Health Enhancement And Resilience Training (HEART)
The Effect of a Stress Reduction Program Using Mindfulness Techniques on Markers of Cellular Stress and Aging
연구 개요
상세 설명
This stress-reduction intervention was added into an ongoing observational study in May of 2013. The parent study is a prospective cohort study of the effects of chronic stress in a group of maternal caregivers with children on the autism spectrum and healthy controls whose children have no diagnosis. Study participants are being invited to enroll in a 12-week stress reduction course based on the principles of mindfulness. They will attend four six-hour workshops and participate in 12 weekly hour-long web video conferencing calls to reinforce what is taught in the workshops.
At the beginning and the end of the intervention, they complete self-report measures of psychological well-being and give saliva samples. Since the women are also participating in the longitudinal study, we have other before and after data for them. These include psycho-social measures, body measurements, psycho-physiology measurements, cognitive tests, actigraphy (for sleep), as well as saliva (for hormones), hair (for hormones) and blood (for telomeres, telomerase, gene expression, circulating hormones, inflammation and oxidative stress).
연구 유형
등록 (실제)
단계
- 해당 없음
연락처 및 위치
연구 장소
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California
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San Francisco, California, 미국, 94118
- University of California, San Francisco
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- Must have at least one child between 2 and 16 at time of enrollment
- Caregivers must have a child diagnosed in that age range diagnosed with an autism spectrum disorder.
- Controls must have a healthy child in that age range. All women must be
Exclusion Criteria:
- Chronic disease, including recent history of cancer
- History of psychiatric disorder, such as bipolar disorder or post-traumatic stress disorder
- Medications, including statins, anti-anxiety drugs, and for controls only anti-depressants.
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 기초 과학
- 할당: 해당 없음
- 중재 모델: 단일 그룹 할당
- 마스킹: 없음(오픈 라벨)
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
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실험적: Stress-reduction class
Study participants enrolled in a 12-week stress reduction course based on the principles of mindfulness.
They attended four six-hour workshops and participated in 12 weekly hour-long web video conferencing calls to reinforce what was taught in the workshops.
We have two groups: chronically-stressed maternal caregivers of children on the autism spectrum and control mothers whose children have no significant psychiatric or physical impairment.
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Study participants enrolled in a 12-week stress reduction course based on the principles of mindfulness.
They attended four six-hour workshops and participated in 12 weekly hour-long web video conferencing calls to reinforce what was taught in the workshops.
We have two groups: chronically-stressed maternal caregivers of children on the autism spectrum and control mothers whose children have no significant psychiatric or physical impairment.
Both groups received similar instruction.
다른 이름들:
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Salivary telomere length
기간: Change from beginning to end of 12-week intervention
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Participants will give saliva samples at the beginning and the end of the intervention.
Salivary telomere length will be analyzed at both time points.
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Change from beginning to end of 12-week intervention
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Psychological Well-Being
기간: Change from beginning to end of 12-week intervention
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We will collect perceived stress, acceptance and awareness of emotions and rumination at the beginning and at the end of the intervention.
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Change from beginning to end of 12-week intervention
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Telomere length from blood cells
기간: Change over six months pre- and post-intervention
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Since participants are also taking part in an ongoing non-interventional longitudinal study, they will provide blood samples at their 18-month study visit, which occurs before the start of the intervention, and at the 24-month study visit, which occurs after the end of the intervention.
We will measure telomere length pre- and post-intervention in a variety of blood cell types.
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Change over six months pre- and post-intervention
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Telomerase
기간: Change over 6 months pre- and post-intervention
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Since participants are also taking part in an ongoing non-interventional longitudinal study, they will provide blood samples at their 18-month study visit, which occurs before the start of the intervention, and at the 24-month study visit, which occurs after the end of the intervention.
We will measure telomerase pre- and post-intervention in a variety of blood cell types.
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Change over 6 months pre- and post-intervention
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Cognitive functioning
기간: Change over six months pre- and post-intervention
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Since participants are also taking part in an ongoing non-interventional longitudinal study, they will complete a battery of cognitive tasks at their 18-month study visit, which occurs before the start of the intervention, and at the 24-month study visit, which occurs after the end of the intervention.
We will be able to assess performance pre- and post-intervention, to see if it improves after the stress-reduction training.
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Change over six months pre- and post-intervention
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공동 작업자 및 조사자
수사관
- 수석 연구원: Elissa S Epel, PhD, University of California, San Francisco
- 수석 연구원: Elizabeth Blackburn, PhD, University of California, San Francisco
- 수석 연구원: Jue Lin, PhD, University of California, San Francisco
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
기타 연구 ID 번호
- 10-02063
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