Vision Rehabilitation Training With Multimodal Feedback in Central Vision Loss
Central vision loss from macular degeneration creates blind spots that impair reading, face recognition, and navigation. Individuals must learn to use peripheral vision, requiring retraining of eye movements. Our preliminary research using high-speed eye tracking demonstrated that people with larger scotomas have impaired eye movement control, and that single-session visual feedback training showed limited immediate benefit, though combining feedback types showed promise.
This study will evaluate whether extended binocular training (5 weekly sessions) with multimodal feedback improves eye movement control in 8-15 participants with bilateral central vision loss. Unlike conventional monocular rehabilitation systems, our approach trains both eyes simultaneously using real-time visual and auditory feedback during saccadic and smooth pursuit tasks. Participants will receive gaze-contingent scotoma awareness feedback, preferred retinal locus feedback, and auditory cues while performing eye tracking exercises.
Primary outcomes include saccadic accuracy (latency, landing error, amplitude) and smooth pursuit parameters (gain, tracking accuracy). Secondary outcomes include contrast sensitivity and self-reported visual function. Success could establish an evidence base for accessible home-based training using virtual reality technology, potentially benefiting millions with macular degeneration.
調査の概要
研究の種類
入学 (推定)
段階
- 適用できない
連絡先と場所
研究連絡先
- 名前：Nicole C Ross, OD
- 電話番号：6175875626
- メール：rossn@neco.edu
研究連絡先のバックアップ
- 名前：Cecilia Idman-Rait, MPH
- メール：idmanraitc@neco.edu
研究場所
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Massachusetts
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Boston、Massachusetts、アメリカ、02115
- 募集
- New England College of Optometry
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コンタクト：
- Nicole C Ross, OD, MSc.
- 電話番号：617-587-5626
- メール：rossn@neco.edu
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コンタクト：
- Cecilia Idman-Rait, MPH
- メール：idmanraitc@neco.edu
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参加基準
適格基準
就学可能な年齢
- 子
- 大人
- 高齢者
健康ボランティアの受け入れ
説明
Inclusion Criteria:
Bilateral central scotomas confirmed via computerized tangent screen Visual acuity between 20/60 and 20/200 (0.5 - 1.00 logMAR) in either eye Stable central vision loss (no change in visual acuity >0.2 logMAR in past 6 months) Age 14 years or older, with diagnosis of macular disease Normal cognitive function (Mini-Mental State Examination score ≥24) Ability to provide informed consent and complete study visits No major hearing loss Fluent in English
Exclusion Criteria:
Unstable ocular disease (e.g., ongoing treatments and/or injections) Peripheral vision loss of less than 40 degrees Conditions affecting oculomotor control independent of CVL
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：他の
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Feedback Training
All participants will receive binocular oculomotor training with multimodal feedback.
Participants will complete 5 weekly training sessions (approximately 60 minutes each) performing saccadic and smooth pursuit eye movement exercises.
Training incorporates three types of feedback presented systematically across sessions: (1) scotoma awareness feedback via gaze-contingent black circle overlay representing the blind spot, (2) preferred retinal locus (PRL) feedback via dynamic gaze-contingent ring showing real-time fixation location, and (3) auditory feedback with tone modulation indicating fixation stability, PRL accuracy, and target acquisition.
Eye movements are recorded using binocular eye tracking at 2000Hz.
Contrast sensitivity is assessed intermittently during training using adaptive Gabor presentations.
Outcomes are measured at baseline (Week 0) and post-training (Week 6).
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Participants will complete 5 weekly training sessions (approximately 60 minutes each) performing eye movement exercises while receiving real-time multimodal feedback. Training includes: Saccadic Training: Visually-guided saccades to targets appearing at randomized locations with instructions to use peripheral (inferior) retinal locus. Targets shift horizontally, vertically, and obliquely to train all saccadic directions. Smooth Pursuit Training: Circular pursuit of moving targets at 2.6°/s in randomized directions with instructions to maintain peripheral gaze above the target. Feedback Modalities (systematically varied across sessions):Scotoma Awareness: Gaze-contingent black circle overlay representing participant's blind spot; Preferred Retinal Locus (PRL) Feedback: Dynamic gaze-contingent ring showing real-time fixation location; Auditory Feedback: Tone modulation indicating fixation stability, PRL accuracy, and target acquisition success; Combined multimodal feedback |
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Change in Saccadic Accuracy (Landing Error)
時間枠：At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Mean distance in degrees between saccade landing position and target location, measured using binocular eye tracking during visually-guided saccade tasks.
Lower values indicate better accuracy.
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At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Change in Saccadic Latency
時間枠：At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Time in milliseconds from target appearance to saccade initiation, measured using binocular eye tracking.
Faster latencies indicate improved oculomotor response.
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At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Change in Smooth Pursuit Gain
時間枠：At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Ratio of eye velocity to target velocity during smooth pursuit tasks (optimal gain = 1.0).
Higher gain values indicate better pursuit tracking accuracy.
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At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Change in Number of Catch-up Saccades During Pursuit
時間枠：At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Mean number of corrective saccades per trial during smooth pursuit tasks.
Fewer catch-up saccades indicate smoother, more accurate pursuit performance.
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At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Change in Contrast Sensitivity Function
時間枠：Baseline, Post-training (Week 6)
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Area under the log contrast sensitivity function (AULCSF) measured using adaptive Gabor presentations during eye movement tasks.
Higher values indicate better contrast sensitivity.
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Baseline, Post-training (Week 6)
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Change in Fixation Stability
時間枠：Baseline, Post-training (Week 6)
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Area of the bivariate contour ellipse at 95% confidence interval of fixation positions during stationary target fixation tasks, measured in square degrees.
Smaller ellipse area indicates more stable fixation.
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Baseline, Post-training (Week 6)
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Change in Vision Related Quality of Life
時間枠：At First study visit - Baseline, at last training session - week 5, and post training (week 11 )
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Baseline, Post-training (Week 6)
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At First study visit - Baseline, at last training session - week 5, and post training (week 11 )
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協力者と研究者
出版物と役立つリンク
便利なリンク
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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