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How Trunk Control Links Autism Severity to Functional Exercise Capacity in Children With ASD

2026年6月6日 更新者：Dr. Mehak Naeem

Trunk Control Mediates the Association Between Autism Severity and Functional Exercise Capacity in Children With Autism Spectrum Disorder

The goal of this observational study is to learn if trunk control (the ability to balance and stabilize the upper body while sitting or moving) links autism severity to functional exercise capacity in children aged 4-12 years with Autism Spectrum Disorder (ASD). The main questions it aims to answer are:

  1. Does trunk control explain why children with more severe ASD have lower functional exercise capacity?
  2. Do trunk control and functional exercise capacity differ across ASD severity levels (Level 1, 2, and 3)?

Participants will complete two assessments in a single 30-40 minute session during their routine clinic visit:

  1. A trunk control test, where a trained physiotherapist observes seated balance and movement.
  2. A 6-Minute Walk Test (6MWT), where the child moves along a flat hospital corridor for 6 minutes and the total distance covered is recorded as a measure of functional exercise capacity.

No treatment or intervention is involved. All assessments are safe, non-invasive, and conducted at a tertiary care children's hospital in Pakistan.

調査の概要

状態

まだ募集していません

条件

詳細な説明

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by decreased cardiorespiratory fitness and motor impairments that limit participation in daily activities. Children with ASD commonly show reduced postural stability and trunk motor control (the ability to maintain and adjust the position of the upper body during movement). These impairments are increasingly recognized as significant contributors to functional limitations in individuals with ASD, yet the precise mechanism linking autism severity to reduced functional exercise capacity has not been formally tested.

This cross-sectional study tests a mediation model: whether trunk motor control explains the relationship between ASD severity and functional exercise capacity. ASD severity is classified using DSM-5 levels (Level 1, 2, and 3) from existing clinical records. Trunk motor control is assessed using the Trunk Impairment Scale (TIS), a validated tool measuring static balance, dynamic balance, and trunk coordination. Functional exercise capacity is measured using the Six-Minute Walk Test (6MWT), conducted per American Thoracic Society guidelines.

Statistical analysis uses bootstrap mediation (PROCESS Model 4, 5,000 resamples), controlling for age, sex, and BMI. This is the first study to examine this mediation pathway in a paediatric hospital setting in Pakistan, where no motor profile has been described in the literature for children with ASD.

研究の種類

観察的

入学 (推定)

200

連絡先と場所

このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。

研究場所

  • パキスタン
    • Punjab Province
      • Lahore、Punjab Province、パキスタン、54782
        • Dr. Saqib Rabbani

参加基準

研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。

適格基準

就学可能な年齢

  • 子

健康ボランティアの受け入れ

はい

サンプリング方法

非確率サンプル

調査対象母集団

Participants will be recruited consecutively from the developmental and rehabilitation paediatric physiotherapy outpatient department of a tertiary care children's hospital in Pakistan.

説明

Inclusion Criteria:

  • Children aged 4-12 years (inclusive) at the time of assessment
  • Confirmed diagnosis of ASD according to DSM-5 criteria, documented in the hospital record by a licensed clinical psychologist or developmental paediatrician
  • Classified at DSM-5 severity Level 1, 2, or 3 in the existing clinical file
  • Currently attending physiotherapy or developmental rehabilitation outpatient services at the hospital
  • Able to attempt the Six-Minute Walk Test (6MWT) with or without verbal prompting
  • Written informed consent from parent or legal guardian; verbal assent from child where developmentally appropriate (aged 7 years and above)

Exclusion Criteria:

  • Co-existing neurological condition independently affecting gait (e.g., cerebral palsy, uncontrolled epilepsy)
  • Orthopaedic condition precluding walking or safe execution of the Trunk Impairment Scale
  • Acute illness, fever, or significant behavioural crisis at the time of the scheduled assessment session
  • Current enrolment in a structured physiotherapy or physical activity intervention programme
  • Caregiver refusal of consent or participant non-cooperation with either assessment tool at the time of the visit

研究計画

このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。

研究はどのように設計されていますか？

デザインの詳細

コホートと介入

グループ/コホート
ASD Level 1 - Requiring Support
Children aged 4-12 years with a confirmed DSM-5 diagnosis of ASD at severity Level 1 (requiring support). Participants undergo a single assessment session comprising the Trunk Impairment Scale (TIS) to measure trunk motor control and the Six-Minute Walk Test (6MWT) to measure functional exercise capacity. No intervention is administered.
ASD Level 2 - Requiring Substantial Support
Children aged 4-12 years with a confirmed DSM-5 diagnosis of ASD at severity Level 2 (requiring substantial support). Participants undergo a single assessment session comprising the Trunk Impairment Scale (TIS) to measure trunk motor control and the Six-Minute Walk Test (6MWT) to measure functional exercise capacity. No intervention is administered.
ASD Level 3 - Requiring Very Substantial Support
Children aged 4-12 years with a confirmed DSM-5 diagnosis of ASD at severity Level 3 (requiring very substantial support). Participants undergo a single assessment session comprising the Trunk Impairment Scale (TIS) to measure trunk motor control and the Six-Minute Walk Test (6MWT) to measure functional exercise capacity. No intervention is administered.

この研究は何を測定していますか？

主要な結果の測定

結果測定
メジャーの説明
時間枠
Functional Exercise Capacity
時間枠：1 Day
Total distance covered in metres during the Six-Minute Walk Test (6MWT), administered in accordance with American Thoracic Society (ATS) guidelines along a 30-metre flat hospital corridor. The 6MWT is a validated, low-cost index of functional exercise capacity applicable to paediatric clinical settings. There is no fixed minimum or maximum value. A greater distance indicates better functional exercise capacity. Whereas a shorter distance indicates poorer functional exercise capacity. 6MWT distance will be analysed as a continuous variable and compared across DSM-5 severity levels.
1 Day

二次結果の測定

結果測定
メジャーの説明
時間枠
Trunk Motor Control
時間枠：1 Day
Total score on the Trunk Impairment Scale (TIS), a validated clinician-administered tool scored from 0 to 23 across three subscales: static sitting balance (0-7), dynamic sitting balance (0-10), and trunk coordination (0-6). Higher scores indicate better trunk motor control.
1 Day

協力者と研究者

ここでは、この調査に関係する人々や組織を見つけることができます。

スポンサー

Dr. Mehak Naeem

研究記録日

これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。

主要日程の研究

研究開始 (推定)

2026年6月1日

一次修了 (推定)

2026年7月1日

研究の完了 (推定)

2026年7月1日

試験登録日

最初に提出

2026年6月2日

QC基準を満たした最初の提出物

2026年6月2日

最初の投稿 (実際)

2026年6月8日

学習記録の更新

投稿された最後の更新 (実際)

2026年6月10日

QC基準を満たした最後の更新が送信されました

2026年6月6日

最終確認日

2026年6月1日

詳しくは

本研究に関する用語

追加の関連 MeSH 用語

その他の研究ID番号

  • UHS/IRB-26/1974

個々の参加者データ (IPD) の計画

個々の参加者データ (IPD) を共有する予定はありますか?

未定

IPD プランの説明

Individual participant data will not be shared, as the study involves a vulnerable paediatric population. Participant confidentiality and privacy are protected under the study's ethical approval conditions and applicable national research regulations of Pakistan.

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米国FDA規制医薬品の研究

いいえ

米国FDA規制機器製品の研究

いいえ

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