QLESP Block for Pain Control in Robotic Partial Nephrectomy
Ultrasound-Guided L2 Level QLESP Block for Postoperative Analgesia in Robot-Assisted Partial Nephrectomy: A Prospective Randomized Controlled Trial
The goal of this clinical trial is to learn if an ultrasound-guided nerve block called QLESP works to reduce pain and the need for strong pain medicines after robotic kidney surgery in adults. The main questions it aims to answer are:
- Does QLESP reduce the total amount of opioid pain medicine participants need in the first 48 hours after surgery?
- Does QLESP lower pain scores and improve recovery quality after surgery? Researchers will compare participants who receive QLESP block to participants who receive the same numbing medicine injected only at the surgical wound sites.
Participants will:
- Be randomly assigned to receive either QLESP or local wound injection before surgery.
- Have a patient-controlled pain pump for 48 hours after surgery.
- Complete pain scores and recovery quality questionnaires at 2, 6, 12, 24, 48, and 72 hours after surgery.
- Be followed until hospital discharge.
調査の概要
研究の種類
入学 (推定)
段階
- 適用できない
連絡先と場所
研究連絡先
- 名前：Xi Wu
- 電話番号：+8615871715431
- メール：wu2018whuh@163.com
研究場所
-
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Hubei
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Wuhan、Hubei、中国、430022
- 募集
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
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コンタクト：
- You-nian Xu
- 電話番号：+8613657263415
- メール：xyn0103@hust.edu.cn
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-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Aged 18 to 75 years
- Scheduled for elective robot-assisted partial nephrectomy (RAPN)
- American Society of Anesthesiologists (ASA) physical status I to III
- Body mass index (BMI) 18 to 35 kg/m²
- Voluntarily signed informed consent form Able to understand pain scoring and use of patient-controlled analgesia (PCA)
Exclusion Criteria:
- Language, communication, or comprehension barriers
- Infection at the intended puncture site
- Coagulopathy or bleeding diathesis
- Known allergy or contraindication to local anesthetics or opioids
- Use of analgesic medications within the past 3 months
- Peripheral neuropathy
- Severe cardiac, hepatic, or renal dysfunction
- Pregnancy or breastfeeding
- Refusal to participate in the study
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：ダブル
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
実験的：QLESP Group
Participants receive ultrasound-guided QLESP block with 30 mL of 0.375% ropivacaine (15 mL in the erector spinae fascial plane and 15 mL in the quadratus lumborum-psoas major interfascial plane) after induction of general anesthesia. |
Local wound infiltration with 30 mL of 0.375% ropivacaine at the port sites performed by the surgeon at the end of surgery. |
|
アクティブコンパレータ：Control Group
Participants receive local wound infiltration with 30 mL of 0.375% ropivacaine at the port sites performed by the surgeon at the end of surgery. |
Ultrasound-guided QLESP block with 30 mL of 0.375% ropivacaine (15 mL injected between the erector spinae muscle and the transverse process at L2 level, followed by 15 mL injected between the quadratus lumborum and psoas major muscles) after induction of general anesthesia. |
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Cumulative Opioid Consumption at 48 Hours Postoperatively
時間枠：From the end of surgery to 48 hours postoperatively.
|
Cumulative opioid consumption measured at 48 hours after surgery |
From the end of surgery to 48 hours postoperatively.
|
協力者と研究者
出版物と役立つリンク
一般刊行物
- Elsharkawy H, Bajracharya GR, El-Boghdadly K, Drake RL, Mariano ER. Comparing two posterior quadratus lumborum block approaches with low thoracic erector spinae plane block: an anatomic study. Reg Anesth Pain Med. 2019 Mar 28:rapm-2018-100147. doi: 10.1136/rapm-2018-100147. Online ahead of print.
- Kadam VR, Van Wijk RM, Ludbrook GL, Thiruvenkatarajan V. Anatomical and ultrasound description of two transmuscular quadratus lumborum block approaches at L2 level and their application in abdominal surgery. Anaesth Intensive Care. 2019 Mar;47(2):141-145. doi: 10.1177/0310057X19839931. Epub 2019 May 15.
- Little C, Rahman S. Quadratus Lumborum Blocks in Nephrectomy: A Narrative Review. Local Reg Anesth. 2021 Apr 19;14:57-65. doi: 10.2147/LRA.S290224. eCollection 2021.
- He Y, Huang M, Zhong Q, Ni H, Yu Z, Zhang X. Analgesic Effect of Ultrasound-Guided Anterior Quadratus Lumborum Block at the L2 Level in Patients Undergoing Laparoscopic Partial Nephrectomy: A Single-Center, Randomized Controlled Trial. Pain Res Manag. 2022 Dec 15;2022:8958859. doi: 10.1155/2022/8958859. eCollection 2022.
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
追加の関連 MeSH 用語
その他の研究ID番号
- WHUH20260711
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
IPD プランの説明
The study protocol and informed consent form did not include provisions for secondary data analysis by external researchers.
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
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