The Effectiveness Of Home-Based Circuit Training On Eye Pressure And Eye Nerve Structures In Patients With Glaucoma
The Effectiveness Of Home-Based Circuit Training On Intraocular Pressure, Retinal Nerve Fiber Layers And Choroidal Thickness In Patients With Glaucoma
The goal of this randomised control trial is to learn about the effect of home based circuit training on patients with primary glaucoma.
The main questions to answer are:
- Is there any difference of intraocular pressure (IOP) in patient with primary glaucoma after 6 weeks and 12 weeks who is performing home-based circuit training compared to patient not performing home-based circuit training?
- Is there any difference of retina nerve fibre layer in patient with primary glaucoma after 6 weeks and 12 weeks who is performing home-based circuit training compared to patient not performing home-based circuit training?
- Is there any difference of choroidal thickness layer in patient with primary glaucoma after 6 weeks and 12 weeks who is performing home-based circuit training compared to patient not performing home-based circuit training?
Researchers will compare patients with primary glaucoma who are performing home-based circuit training and not performing home-based circuit training to see if any affect to intraocular pressure, retina nerve fibre layer and choroidal thickness.
調査の概要
詳細な説明
Glaucoma is the leading cause of irreversible blindness worldwide. According to a study, it is known that East Asia has the highest number of people with glaucoma (25.20 million), followed by South- Central Asia (17.06 million) and South East Asia (6.92 million). The global prevalence of glaucoma especially in people aged 40 to 80 years is estimated to be 3.5%. The most important risk factor for glaucoma is aging. With the growing number and proportion of older population, it is projected that 111.8 million people will have glaucoma in 2040. The degeneration of retinal ganglion cells (RGCs) and their axons result in an irreversible loss of vision that has a strong correlation with increasing age. The relationship between exercise and glaucoma is complex as various components of physical activity such as fluctuations in blood pressure, body posture, and Valsalva manoeuvres can influence intraocular pressure (IOP) and ocular perfusion pressure, both of which may play roles in glaucoma pathophysiology.
The investigator would like to evaluate the effect of 12 weeks home-based circuit training on intraocular pressure (IOP), retinal nerve fibre layer thickness (RNFL) and choroidal thickness in patients with primary glaucoma. This is a randomised controlled study involving primary glaucoma patients who are attending ophthalmology clinic at Hospital Universiti Sains Malaysia. Evaluation of study sample includes baseline ocular examination, IOP and Optical Coherence Tomography Retinal Nerve Fibre Layer (OCT RNFL) and sub foveal choroidal thickness. Subjects who fulfil the inclusion and exclusion criteria for the study will be selected.
Patients in Group A will perform home-based circuit training for 12 weeks while other Group B (control group) will not perform home-based circuit training. IOP, OCT RNFL and choroidal thickness measurement will be taken at baseline, 6 weeks and 12 weeks post recruitment of subjects. All patients will be given exercise diary to note down their exercise adherence.
研究の種類
入学 (推定)
段階
- 適用できない
連絡先と場所
研究連絡先
- 名前：THARANI ELUMALAI, MBBS
- 電話番号：+60123789645
- メール：tharanicrystaline93@gmail.com
研究場所
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Kelantan
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Kubang Kerian、Kelantan、マレーシア、16150
- Universiti Sains Malaysia
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コンタクト：
- THARANI ELUMALAI, MBBS
- 電話番号：0123789645
- メール：tharanicrystaline93@gmail.com
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-
参加基準
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
説明
Inclusion Criteria:
- Age ≥ 18 - 70 years old
- Known case of POAG, PACG, JOAG, NTG
- Phakic without visually significant cataract
- Pseudophakic for more than 3 months prior to recruitment
- Achieved target IOP
- Physically not performing routine exercises
Exclusion Criteria:
- Bilateral eye visual acuity of less than 6/60
- Bilateral eye visual field defect of less than 10 degrees from fixation
- Patient with media opacities that affect the reliability of OCT measurements such as cornea opacity, dense cataract with Lens opacification classification system (LOCS III) of more than grade 2, vitreous haemorrhage
- Patient who underwent intraocular surgery (other than uncomplicated cataract surgery), including anti-vascular endothelial growth factor injection within past 6 months
- Ocular disease such as cornea ulcer, uveitis, age-related macula degeneration
- Physical disabilities such as stroke, limbs amputation
- Uncontrolled systemic diseases eg diabetes, hypertension
- Morbid Obesity (BMI > 40)
- Dementia or any psychiatric diseases
- Smoking
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：支持療法
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：ダブル
武器と介入
参加者グループ / アーム |
介入・治療 |
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実験的：Home-Based Circuit Training
Patients in Group A will be performing home-based circuit training three times per week for 12 weeks.
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Participants assigned to the intervention group will perform a home-based circuit training program in addition to receiving standard glaucoma care.
The exercise program consists of seven home-based exercises, including two aerobic exercises and five resistance-based exercises performed in a circuit format.
Each session will last 30 minutes for week 1-6 and 60 minutes for week 7-12.
It is performed three times per week on alternate days for 12 weeks, and is conducted at moderate intensity.
Participants will continue their prescribed glaucoma medications throughout the study.
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介入なし：Control Group
Patients in Group B will not will be performing
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
時間枠 |
|---|---|
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Intraocular pressure
時間枠：Baseline, at 6 weeks and at 12 weeks
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Baseline, at 6 weeks and at 12 weeks
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Retinal Nerve Fiber Layer
時間枠：Baseline, at 6 weeks and at 12 weeks
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Baseline, at 6 weeks and at 12 weeks
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Choroidal Thickness
時間枠：Baseline, at 6 weeks and at 12 weeks
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Baseline, at 6 weeks and at 12 weeks
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協力者と研究者
出版物と役立つリンク
一般刊行物
- Zhu MM, Lai JSM, Choy BNK, Shum JWH, Lo ACY, Ng ALK, Chan JCH, So KF. Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and glaucoma-related mental health. Acta Ophthalmol. 2018 Sep;96(6):e676-e691. doi: 10.1111/aos.13661. Epub 2018 Jan 16.
- Gonzalez-Devesa D, Suarez-Iglesias D, Diz JC, Esmerode-Iglesias A, Ayan C. Systematic review on the impact of exercise on intraocular pressure in glaucoma patients. Int Ophthalmol. 2024 Aug 19;44(1):351. doi: 10.1007/s10792-024-03216-4.
- Anderson AJ. Exercise and Glaucoma: Positive Steps Toward Finding Another Modifiable Risk Factor to Prevent Vision Loss. Ophthalmology. 2019 Jul;126(7):965-966. doi: 10.1016/j.ophtha.2018.12.035. No abstract available.
- Tribble JR, Hui F, Joe M, Bell K, Chrysostomou V, Crowston JG, Williams PA. Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma. Cells. 2021 Feb 1;10(2):295. doi: 10.3390/cells10020295.
- Gildea D, Doyle A, O'Connor J. The Effect of Exercise on Intraocular Pressure and Glaucoma. J Glaucoma. 2024 Jun 1;33(6):381-386. doi: 10.1097/IJG.0000000000002411. Epub 2024 May 10.
研究記録日
主要日程の研究
研究開始 (推定)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
IPD プランの説明
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
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