Vision Rehabilitation Training With Multimodal Feedback in Central Vision Loss
Central vision loss from macular degeneration creates blind spots that impair reading, face recognition, and navigation. Individuals must learn to use peripheral vision, requiring retraining of eye movements. Our preliminary research using high-speed eye tracking demonstrated that people with larger scotomas have impaired eye movement control, and that single-session visual feedback training showed limited immediate benefit, though combining feedback types showed promise.
This study will evaluate whether extended binocular training (5 weekly sessions) with multimodal feedback improves eye movement control in 8-15 participants with bilateral central vision loss. Unlike conventional monocular rehabilitation systems, our approach trains both eyes simultaneously using real-time visual and auditory feedback during saccadic and smooth pursuit tasks. Participants will receive gaze-contingent scotoma awareness feedback, preferred retinal locus feedback, and auditory cues while performing eye tracking exercises.
Primary outcomes include saccadic accuracy (latency, landing error, amplitude) and smooth pursuit parameters (gain, tracking accuracy). Secondary outcomes include contrast sensitivity and self-reported visual function. Success could establish an evidence base for accessible home-based training using virtual reality technology, potentially benefiting millions with macular degeneration.
Visão geral do estudo
Status
Intervenção / Tratamento
Tipo de estudo
Inscrição (Estimado)
Estágio
- Não aplicável
Contactos e Locais
Contato de estudo
- Nome: Nicole C Ross, OD
- Número de telefone: 6175875626
- E-mail: rossn@neco.edu
Estude backup de contato
- Nome: Cecilia Idman-Rait, MPH
- E-mail: idmanraitc@neco.edu
Locais de estudo
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Massachusetts
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Boston, Massachusetts, Estados Unidos, 02115
- Recrutamento
- New England College of Optometry
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Contato:
- Nicole C Ross, OD, MSc.
- Número de telefone: 617-587-5626
- E-mail: rossn@neco.edu
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Contato:
- Cecilia Idman-Rait, MPH
- E-mail: idmanraitc@neco.edu
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Critérios de participação
Critérios de elegibilidade
Idades elegíveis para estudo
- Filho
- Adulto
- Adulto mais velho
Aceita Voluntários Saudáveis
Descrição
Inclusion Criteria:
Bilateral central scotomas confirmed via computerized tangent screen Visual acuity between 20/60 and 20/200 (0.5 - 1.00 logMAR) in either eye Stable central vision loss (no change in visual acuity >0.2 logMAR in past 6 months) Age 14 years or older, with diagnosis of macular disease Normal cognitive function (Mini-Mental State Examination score ≥24) Ability to provide informed consent and complete study visits No major hearing loss Fluent in English
Exclusion Criteria:
Unstable ocular disease (e.g., ongoing treatments and/or injections) Peripheral vision loss of less than 40 degrees Conditions affecting oculomotor control independent of CVL
Plano de estudo
Como o estudo é projetado?
Detalhes do projeto
- Finalidade Principal: Outro
- Alocação: N / D
- Modelo Intervencional: Atribuição de grupo único
- Mascaramento: Nenhum (rótulo aberto)
Armas e Intervenções
Grupo de Participantes / Braço |
Intervenção / Tratamento |
|---|---|
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Experimental: Feedback Training
All participants will receive binocular oculomotor training with multimodal feedback.
Participants will complete 5 weekly training sessions (approximately 60 minutes each) performing saccadic and smooth pursuit eye movement exercises.
Training incorporates three types of feedback presented systematically across sessions: (1) scotoma awareness feedback via gaze-contingent black circle overlay representing the blind spot, (2) preferred retinal locus (PRL) feedback via dynamic gaze-contingent ring showing real-time fixation location, and (3) auditory feedback with tone modulation indicating fixation stability, PRL accuracy, and target acquisition.
Eye movements are recorded using binocular eye tracking at 2000Hz.
Contrast sensitivity is assessed intermittently during training using adaptive Gabor presentations.
Outcomes are measured at baseline (Week 0) and post-training (Week 6).
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Participants will complete 5 weekly training sessions (approximately 60 minutes each) performing eye movement exercises while receiving real-time multimodal feedback. Training includes: Saccadic Training: Visually-guided saccades to targets appearing at randomized locations with instructions to use peripheral (inferior) retinal locus. Targets shift horizontally, vertically, and obliquely to train all saccadic directions. Smooth Pursuit Training: Circular pursuit of moving targets at 2.6°/s in randomized directions with instructions to maintain peripheral gaze above the target. Feedback Modalities (systematically varied across sessions):Scotoma Awareness: Gaze-contingent black circle overlay representing participant's blind spot; Preferred Retinal Locus (PRL) Feedback: Dynamic gaze-contingent ring showing real-time fixation location; Auditory Feedback: Tone modulation indicating fixation stability, PRL accuracy, and target acquisition success; Combined multimodal feedback |
O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
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Change in Saccadic Accuracy (Landing Error)
Prazo: At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Mean distance in degrees between saccade landing position and target location, measured using binocular eye tracking during visually-guided saccade tasks.
Lower values indicate better accuracy.
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At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Medidas de resultados secundários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
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Change in Saccadic Latency
Prazo: At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Time in milliseconds from target appearance to saccade initiation, measured using binocular eye tracking.
Faster latencies indicate improved oculomotor response.
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At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Change in Smooth Pursuit Gain
Prazo: At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Ratio of eye velocity to target velocity during smooth pursuit tasks (optimal gain = 1.0).
Higher gain values indicate better pursuit tracking accuracy.
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At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Change in Number of Catch-up Saccades During Pursuit
Prazo: At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Mean number of corrective saccades per trial during smooth pursuit tasks.
Fewer catch-up saccades indicate smoother, more accurate pursuit performance.
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At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )
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Change in Contrast Sensitivity Function
Prazo: Baseline, Post-training (Week 6)
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Area under the log contrast sensitivity function (AULCSF) measured using adaptive Gabor presentations during eye movement tasks.
Higher values indicate better contrast sensitivity.
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Baseline, Post-training (Week 6)
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Change in Fixation Stability
Prazo: Baseline, Post-training (Week 6)
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Area of the bivariate contour ellipse at 95% confidence interval of fixation positions during stationary target fixation tasks, measured in square degrees.
Smaller ellipse area indicates more stable fixation.
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Baseline, Post-training (Week 6)
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Change in Vision Related Quality of Life
Prazo: At First study visit - Baseline, at last training session - week 5, and post training (week 11 )
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Baseline, Post-training (Week 6)
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At First study visit - Baseline, at last training session - week 5, and post training (week 11 )
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Colaboradores e Investigadores
Patrocinador
Publicações e links úteis
Links úteis
Datas de registro do estudo
Datas Principais do Estudo
Início do estudo (Real)
Conclusão Primária (Estimado)
Conclusão do estudo (Estimado)
Datas de inscrição no estudo
Enviado pela primeira vez
Enviado pela primeira vez que atendeu aos critérios de CQ
Primeira postagem (Real)
Atualizações de registro de estudo
Última Atualização Postada (Real)
Última atualização enviada que atendeu aos critérios de controle de qualidade
Última verificação
Mais Informações
Termos relacionados a este estudo
Termos MeSH relevantes adicionais
- Manifestações Neurológicas
- Doenças do Sistema Nervoso
- Doenças oculares
- Distúrbios da Visão
- Distúrbios da Sensação
- Doenças Retinianas
- Cegueira
- Degeneração Retiniana
- Condições Patológicas, Sinais e Sintomas
- Sinais e sintomas
- Visão, Baixa
- Degeneração macular
- Cegueira Cortical
- Terapêutica
- Terapias mente-corpo
- Terapias complementares
- Terapia comportamental
- Psicoterapia
- Disciplinas e atividades comportamentais
- Feedback, psicológico
- Biofeedback, psicologia
Outros números de identificação do estudo
- Saccades 2.0
Plano para dados de participantes individuais (IPD)
Planeja compartilhar dados de participantes individuais (IPD)?
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