Infertility and Endometriosis Cohort (EndoFertil)
Infertility and Endometriosis : a Prospective Cohort Study
Nowadays, one in six couples consults for fertility problems. If the standard examination and tests do not reveal any cause of infertility, the woman may undergo a laparoscopic exploration which reveals endometriosis in more than 50% of cases.
Endometriosis is an inflammatory disease defined as the presence of endometrial tissue out of the uterine cavity. It is frequent (1 in 10 women) and associated with a high economic burden (22 billion dollars in 2002 in the USA) and important decrease in quality of life. Physiopathological mechanisms and risk factors for endometriosis are not well identified.
A woman with endometriosis is 20 times more at risk of infertility. Fecundity rate of a 25-year-old couple is about 15 to 20% in the general population and only 2 to 10% in case of endometriosis.
There are many manifestations of this disease (infertility, pelvic pain) and the anatomo-clinical correlation is not good. The presently used international classification (American Fertility Society revised in 1985, AFSr) does not predict the chance of pregnancy. New scores such as the Endometriosis Fertility Index (EFI) have been proposed to do so, but need to be validated. Treatment for endometriosis-related infertility is not consensual.
A prospective cohort study would give access to clinical data of patients followed in our center, so as to identify clinical factors predicting pregnancy and to help treatment decision for women with endometriosis suffering from infertility.
연구 개요
연구 유형
등록 (예상)
단계
- 해당 없음
연락처 및 위치
연구 장소
-
-
Herault
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Montpellier, Herault, 프랑스, 34295
- 모병
- University Hospital Montpellier
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연락하다:
- Herve Dechaud, MD,PhD
- 전화번호: +33467336532
- 이메일: h-dechaud@chu-montpellier.fr
-
수석 연구원:
- Herve Dechaud, MD,PhD
-
-
참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion criteria:
- Woman from 18 to 41 years old.
- Dealing with infertility,
- With a normal pelvic echography and hysterosalpingography, a normal hormonal status and a partner with a normal sperm.
- For whom a laparoscopic exploration finds endometriosis.
- Consenting to participate to the study.
Exclusion criteria:
- Any contraindication for general anesthesia or for laparoscopy.
- Any contraindication for pregnancy.
- Follow-up is impossible.
- Consent is impossible.
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 할당: 해당 없음
- 중재 모델: 단일 그룹 할당
- 마스킹: 없음(오픈 라벨)
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
|---|---|
|
다른: endometriosis cohort
females suffer from endometriosis
|
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
live birth date
기간: 3 years
|
Assessment of the number of live birth in the 3 years following the laparoscopic exploration making the diagnosis of endometriosis
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3 years
|
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Quality of life
기간: 3 years
|
Assessment of the quality of life relating to infertility and endometriosis in the 3 years following laparoscopic exploration making the diagnosis of endometriosis.
|
3 years
|
|
pain symptoms
기간: 3 years
|
Assessment of the pain symptoms relating to infertility and endometriosis in the 3 years following laparoscopic exploration making the diagnosis of endometriosis.
|
3 years
|
공동 작업자 및 조사자
수사관
- 수석 연구원: Herve Dechaud, MD,PhD, University Hospital, Montpellier
연구 기록 날짜
연구 주요 날짜
연구 시작
기본 완료 (예상)
연구 완료 (예상)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (추정)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
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