A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events (DEVOTE)
2019년 7월 10일 업데이트: Novo Nordisk A/S
This trial is conducted globally.
The aim of this trial is to compare cardiovascular safety of insulin degludec versus insulin glargine in subjects with type 2 diabetes at high risk of cardiovascular events.
연구 개요
연구 유형
중재적
등록 (실제)
7637
단계
- 3단계
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 장소
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Athens, 그리스, GR-17562
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Athens, 그리스, GR-11527
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Athens, 그리스, GR-115 27
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Athens, 그리스, GR-10552
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Thessaloniki, 그리스, GR-57001
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Thessaloniki, 그리스, GR-54642
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Eastern Cape
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Port Elizabeth, Eastern Cape, 남아프리카, 6045
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Port Elizabeth, Eastern Cape, 남아프리카, 6014
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Gauteng
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Johannesburg, Gauteng, 남아프리카, 2193
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Johannesburg, Gauteng, 남아프리카, 1818
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Johannesburg, Gauteng, 남아프리카, 2198
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Pretoria, Gauteng, 남아프리카, 0001
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KwaZulu-Natal
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Durban, KwaZulu-Natal, 남아프리카, 4001
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Durban, KwaZulu-Natal, 남아프리카, 4092
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Umkomaas, KwaZulu-Natal, 남아프리카, 4170
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Mpumalanga
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Middleburg, Mpumalanga, 남아프리카, 1055
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North West
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Brits, North West, 남아프리카, 0250
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Western Cape
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Cape Town, Western Cape, 남아프리카, 7130
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Cape Town, Western Cape, 남아프리카, 7500
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Cape Town, Western Cape, 남아프리카, 7700
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Cape Town, Western Cape, 남아프리카, 7460
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Goyang, 대한민국, 10380
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Seoul, 대한민국, 02841
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Seoul, 대한민국, 03080
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Suwon-si, Gyeonggi-do, 대한민국, 16247
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Ekaterinburg, 러시아 연방, 620102
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Kemerovo, 러시아 연방, 650002
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Kirov, 러시아 연방, 610014
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Krasnodar, 러시아 연방, 350012
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Krasnodar, 러시아 연방, 350086
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Moscow, 러시아 연방, 123423
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Moscow, 러시아 연방, 111539
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Nizhny Novgorod, 러시아 연방, 603018
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Rostov-on-Don, 러시아 연방, 344068
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Saint-Petersburg, 러시아 연방, 194356
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Saint-Petersburg, 러시아 연방, 195213
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Saint-Petersburg, 러시아 연방, 191119
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Saratov, 러시아 연방, 410053
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Saratov, 러시아 연방, 410031
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St. Petersburg, 러시아 연방, 194354
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St. Petersburg, 러시아 연방, 196084
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Syktyvkar, 러시아 연방, 167981
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Tumen, 러시아 연방, 625023
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Tver, 러시아 연방, 170036
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Ulianovsk, 러시아 연방, 432063
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Volgograd, 러시아 연방, 400131
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Yaroslavl, 러시아 연방, 150010
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Alba
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Alba Iulia, Alba, 루마니아, 510053
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Maramures
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Baia Mare, Maramures, 루마니아, 430222
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Mures
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Targu Mures, Mures, 루마니아, 540142
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Prahova
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Ploiesti, Prahova, 루마니아, 100163
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Alor Setar, 말레이시아, 05460
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Kota Samarahan, 말레이시아, 94300
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Kuala Lumpur, 말레이시아, 59100
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Kuantan, 말레이시아, 25100
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Melaka, 말레이시아, 75400
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Serdang, 말레이시아, 43000
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Seremban, 말레이시아, 70300
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Aguascalientes, 멕시코, 20230
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Chihuahua, 멕시코, 31200
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San Luis Potosi, 멕시코, 78200
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Jalisco
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Guadalajara, Jalisco, 멕시코, 44600
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Guadalajara, Jalisco, 멕시코, 44130
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Guadalajara, Jalisco, 멕시코, 44650
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Guadalajara, Jalisco, 멕시코, 44670
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Guadalajara, Jalisco, 멕시코, 44150
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Morelos
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Cuernavaca, Morelos, 멕시코, 62250
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México, D.F.
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Distrito Federal, México, D.F., 멕시코, 14080
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Alabama
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Birmingham, Alabama, 미국, 35294
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Birmingham, Alabama, 미국, 35216
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Montgomery, Alabama, 미국, 36106
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Montgomery, Alabama, 미국, 36109
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Arizona
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Gilbert, Arizona, 미국, 85295
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Glendale, Arizona, 미국, 85308
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Litchfield Park, Arizona, 미국, 85340
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Phoenix, Arizona, 미국, 85050
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Tucson, Arizona, 미국, 85714
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Tucson, Arizona, 미국, 85704
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Tucson, Arizona, 미국, 85723
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Arkansas
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Little Rock, Arkansas, 미국, 72205
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Little Rock, Arkansas, 미국, 72205-5446
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Searcy, Arkansas, 미국, 72143
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California
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Chula Vista, California, 미국, 91910
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Concord, California, 미국, 94520
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Downey, California, 미국, 90242
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Duarte, California, 미국, 91010
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Encino, California, 미국, 91436
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Fresno, California, 미국, 93720
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Greenbrae, California, 미국, 94904
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Huntington Beach, California, 미국, 92648
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Inglewood, California, 미국, 90301
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La Jolla, California, 미국, 92037
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La Mesa, California, 미국, 91942
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Lancaster, California, 미국, 93534
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Long Beach, California, 미국, 90822
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Los Alamitos, California, 미국, 90720
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Mission Hills, California, 미국, 91345
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Montclair, California, 미국, 91763
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Monterey, California, 미국, 93940
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North Hollywood, California, 미국, 91606
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Palm Springs, California, 미국, 92262
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Poway, California, 미국, 92064
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San Diego, California, 미국, 92111
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San Diego, California, 미국, 92120
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San Ramon, California, 미국, 94583
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Santa Ana, California, 미국, 92704
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Sherman Oaks, California, 미국, 91403
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Thousand Oaks, California, 미국, 91360
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Tustin, California, 미국, 92780
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Ventura, California, 미국, 93003
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Vista, California, 미국, 92083
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Westminster, California, 미국, 92683
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Colorado
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Colorado Springs, Colorado, 미국, 80909
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Denver, Colorado, 미국, 80220
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Denver, Colorado, 미국, 80246
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Golden, Colorado, 미국, 80401
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Connecticut
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Danbury, Connecticut, 미국, 06810
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Norwalk, Connecticut, 미국, 06851
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Waterbury, Connecticut, 미국, 06708
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Florida
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Boca Raton, Florida, 미국, 33433
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Boynton Beach, Florida, 미국, 33472
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Bradenton, Florida, 미국, 34201
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Brandon, Florida, 미국, 33511
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Clearwater, Florida, 미국, 33756
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Cooper City, Florida, 미국, 33024
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Fleming Island, Florida, 미국, 32003
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Fort Lauderdale, Florida, 미국, 33316
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Gainesville, Florida, 미국, 32610
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Green Cove Springs, Florida, 미국, 32043
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Hialeah, Florida, 미국, 33012
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Jacksonville, Florida, 미국, 32216
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Jacksonville, Florida, 미국, 32207
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Miami, Florida, 미국, 33135
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Miami, Florida, 미국, 33136
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Miami, Florida, 미국, 33183
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Miami, Florida, 미국, 33155
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Miami, Florida, 미국, 33165
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Naples, Florida, 미국, 34119
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New Port Richey, Florida, 미국, 34652
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Orlando, Florida, 미국, 32806
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Panama City, Florida, 미국, 32401
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Ponte Vedra, Florida, 미국, 32081
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Port Charlotte, Florida, 미국, 33952
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Port Orange, Florida, 미국, 32127
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South Miami, Florida, 미국, 33143
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Tampa, Florida, 미국, 33624
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Tampa, Florida, 미국, 33619
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Georgia
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Atlanta, Georgia, 미국, 30339
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Decatur, Georgia, 미국, 30033
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Dunwoody, Georgia, 미국, 30338
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Lawrenceville, Georgia, 미국, 30046
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Roswell, Georgia, 미국, 30076
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Savannah, Georgia, 미국, 31406
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Hawaii
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Honolulu, Hawaii, 미국, 96814
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Idaho
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Idaho Falls, Idaho, 미국, 83404-7596
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Illinois
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Addison, Illinois, 미국, 60101
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Champaign, Illinois, 미국, 61821
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Chicago, Illinois, 미국, 60607
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Chicago, Illinois, 미국, 60616
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Crystal Lake, Illinois, 미국, 60012
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Gurnee, Illinois, 미국, 60031
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Hines, Illinois, 미국, 60141
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Springfield, Illinois, 미국, 62711
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Springfield, Illinois, 미국, 62702
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Indiana
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Brownsburg, Indiana, 미국, 46112
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Evansville, Indiana, 미국, 47714
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Franklin, Indiana, 미국, 46131
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Greenfield, Indiana, 미국, 46140
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Indianapolis, Indiana, 미국, 46254
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Michigan City, Indiana, 미국, 46360
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Muncie, Indiana, 미국, 47304
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Iowa
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Council Bluffs, Iowa, 미국, 51501
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Kansas
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Wichita, Kansas, 미국, 67205
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Kentucky
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Lexington, Kentucky, 미국, 40503
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Lexington, Kentucky, 미국, 40502
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Louisville, Kentucky, 미국, 40213
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Louisville, Kentucky, 미국, 40206
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Madisonville, Kentucky, 미국, 42431
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Louisiana
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Monroe, Louisiana, 미국, 71203
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New Orleans, Louisiana, 미국, 70119
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Shreveport, Louisiana, 미국, 71103
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Slidell, Louisiana, 미국, 70461-4231
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Maine
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Bangor, Maine, 미국, 04401
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Maryland
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Hyattsville, Maryland, 미국, 20782
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Rockville, Maryland, 미국, 20852
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Massachusetts
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Watertown, Massachusetts, 미국, 02472
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Worcester, Massachusetts, 미국, 01655
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Michigan
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Ann Arbor, Michigan, 미국, 48106
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Ann Arbor, Michigan, 미국, 48105
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Buckley, Michigan, 미국, 49620
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Detroit, Michigan, 미국, 48201
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Detroit, Michigan, 미국, 48202
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Kalamazoo, Michigan, 미국, 49009
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Livonia, Michigan, 미국, 48152
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Troy, Michigan, 미국, 48098
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Mississippi
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Olive Branch, Mississippi, 미국, 38654
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Missouri
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Hazelwood, Missouri, 미국, 63042
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Jefferson City, Missouri, 미국, 65109
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Kansas City, Missouri, 미국, 64111
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Montana
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Billings, Montana, 미국, 59101
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Kalispell, Montana, 미국, 59901
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Nebraska
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Elkhorn, Nebraska, 미국, 68022
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Fremont, Nebraska, 미국, 68025
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Omaha, Nebraska, 미국, 68114
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Omaha, Nebraska, 미국, 68105
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Omaha, Nebraska, 미국, 68124
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Omaha, Nebraska, 미국, 68144
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Omaha, Nebraska, 미국, 68198-4120
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Nevada
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Las Vegas, Nevada, 미국, 89148
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Las Vegas, Nevada, 미국, 89128
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Las Vegas, Nevada, 미국, 89120
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New Hampshire
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Nashua, New Hampshire, 미국, 03063
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New Jersey
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East Brunswick, New Jersey, 미국, 08816
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Hoboken, New Jersey, 미국, 07030
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New York
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Albany, New York, 미국, 12206
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Lake Success, New York, 미국, 11042
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Mineola, New York, 미국, 11501
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New Windsor, New York, 미국, 12553
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New York, New York, 미국, 10029
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North Massapequa, New York, 미국, 11758-1802
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Northport, New York, 미국, 11768
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Rochester, New York, 미국, 14607
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West Seneca, New York, 미국, 14224
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Westfield, New York, 미국, 14787
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North Carolina
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Asheville, North Carolina, 미국, 28803
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Asheville, North Carolina, 미국, 28801
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Burlington, North Carolina, 미국, 27215
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Cary, North Carolina, 미국, 27518
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Chapel Hill, North Carolina, 미국, 27517
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Charlotte, North Carolina, 미국, 28209
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Greenville, North Carolina, 미국, 27834
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Lexington, North Carolina, 미국, 27292
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Morehead City, North Carolina, 미국, 28557
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New Bern, North Carolina, 미국, 28562
- Novo Nordisk Investigational Site
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Statesville, North Carolina, 미국, 28625
- Novo Nordisk Investigational Site
-
Whiteville, North Carolina, 미국, 28472
- Novo Nordisk Investigational Site
-
Wilmington, North Carolina, 미국, 28401
- Novo Nordisk Investigational Site
-
Winston-Salem, North Carolina, 미국, 27103
- Novo Nordisk Investigational Site
-
-
North Dakota
-
Fargo, North Dakota, 미국, 58104
- Novo Nordisk Investigational Site
-
-
Ohio
-
Cincinnati, Ohio, 미국, 45236
- Novo Nordisk Investigational Site
-
Cleveland, Ohio, 미국, 44195
- Novo Nordisk Investigational Site
-
Cleveland, Ohio, 미국, 44106-1702
- Novo Nordisk Investigational Site
-
Cleveland, Ohio, 미국, 44121
- Novo Nordisk Investigational Site
-
Columbus, Ohio, 미국, 43235
- Novo Nordisk Investigational Site
-
Delaware, Ohio, 미국, 43015
- Novo Nordisk Investigational Site
-
Franklin, Ohio, 미국, 45005
- Novo Nordisk Investigational Site
-
Maumee, Ohio, 미국, 43537
- Novo Nordisk Investigational Site
-
Mentor, Ohio, 미국, 44060
- Novo Nordisk Investigational Site
-
Perrysburg, Ohio, 미국, 43551
- Novo Nordisk Investigational Site
-
-
Oklahoma
-
Norman, Oklahoma, 미국, 73069
- Novo Nordisk Investigational Site
-
Oklahoma City, Oklahoma, 미국, 73104
- Novo Nordisk Investigational Site
-
-
Oregon
-
Portland, Oregon, 미국, 97239-3098
- Novo Nordisk Investigational Site
-
-
Pennsylvania
-
Altoona, Pennsylvania, 미국, 16602
- Novo Nordisk Investigational Site
-
Beaver, Pennsylvania, 미국, 15009
- Novo Nordisk Investigational Site
-
Danville, Pennsylvania, 미국, 17822
- Novo Nordisk Investigational Site
-
Hermitage, Pennsylvania, 미국, 16148
- Novo Nordisk Investigational Site
-
Philadelphia, Pennsylvania, 미국, 19107
- Novo Nordisk Investigational Site
-
Philadelphia, Pennsylvania, 미국, 19114
- Novo Nordisk Investigational Site
-
Pittsburgh, Pennsylvania, 미국, 15243
- Novo Nordisk Investigational Site
-
Pittsburgh, Pennsylvania, 미국, 15212
- Novo Nordisk Investigational Site
-
Smithfield, Pennsylvania, 미국, 15478
- Novo Nordisk Investigational Site
-
Uniontown, Pennsylvania, 미국, 15401
- Novo Nordisk Investigational Site
-
Upper Darby, Pennsylvania, 미국, 19082
- Novo Nordisk Investigational Site
-
Wilkes-Barre, Pennsylvania, 미국, 18702
- Novo Nordisk Investigational Site
-
-
South Carolina
-
Anderson, South Carolina, 미국, 29621
- Novo Nordisk Investigational Site
-
Greer, South Carolina, 미국, 29651
- Novo Nordisk Investigational Site
-
Moncks Corner, South Carolina, 미국, 29461
- Novo Nordisk Investigational Site
-
Murrells Inlet, South Carolina, 미국, 29576
- Novo Nordisk Investigational Site
-
Myrtle Beach, South Carolina, 미국, 29572
- Novo Nordisk Investigational Site
-
Orangeburg, South Carolina, 미국, 29118
- Novo Nordisk Investigational Site
-
Spartanburg, South Carolina, 미국, 29303
- Novo Nordisk Investigational Site
-
-
Tennessee
-
Chattanooga, Tennessee, 미국, 37404
- Novo Nordisk Investigational Site
-
Chattanooga, Tennessee, 미국, 37411
- Novo Nordisk Investigational Site
-
Chattanooga, Tennessee, 미국, 37404-1192
- Novo Nordisk Investigational Site
-
Kingsport, Tennessee, 미국, 37660
- Novo Nordisk Investigational Site
-
Knoxville, Tennessee, 미국, 37938
- Novo Nordisk Investigational Site
-
Memphis, Tennessee, 미국, 38119
- Novo Nordisk Investigational Site
-
Memphis, Tennessee, 미국, 38163
- Novo Nordisk Investigational Site
-
Nashville, Tennessee, 미국, 37212
- Novo Nordisk Investigational Site
-
Nashville, Tennessee, 미국, 37203
- Novo Nordisk Investigational Site
-
Nashville, Tennessee, 미국, 37208
- Novo Nordisk Investigational Site
-
Tullahoma, Tennessee, 미국, 37388
- Novo Nordisk Investigational Site
-
-
Texas
-
Arlington, Texas, 미국, 76012
- Novo Nordisk Investigational Site
-
Austin, Texas, 미국, 78731
- Novo Nordisk Investigational Site
-
Austin, Texas, 미국, 78749
- Novo Nordisk Investigational Site
-
Austin, Texas, 미국, 78705
- Novo Nordisk Investigational Site
-
Carrollton, Texas, 미국, 75010
- Novo Nordisk Investigational Site
-
Carrollton, Texas, 미국, 75007
- Novo Nordisk Investigational Site
-
Corpus Christi, Texas, 미국, 78404
- Novo Nordisk Investigational Site
-
Dallas, Texas, 미국, 75230
- Novo Nordisk Investigational Site
-
Dallas, Texas, 미국, 75390-9302
- Novo Nordisk Investigational Site
-
Dallas, Texas, 미국, 75231
- Novo Nordisk Investigational Site
-
Dallas, Texas, 미국, 75246
- Novo Nordisk Investigational Site
-
Fort Worth, Texas, 미국, 76117
- Novo Nordisk Investigational Site
-
Fort Worth, Texas, 미국, 76132
- Novo Nordisk Investigational Site
-
Houston, Texas, 미국, 77024
- Novo Nordisk Investigational Site
-
Houston, Texas, 미국, 77061
- Novo Nordisk Investigational Site
-
Houston, Texas, 미국, 77008
- Novo Nordisk Investigational Site
-
Houston, Texas, 미국, 77070
- Novo Nordisk Investigational Site
-
Houston, Texas, 미국, 77099
- Novo Nordisk Investigational Site
-
Houston, Texas, 미국, 77060
- Novo Nordisk Investigational Site
-
Houston, Texas, 미국, 77029
- Novo Nordisk Investigational Site
-
Houston, Texas, 미국, 77093
- Novo Nordisk Investigational Site
-
Humble, Texas, 미국, 77338
- Novo Nordisk Investigational Site
-
Hurst, Texas, 미국, 76054
- Novo Nordisk Investigational Site
-
Irving, Texas, 미국, 75039
- Novo Nordisk Investigational Site
-
Lewisville, Texas, 미국, 75067
- Novo Nordisk Investigational Site
-
Longview, Texas, 미국, 75605
- Novo Nordisk Investigational Site
-
Lubbock, Texas, 미국, 79423
- Novo Nordisk Investigational Site
-
Midland, Texas, 미국, 79707
- Novo Nordisk Investigational Site
-
Odessa, Texas, 미국, 79761
- Novo Nordisk Investigational Site
-
Pearland, Texas, 미국, 77584
- Novo Nordisk Investigational Site
-
Richardson, Texas, 미국, 75080
- Novo Nordisk Investigational Site
-
Round Rock, Texas, 미국, 78681
- Novo Nordisk Investigational Site
-
San Antonio, Texas, 미국, 78229
- Novo Nordisk Investigational Site
-
San Antonio, Texas, 미국, 78215
- Novo Nordisk Investigational Site
-
San Antonio, Texas, 미국, 78228-6205
- Novo Nordisk Investigational Site
-
San Antonio, Texas, 미국, 78258
- Novo Nordisk Investigational Site
-
Splendora, Texas, 미국, 77372
- Novo Nordisk Investigational Site
-
Sugar Land, Texas, 미국, 77478
- Novo Nordisk Investigational Site
-
Sugar Land, Texas, 미국, 77479
- Novo Nordisk Investigational Site
-
Waco, Texas, 미국, 76710
- Novo Nordisk Investigational Site
-
-
Utah
-
Salt Lake City, Utah, 미국, 84102
- Novo Nordisk Investigational Site
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Salt Lake City, Utah, 미국, 84132
- Novo Nordisk Investigational Site
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-
Vermont
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Bennington, Vermont, 미국, 05201
- Novo Nordisk Investigational Site
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South Burlington, Vermont, 미국, 05403
- Novo Nordisk Investigational Site
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Virginia
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Midlothian, Virginia, 미국, 23114
- Novo Nordisk Investigational Site
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Norfolk, Virginia, 미국, 23510
- Novo Nordisk Investigational Site
-
Richmond, Virginia, 미국, 23249
- Novo Nordisk Investigational Site
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Winchester, Virginia, 미국, 22601-3834
- Novo Nordisk Investigational Site
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Washington
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Richland, Washington, 미국, 99352
- Novo Nordisk Investigational Site
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Spokane, Washington, 미국, 99201
- Novo Nordisk Investigational Site
-
-
Wisconsin
-
Kenosha, Wisconsin, 미국, 53144
- Novo Nordisk Investigational Site
-
Milwaukee, Wisconsin, 미국, 53209
- Novo Nordisk Investigational Site
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Milwaukee, Wisconsin, 미국, 53295
- Novo Nordisk Investigational Site
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-
-
-
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Fortaleza, 브라질, 60430-350
- Novo Nordisk Investigational Site
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Porto Alegre, 브라질, 90035-170
- Novo Nordisk Investigational Site
-
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Ceara
-
Fortaleza, Ceara, 브라질, 60115-282
- Novo Nordisk Investigational Site
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Distrito Federal
-
Brasília, Distrito Federal, 브라질, 71625-009
- Novo Nordisk Investigational Site
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Goias
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Aparecida de Goiania, Goias, 브라질, 74935-530
- Novo Nordisk Investigational Site
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Para
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Belém, Para, 브라질, 66073-000
- Novo Nordisk Investigational Site
-
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Sao Paulo
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Mogi das Cruzes, Sao Paulo, 브라질, 08780-090
- Novo Nordisk Investigational Site
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São Paulo, Sao Paulo, 브라질, 05403-000
- Novo Nordisk Investigational Site
-
São Paulo, Sao Paulo, 브라질, 01223-001
- Novo Nordisk Investigational Site
-
São Paulo, Sao Paulo, 브라질, 01228-000
- Novo Nordisk Investigational Site
-
São Paulo, Sao Paulo, 브라질, 01228-200
- Novo Nordisk Investigational Site
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-
-
-
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Granada, 스페인, 18012
- Novo Nordisk Investigational Site
-
Granada, 스페인, 18003
- Novo Nordisk Investigational Site
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Madrid, 스페인, 28046
- Novo Nordisk Investigational Site
-
Málaga, 스페인, 29006
- Novo Nordisk Investigational Site
-
Sevilla, 스페인, 41009
- Novo Nordisk Investigational Site
-
Valencia, 스페인, 46014
- Novo Nordisk Investigational Site
-
Valencia, 스페인, 46015
- Novo Nordisk Investigational Site
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-
-
-
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Caba, 아르헨티나, C1440AAD
- Novo Nordisk Investigational Site
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Cordoba, 아르헨티나, 5000
- Novo Nordisk Investigational Site
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Mar del Plata, 아르헨티나, B7600FZN
- Novo Nordisk Investigational Site
-
Rosario, 아르헨티나, S2000CUD
- Novo Nordisk Investigational Site
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Zarate, 아르헨티나, B2800DGH
- Novo Nordisk Investigational Site
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-
-
-
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Algiers, 알제리, 16000
- Novo Nordisk Investigational Site
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Constantine, 알제리, 25000
- Novo Nordisk Investigational Site
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Oran, 알제리, 31000
- Novo Nordisk Investigational Site
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Sidi Bel Abbes, 알제리, 22000
- Novo Nordisk Investigational Site
-
-
-
-
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Bristol, 영국, BS10 5NB
- Novo Nordisk Investigational Site
-
Dundee, 영국, DD1 9SY
- Novo Nordisk Investigational Site
-
Edinburgh, 영국, EH4 2XU
- Novo Nordisk Investigational Site
-
Guildford, 영국, GU2 7XX
- Novo Nordisk Investigational Site
-
Norwich, 영국, NR4 7TJ
- Novo Nordisk Investigational Site
-
Nuneaton, 영국, CV10 7DJ
- Novo Nordisk Investigational Site
-
Stevenage, 영국, SG1 4AB
- Novo Nordisk Investigational Site
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Wolverhampton, 영국, WV10 0QP
- Novo Nordisk Investigational Site
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-
-
-
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Bari, 이탈리아, 70124
- Novo Nordisk Investigational Site
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Bergamo, 이탈리아, 24127
- Novo Nordisk Investigational Site
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Catanzaro, 이탈리아, 88100
- Novo Nordisk Investigational Site
-
Chieti, 이탈리아, 66100
- Novo Nordisk Investigational Site
-
Milano, 이탈리아, 20122
- Novo Nordisk Investigational Site
-
Milano, 이탈리아, 20162
- Novo Nordisk Investigational Site
-
Milano (MI), 이탈리아, 20132
- Novo Nordisk Investigational Site
-
Olbia, 이탈리아, 07026
- Novo Nordisk Investigational Site
-
Padova, 이탈리아, 35143
- Novo Nordisk Investigational Site
-
Palermo, 이탈리아, 90127
- Novo Nordisk Investigational Site
-
Ravenna, 이탈리아, 48121
- Novo Nordisk Investigational Site
-
Roma, 이탈리아, 00161
- Novo Nordisk Investigational Site
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Roma, 이탈리아, 00133
- Novo Nordisk Investigational Site
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Sesto San Giovanni (MI), 이탈리아, 20099
- Novo Nordisk Investigational Site
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-
-
-
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Ludhiana, 인도, 141001
- Novo Nordisk Investigational Site
-
New Delhi, 인도, 110001
- Novo Nordisk Investigational Site
-
-
Andhra Pradesh
-
Hyderabad, Andhra Pradesh, 인도, 500034
- Novo Nordisk Investigational Site
-
Hyderbad, Andhra Pradesh, 인도, 500 012
- Novo Nordisk Investigational Site
-
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Gujarat
-
Ahmedabad, Gujarat, 인도, 380006
- Novo Nordisk Investigational Site
-
Ahmedabad, Gujarat, 인도, 380052
- Novo Nordisk Investigational Site
-
Ahmedabad, Gujarat, 인도, 380007
- Novo Nordisk Investigational Site
-
Ahmedabad, Gujarat, 인도, 380016
- Novo Nordisk Investigational Site
-
-
Haryana
-
Gurgaon, Haryana, 인도, 122001
- Novo Nordisk Investigational Site
-
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Karnataka
-
Bangalore, Karnataka, 인도, 560034
- Novo Nordisk Investigational Site
-
Bangalore, Karnataka, 인도, 560 017
- Novo Nordisk Investigational Site
-
-
Kerala
-
Kozhikode, Kerala, 인도, 673017
- Novo Nordisk Investigational Site
-
-
Madhya Pradesh
-
Indore, Madhya Pradesh, 인도, 452010
- Novo Nordisk Investigational Site
-
-
Maharashtra
-
Goa, Maharashtra, 인도, 403 202
- Novo Nordisk Investigational Site
-
Mumbai, Maharashtra, 인도, 400008
- Novo Nordisk Investigational Site
-
Mumbai, Maharashtra, 인도, 400012
- Novo Nordisk Investigational Site
-
Mumbai, Maharashtra, 인도, 400022
- Novo Nordisk Investigational Site
-
Mumbai, Maharashtra, 인도, 400010
- Novo Nordisk Investigational Site
-
Mumbai, Maharashtra, 인도, 400007
- Novo Nordisk Investigational Site
-
Pune, Maharashtra, 인도, 411001
- Novo Nordisk Investigational Site
-
Pune, Maharashtra, 인도, 411040
- Novo Nordisk Investigational Site
-
-
New Delhi
-
New Dehli, New Delhi, 인도, 110029
- Novo Nordisk Investigational Site
-
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Orissa
-
Bhubaneswar, Orissa, 인도, 751005
- Novo Nordisk Investigational Site
-
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Punjab
-
Mohali, Punjab, 인도, 160062
- Novo Nordisk Investigational Site
-
-
Tamil Nadu
-
Chennai, Tamil Nadu, 인도, 600086
- Novo Nordisk Investigational Site
-
Chennai, Tamil Nadu, 인도, 600031
- Novo Nordisk Investigational Site
-
Coimbatore, Tamil Nadu, 인도, 641018
- Novo Nordisk Investigational Site
-
-
Uttar Pradesh
-
Lucknow, Uttar Pradesh, 인도, 226014
- Novo Nordisk Investigational Site
-
-
West Bengal
-
Kolkata, West Bengal, 인도, 700020
- Novo Nordisk Investigational Site
-
Kolkata, West Bengal, 인도, 700054
- Novo Nordisk Investigational Site
-
-
-
-
-
Chuo-ku, Tokyo, 일본, 103-0002
- Novo Nordisk Investigational Site
-
Kanagawa, 일본, 235-0045
- Novo Nordisk Investigational Site
-
Kumamoto, 일본, 862-0976
- Novo Nordisk Investigational Site
-
Miyazaki, 일본, 880-0034
- Novo Nordisk Investigational Site
-
Nagano, 일본, 390-8621
- Novo Nordisk Investigational Site
-
Ota-ku, 일본, 144 0035
- Novo Nordisk Investigational Site
-
Ota-ku, Tokyo, 일본, 1430015
- Novo Nordisk Investigational Site
-
Shinjuku-ku, Tokyo, 일본, 162-8655
- Novo Nordisk Investigational Site
-
-
-
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Alberta
-
Edmonton, Alberta, 캐나다, T5J 3N4
- Novo Nordisk Investigational Site
-
-
Manitoba
-
Winnipeg, Manitoba, 캐나다, R3E 3P4
- Novo Nordisk Investigational Site
-
-
Ontario
-
Chatham, Ontario, 캐나다, N7L 1C1
- Novo Nordisk Investigational Site
-
Ottawa, Ontario, 캐나다, K1K 4L2
- Novo Nordisk Investigational Site
-
Sarnia, Ontario, 캐나다, N7T 4X3
- Novo Nordisk Investigational Site
-
-
Quebec
-
Laval, Quebec, 캐나다, H7T 2P5
- Novo Nordisk Investigational Site
-
-
-
-
-
Bjelovar, 크로아티아, 43000
- Novo Nordisk Investigational Site
-
Osijek, 크로아티아, 31 000
- Novo Nordisk Investigational Site
-
Slavonski Brod, 크로아티아, 35 000
- Novo Nordisk Investigational Site
-
Zagreb, 크로아티아, 10 000
- Novo Nordisk Investigational Site
-
Zagreb, 크로아티아, 10000
- Novo Nordisk Investigational Site
-
-
-
-
-
Bangkok, 태국, 10400
- Novo Nordisk Investigational Site
-
Bangkok, 태국, 10330
- Novo Nordisk Investigational Site
-
Bangkoknoi, Bangkok, 태국, 10700
- Novo Nordisk Investigational Site
-
Chiang Mai, 태국, 50200
- Novo Nordisk Investigational Site
-
Nakhon Ratchasima, 태국, 30000
- Novo Nordisk Investigational Site
-
-
-
-
-
Bytom, 폴란드, 41-902
- Novo Nordisk Investigational Site
-
Gdansk, 폴란드, 80-546
- Novo Nordisk Investigational Site
-
Krakow, 폴란드, 31-455
- Novo Nordisk Investigational Site
-
Oswiecim, 폴란드, 32-600
- Novo Nordisk Investigational Site
-
Poznan, 폴란드, 60-589
- Novo Nordisk Investigational Site
-
Szczecin, 폴란드, 70-506
- Novo Nordisk Investigational Site
-
Warszawa, 폴란드, 02-507
- Novo Nordisk Investigational Site
-
Zamosc, 폴란드, 22-400
- Novo Nordisk Investigational Site
-
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참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
50년 이상 (성인, 고령자)
건강한 자원 봉사자를 받아들입니다
아니
연구 대상 성별
모두
설명
Inclusion Criteria: - Type 2 diabetes - Age above or equal to 50 years with predefined previous cardiovascular disease(s) or renal disease or age above or equal to 60 years with predefined cardiovascular risk factors - HbA1c (glycosylated haemoglobin) above or equal to 7.0% or HbA1c below 7.0% and current insulin treatment corresponding to above or equal to 20 U of basal insulin per day - One or more oral or injectable antidiabetic agent(s) Exclusion Criteria: - An acute coronary or cerebrovascular event in the previous 60 days - Planned coronary, carotid or peripheral artery revascularisation - Chronic heart failure NYHA (New York Heart Association) class IV - Current or past (within the last 5 years) malignant neoplasms (except basal cell and squamous cell skin carcinoma)
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 더블
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
|---|---|
|
실험적: Insulin degludec (IDeg)
All subjects will continue their current antidiabetic therapy except for the basal insulin component (if any) that will be replaced by the investigational product.
|
Injected once daily subcutaneously (s.c., under the skin)
|
|
활성 비교기: Insulin glargine (IGlar)
All subjects will continue their current antidiabetic therapy except for the basal insulin component (if any) that will be replaced by the investigational product.
|
Injected once daily subcutaneously (s.c., under the skin)
|
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Time From Randomisation to First Occurrence of a Major Adverse Cardiovascular Event (MACE): Cardiovascular Death, Non-fatal Myocardial Infarction, or Non-fatal Stroke
기간: From randomisation to individual end of trial date (maximum patient year observation: 2.75 years)
|
Time from randomisation to first occurrence of an event adjudication committee (EAC)-confirmed 3-component major adverse cardiovascular event (MACE): cardiovascular death, non-fatal myocardial infarction, or nonfatal stroke.
Events with EAC-confirmed onset date between randomisation and individual end of trial were included in the analyses.
The number of subjects experiencing first EAC-confirmed MACEs, date between randomisation to the end of trial, both days included were presented.
The trial was event driven and planned to last up to a maximum of 60.5 months.
The actual trial duration (time from first subject first visit to last subject last visit) was 35.6 months.
The maximum trial duration for a single subject was 33.1 months.
|
From randomisation to individual end of trial date (maximum patient year observation: 2.75 years)
|
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Number of EAC-confirmed Severe Hypoglycaemic Episodes
기간: From randomisation to individual end of trial (maximum patient year observation: 2.75 years)
|
Number of severe hypoglycaemic episodes from week 0 to the last assessment (up to 35.6 months).
The episode of severe hypoglycaemia is an episode requiring assistance of another person to actively administer carbohydrate, glucagon, or take other corrective actions.
The trial was event driven and planned to last up to a maximum of 60.5 months.
The actual trial duration (time from first subject first visit to last subject last visit) was 35.6 months.
The maximum trial duration for a single subject was 33.1 months.
|
From randomisation to individual end of trial (maximum patient year observation: 2.75 years)
|
|
Occurrence of at Least One EAC Confirmed Severe Hypoglycaemic Episode Within a Subject (Yes/no)
기간: From randomisation to individual end of trial date (maximum patient year observation: 2.75 years)
|
Occurrence of at least one EAC-confirmed severe hypoglycaemic episode within a subject from week 0 to the last assessment (up to 35.6 months).
The episode of severe hypoglycaemia is an episode requiring assistance of another person to actively administer carbohydrate, glucagon, or take other corrective actions.
|
From randomisation to individual end of trial date (maximum patient year observation: 2.75 years)
|
|
Change in Glycosylated Haemoglobin (HbA1c)
기간: Randomisation to 24 months
|
Mean change in HbA1c from week 0 to month 24.
|
Randomisation to 24 months
|
공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
스폰서
간행물 및 유용한 링크
연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.
일반 간행물
- Pollock RF, Heller S, Pieber TR, Woo V, Gundgaard J, Hallen N, Luckevich M, Tutkunkardas D, Zinman B; DEVOTE Study Group. Short-term cost-utility of degludec versus glargine U100 for patients with type 2 diabetes at high risk of hypoglycaemia and cardiovascular events: A Canadian setting (DEVOTE 9). Diabetes Obes Metab. 2019 Jul;21(7):1706-1714. doi: 10.1111/dom.13730. Epub 2019 Apr 14.
- Pollock RF, Valentine WJ, Marso SP, Andersen A, Gundgaard J, Hallen N, Tutkunkardas D, Magnuson EA, Buse JB; DEVOTE study group. Long-term Cost-effectiveness of Insulin Degludec Versus Insulin Glargine U100 in the UK: Evidence from the Basal-bolus Subgroup of the DEVOTE Trial (DEVOTE 16). Appl Health Econ Health Policy. 2019 Oct;17(5):615-627. doi: 10.1007/s40258-019-00494-3.
- Marso SP, McGuire DK, Zinman B, Poulter NR, Emerson SS, Pieber TR, Pratley RE, Haahr PM, Lange M, Frandsen KB, Rabol R, Buse JB. Design of DEVOTE (Trial Comparing Cardiovascular Safety of Insulin Degludec vs Insulin Glargine in Patients With Type 2 Diabetes at High Risk of Cardiovascular Events) - DEVOTE 1. Am Heart J. 2016 Sep;179:175-83. doi: 10.1016/j.ahj.2016.06.004. Epub 2016 Jun 18.
- Marso SP, McGuire DK, Zinman B, Poulter NR, Emerson SS, Pieber TR, Pratley RE, Haahr PM, Lange M, Brown-Frandsen K, Moses A, Skibsted S, Kvist K, Buse JB; DEVOTE Study Group. Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes. N Engl J Med. 2017 Aug 24;377(8):723-732. doi: 10.1056/NEJMoa1615692. Epub 2017 Jun 12.
- Zinman B, Marso SP, Poulter NR, Emerson SS, Pieber TR, Pratley RE, Lange M, Brown-Frandsen K, Moses A, Ocampo Francisco AM, Barner Lekdorf J, Kvist K, Buse JB; DEVOTE Study Group. Day-to-day fasting glycaemic variability in DEVOTE: associations with severe hypoglycaemia and cardiovascular outcomes (DEVOTE 2). Diabetologia. 2018 Jan;61(1):48-57. doi: 10.1007/s00125-017-4423-z. Epub 2017 Sep 15.
- Pieber TR, Marso SP, McGuire DK, Zinman B, Poulter NR, Emerson SS, Pratley RE, Woo V, Heller S, Lange M, Brown-Frandsen K, Moses A, Barner Lekdorf J, Lehmann L, Kvist K, Buse JB; DEVOTE Study Group. DEVOTE 3: temporal relationships between severe hypoglycaemia, cardiovascular outcomes and mortality. Diabetologia. 2018 Jan;61(1):58-65. doi: 10.1007/s00125-017-4422-0. Epub 2017 Sep 15.
- Pollock RF, Valentine WJ, Marso SP, Gundgaard J, Hallen N, Hansen LL, Tutkunkardas D, Buse JB; DEVOTE Study Group. DEVOTE 5: Evaluating the Short-Term Cost-Utility of Insulin Degludec Versus Insulin Glargine U100 in Basal-Bolus Regimens for Type 2 Diabetes in the UK. Diabetes Ther. 2018 Jun;9(3):1217-1232. doi: 10.1007/s13300-018-0430-4. Epub 2018 Apr 30.
- Theilgaard H, Mollerup I, Helmark IC, Endahl L, Hoskin S, Hvelplund A, Amby LK, Moses AC. Developing, Planning and Conducting an Interim Analysis: Lessons From the DEVOTE Cardiovascular Outcomes Trial (Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Patients With Type 2 Diabetes at High Risk of Cardiovascular Events). Ther Innov Regul Sci. 2019 Mar;53(2):279-286. doi: 10.1177/2168479018776943. Epub 2018 May 24.
- Brown-Frandsen K, Emerson SS, McGuire DK, Pieber TR, Poulter NR, Pratley RE, Zinman B, Ranthe MF, Gron R, Lange M, Moses AC, Orsy P, Buse JB; DEVOTE Study Group. Lower rates of cardiovascular events and mortality associated with liraglutide use in patients treated with basal insulin: A DEVOTE subanalysis (DEVOTE 10). Diabetes Obes Metab. 2019 Jun;21(6):1437-1444. doi: 10.1111/dom.13677. Epub 2019 Apr 1.
- Pratley RE, Emerson SS, Franek E, Gilbert MP, Marso SP, McGuire DK, Pieber TR, Zinman B, Hansen CT, Hansen MV, Mark T, Moses AC, Buse JB; DEVOTE Study Group. Cardiovascular safety and lower severe hypoglycaemia of insulin degludec versus insulin glargine U100 in patients with type 2 diabetes aged 65 years or older: Results from DEVOTE (DEVOTE 7). Diabetes Obes Metab. 2019 Jul;21(7):1625-1633. doi: 10.1111/dom.13699. Epub 2019 Apr 15.
- Klein KR, Franek E, Marso S, Pieber TR, Pratley RE, Gowda A, Kvist K, Buse JB. Hemoglobin glycation index, calculated from a single fasting glucose value, as a prediction tool for severe hypoglycemia and major adverse cardiovascular events in DEVOTE. BMJ Open Diabetes Res Care. 2021 Nov;9(2):e002339. doi: 10.1136/bmjdrc-2021-002339.
- Amod A, Buse JB, McGuire DK, Pieber TR, Pop-Busui R, Pratley RE, Zinman B, Hansen MB, Jia T, Mark T, Poulter NR; DEVOTE Study Group. Risk factors for kidney disorders in patients with type 2 diabetes at high cardiovascular risk: An exploratory analysis (DEVOTE 12). Diab Vasc Dis Res. 2020 Nov-Dec;17(6):1479164120970933. doi: 10.1177/1479164120970933.
- Heller S, Lingvay I, Marso SP, Philis-Tsimikas A, Pieber TR, Poulter NR, Pratley RE, Hachmann-Nielsen E, Kvist K, Lange M, Moses AC, Andresen MT, Buse JB; DEVOTE Study Group. Risk of severe hypoglycaemia and its impact in type 2 diabetes in DEVOTE. Diabetes Obes Metab. 2020 Dec;22(12):2241-2247. doi: 10.1111/dom.14049. Epub 2020 Jul 9.
- Pratley RE, Husain M, Lingvay I, Pieber TR, Mark T, Saevereid HA, Moller DV, Zinman B; DEVOTE Study Group. Heart failure with insulin degludec versus glargine U100 in patients with type 2 diabetes at high risk of cardiovascular disease: DEVOTE 14. Cardiovasc Diabetol. 2019 Nov 15;18(1):156. doi: 10.1186/s12933-019-0960-8.
연구 기록 날짜
이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.
연구 주요 날짜
연구 시작 (실제)
2013년 10월 29일
기본 완료 (실제)
2016년 10월 16일
연구 완료 (실제)
2016년 10월 16일
연구 등록 날짜
최초 제출
2013년 10월 8일
QC 기준을 충족하는 최초 제출
2013년 10월 8일
처음 게시됨 (추정)
2013년 10월 10일
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
2019년 7월 24일
QC 기준을 충족하는 마지막 업데이트 제출
2019년 7월 10일
마지막으로 확인됨
2019년 7월 1일
추가 정보
이 연구와 관련된 용어
추가 관련 MeSH 약관
기타 연구 ID 번호
- EX1250-4080
- 2013-002371-17 (EudraCT 번호)
- U1111-1141-7614 (기타 식별자: WHO)
- JapicCTI-142464 (레지스트리 식별자: JAPIC)
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
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