A Drug-drug Interaction Study of Oral 1250 mg of Vatalinib Administered Under Fasting and Fed Conditions With a Proton-pump Inhibitor in Healthy Sterile or Postmenopausal Female Volunteers

Inclusion criteria

• Healthy female
• Surgically sterile or post-menopausal
• At least a weight of 50 kg and have a body mass index (BMI) ≤33.0
• Non-smokers or those who smoke 25 cigarettes or less per day Exclusion criteria
• Use of certain prescription and over the counter drugs
• Having received an investigational drug within 30 days prior to dosing
• Donation of plasma or donation or loss of whole blood prior to administration of the study medication
• Any clinically significant laboratory tests
• Abnormal cardiac function
• A positive test for HIV, Hepatitis B or C
• A positive alcohol test or drug test
• Known allergy to Vatalinib or Omeprazole
• Any surgical or medical condition which might significantly alter the absorption, distribution, metabolism and excretion or drugs.

Other protocol-defined inclusion/exclusion criteria may apply