り当て：非ランダム化
- 介入モデル：並列代入
- マスキング：独身
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
アクティブコンパレータ：Active comparator
Control group with obesity under Resistant Training
|
The 20-week RT program will consist of three sessions per week, each lasting for 1 hour that will be applied to both control obese (CG) and morbid obese (MO) group.
All sessions will start with 15 minutes warm-up with continuous walking and joint mobility and flexibility exercises, 5 minutes of cool down and stretching, in order for preventing injuries.
Sessions will include 4 to 8 RT exercises targeting different muscle groups; 1. forearm, 2. knee flexors and 3. extensors, 3. trunk, 4. chest, 5. shoulder elevators, 6. horizontal shoulder flexors and 7. extensors, and 8. plantar flexors.
The exercises for each muscle group will be performed in 3 sets of as many repetitions (continuous concentric/eccentric voluntary contraction) possible in 1 minute followed by 2.0 minutes of passive recovery.
Before the RT program, each participant will be measure using the subjective modified Borg scale (1-10 points), in order of identifying the muscle failure into 1 minute of exercise.
他の名前：
|
|
実験的：Experimental group with morbid obesity
Experimental group with morbid obesity under Resistant Training
|
The 20-week RT program will consist of three sessions per week, each lasting for 1 hour that will be applied to both control obese (CG) and morbid obese (MO) group.
All sessions will start with 15 minutes warm-up with continuous walking and joint mobility and flexibility exercises, 5 minutes of cool down and stretching, in order for preventing injuries.
Sessions will include 4 to 8 RT exercises targeting different muscle groups; 1. forearm, 2. knee flexors and 3. extensors, 3. trunk, 4. chest, 5. shoulder elevators, 6. horizontal shoulder flexors and 7. extensors, and 8. plantar flexors.
The exercises for each muscle group will be performed in 3 sets of as many repetitions (continuous concentric/eccentric voluntary contraction) possible in 1 minute followed by 2.0 minutes of passive recovery.
Before the RT program, each participant will be measure using the subjective modified Borg scale (1-10 points), in order of identifying the muscle failure into 1 minute of exercise.
他の名前：
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Fasting glucose
時間枠：Change from Baseline Fasting glucose at 20-weeks of Resistant Training
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Component of the Metabolic Syndrome
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Change from Baseline Fasting glucose at 20-weeks of Resistant Training
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|
High density lipoprotein
時間枠：Change from Baseline High density lipoprotein at 20-weeks of Resistant Training
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Component of the Metabolic Syndrome
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Change from Baseline High density lipoprotein at 20-weeks of Resistant Training
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Systolic blood pressure and diastolic blood pressure
時間枠：from Baseline Systolic blood pressure and diastolic blood after 20-weeks of Resistant Training
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Component of the Metabolic Syndrome
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from Baseline Systolic blood pressure and diastolic blood after 20-weeks of Resistant Training
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Waist circumference
時間枠：Change from Baseline Waist circumference at 20-weeks of Resistant Training
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Component of the Metabolic Syndrome
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Change from Baseline Waist circumference at 20-weeks of Resistant Training
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Triglycerides
時間枠：Change from Baseline Triglycerides at 20-weeks of Resistant Training
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Component of the Metabolic Syndrome
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Change from Baseline Triglycerides at 20-weeks of Resistant Training
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Body mass index
時間枠：Change from Baseline Body mass index at 20-weeks of Resistant Training
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Anthropometric
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Change from Baseline Body mass index at 20-weeks of Resistant Training
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Body mass
時間枠：Change from Baseline Body mass at 20-weeks of Resistant Training
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Anthropometric
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Change from Baseline Body mass at 20-weeks of Resistant Training
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|
Total cholesterol
時間枠：Change from Baseline Total cholesterol at 20-weeks of Resistant Training
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Measured by plasma sample
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Change from Baseline Total cholesterol at 20-weeks of Resistant Training
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|
Low density lipoprotein
時間枠：Change from Baseline Low density lipoprotein at 20-weeks of Resistant Training
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Measured by plasma sample
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Change from Baseline Low density lipoprotein at 20-weeks of Resistant Training
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|
Six minutes walking test
時間枠：Change from Baseline Six minutes walking test density lipoprotein at 20-weeks of Resistant Training
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Endurance performance
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Change from Baseline Six minutes walking test density lipoprotein at 20-weeks of Resistant Training
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One maximum repetition of biceps curl
時間枠：Change from Baseline One maximum repetition of biceps curl at 20-weeks of Resistant Training
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Strength Performance
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Change from Baseline One maximum repetition of biceps curl at 20-weeks of Resistant Training
|
|
Handgrip muscle strength
時間枠：Change from Baseline Handgrip muscle strength at 20-weeks of Resistant Training
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Muscle strength
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Change from Baseline Handgrip muscle strength at 20-weeks of Resistant Training
|
協力者と研究者
スポンサー
捜査官
- スタディディレクター：Cristian ALvarez, PhD、Universidad de Los Lagos
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
追加の関連 MeSH 用語
その他の研究ID番号
- RP08042019
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
IPD プランの説明
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
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