Physiological Effects of External PEEP in Controlled Mechanical Ventiated Patients With autoPEEP
Effects of External PEEP in Controlled Mechanical Ventiated Patients With autoPEEP. A Physiological Study
This experimental physiologic study is conducted to determine the effect of different mechanical ventilation settings (in terms of positive end-expiratory pressure) on patients receiving mechanical ventilation with expiratory flow obstruction and autoPEEP. The main question it aims to answer In patients with autoPEEP, what is the effect of applying external PEEP on gas exchange and the lung emptying pattern in patients with total ventilatory support? Participants must comply:
- Age > 17 years.
- Invasive mechanical ventilation (endotracheal tube or tracheostomy) in controlled mode, with SpO2 > 90%, for more than 12 hours.
- No contraindications for abdominal compression.
- Presence of autoPEEP greater than 3 cmH2O measured in mechanical ventilation with total support and ZEEP.
- Total mechanical respiratory support, without respiratory muscle activity (inspiratory or expiratory).
調査の概要
詳細な説明
研究の種類
入学 (推定)
段階
- 適用できない
連絡先と場所
研究場所
-
-
-
Buenos Aires、アルゼンチン
- Hospital Santojanni
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-
参加基準
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
説明
Inclusion Criteria:
Age > 17 years. Invasive mechanical ventilation (endotracheal tube or tracheostomy) in controlled mode, with SpO2 > 90%, for more than 12 hours.
No contraindications for abdominal compression. AutoPEEP greater than 3 cmH2O measured during mechanical ventilation with full support and ZEEP.
Full mechanical respiratory support, with no respiratory muscle activity (inspiratory or expiratory).
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Exclusion Criteria:
Cardiovascular instability: Hypotension (MAP < 60 mmHg), hypertension (SBP > 180 mmHg), heart rate < 40 bpm or > 150 bpm.
Refusal to participate in the study by a family member (without signed informed consent).
Evidence of air leak: Pneumothorax, subcutaneous emphysema, pneumomediastinum. Intracranial hypertension (ICP > 20 mmHg). Pregnant patient. Body Mass Index greater than 40 kg/m².
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：PEEP titration
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External PEEP will be increased by 3 cmH₂O, from 0 to 15 cmH₂O.
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
To evaluate the expiratory time constant as a function of external PEEP.
時間枠：1 hour
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Methodology: the expiratory pattern is defined through the expiratory time constant at different PEEP levels relative to the reference (ZEEP).
|
1 hour
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
To evaluate thel effect of external PEEP in gas exchange respect to reference (ZEEP)
時間枠：1 hour
|
Gas exchange: Methodology: Arterial blood gas samples (PaO2 and PaCO2 in mmHg) are taken after a 15-minute stability period at three time points: without external PEEP (reference), and 3 cmH2O below and 3 cmH2O above final PEEP.
|
1 hour
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協力者と研究者
出版物と役立つリンク
一般刊行物
- Pepe PE, Marini JJ. Occult positive end-expiratory pressure in mechanically ventilated patients with airflow obstruction: the auto-PEEP effect. Am Rev Respir Dis. 1982 Jul;126(1):166-70. doi: 10.1164/arrd.1982.126.1.166.
- Lourens MS, van den Berg B, Aerts JG, Verbraak AF, Hoogsteden HC, Bogaard JM. Expiratory time constants in mechanically ventilated patients with and without COPD. Intensive Care Med. 2000 Nov;26(11):1612-8. doi: 10.1007/s001340000632.
- Roesthuis LH, van der Hoeven JG, Guerin C, Doorduin J, Heunks LMA. Three bedside techniques to quantify dynamic pulmonary hyperinflation in mechanically ventilated patients with chronic obstructive pulmonary disease. Ann Intensive Care. 2021 Dec 4;11(1):167. doi: 10.1186/s13613-021-00948-9.
- Lemyze M, Favory R, Alves I, Perez T, Mathieu D. Manual compression of the abdomen to assess expiratory flow limitation during mechanical ventilation. J Crit Care. 2012 Feb;27(1):37-44. doi: 10.1016/j.jcrc.2011.05.011. Epub 2011 Jul 27.
- Dawson SV, Elliott EA. Wave-speed limitation on expiratory flow-a unifying concept. J Appl Physiol Respir Environ Exerc Physiol. 1977 Sep;43(3):498-515. doi: 10.1152/jappl.1977.43.3.498.
- Valta P, Corbeil C, Lavoie A, Campodonico R, Koulouris N, Chasse M, Braidy J, Milic-Emili J. Detection of expiratory flow limitation during mechanical ventilation. Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 1):1311-7. doi: 10.1164/ajrccm.150.5.7952558.
- HYATT RE. The interrelationships of pressure, flow, and volume during various respiratory maneuvers in normal and emphysematous subjects. Am Rev Respir Dis. 1961 May;83:676-83. doi: 10.1164/arrd.1961.83.5.676. No abstract available.
- Kimball WR, Leith DE, Robins AG. Dynamic hyperinflation and ventilator dependence in chronic obstructive pulmonary disease. Am Rev Respir Dis. 1982 Dec;126(6):991-5. doi: 10.1164/arrd.1982.126.6.991.
- Jonson B, Nordstrom L, Olsson SG, Akerback D. Monitoring of ventilation and lung mechanics during automatic ventilation. A new device. Bull Physiopathol Respir (Nancy). 1975 Sep-Oct;11(5):729-43.
- Bergman NA. Intrapulmonary gas trapping during mechanical ventilation at rapid frequencies. Anesthesiology. 1972 Dec;37(6):626-33. doi: 10.1097/00000542-197212000-00011. No abstract available.
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- Hospitalsantojanni.2
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