이 페이지는 자동 번역되었으며 번역의 정확성을 보장하지 않습니다. 참조하십시오 영문판 원본 텍스트의 경우.

EASi-KIDNEY™(엠파글리플로진과 결합한 BI 690517을 이용한 심장 및 신장 보호 연구)

2026년 10월 27일 업데이트: Boehringer Ingelheim

만성 신장 질환 환자를 대상으로 알도스테론 합성효소 억제제 BI 690517과 엠파글리플로진을 병용한 다기관, 국제, 무작위, 이중 맹검, 위약 대조 임상 시험

This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study. The study is open to people who take other medicines called angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). People who already take empagliflozin or any other sodium-glucose cotransporter-2 inhibitor (SGLT2i) can also join. The study is also open to people who currently do not take any of these treatments. The purpose of this study is to find out whether a medicine called BI 690517 helps people with chronic kidney disease when taken in combination with a study medicine called empagliflozin. Worsening of kidney function increases the risk for kidney failure, cardiovascular disease, and heart failure hospitalisation.

After a run-in period, during which participants are confirmed to be receiving clinically appropriate renin-angiotensin system blockade and are established on empagliflozin, they are randomly assigned (by chance) to 1 of 2 groups. One group receives BI 690517 tablets, and the other group receives placebo tablets. Placebo tablets look like BI 690517 but do not contain any medicine. Participants take 1 study tablet once a day, in addition to empagliflozin, for the duration of the study.

The doctors document when participants experience worsening of their kidney disease, go to hospital due to heart failure, or die of cardiovascular problems during the study. The time to these events is compared between the 2 treatment groups to see whether the treatment works. The study continues until the required number of events have occurred which is about 3 to 4 years. During this time, participants visit the study site about 5 times within the first 6 months. Then they visit the study site every 6 months. At the visits, doctors regularly check participants' health, take blood and urine samples, measure blood pressure and weight, check kidney function, and take note of any unwanted effects.

연구 개요

상태

모집하지 않고 적극적으로

정황

개입 / 치료

연구 유형

중재적

등록 (실제)

8371

단계

  • 3단계

연락처 및 위치

이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.

연구 장소

  • 뉴질랜드
      • Auckland, 뉴질랜드, 1023
        • Auckland City Hospital
      • Auckland, 뉴질랜드, 2025
        • Middlemore Hospital
      • Auckland, Takapuna, 뉴질랜드, 0620
        • North Shore Hospital
      • New Plymouth, 뉴질랜드, 4310
        • Taranaki Base Hospital
    • Northland
      • Whangarei, Northland, 뉴질랜드, 0110
        • Whangarei Hospital
    • Otago
      • Dunedin, Otago, 뉴질랜드, 9016
        • Dunedin Hospital
    • Waikato Region
      • Hamilton, Waikato Region, 뉴질랜드, 3240
        • Waikato Hospital
  • 대만
      • Kaohsiung City, 대만, 824005
        • E-Da Hospital
      • Luodong Township, 대만, 265
        • Lotung Poh-Ai Hospital
      • New Taipei City, 대만, 220
        • Far Eastern Memorial Hospital
      • New Taipei City, 대만, 23561
        • Taipei Medical University-Shuang Ho Hospital
      • New Taipei City, 대만, 23142
        • Taipei Tzu Chi Hospital
      • New Taipei City, 대만, 243089
        • Fu Jen Catholic University Hospital
      • Taichung, 대만, 404
        • China Medical University Hospital
      • Taichung, 대만, 402
        • Chung Shan Medical University Hospital
      • Taichung, 대만, 435
        • Tungs' Taichung MetroHarbor Hospital
      • Taichung, 대만, 407219
        • Taichung Veterans General Hospital
      • Tainan, 대만, 70403
        • National Cheng Kung University Hospital
      • Tainan, 대만, 736402
        • Chi Mei Hospital, Liouying
      • Taipei, 대만, 110
        • Taipei Medical University Hospital
      • Taipei, 대만, 10449
        • Mackay Memorial Hospital
      • Taipei, 대만, 112
        • Taipei Veterans General Hospital
      • Taipei, 대만, 106
        • Cathay General Hospital
      • Taipei, 대만, 11696
        • Taipei Municipal Wanfang Hospital
      • Taipei, 대만, 111045
        • Shin Kong Wu Ho-Su Memorial Hospital
      • Taoyuan City, 대만, 333
        • Chang Gung Memorial Hospital, Linkou
      • Taoyuan City, 대만, 330
        • TaoYuan General Hospital
  • 대한민국
      • Ansan-si, 대한민국, 15355
        • Korea University Ansan Hospital
      • Busan, 대한민국, 49241
        • Pusan National University Hospital
      • Cheonan-si, 대한민국, 31151
        • Soon Chun Hyang University Hospital Cheonan
      • Cheongju-si, 대한민국, 28644
        • Chungbuk National University Hospital
      • Daegu, 대한민국, 41944
        • Kyungpook National University Hospital
      • Deagu, 대한민국, 42601
        • Keimyung University Dongsan Hospital
      • Goyang-si, 대한민국, 10380
        • Inje University Ilsan Paik Hospital
      • Guri-si, 대한민국, 11923
        • Hanyang University Guri Hospital
      • Gwangmyeong, 대한민국, 14353
        • Chung-Ang University Gwangmyeong Hospital
      • Incheon, 대한민국, 21431
        • The Catholic University of Korea, Incheon St. Mary's Hospital
      • Seongnam-si, 대한민국, 13496
        • CHA Bundang Medical Center
      • Seoul, 대한민국, 03080
        • Seoul National University Hospital
      • Seoul, 대한민국, 03722
        • Severance Hospital
      • Seoul, 대한민국, 06273
        • Gangnam Severance Hospital
      • Seoul, 대한민국, 08308
        • Korea University Guro Hospital
      • Seoul, 대한민국, 07345
        • The Catholic University of Korea, Yeouido St.Mary's Hospital
      • Seoul, 대한민국, 07061
        • SMG-SNU Boramae Medical Center
      • Wŏnju, 대한민국, 26426
        • Yonsei University Wonju Severance Christian Hospital
  • 덴마크
      • Aalborg, 덴마크, 9000
        • Aalborg Universitetsshospital
      • Copenhagen, 덴마크, 2100
        • Rigshospitalet, København
      • Herlev, 덴마크, 2730
        • Herlev and Gentofte Hospital
      • Herlev, 덴마크, 2730
        • Steno Diabetes Center Copenhagen
      • Kolding, 덴마크, 6000
        • Kolding Hospital
      • Odense, 덴마크, 5000
        • Odense University Hospital
      • Roskilde, 덴마크, 4000
        • Zealand University Hospita; Roskilde
  • 독일
      • Aachen, 독일, 52074
        • Universitätsklinikum Aachen, AöR
      • Bad Kreuznach, 독일, 55543
        • KfH-Nierenzentrum Bad Kreuznach
      • Bad Nenndorf, 독일, 31542
        • Nephrologische Gemeinschaftspraxis Bad Nenndorf
      • Bad Oeynhausen, 독일, 32545
        • Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen
      • Berlin, 독일, 10249
        • Vivantes Klinikum im Friedrichshain
      • Berlin, 독일, 12627
        • Praxis für Nierenkrankheiten und Dialyse Helle Mitte
      • Bonn, 독일, 53127
        • Universitätsklinikum Bonn AöR
      • Braunschweig, 독일, 38126
        • Städtisches Klinikum Braunschweig gGmbH
      • Cloppenburg, 독일, 49661
        • St.-Josefs-Hospital Cloppenburg
      • Coburg, 독일, 96450
        • KfH Nierenzentrum Coburg
      • Dortmund, 독일, 44137
        • Klinikum Dortmund gGmbH
      • Düsseldorf, 독일, 40225
        • Universitätsklinikum Düsseldorf
      • Elsenfeld, 독일, 63820
        • Dialysezentrum Elsenfeld
      • Frankfurt, 독일, 60596
        • ClinPhenomics CVC GmbH
      • Frankfurt am Main, 독일, 60596
        • Universitätsklinikum Frankfurt
      • Frankfurt am Main, 독일, 60431
        • Agaplesion Markus Krankenhaus
      • Freiburg im Breisgau, 독일, 79100
        • Nierenzentrum Freiburg
      • Giessen, 독일, 35392
        • Universitätsklinikum Gießen und Marburg GmbH
      • Greifswald, 독일, 17489
        • Universitätsmedizin Greifswald
      • Halle, 독일, 06097
        • Universitätsklinikum Halle (Saale) AöR
      • Hamburg, 독일, 20246
        • Universitätsklinikum Hamburg, Eppendorf
      • Hanover, 독일, 30625
        • Medizinische Hochschule Hannover
      • Hanover, 독일, 30625
        • Zentrum Für Nieren Hochdruck und Stoffwechselerkrankungen
      • Heilbronn, 독일, 74076
        • BAG für Nephrologie und Dialyse
      • Herne, 독일, 44625
        • Ruhr-Universität Bochum
      • Homburg, 독일, 66421
        • Universität des Saarlandes
      • Jena, 독일, 07747
        • Universitätsklinikum Jena
      • Kiel, 독일, 24105
        • Universitätsklinikum Schleswig-Holstein, Campus Kiel
      • Konstanz, 독일, 78464
        • Klinikum Konstanz
      • Kronach, 독일, 96317
        • KfH-Nierenzentrum Kronach
      • Landshut, 독일, 84036
        • Dr. Vehling-Kaiser MVZ GmbH
      • Leipzig, 독일, 04129
        • KfH Nierenzentrum Leipzig
      • Lingen, 독일, 49808
        • Nephrologisches Zentrum Emsland
      • Magdeburg, 독일, 39120
        • Otto-von-Guericke-Universität Magdeburg
      • Mainz, 독일, 55131
        • Universitätsmedizin der Johannes Gutenberg-Universität Mainz
      • München, 독일, 81675
        • Klinikum rechts der Isar der Technischen Universität München
      • München, 독일, 80336
        • Klinikum der Universität München - Campus Innenstadt
      • Neckarsulm, 독일, 74172
        • Dialysezentrum Neckarsulm
      • Neuruppin, 독일, 16816
        • Universitätsklinikum Ruppin-Brandenburg
      • Nuremberg, 독일, 90471
        • Klinikum Nürnberg
      • Rostock, 독일, 18057
        • Universitätsmedizin Rostock
      • Rotenburg (Wümme), 독일, 27356
        • Dialysezentrum Rotenburg
      • Schweinfurt, 독일, 97421
        • MVZ Dialysezentrum Schweinfurt
      • Solingen, 독일, 42653
        • Städtisches Klinikum Solingen gGmbH
      • Springe, 독일, 31832
        • Nephrologische Gemeinschaftspraxis Springe
      • Stuttgart, 독일, 70376
        • Robert-Bosch-Krankenhaus GmbH
      • Traunstein, 독일, 83278
        • KfH-Nierenzentrum Traunstein
      • Trier, 독일, 54292
        • Medizinisches Versorgungszentrum der Barmherzigen Brüder Trier gGmbH
      • Villingen-Schwenningen, 독일, 78052
        • Nephrologisches Zentrum Villingen-Schwenningen
      • Wiesbaden, 독일, 65191
        • Nierenzentrum Wiesbaden
      • Wuppertal, 독일, 42283
        • Helios Universitätsklinikum Wuppertal
      • Würzburg, 독일, 97078
        • Universitätsklinikum Würzburg AÖR
  • 말레이시아
      • Ampang, 말레이시아, 68000
        • Hospital Ampang
      • Batu Caves, 말레이시아, 68100
        • Hospital Selayang
      • Batu Pahat, 말레이시아, 83000
        • Hospital Sultanah Nora Ismail
      • George Town, 말레이시아, 10990
        • Hospital Pulau Pinang-Pulau Pinang-21953
      • Ipoh, 말레이시아, 30450
        • Hospital Raja Permaisuri Bainun
      • Johor Bahru, 말레이시아, 80100
        • Hospital Sultanah Aminah
      • Johor Bahru, 말레이시아, 81100
        • Hospital Sultan Ismail
      • Kajang, 말레이시아, 43000
        • Hospital Sultan Idris Shah Serdang
      • Kajang, Selangor, 말레이시아, 43000
        • Hospital Kajang
      • Klang, 말레이시아, 41200
        • Hospital Tengku Ampuan Rahimah
      • Kota Bharu, 말레이시아, 15586
        • Hospital Raja Perempuan Zainab II
      • Kota Kinabalu, 말레이시아, 88586
        • Hospital Queen Elizabeth
      • Kuala Lumpur, 말레이시아, 50586
        • Hospital Kuala Lumpur
      • Kuala Lumpur, 말레이시아, 59100
        • University Malaya Medical Centre
      • Kuala Pilah, 말레이시아, 72000
        • Hospital Tuanku Ampuan Najihah
      • Kuantan, 말레이시아, 25100
        • Hospital Tengku Ampuan Afzan
      • Kuching, 말레이시아, 93586
        • Hospital Umum Sarawak
      • Kulim, 말레이시아, 09090
        • Hospital Kulim
      • Malacca, 말레이시아, 75400
        • Hospital Melaka
      • Muar town, 말레이시아, 84000
        • Hospital Pakar Sultanah Fatimah
      • Perai, 말레이시아, 13700
        • Hospital Seberang Jaya
      • Serdang, 말레이시아, 43400
        • Hospital Sultan Abdul Aziz Shah
      • Seremban, 말레이시아, 70300
        • Hospital Tuanku Ja'afar
      • Taiping, 말레이시아
        • Hospital Taiping
      • Teluk Intan, 말레이시아, 36000
        • Hospital Teluk Intan
      • Temerluh, 말레이시아, 28000
        • Hospital Sultan Haji Ahmad Shah
  • 멕시코
      • Aguascalientes, 멕시코, 20259
        • Centenario Hospital Miguel Hidalgo
      • Cuernavaca, 멕시코, 62250
        • Instituto de Diabetes, Obesidad y Nutrición S.C.
      • Culiacán, 멕시코, CP 80020
        • Neurociencias Estudios Clinicos S.C.
      • Durango, 멕시코, 34000
        • Instituto de investigación aplicado a la neurociencia
      • Guadalajara, 멕시코, 44670
        • Unidad de Investigación Clinica y Atencion Medica HEPA SC
      • Guadalajara, 멕시코, 44340
        • Centro de Investigacion Clinica y Medicina Traslacional (CIMeT)
      • Guadalajara, 멕시코, 44340
        • Centro Medico Nacional de Occidente/ Centro De Investigacion Biomedica De Occidente
      • Mexico City, 멕시코, 03100
        • Health Pharma Professional Research S.A. de C.V.
      • Mexico City, 멕시코, 03650
        • Soluciones Terapéuticas Médico Quirúrgicas S. de R.L. de C.V.
      • Mexico City, 멕시코, 07760
        • Hospital Juárez de México
      • Monterrey, 멕시코, 64460
        • Hospital Universitario Dr Jose Eleuterio Gonzalez
      • Monterrey, 멕시코, 64310
        • Iecsi S.C.
      • Monterrey, 멕시코, CP 64040
        • Renall Monterrey
      • Morelia, 멕시코, 58260
        • Centro de Investigación Clínica Chapultepec S.A. de C.V.
      • Mérida, 멕시코, 97070
        • Medical Care & Research SA de CV
      • Mérida, 멕시코, 97125
        • Merida Investigación Clínica
      • Tlajomulco de Zúñiga, 멕시코, 45653
        • IMSS Regional General Hospital 180
      • Tlalpan, 멕시코, 14080
        • Instituto Nacional de Cardiologia Ignacio Chavez
      • Veracruz, 멕시코, 91900
        • FAICIC S de RL de C.V.
      • Veracruz, 멕시코, 91910
        • Sociedad de Metabolismo y Corazón S.C.
  • 미국
    • Alabama
      • Huntsville, Alabama, 미국, 35805-4104
        • Apogee Clinical Research
    • Arizona
      • Surprise, Arizona, 미국, 85374-4840
        • Southwest Kidney Institute
    • California
      • Beverly Hills, California, 미국, 90211
        • National Heart Institute
      • Sylmar, California, 미국, 91342
        • Olive View - UCLA Medical Cente
      • West Hills, California, 미국, 91307
        • Interventional Cardiology Medical Group
    • Colorado
      • Littleton, Colorado, 미국, 80120
        • South Denver Cardiology Associates
    • Florida
      • Boca Raton, Florida, 미국, 33434
        • Flourish Research
      • Gainesville, Florida, 미국, 32608
        • University of Florida Health Shands Hospital
      • Jacksonville Beach, Florida, 미국, 32250-4303
        • Florida Kidney Physicians LLC
      • Miami, Florida, 미국, 33126
        • Total Research Group, LLC
      • Miami, Florida, 미국, 33127
        • Bioresearch Partner
    • Georgia
      • Atlanta, Georgia, 미국, 30322
        • Emory University School of Medicine
      • Decatur, Georgia, 미국, 30033-4004
        • Joseph Maxwell Cleland Atlanta VA Medical Center
      • Macon, Georgia, 미국, 31210-1359
        • East Coast Institute For Research LLC
    • Idaho
      • Coeur d'Alene, Idaho, 미국, 83814
        • Kootenai Research Services
    • Illinois
      • Chicago, Illinois, 미국, 60611
        • Northwestern University
    • Kansas
      • Kansas City, Kansas, 미국, 66160
        • University of Kansas Medical Center
      • Wichita, Kansas, 미국, 67214
        • Kansas Nephrology Research Institute, LLC
    • Kentucky
      • Louisville, Kentucky, 미국, 40202
        • University of Louisville
    • Maryland
      • Baltimore, Maryland, 미국, 21239
        • Medstar Health Research Institute
    • Michigan
      • Saint Joseph, Michigan, 미국, 49085-8511
        • Lake Michigan Nephrology
      • Shelby, Michigan, 미국, 48315
        • St. Clair Nephrology Research, LLC
    • Minnesota
      • Minneapolis, Minnesota, 미국, 55417
        • Minneapolis VA Health Care System
    • Mississippi
      • Brookhaven, Mississippi, 미국, 39601-2326
        • Southwest Mississippi Nephrology, Pllc
    • Nebraska
      • North Platte, Nebraska, 미국, 69101-0614
        • Great Plains Nephrology
    • Nevada
      • North Las Vegas, Nevada, 미국, 89086
        • VA Southern Nevada Healthcare System
      • Reno, Nevada, 미국, 89511
        • Sierra Nevada Specialty Care
    • New Hampshire
      • Portsmouth, New Hampshire, 미국, 03801
        • Seacoast Kidney and Hypertension Specialists
    • New Jersey
      • Bridgewater, New Jersey, 미국, 08807
        • Advanced Heart Care, LLC
    • New Mexico
      • Albuquerque, New Mexico, 미국, 87106
        • UNM Health Science Center
    • New York
      • New York, New York, 미국, 10010-5011
        • VA New York Harbor Healthcare System
    • North Carolina
      • Charlotte, North Carolina, 미국, 28208-0014
        • Metrolina Nephrology Associates, PA
      • Charlotte, North Carolina, 미국, 28277
        • Metrolina Nephrology Associates, PA
      • Greensboro, North Carolina, 미국, 27405-3654
        • Carolina Kidney Associates
      • Winston-Salem, North Carolina, 미국, 27103
        • Brookview Hills Research Associates LLC
    • Ohio
      • Cleveland, Ohio, 미국, 44106
        • University Hospitals Cleveland Medical Center
    • Pennsylvania
      • Philadelphia, Pennsylvania, 미국, 19140
        • Temple University
      • Philadelphia, Pennsylvania, 미국, 19114-1028
        • Northeast Endocrine Metabolic Associates
      • Upland, Pennsylvania, 미국, 19013
        • Clinical Renal Associates
    • Rhode Island
      • East Providence, Rhode Island, 미국, 02914-2641
        • Nephrology Associates, Inc
    • Tennessee
      • Memphis, Tennessee, 미국, 38104
        • University of Tennessee
    • Texas
      • Austin, Texas, 미국, 78751
        • Research Management, Inc - Austin
      • DeSoto, Texas, 미국, 75115-2011
        • Dallas Nephrology Associates Medical Clinic
      • El Paso, Texas, 미국, 79935
        • Academy Of Diabetes, Thyroid And Endocrine, PA
      • Lufkin, Texas, 미국, 75904
        • P&I Clinical Research, LLC
      • Lufkin, Texas, 미국, 75904
        • Texas Institute for Kidney and Endocrine Disorders
      • Pasadena, Texas, 미국, 77504-1944
        • Renal Specialists of Houston, PA
      • San Antonio, Texas, 미국, 78207
        • University Health
    • Virginia
      • Charlottesville, Virginia, 미국, 22903
        • University of Virginia Health System
      • Manassas, Virginia, 미국, 20110
        • Kidney and Hypertension Specialists, PLLC
      • Newport News, Virginia, 미국, 23606
        • Tidewater Physicians Multispecialty Group
      • Salem, Virginia, 미국, 24153
        • Salem VA Medical Center
    • Washington
      • Spokane, Washington, 미국, 99204
        • Providence Medical Research Center
  • 벨기에
      • Bruges, 벨기에, 8000
        • AZ Sint-Jan Brugge
      • Genk, 벨기에, 3600
        • Ziekenhuis Oost-Limburg
      • Jette, 벨기에, 1090
        • UZ Brussel
      • Liège, 벨기에, 4000
        • Centre Hospitalier Universitaire de Liège
  • 브라질
      • Aracaju, 브라질, 49055-530
        • Centro de Pesquisa Clínica do Coração
      • Belo Horizonte, 브라질, 30150-320
        • Santa Casa de Belo Horizonte
      • Belo Horizonte, 브라질, 30220-330
        • Centro de Pesquisa do Hospital Evangelico de Belo Horizonte
      • Botucatu, 브라질, 18618-686
        • Universidade Estadual Paulista "Julio De Mesquita Filho"
      • Bragança Paulista, 브라질, 1291-6542
        • Hospital Universitário São Francisco na Providência de Deus
      • Campinas, 브라질, 13073-350
        • CEG - Centro de Endocrinologia Geloneze
      • Centro Linhares, 브라질, 29900010
        • Instituto Cardiovascular de Linhares Ltda
      • Curitiba, 브라질, 80230-130
        • PUC Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da PUC-PR
      • Fortaleza, 브라질, 60416-000
        • Hospital Universitário Walter Cantidio - UFC
      • Fortaleza, 브라질, 60430-350
        • Centro de Pesquisas em Diabetes e Doencas Metabolicas
      • Goiânia, 브라질, 74230-035
        • Clínica CENDI Endocrinologia e Diabetes
      • Goiânia, 브라질, 74453200
        • Hospital Ruy Azeredo
      • Joinville, 브라질, 89227-680
        • Fundação Pró-Rim Joinville
      • Juiz de Fora, 브라질, 36033-318
        • Galileo Medical Research Ltda
      • Maceió, 브라질, 57051-160
        • Centro de Pesquisas Clínicas Dr. Marco Mota
      • Natal, 브라질, 59012300
        • Hospital Universitário Onofre Lopes
      • Porto Alegre, 브라질, 90610-000
        • Hospital Sao Lucas da PUCRS
      • Porto Alegre, 브라질, 90035-903
        • Hospital de Clinicas de Porto Alegre
      • Porto Alegre, 브라질, 90560-032
        • Hospitalar Moinhos de Vento
      • Recife, 브라질, 50070902
        • IMIP Pernambuco
      • Recife, 브라질, 50720110
        • AME Saúde
      • Recife, 브라질, 50740900
        • Hospital das Clinicas da Universidade Federal de Pernambuco
      • Salvador, 브라질, 40110160
        • Fundação Bahiana de Infectologia
      • São Bernardo do Campo, 브라질, 09715-090
        • CEMEC - Centro Multidisciplinar de Estudos Clínicos
      • São José do Rio Preto, 브라질, 15090-000
        • Hospital de Base
      • São José dos Campos, 브라질, 12230-001
        • CIPES - Centro Internacional de Pesquisa Clínica
      • São Paulo, 브라질, 0402-9001
        • Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo
      • São Paulo, 브라질, 04023900
        • Fundacao Oswaldo Ramos (Hospital do Rim)
      • São Paulo, 브라질, 05403-000
        • Hospital das Clinicas da Faculdade de Medicina da USP
      • Teresina, 브라질, 64049550
        • Hospital Universitário da Universidade Federal do Piauí
      • Vitória, 브라질, 29043-260
        • Hospital Universitário Cassiano Antônio Moraes
      • Votuporanga, 브라질, 15505-189
        • Clínica Cardiológica
  • 스웨덴
      • Danderyd, 스웨덴, 182 88
        • Danderyds Sjukhus AB
      • Gothenburg, 스웨덴, 413 46
        • Sahlgrenska Universitetsjukhuset
      • Linköping, 스웨덴, 581 85
        • Universitetssjukhuset Linköping
      • Lund, 스웨덴, 221 85
        • Skånes Universitetssjukhus, Lund
      • Stockholm, 스웨덴, 14157
        • Karolinska University Hospital
      • Sundsvall, 스웨덴, 856 43
        • Region Vaesternorrland
      • Uppsala, 스웨덴, 751 85
        • Akademiska sjukhuset
  • 아르헨티나
      • Bariloche, 아르헨티나, 8500
        • Fundacion INTECNUS
      • Buenos Aires, 아르헨티나, 1407
        • Terapia Renal Domiciliaria
      • Buenos Aires, 아르헨티나, B6000
        • Centro de Salud Renal Junin SRL
      • Buenos Aires, 아르헨티나, C1061AAE
        • Dres. Iribarren & Asoc. Consultario
      • Buenos Aires, 아르헨티나, C1430CKE
        • Glenny Corp - Centro Medico Saavedra
      • CABA, 아르헨티나, 1425
        • CPSIC SRL - Cardiologia Palermo
      • Catamarca, 아르헨티나, K4703AFI
        • Sanatorio Pasteur S.A
      • Ciudad Autonoma Buenos Aires, 아르헨티나, C1431FWO
        • CEMIC
      • Lanús Este, 아르헨티나, B1824KAJ
        • CIMEL Chahin - Chahin S.A.
      • Mar del Plata, 아르헨티나, B7612
        • Centro Nefrologico del Mar
      • Rafaela, 아르헨티나, S2300
        • Mains Bleues
      • Rosario, 아르헨티나, S2000GAP
        • Hospital Privado de Rosario
      • Rosario, 아르헨티나, S2013
        • Sanatorio Parque S.A.
      • Salta, 아르헨티나, A4400
        • Instituto de Nefrourologia y Nutricion de Salta
      • San Juan, 아르헨티나, J5400
        • Clinica El Castaño
      • San Miguel de Tucumán, 아르헨티나, 4000
        • Centro de Investigaciones Medicas Tucuman
      • San Miguel de Tucumán, 아르헨티나, 4000
        • Centro Integral de Medicina Respiratoria - CIMER
      • Santa Fe, 아르헨티나, 2000
        • Instituto de Investigaciones Clinicas de Rosario
      • Villa Domínico, 아르헨티나, B1872EEB
        • CEREHA S.A.- Centro de Estudios Renales e Hipertension Arterial
  • 영국
      • Antrim, 영국, BT41 2RL
        • Antrim Area Hospital
      • Basildon, 영국, SS16 5NL
        • Basildon Hospital
      • Belfast, 영국, BT16 1RH
        • Ulster Hospital
      • Belfast, 영국, BT9 7AB
        • Beltfast City Hospital
      • Birmingham, 영국, B15 2WB
        • Queen Elizabeth Hospital Birmingham
      • Birmingham, 영국, B11 4AN
        • Fernley Medical Centre
      • Birmingham, 영국, B19 1TT
        • Burbury Medical Centre
      • Birmingham, 영국, B31 3HB
        • West Heath Surgery
      • Birmingham, 영국, B32 2TJ
        • Ridgacre House Surgery
      • Blackburn, 영국, BB2 1AX
        • Oakenhurst Medical Practice
      • Brighton, 영국, BN2 1ES
        • Royal County Sussex Hospital
      • Bristol, 영국, BS10 5NB
        • Southmead Hospital
      • Bristol, 영국, BS11 0QE
        • Pioneer Ridingleaze
      • Bristol, 영국, BS2 0AN
        • Lawrence Hill Health Centre
      • Bristol, 영국, BS34 5TF
        • Coniston Medical Practice
      • Bury St Edmunds, 영국, IP33 2QZ
        • West Suffolk Hospital
      • Chelmsford, 영국, CM1 7ET
        • Broomfield Hospital
      • Chippenham, 영국, SN14 6GT
        • Hathaway Medical Centre
      • Clevedon, 영국, BS21 6DG
        • Clevedon Medical Centre
      • Cosham, 영국, PO6 3LY
        • Queen Alexandra Hospital
      • County Down, 영국, BT35 8DR
        • Daisy Hill Hospital
      • Coventry, 영국, CV2 2DX
        • University Hospital Coventry
      • Cramlington, 영국, NE23 6US
        • The Village Surgery
      • Darlington, 영국, DL3 6HZ
        • Orchard Court Surgery
      • Dartford, 영국, DA2 8DA
        • Darent Valley Hospital
      • Dorchester, 영국, DT1 2JY
        • Dorset County Hospital
      • Dudley, 영국, DY1 2HQ
        • Russells Hall Hospital
      • Durham, 영국, DH1 3JX
        • University Health Centre
      • Fulwood, 영국, PR2 9HT
        • Highland Clinical Research Facility
      • Gillingham, 영국, ME7 2BU
        • Woodlands Family Practice
      • Gloucester, 영국, GL1 3NN
        • Gloucestershire Royal Hospital
      • Great Yarmouth, 영국, NR31 6LA
        • James Paget University Hospital
      • Guisborough, 영국, TS14 7DJ
        • The Garth Surgery
      • Hereford, 영국, HR1 2BN
        • Hereford County Hospital
      • Ipswich, 영국, IP4 5PD
        • Ipswich Hospital (UK)
      • Kings Lynn, 영국, PE30 4ET
        • The Queen Elizabeth Hospital
      • Leeds, 영국, LS26 9AA
        • Pinfold Surgery
      • Leominster, 영국, HR6 8HD
        • Ryeland Surgery
      • Little Horton Lane, 영국, BD5 0NA
        • St Luke's Hospital
      • Liverpool, 영국, L9 7AL
        • Aintree University Hospital
      • London, 영국, SE1 9RT
        • Guy's Hospital
      • London, 영국, SE5 9RS
        • King's College Hospital
      • London, 영국, SW17 0QT
        • St George's Hospital
      • London, 영국, W12 0HS
        • Hammersmith Hospital
      • London, 영국, N18 1QX
        • North Middlesex University Hospital
      • London, 영국, W6 7HY
        • Richford Gate Medical Practice
      • Londonderry, 영국, BT47 6SB
        • Altnagelvin Area Hospital
      • Metropolitan Borough of Wirral, 영국, CH49 5PE
        • Arrowe Park Hospital
      • Middlesbrough, 영국, TS5 6HA
        • Linthorpe Surgery
      • Norfolk, 영국, NR4 7UY
        • Norfolk and Norwich University Hospital
      • Northampton, 영국, NN1 5BD
        • Northampton General Hospital
      • Oxford, 영국, OX3 7LE
        • Churchill Hospital
      • Oxford, 영국, OX16 9AD
        • Banbury Cross Health Centre
      • Oxford, 영국, OX4 1XB
        • St Bartholomews & Hollow Way Med Centre
      • Pickering, 영국, YO18 8BL
        • Pickering Medical Practice
      • Poole, 영국, BH14 8EE
        • Lilliput Surgery
      • Reading, 영국, RG1 5AN
        • Royal Berkshire Hospital
      • Redditch, 영국, B98 7UB
        • Alexandra Hospital
      • Salford, 영국, M6 8HD
        • Salford Royal Hospital
      • Shrewsbury, 영국, SY3 8XQ
        • Royal Shrewsbury Hospital
      • St Helens, 영국, WA9 3DA
        • St Helens Hospital
      • Stevenage, 영국, SG1 4AB
        • Lister Hospital
      • Swindon, 영국, SN3 6BB
        • Great Western Hospital
      • Truro, 영국, TR1 3LJ
        • Royal Cornwall Hospital
      • Wantage, 영국, OX12 9BN
        • Church Street Practice
      • Westcliff-on-Sea, 영국, SS0 0RY
        • Southend University Hospital
      • Weston-super-Mare, 영국, BS24 7PR
        • 168 Parklands Medical Centre
      • Whitstable, 영국, CT5 3SE
        • Estuary View Medical Centre
      • Witney, 영국, OX28 6JS
        • Windrush Medical Practice
      • Witney, 영국, OX29 4QB
        • Eynsham Medical Centre
      • York, 영국, YO24 2RQ
        • Woodthorpe Surgery
  • 이탈리아
      • Alessandria, 이탈리아, 15121
        • Ospedale SS. Antonio e Biagio e C. Arrigo - AOUAL
      • Asti, 이탈리아, 14100
        • Asti-Ospedale Cardinal Massaia
      • Bari, 이탈리아, 70124
        • Azienda Universitaria Ospedaliera Consorziale Policlinico Bari
      • Bergamo, 이탈리아, 24127
        • ASST Papa Giovanni XXIII
      • Bologna, 이탈리아, 40138
        • Policlinico S. Orsola-Malpighi
      • Cagliari, 이탈리아, 09100
        • Azienda Ospedaliera ARNAS G. Brotzu
      • Chieri, 이탈리아, 10023
        • Chieri-Ospedale Maggiore
      • Chieti, 이탈리아, 66100
        • Ospedale SS Annunziata
      • Cuneo, 이탈리아, 12100
        • A.S.O. S. Croce e Carle
      • Florence, 이탈리아, 50134
        • A. O. Universitaria Careggi
      • Florence, 이탈리아, 50124
        • Firenze-Ospedale San Giovanni di Dio
      • Genova, 이탈리아, 16132
        • Azienda Ospedaliera San Martino
      • Imola, 이탈리아, 40026
        • Ospedale di Imola S. Maria della Scaletta
      • Milan, 이탈리아, 20132
        • Ospedale San Raffaele S.r.l.
      • Milan, 이탈리아, 20142
        • Asst Santi Paolo E Carlo
      • Monza, 이탈리아, 20900
        • Fondazione IRCCS San Gerardo dei Tintori
      • Novara, 이탈리아, 28100
        • Ospedale Maggiore della Carità
      • Padova, 이탈리아, 35128
        • Azienda Ospedaliera di Padova
      • Parma, 이탈리아, 43126
        • Azienda Ospedaliera Unversitaria di Parma
      • Pavia, 이탈리아, 27100
        • Fondazione Salvatore Maugeri
      • Perugia, 이탈리아, 06129
        • Azienda Ospedaliera di Perugia
      • Pisa, 이탈리아, 56126
        • Azienda Ospedaliera Universitaria Pisana
      • Prato, 이탈리아, 59100
        • Prato-Ospedale Santo Stefano
      • Roma, 이탈리아, 00189
        • Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
      • San Fermo della Battaglia, 이탈리아, 22020
        • Azienda Socio Sanitaria Territoriale Lariana
      • San Giovanni Rotondo (Foggia), 이탈리아, 71013
        • IRCCS Ospedale "Casa Sollievo della Sofferenza"
      • Savona, 이탈리아, 17100
        • Azienda Socio Sanitaria Ligure 2
      • Sesto San Giovanni, 이탈리아, 20099
        • IRCCS MultiMedica
      • Todi, 이탈리아, 06059
        • Todi-Nuovo Ospedale Media Valle del Tevere
      • Turin, 이탈리아, 0100
        • Torino-Ospedale Oftalmico
      • Verbania, 이탈리아, 28922
        • Ospedale Castelli - Verbania
      • Vicenza, 이탈리아, 36100
        • Ospedale San Bortolo
  • 인도
      • Bangalore, 인도, 560034
        • St John's Medical College
      • Bangalore, 인도, 560017
        • Manipal Hospitals, Old Airport Road
      • Bangalore, 인도, 560076
        • Apollo Hospital - Bangalore
      • Bathinda, 인도, 151001
        • All India Institute of Medical Sciences, Bathinda
      • Bhubaneswar, 인도, 751005
        • Apollo Hospitals - Bhubaneswar
      • Bhubaneswar, 인도, 751019
        • All India Institute of Medical Sciences Bhubaneswar
      • Bilāspur, 인도, 174001
        • All India Institute of Medical Sciences, Bilaspur
      • Chandigarh, 인도, 160012
        • Post Graduate Institute of Medical Education and Research
      • Chennai, 인도, 600006
        • Apollo Hospital - Chennai
      • Chennai, 인도, 600095
        • Apollo Speciality Hospitals, Vanagaram
      • Dwārka, 인도, 110075
        • Aakash Healthcare Super Speciality Hospital
      • Faridabad, 인도, 121002
        • Accord Superspeciality Hospital
      • Faridabad, 인도, 121002
        • Amrita Hospital Faridabad
      • Guhugram, 인도, 122011
        • Marengo Asia Hospitals, Guhugram
      • Guntur, 인도, 522001
        • Vedenta Hospitals
      • Gurugram, 인도, 122001
        • Artemis Hospital
      • Hubli, 인도, 580021
        • Karnataka Institute of Medical Sciences, Hubli
      • Hyderabad, 인도, 500082
        • Nizam's Institute of Medical Sciences
      • Hyderabad, 인도, 500012
        • Osmania Medical College & Hospital
      • Hyderabad, 인도, 500033
        • Apollo Hospitals Jubilee Hills
      • Hyderabad, 인도, 500058
        • Apollo DRDO Hospital
      • Jalandhar, 인도, 144012
        • Fortis Hospital, Jalandhar
      • Jodhpur, 인도, 342005
        • All India Institute of Medical Sciences, Jodhpur
      • Kochi, 인도, 682041
        • Amrita Institute of Medical Sciences and Research Centre
      • Kolkata, 인도, 700014
        • Nil Ratan Sircar Medical College & Hospital
      • Kolkata, 인도
        • Manipal Hospitals, EM Bypass
      • Kozhikode, 인도, 673009
        • IQRAA International hospital & research centre.
      • Lucknow, 인도, 226003
        • King George's Medical University
      • Lucknow, 인도, 226014
        • Sanjay Gandhi Post Graduate Institute of Medical Sciences
      • Lucknow, 인도, 226010
        • Dr Ram Manohar Lohia Institute of Medical Sciences
      • Madurai, 인도, 625107
        • Meenakshi Mission Hospital & Research Centre
      • Madurai, K.K. Nagar, 인도, 625020
        • Apollo Speciality Hospital
      • Mangaluru, 인도, 575001
        • Kasturba Medical College and Hospital
      • Mysore, 인도, 570023
        • Apollo BGS Hospital
      • Mānesar, 인도, 122052
        • Fortis Hospital, Manesar
      • Nadiād, 인도, 387001
        • Muljibhai Patel Urological Hospital
      • New Delhi, 인도, 110029
        • All India Institute of Medical Sciences
      • New Delhi, 인도, 110026
        • Maharaja Agrasen Hospital
      • New Delhi, 인도, 110017
        • Max Super Specialty Hospital, Saket
      • New Delhi, 인도, 110025
        • Epitome Kidney Urology Institute and Lions Hospital
      • New Delhi, 인도, 110070
        • Fortis Flt. Lt. Rajan Dhall Hospital
      • New Delhi, 인도, 110075
        • Venkateshwar Hospital
      • Patna, 인도, 800014
        • Indira Gandhi Institute of Medical Sciences
      • Puducherry, 인도, 605006
        • Jawaharlal Institute of Postgraduate Medical Education
      • Raipur, 인도, 492099
        • All India Institute of Medical Sciences
      • Raipur, 인도, 492001
        • DKS Post Graduate Institute & Research Center, Raipur (C.G)
      • Ranchi, 인도, 834001
        • Raj Hospitals
      • Ranchi, 인도, 834004
        • Paras HEC, Ranchi
      • Rohtak, 인도, 124001
        • Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
      • Secunderabad, 인도, 500003
        • Yashoda Hospitals - Secunderabad
      • Trivandrum, 인도, 695029
        • Kimshealth
      • Vadodara, 인도, 390021
        • Aman Hospital & Research Center
      • Vellore, 인도, 632517
        • Christian Medical College, Vellore
      • Visakhapatnam, 인도, 530040
        • Apollo Hospitals Health City
  • 일본
      • Asahikawa-Shi, 일본, 078-8510
        • Asahikawa Medical University Hospital
      • Chiba, 일본, 260-8677
        • Chiba University Hospital
      • Chuo-Shi, 일본, 409-3898
        • University of Yamanashi Hospital
      • Fukuoka, 일본, 812-8582
        • Kyushu University Hospital
      • Isehara, 일본, 259-1193
        • Tokai University Hospital
      • Izumo, 일본, 693-8501
        • Shimane University Hospital
      • Kurashiki-Shi, 일본, 701-0192
        • Kawasaki Medical School Hospital
      • Kurume, 일본, 830-0011
        • Kurume University Hospital
      • Kyoto, 일본, 606-8507
        • Kyoto University Hospital
      • Nagakute, 일본, 480-1195
        • Aichi Medical University Hospital
      • Nagoya, 일본, 466-8560
        • Nagoya University Hospital
      • Nagoya, 일본, 455-8530
        • Chubu Rosai Hospital
      • Okayama, 일본, 700-8558
        • Okayama University Hospital
      • Osaka, 일본, 553-0003
        • Kansai Electric Power Hospital
      • Sendai, 일본, 980-8547
        • Tohoku University Hospital
      • Tokyo, 일본, 160-8582
        • Keio University Hospital
      • Tokyo, 일본, 105-8470
        • Toranomon Hospital
      • Tokyo, 일본, 104-8560
        • St. Luke's International Hospital
      • Tokyo, 일본, 173-8606
        • Teikyo University Hospital
      • Tokyo, 일본, 113-8431
        • Juntendo University Hospital
      • Tokyo, 일본, 113-8655
        • The University of Tokyo Hospital
      • Tokyo, 일본, 162-8655
        • National Center for Global Health and Medicine
      • Tokyo, Chuo-ku, 일본, 103-0027
        • Tokyo-Eki Center-building Clinic
      • Yokohama, 일본, 236-0004
        • Yokohama City University Hospital
      • Ōtsu, 일본, 520-2192
        • Shiga University of Medical Science Hospital
  • 중국
      • Anshan, 중국, 114000
        • Ansteel Group General Hospital
      • Beijing, 중국, 100029
        • Beijing AnZhen Hospital, Capital Medical University
      • Beijing, 중국, 100029
        • Peking University Third Hospital
      • Beijing, 중국, 100037
        • Fuwai Hospital, CAMS&PUMC
      • Changzhi, 중국, 046000
        • Heping Hospital Affiliated to Changzhi Medical College
      • Chaoyang, 중국, 122000
        • The Second Hospital of Chaoyang
      • Chengdu, 중국, 610041
        • Affiliated Hospital of Chengdu University
      • Chengdu, 중국, 610041
        • West China Fourth Hospital of Sichuan University
      • Chifeng, 중국, 024000
        • Affiliated Hospital of Chifeng University
      • Chongqing, 중국, 402160
        • The Affiliated Yongchuan Hospital of Chongqing Medical University
      • Foshan, 중국, 528500
        • Gaoming People's Hospital
      • Fuyang, 중국, 236400
        • Linquan County People's Hospital
      • Gaozhou, 중국, 525200
        • Gaozhou People's Hospital
      • Guangzhou, 중국, 510180
        • Guangzhou First People's Hospital
      • Guangzhou, 중국, 510240
        • Guangzhou Red Cross Hospital
      • Guangzhou, 중국, 510665
        • The Third Affiliated Hospital of Southern Medical University
      • Guangzhou, 중국, 510925
        • The Fifth Affiliated Hospital of Southern Medical University
      • Guangzhou, 중국, 528200
        • Guangdong Provincial Hospital of Chinese Medicine
      • Haikou, 중국, 570311
        • Hainan General Hospital
      • Hanghzhou, 중국, 310022
        • Shulan(Hanghzhou) Hospital
      • Hangzhou, 중국, 310030
        • Zhejiang Hospital
      • Harbin, 중국, 150001
        • The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
      • Harbin, 중국, 150066
        • The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
      • Hefei, 중국, 230011
        • The Second People's Hospital of Hefei
      • Hohot, 중국, 010010
        • International Mongolian Hospital of Inner Mongolia
      • Huangshi, 중국, 435000
        • Huangshi Central Hospital
      • Jingzhou, 중국, 434020
        • Jingzhou Central Hospital
      • Jiyuan, 중국, 454650
        • Henan Jiyuan People's Hospital
      • Liuzhou, 중국, 545006
        • Liuzhou People's Hospital
      • Luoyang, 중국, 471002
        • Luoyang Third People's Hospital
      • Luoyang, 중국, 471000
        • Oriental Hospital
      • Luoyang, 중국, 471009
        • Luoyang Central Hospital
      • Luoyang, 중국, 471900
        • Luoyang Yanshi People's Hospital
      • Meishan, 중국, 620010
        • Meishan People's Hospital
      • Nanchang, 중국, 330000
        • Jiangxi Branch Hospital of Xiangya Hospital of Central South University
      • Qingdao, 중국, 266034
        • Qingdao Cardiovascular Hospital
      • Shanghai, 중국, 200072
        • Shanghai Tenth People's Hospital
      • Shantou, 중국, 515041
        • Second Hospital Affiliated to Shantou Medical University
      • Shantou, 중국, 515031
        • Shantou Central Hospital
      • Shaoguan, 중국, 512000
        • Shaoguan First People's Hospital
      • Shaoxing, 중국, 312000
        • Shaoxing Second Hospital
      • Shenzhen, 중국, 518052
        • Shenzhen Nanshan People's Hospital
      • Shenzhen, 중국, 518107
        • The Seventh Affiliated Hospital, Sun Yat-sen University
      • Shijiazhuang, 중국, 050011
        • Shijiazhuang People's Hospital
      • Songyuan, 중국, 138000
        • Songyuan Jilin Oilfield Hospital
      • Taizhou, 중국, 317000
        • Taizhou Hospital of Zhejiang Province
      • Tianjin, 중국, 300140
        • The Fourth Central Hospital of Tianjin
      • Wuhan, 중국, 430000
        • Wuhan Fourth Hospital
      • Wuhan, 중국, 430015
        • Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine
      • Xiamen, 중국, 361006
        • Xiamen Cardiovascular Hospital Xiamen University
      • Xinxiang, 중국, 453000
        • Xinxiang Central Hospital
      • Xinxiang, 중국, 453100
        • The First Affiliated Hospital of Xinxiang Medical University
      • Zhangjiakou, 중국, 075000
        • The First Affiliated Hospital of Hebei North University
      • Zhengzhou, 중국, 450053
        • The Ninth People's Hospital of Zhengzhou
      • Zhuhai, 중국, 519000
        • Zhuhai People's Hospital
      • Zhumadian, 중국, 463000
        • Zhumadian Central Hospital
      • Zhuzhou, 중국, 412000
        • Zhuzhou Central Hospital
      • Zhuzhou, 중국, 412007
        • Zhuzhou Central Hospital
      • Ürümqi, 중국, 830054
        • The First Affiliated Hospital of Xinjiang Medical University
  • 캐나다
      • Montreal, 캐나다, H2X 0A9
        • Centre hospitalier de l'Université de Montréal (CHUM)
      • Québec, 캐나다, G1V 4T3
        • Diex Recherche Québec
      • Québec, 캐나다, G1R 2J6
        • CHU de Quebec-Universite Laval Research Centre
    • Alberta
      • Edmonton, Alberta, 캐나다, T6G 2P4
        • University of Alberta Hospital (University of Alberta)
    • British Columbia
      • Kamloops, British Columbia, 캐나다, V2C 2T1
        • Royal Inland Hospital
      • Kelowna, British Columbia, 캐나다, V1Y 1T2
        • Kelowna General Hospital
      • Prince George, British Columbia, 캐나다, V2M 1S2
        • Northern Health
      • Surrey, British Columbia, 캐나다, V3W 1J8
        • Fraser Health
      • Vancouver, British Columbia, 캐나다, V5Z 1M9
        • Vancouver General Hospital
      • Vancouver, British Columbia, 캐나다, V1Y 1S1
        • St. Paul's Hospital (Vancouver)
    • Montréal
      • Québec, Montréal, 캐나다, H4J 1C5
        • CIUSSS Nord de l'île de Montreal
    • Nova Scotia
      • Halifax, Nova Scotia, 캐나다, B3H 1V7
        • Centre for Clinical Research
    • Ontario
      • Brampton, Ontario, 캐나다, L6S 0C6
        • Centricity Research (Brampton)
      • Concord, Ontario, 캐나다, L4K 4M2
        • Centricity Research (Vaughan)
      • Kingston, Ontario, 캐나다, K7L 3N6
        • Queen's University
      • London, Ontario, 캐나다, N6A 5W9
        • London Regional Cancer Program - London Health Sciences Ctr.
      • Oshawa, Ontario, 캐나다, L1G 2B9
        • Lakeridge Health Oshawa
      • Ottawa, Ontario, 캐나다, K1H 7W9
        • The Ottawa Hospital
      • Toronto, Ontario, 캐나다, M5G 2N2
        • Toronto General Hospital
      • Toronto, Ontario, 캐나다, M4G 3E8
        • Sunnybrook Health Sciences Centre
      • Toronto, Ontario, 캐나다, M5C2T2
        • St. Michael's Hospital
    • Quebec
      • Montreal, Quebec, 캐나다, H3G 1A4
        • McGill University Health Centre (MUHC)
      • Montreal, Quebec, 캐나다, H1T 2M4
        • CIUSSS de l'Est-de-l'Île-de-Montréal
      • Sherbrooke, Quebec, 캐나다, J1H 5N4
        • CIUSSS de l Estrie-CHUS
  • 포르투갈
      • Aveiro, 포르투갈, 3814-501
        • ULS da Região de Aveiro
      • Braga, 포르투갈, 4710-243
        • Centro Clínico Académico de Braga (2CA-Braga)
      • Carnaxide, 포르투갈, 2790-134
        • CHLO, EPE - Hospital de Santa Cruz
      • Castelo Branco, 포르투갈, 6000-085
        • Unidade Local de Saúde de Castelo Branco, E.P.E
      • Coimbra, 포르투갈, 3004-561
        • CHUC - Centro Hospitalar e Universitario de Coimbra, EPE
      • Faro, 포르투갈, 8000-386
        • Unidade Local de Saúde do Algarve, E.P.E
      • Funchal, 포르투갈, 9004-514
        • SESARAM
      • Lisbon, 포르투갈, 1069-166
        • ULS de São José
      • Lisbon, 포르투갈, 1649-035
        • Unidade Local de Saúde Santa Maria
      • Loures, 포르투갈, 2674-514
        • Hospital Beatriz Ângelo
      • Porto, 포르투갈, 4200-319
        • Centro Hospitalar Universitário São João,EPE
      • Senhora da Hora, 포르투갈, 4464-513
        • Unidade Local de Saúde de Matosinhos
      • Setúbal, 포르투갈, 2910-549
        • Unidade Local De Saude Da Arrabida E.P.E.
      • Viseu, 포르투갈, 3504-509
        • Unidade Local De Saude De Viseu Dao-Lafoes E.P.E.
  • 호주
      • New South Wales, 호주, 2019
        • Macquarie University
      • New South Wales, 호주, 2145
        • Westmead Hospital
    • New South Wales
      • Concord, New South Wales, 호주, 2139
        • Concord Hospital
      • Gosford, New South Wales, 호주, 2250
        • Renal Research, Gosford
      • Kingswood, New South Wales, 호주, 2747
        • Nepean Hospital
      • Kogarah, New South Wales, 호주, 2217
        • St George Hospital
      • Liverpool, New South Wales, 호주, 2170
        • Liverpool Hospital
      • Port Macquarie, New South Wales, 호주, 2444
        • Port Macquarie Base Hospital (PMBH)
    • Queensland
      • Pialba, Queensland, 호주, 4655
        • Hervey Bay Hospital
      • Southport, Queensland, 호주, 4222
        • Griffith University
      • Southport, Queensland, 호주, 4215
        • AOVO Clinical Trials
      • Toowoomba, Queensland, 호주, 4350
        • Toowoomba Hospital
    • South Australia
      • Bedford Park, South Australia, 호주, 5042
        • Flinders Medical Centre
    • Victoria
      • Box Hill, Victoria, 호주, 3128
        • Eastern Health-Box Hill Hospital
      • Heidelberg Heights, Victoria, 호주, 3081
        • Austin Health
      • Melbourne, Victoria, 호주, 3004
        • The Alfred Hospital
      • Melbourne, Victoria, 호주, 3065
        • St Vincent's Hospital Melbourne
      • St Albans, Victoria, 호주, 3021
        • Sunshine Hospital

참여기준

연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.

자격 기준

공부할 수 있는 나이

18년 이상 (성인, 고령자)

건강한 자원 봉사자를 받아들입니다

아니

연구 대상 성별

모두

설명

Key Inclusion Criteria:

  • Evidence of chronic kidney disease (CKD) at risk of kidney disease progression is defined on the basis of local laboratory results recorded at least 3 months before and at the time of the Screening visit, and requires:

    1. Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR ≥20 <45 mL/min/1.73m² (irrespective of diabetes status); or
    2. No self-reported diabetes: CKD-EPI eGFR ≥45 <90 mL/min/1.73m² with urine albumin-to-creatinine ratio (uACR) ≥150 mg/g (or protein-to-creatinine ratio ≥225 mg/g); or
    3. Self-reported diabetes: CKD-EPI eGFR ≥45 <90 mL/min/1.73m² with uACR ≥30 mg/g (or protein-to-creatinine ratio ≥45 mg/g).

  • Neither requires an Aldosterone Synthase inhibitor (ASi) or Mineralocorticoid Receptor Antagonist (MRA), nor that such treatment is definitely inappropriate.

Key Exclusion Criteria:

  • Blood potassium of >5.2 mmol/L at screening visit
  • Blood Alanine Transaminase (ALT) or Aspartate Transaminase (AST) >3x Upper Limit of Normal (ULN) at Screening visit (only one is required, with ALT preferred)
  • Known liver cirrhosis
  • On dialysis, functioning kidney transplant, or scheduled living donor transplant
  • Treated with new immunosuppression therapy for new (or relapse/flare of pre-existing) kidney disease within the last 60 days
  • Receiving more than one Renin-Angiotensin System (RAS) inhibitor (i.e. on dual therapy with two of an Angiotensin-Converting Enzyme inhibitor (ACEi), Angiotensin Receptor Blocker (ARB) or direct renin inhibitor)
  • Currently treated with an Mineralocorticoid Receptor Antagonist (MRA) (e.g. spironolactone, eplerenone, finerenone)
  • Currently treated with systemic mineralocorticoid replacement therapy (e.g. fludrocortisone) Further exclusion criteria apply.

공부 계획

이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.

연구는 어떻게 설계됩니까?

디자인 세부사항

  • 주 목적: 치료
  • 할당: 무작위
  • 중재 모델: 병렬 할당
  • 마스킹: 네 배로

무기와 개입

참가자 그룹 / 팔
개입 / 치료
실험적: 파트 2: 무작위 치료, 추적기간, 치료군
의약품: Empagliflozin

Empagliflozin (called Type E)

의약품: BI 690517

BI 690517 (called Type M randomized treatment)

다른 이름들:
  • 비카드로스타트
위약 비교기: 파트 2: 추적 기간, 위약군
의약품: Empagliflozin

Empagliflozin (called Type E)

의약품: Placebo matching BI 690517

Placebo matching BI 690517
다른: Part 1: Run-in period (all participants)
  • Participant will receive empagliflozin (called Type E) together with study tablets (called Type F) prior to later randomisation to the main study treatment (Type M).
  • This run-in period allows empagliflozin to be established and have its effects on kidney function before randomisation, and to make sure participant can tolerate empagliflozin long-term. Participants will not routinely know whether type F treatment is active or inactive so that participants can become familiar with taking main study tablet (Type M) after randomization.
의약품: Empagliflozin

Empagliflozin (called Type E)

연구는 무엇을 측정합니까?

주요 결과 측정

결과 측정
측정값 설명
기간
Time to first occurrence of the primary composite outcome of: (i) Kidney disease progression*; or (ii) Hospitalization for heart failure; or (iii) Cardiovascular death.
기간: up to 4 years

Kidney disease progression is defined as kidney failure or a sustained decline of ≥40% in estimated Glomerular Filtration Rate (eGFR) from randomization
up to 4 years

2차 결과 측정

결과 측정
기간
신장 질환 진행 또는 심혈관 사망의 첫 번째 사건까지의 시간
기간: 최대 4년
최대 4년
Key secondary outcome: Time to first event of kidney failure, hospitalization for heart failure or cardiovascular death
기간: up to 4 years
up to 4 years
Key secondary outcome: Time to first event of hospitalization for heart failure or cardiovascular death
기간: up to 4 years
up to 4 years
Key secondary outcome: Occurrences of hospitalizations from any cause (first and any subsequent, combined) or death from any cause
기간: up to 4 years
up to 4 years
Key secondary outcome: Time to death from any cause
기간: up to 4 years
up to 4 years
Key secondary outcome: Annual rate of change in eGFR from 1 month until last scheduled visit (i.e. chronic eGFR slope)
기간: up to 4 years
up to 4 years

공동 작업자 및 조사자

여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.

스폰서

Boehringer Ingelheim

간행물 및 유용한 링크

연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.

유용한 링크

연구 기록 날짜

이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.

연구 주요 날짜

연구 시작 (실제)

2024년 8월 30일

기본 완료 (추정된)

2026년 12월 31일

연구 완료 (추정된)

2026년 12월 31일

연구 등록 날짜

최초 제출

2024년 7월 29일

QC 기준을 충족하는 최초 제출

2024년 7월 29일

처음 게시됨 (실제)

2024년 8월 1일

연구 기록 업데이트

마지막 업데이트 게시됨 (실제)

2026년 10월 28일

QC 기준을 충족하는 마지막 업데이트 제출

2026년 10월 27일

마지막으로 확인됨

2026년 10월 1일

추가 정보

이 연구와 관련된 용어

추가 관련 MeSH 약관

기타 연구 ID 번호

  • 1378-0006
  • 2024-511025-63-00 (레지스트리 식별자: CTIS)
  • U1111-1306-5049 (레지스트리 식별자: WHO register (ICTRP))

개별 참가자 데이터(IPD) 계획

개별 참가자 데이터(IPD)를 공유할 계획입니까?

예

IPD 계획 설명

Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.clinicalstudies.boehringer-ingelheim.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement".

Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.

IPD 공유 기간

One year after the approval has been granted by major Regulatory Authorities and after the primary manuscript has been accepted for publication, or after termination of the development program.

IPD 공유 액세스 기준

For study documents - upon signing of a 'Document Sharing Agreement'. For study data - 1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.

IPD 공유 지원 정보 유형

  • 연구_프로토콜
  • 수액
  • CSR

약물 및 장치 정보, 연구 문서

미국 FDA 규제 의약품 연구

예

미국 FDA 규제 기기 제품 연구

아니

이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .

구독하다