Platelet-Rich Plasma With or Without Tadalafil for Erectile Dysfunction
Efficacy of Intracavernosal Injection of Platelet-Rich Plasma Alone Versus Combined With Oral Tadalafil in The Management of Erectile Dysfunction; A Prospective Randomized Study
Platelet-rich plasma is being studied as a regenerative treatment option for erectile dysfunction, but it is unclear whether adding daily tadalafil gives additional benefit over platelet-rich plasma alone. This study evaluates adult men with mild to mild-moderate erectile dysfunction who had an inadequate response to previous phosphodiesterase type 5 inhibitor treatment.
Participants were randomly assigned to receive either intracavernosal platelet-rich plasma injections combined with oral tadalafil 5 milligrams once daily, or intracavernosal platelet-rich plasma injections alone. The platelet-rich plasma injection protocol consisted of three intracavernosal treatment sessions spaced two weeks apart. Erectile function was assessed using the International Index of Erectile Function-5 questionnaire at baseline and during follow-up at 1, 3, and 6 months. Penile duplex Doppler ultrasound was performed at baseline and after 6 months to assess erectile blood-flow parameters.
The study hypothesis is that adding daily tadalafil to intracavernosal platelet-rich plasma may produce greater improvement in patient-reported erectile function compared with platelet-rich plasma alone, while also allowing assessment of whether this improvement is accompanied by measurable changes in penile Doppler parameters. The study included 156 participants in the final analysis, with 78 participants in each treatment group.
調査の概要
研究の種類
入学 (実際)
段階
- フェーズ 4
連絡先と場所
研究場所
-
-
Qalyubia Governorate
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Banhā、Qalyubia Governorate、エジプト、13511
- Benha University Hospital
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参加基準
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
説明
Inclusion Criteria:
- Adult men aged 18 years or older.
- Diagnosis of mild to mild-moderate erectile dysfunction according to the International Index of Erectile Function-5.
- Inadequate response to previous phosphodiesterase type 5 inhibitor treatment.
- Eligible for intracavernosal platelet-rich plasma injection.
- Eligible for oral tadalafil treatment.
- Baseline penile duplex Doppler ultrasound assessment available.
Exclusion Criteria:
- Severe erectile dysfunction.
- Peyronie's disease.
- Previous major pelvic surgery.
- Previous pelvic trauma.
- Known bleeding or coagulation disorder.
- Contraindication to phosphodiesterase type 5 inhibitors, including nitrate therapy.
- Significant cardiac disease contraindicating tadalafil use.
- Total testosterone less than 300 nanograms per deciliter.
- Refusal or inability to provide written informed consent.
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Platelet-Rich Plasma Plus Tadalafil
Participants received intracavernosal platelet-rich plasma injections combined with oral tadalafil.
Tadalafil was given as 5 milligrams tablet by mouth once daily.
Platelet-rich plasma was prepared from autologous whole blood using a two-step centrifugation method, activated with calcium chloride, and injected intracavernosally using a fine-gauge needle after topical local anesthesia.
The injection protocol consisted of three treatment sessions spaced two weeks apart.
|
Tadalafil was administered orally as a 5 milligram tablet once daily in combination with intracavernosal platelet-rich plasma injections.
It was used as adjunct pharmacologic therapy to support erectile function during the study follow-up period.
Autologous platelet-rich plasma was prepared from whole blood using a two-step centrifugation technique and activated with calcium chloride before administration.
It was injected intracavernosally using a fine-gauge needle after topical local anesthesia.
The treatment protocol included three intracavernosal injection sessions spaced two weeks apart.
|
|
アクティブコンパレータ：Platelet-Rich Plasma Alone
Participants received intracavernosal platelet-rich plasma injections alone without adjunct oral tadalafil.
Platelet-rich plasma was prepared from autologous whole blood using a two-step centrifugation method, activated with calcium chloride, and injected intracavernosally using a fine-gauge needle after topical local anesthesia.
The injection protocol consisted of three treatment sessions spaced two weeks apart.
|
Autologous platelet-rich plasma was prepared from whole blood using a two-step centrifugation technique and activated with calcium chloride before administration.
It was injected intracavernosally using a fine-gauge needle after topical local anesthesia.
The treatment protocol included three intracavernosal injection sessions spaced two weeks apart.
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Change in International Index of Erectile Function-5 Score
時間枠：Baseline, 1 month, 3 months, and 6 months after treatment initiation
|
Erectile function was assessed using the International Index of Erectile Function-5 questionnaire.
The total score ranges from 5 to 25, with higher scores indicating better erectile function.
Scores were compared over time between the platelet-rich plasma plus tadalafil group and the platelet-rich plasma alone group.
|
Baseline, 1 month, 3 months, and 6 months after treatment initiation
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Change in Penile Peak Systolic Velocity
時間枠：Baseline and 6 months after treatment initiation
|
Peak systolic velocity was measured by penile duplex Doppler ultrasound after pharmacologic stimulation.
It was used to assess arterial penile blood flow.
Higher values indicate better arterial inflow.
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Baseline and 6 months after treatment initiation
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Change in Penile End-Diastolic Velocity
時間枠：Baseline and 6 months after treatment initiation
|
End-diastolic velocity was measured by penile duplex Doppler ultrasound after pharmacologic stimulation.
It was used to assess venous outflow status during erection.
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Baseline and 6 months after treatment initiation
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Change in Penile Resistive Index
時間枠：Baseline and 6 months after treatment initiation
|
Resistive index was calculated from penile duplex Doppler ultrasound parameters after pharmacologic stimulation.
It was used as an additional measure of penile vascular resistance and erectile hemodynamics.
|
Baseline and 6 months after treatment initiation
|
協力者と研究者
スポンサー
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
キーワード
追加の関連 MeSH 用語
その他の研究ID番号
- MD 5-10-2025
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
IPD プランの説明
IPD 共有時間枠
IPD 共有アクセス基準
IPD 共有サポート情報タイプ
- STUDY_PROTOCOL
- SAP
- ICF
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
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