Prevalence of Hypotension Associated With Preload Dependence During Continuous Renal Replacement Therapy (PRELOAD-CRRT)
Per-dialytic hypotension is common in Intensive Care Unit patients under continuous renal replacement therapy, and occurs in nearly 50% of the patients. To date, there is a lack of study having characterized the underlying mechanism of hypotension in this setting. New diagnostic methods are now available with high reliability to identify hypovolemia as the underlying cause of hypotension, among which change in cardiac index during passive leg raising may be the less affected by restrictive validity criteria. A change in cardiac index greater than 10% during this test is highly predictive of preload dependence, i.e the probability than cardiac index will increase if cardiac preload increases.
The aim of this study is then to identify, among hypotensive episodes occurring during renal replacement therapy in Intensive Care Unit patients, the percentage of episodes related to preload dependence as identified by passive leg raising.
연구 개요
연구 유형
등록 (실제)
연락처 및 위치
연구 장소
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Lyon, 프랑스, 69004
- Service de réanimation médicale- Hôpital de la Croix-Rousse
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
샘플링 방법
연구 인구
설명
Inclusion Criteria:
- Intensive Care Unit patients with acute kidney injury
- under continuous renal replacement therapy initiated since less than 24 hours
- under hemodynamic monitoring by the PiCCO® device.
Exclusion Criteria:
- lower limb amputation
- inferior vena cava compression
- intracranial hypertension
- age below 18 year
- pregnancy
- advance directives to withhold or withdraw life sustaining treatment,
- lack of written informed consent by patient or next of kin
- lack of affiliation to social security as required by French regulation
- patient under a legal protective measure
- previous inclusion in current study
- inclusion in another research study
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
코호트 및 개입
그룹/코호트 |
개입 / 치료 |
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Patients with acute kidney injury
Intensive care unit patients with acute kidney injury.
Patients under continuous renal replacement therapy and hemodynamic monitoring.
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Measurement of hypotensive episodes related to preload dependance.
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Presence of hypotensive episode by hemodynamic monitoring
기간: 7 days
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An hypotensive episode is defined as mean arterial pressure < 65 mm Hg and one of the following events :
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7 days
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Preload dependence identified by cardiac index greater than 10% during passive leg raising
기간: 7 days
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The passive leg raising allows to identify the percentage of hypotensive episodes related to preload dependence. A change in cardiac index greater than 10% during this test is highly predictive of preload dependence, i.e the probability than cardiac index will increase if cardiac preload increases. |
7 days
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공동 작업자 및 조사자
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
신장 손상에 대한 임상 시험
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The Second Hospital of Qinhuangdao완전한
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National Health Service, United KingdomUniversity of Bradford완전한
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University Hospital, Basel, Switzerland아직 모집하지 않음