Study to Assess Effectiveness of Oral Atogepant in Adult Participants For Prevention of Migraine in the United Kingdom (PRACTICE)
Patient-Reported Outcomes and Healthcare Resource Use in Patients Initiated With Atogepant in a Primary Care Setting for the Prevention of Migraine: An Ambi-spective Real-World Study in the UK (PRACTICE)
Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound. The study will assess the effectiveness of atogepant for the preventive treatment of migraine in adult patients in the UK.
Atogepant is an approved drug for preventive treatment of migraine in adults. Approximately 200 adult participants who are prescribed atogepant by their doctors will be enrolled in this study in the UK.
Participants will receive atogepant oral tablets as prescribed by their physician. Participants will be followed for up to week 48.
There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.
調査の概要
状態
条件
詳細な説明
研究の種類
入学 (推定)
連絡先と場所
研究連絡先
- 名前：AbbVie Ltd
- 電話番号：+44 (0) 1628 561090
- メール：ukmedinfo@abbvie.com
参加基準
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Physician-confirmed diagnosis of migraine, classified as either episodic or chronic.
- Have at least 1-year history of migraine with or without aura consistent with a diagnosis according to the International Classification of Headache Disorders 3rd edition (ICHD-3), 2018.
- Without prior exposure to atogepant who are being prescribed atogepant in primary care for the prophylaxis of migraine with at least 4 migraine days per month.
- Decision to initiate atogepant was made by a prescribing general practitioner (GP) or appropriate primary care health care professional (HCP) within a primary care setting, prior to and independent of any decision to approach the patient regarding participation in the study.
- Willing and able to comply with the requirements of the study, including being able to read and comprehend written English at a level sufficient to understand and complete study patient-reported outcomes (PROs).
- Not on concomitant preventive medication for migraine or have been on a stable preventive medication for migraine for at least 3 months prior to enrolment.
- Access to a suitable device (e.g., laptop, tablet, or smartphone) to complete PRO measures.
Exclusion Criteria:
- Previously exposed to atogepant as routine therapy before the study period or from clinical trials experience prior to entry.
- Enrolled in any interventional studies that may include investigational compounds for migraine.
- Initiated on atogepant in secondary care and subsequently maintained in primary care.
- Initiated on atogepant in primary care following specialist input via an 'advice and guidance' pathway.
- Contraindications to atogepant administration as per local labelling.
- Pregnant or planning to be pregnant or women of childbearing potential not using contraception.
- In the opinion of the prescribing GP or appropriate primary care HCP, the patient has a history or current evidence of any condition that might interfere with the patient's ability to comply with the study requirements.
研究計画
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
|---|
|
アトゲパント
参加者は、現地のラベルに従って医師の処方に従ってアトゲパントを受け取ります。
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Percentage of Participants Achieving a Rating of "Much Better" or "Very Much Better" Following Atogepant Initiation As Assessed by Patient's Global Impression of Change (PGI-C)
時間枠：Up to approximately 12 Weeks
|
PGI-C is a single item questionnaire used to measure the patient's impression of overall change in migraine since the first dose of atogepant.
The measure uses a 7-point rating scale with responses ranging from "very much better" to "very much worse".
|
Up to approximately 12 Weeks
|
協力者と研究者
スポンサー
捜査官
- スタディディレクター：ABBVIE INC.、AbbVie
研究記録日
主要日程の研究
研究開始 (推定)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。