EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)

August 20, 2026 updated by: Boehringer Ingelheim

A Multicenter, International, Randomized, Double-blind, Placebo-controlled Clinical Trial of the Aldosterone Synthase Inhibitor BI 690517 in Combination With Empagliflozin in Patients With Chronic Kidney Disease

This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study. The study is open to people who take other medicines called angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). People who already take empagliflozin or any other sodium-glucose cotransporter-2 inhibitor (SGLT2i) can also join. The study is also open to people who currently do not take any of these treatments. The purpose of this study is to find out whether a medicine called BI 690517 helps people with chronic kidney disease when taken in combination with a study medicine called empagliflozin. Worsening of kidney function increases the risk for kidney failure, cardiovascular disease, and heart failure hospitalisation.

After a run-in period, during which participants are confirmed to be receiving clinically appropriate renin-angiotensin system blockade and are established on empagliflozin, they are randomly assigned (by chance) to 1 of 2 groups. One group receives BI 690517 tablets, and the other group receives placebo tablets. Placebo tablets look like BI 690517 but do not contain any medicine. Participants take 1 study tablet once a day, in addition to empagliflozin, for the duration of the study.

The doctors document when participants experience worsening of their kidney disease, go to hospital due to heart failure, or die of cardiovascular problems during the study. The time to these events is compared between the 2 treatment groups to see whether the treatment works. The study continues until the required number of events have occurred which is about 3 to 4 years. During this time, participants visit the study site about 5 times within the first 6 months. Then they visit the study site every 6 months. At the visits, doctors regularly check participants' health, take blood and urine samples, measure blood pressure and weight, check kidney function, and take note of any unwanted effects.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

11000

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Argentina
      • Bariloche, Argentina, 8500
      • Buenos Aires, Argentina, C1430CKE
        • Recruiting
        • Glenny Corp - Centro Medico Saavedra
        • Contact:
      • Buenos Aires, Argentina, B6000
      • Buenos Aires, Argentina, C1061AAE
        • Recruiting
        • Dres. Iribarren & Asoc. Consultario
        • Contact:
      • Buenos Aires, Argentina, 1407
      • CABA, Argentina, 1425
      • Catamarca, Argentina, K4703AFI
      • Ciudad Autonoma Buenos Aires, Argentina, C1431FWO
      • Lanús Este, Argentina, B1824KAJ
      • Mar del Plata, Argentina, B7612
      • Rafaela, Argentina, S2300
      • Rosario, Argentina, S2000GAP
      • Rosario, Argentina, S2013
      • Salta, Argentina, A4400
        • Recruiting
        • Instituto de Nefrourología y Nutrición de Salta
        • Contact:
      • San Juan, Argentina, J5400
      • San Miguel de Tucumán, Argentina, 4000
        • Recruiting
        • Centro Integral de Medicina Respiratoria - CIMER
        • Contact:
      • San Miguel de Tucumán, Argentina, 4000
        • Recruiting
        • Centro de Investigaciones Medicas Tucuman
        • Contact:
      • Santa Fe, Argentina, 2000
        • Recruiting
        • Instituto de Investigaciones Clinicas de Rosario
        • Contact:
      • Villa Domínico, Argentina, B1872EEB
        • Recruiting
        • CEREHA S.A.- Centro de Estudios Renales e Hipertension Arterial
        • Contact:
  • Australia
      • New South Wales, Australia, 2019
      • New South Wales, Australia, 2145
    • New South Wales
      • Gosford, New South Wales, Australia, 2250
      • Liverpool, New South Wales, Australia, 2170
      • Port Macquarie, New South Wales, Australia, 2444
    • South Australia
      • Bedford Park, South Australia, Australia, 5042
    • Victoria
      • Box Hill, Victoria, Australia, 3128
      • Heidelberg Heights, Victoria, Australia, 3081
      • Melbourne, Victoria, Australia, 3065
      • St Albans, Victoria, Australia, 3021
  • Belgium
      • Bruges, Belgium, 8000
      • Genk, Belgium, 3600
      • Jette, Belgium, 1090
  • Brazil
      • Aracaju, Brazil, 49055-530
        • Recruiting
        • Centro de Pesquisa Clinica do Coracao
        • Contact:
      • Belo Horizonte, Brazil, 30150-320
        • Recruiting
        • Santa Casa de Belo Horizonte
        • Contact:
      • Belo Horizonte, Brazil, 30220-330
        • Recruiting
        • Centro de Pesquisa do Hospital Evangelico de Belo Horizonte
        • Contact:
      • Bragança Paulista, Brazil, 1291-6542
        • Recruiting
        • Hospital Universitário São Francisco na Providência de Deus
        • Contact:
      • Campinas, Brazil, 13073-350
        • Recruiting
        • CEG - Centro de Endocrinologia Geloneze
        • Contact:
      • Centro Linhares, Brazil, 29900010
        • Recruiting
        • Instituto Cardiovascular de Linhares Ltda
        • Contact:
      • Curitiba, Brazil, 80230-130
        • Recruiting
        • PUC Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da PUC-PR
        • Contact:
      • Fortaleza, Brazil, 60416-000
        • Recruiting
        • Hospital Universitário Walter Cantídio - UFC
        • Contact:
      • Fortaleza, Brazil, 60430-350
        • Recruiting
        • Centro de Pesquisas em Diabetes e Doencas Metabolicas
        • Contact:
      • Goiânia, Brazil, 74230-035
        • Recruiting
        • Clínica CENDI Endocrinologia e Diabetes
        • Contact:
      • Goiânia, Brazil, 74453200
      • Joinville, Brazil, 89227-680
        • Recruiting
        • Fundação Pró-Rim Joinville
        • Contact:
      • Juiz de Fora, Brazil, 36033-318
        • Recruiting
        • Galileo Medical Research Ltda
        • Contact:
      • Maceió, Brazil, 57051-160
        • Recruiting
        • Centro de Pesquisas Clínicas Dr. Marco Mota
        • Contact:
      • Natal, Brazil, 59012300
        • Recruiting
        • Hospital Universitário Onofre Lopes
        • Contact:
      • Porto Alegre, Brazil, 90035-903
        • Recruiting
        • Hospital De Clinicas De Porto Alegre
        • Contact:
      • Porto Alegre, Brazil, 90610-000
        • Recruiting
        • Hospital Sao Lucas da Pucrs
        • Contact:
      • Porto Alegre, Brazil, 90560-032
        • Recruiting
        • Hospitalar Moinhos de Vento
        • Contact:
      • Recife, Brazil, 50720110
      • Recife, Brazil, 50740900
        • Recruiting
        • Hospital das Clínicas da Universidade Federal de Pernambuco
        • Contact:
      • Recife, Brazil, 50070902
      • Salvador, Brazil, 40110160
        • Recruiting
        • Fundação Bahiana de Infectologia
        • Contact:
      • São Bernardo do Campo, Brazil, 09715-090
        • Recruiting
        • CEMEC - Centro Multidisciplinar de Estudos Clínicos
        • Contact:
      • São José do Rio Preto, Brazil, 15090-000
      • São José dos Campos, Brazil, 12230-001
        • Recruiting
        • CIPES - Centro Internacional de Pesquisa Clínica
        • Contact:
      • São Paulo, Brazil, 05403-000
        • Recruiting
        • Hospital Das Clinicas Da Faculdade De Medicina Da USP
        • Contact:
      • São Paulo, Brazil, 04023900
        • Recruiting
        • Fundacao Oswaldo Ramos (Hospital do Rim)
        • Contact:
      • São Paulo, Brazil, 0402-9001
        • Recruiting
        • Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo
        • Contact:
      • Teresina, Brazil, 64049550
        • Recruiting
        • Hospital Universitário da Universidade Federal do Piauí
        • Contact:
      • Vitória, Brazil, 29043-260
        • Recruiting
        • Hospital Universitário Cassiano Antônio Moraes
        • Contact:
      • Votuporanga, Brazil, 15505-189
  • Canada
      • Montreal, Canada, H2X 0A9
        • Recruiting
        • Centre Hospitalier de l'Université de Montréal (CHUM)
        • Contact:
      • Québec, Canada, G1V 4T3
      • Québec, Canada, G1R 2J6
        • Recruiting
        • CHU de Quebec-Universite Laval Research Centre
        • Contact:
    • Alberta
      • Edmonton, Alberta, Canada, T6G 2P4
        • Recruiting
        • University of Alberta Hospital (University of Alberta)
        • Contact:
    • British Columbia
      • Kamloops, British Columbia, Canada, V2C 2T1
      • Kelowna, British Columbia, Canada, V1Y 1T2
        • Recruiting
        • Kelowna General Hospital
        • Contact:
      • Prince George, British Columbia, Canada, V2M 1S2
      • Surrey, British Columbia, Canada, V3W 1J8
      • Vancouver, British Columbia, Canada, V5Z 1M9
        • Recruiting
        • Vancouver General Hospital
        • Contact:
      • Vancouver, British Columbia, Canada, V1Y 1S1
        • Recruiting
        • St. Paul's Hospital (Vancouver)
        • Contact:
    • Montréal
      • Québec, Montréal, Canada, H4J 1C5
        • Recruiting
        • CIUSSS Nord de l'île de Montreal
        • Contact:
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 1V7
        • Recruiting
        • Centre for Clinical Research
        • Contact:
    • Ontario
      • Brampton, Ontario, Canada, L6S 0C6
        • Recruiting
        • Centricity Research (Brampton)
        • Contact:
      • Concord, Ontario, Canada, L4K 4M2
        • Recruiting
        • Centricity Research (Vaughan)
        • Contact:
      • Kingston, Ontario, Canada, K7L 3N6
      • London, Ontario, Canada, N6A 5W9
        • Recruiting
        • London Regional Cancer Program - London Health Sciences Ctr.
        • Contact:
      • Oshawa, Ontario, Canada, L1G 2B9
        • Recruiting
        • Lakeridge Health Oshawa
        • Contact:
      • Ottawa, Ontario, Canada, K1H 7W9
      • Toronto, Ontario, Canada, M5G 2N2
        • Recruiting
        • Toronto General Hospital
        • Contact:
      • Toronto, Ontario, Canada, M4G 3E8
        • Recruiting
        • Sunnybrook Health Sciences Centre
        • Contact:
      • Toronto, Ontario, Canada, M5C2T2
    • Quebec
      • Montreal, Quebec, Canada, H1T 2M4
        • Recruiting
        • CIUSSS de l'Est-de-l'Île-de-Montréal
        • Contact:
      • Montreal, Quebec, Canada, H3G 1A4
        • Recruiting
        • McGill University Health Centre (MUHC)
        • Contact:
      • Sherbrooke, Quebec, Canada, J1H 5N4
        • Recruiting
        • CIUSSS de l Estrie-CHUS
        • Contact:
  • China
      • Anshan, China, 114000
        • Recruiting
        • Ansteel Group General Hospital
        • Contact:
      • Beijing, China, 100029
        • Recruiting
        • Beijing Anzhen Hospital, Capital Medical University
        • Contact:
      • Beijing, China, 100037
        • Recruiting
        • Fuwai Hospital, CAMS&PUMC
        • Contact:
      • Beijing, China, 100029
        • Recruiting
        • Peking University Third Hospital
        • Contact:
      • Changzhi, China, 046000
        • Recruiting
        • Heping Hospital Affiliated to Changzhi Medical College
        • Contact:
      • Chaoyang, China, 122000
        • Recruiting
        • The Second Hospital of Chaoyang
        • Contact:
      • Chengdu, China, 610041
        • Recruiting
        • West China Fourth Hospital of Sichuan University
        • Contact:
      • Chifeng, China, 024000
        • Recruiting
        • Affiliated Hospital of Chifeng University
        • Contact:
      • Chongqing, China, 402160
        • Recruiting
        • The Affiliated Yongchuan Hospital of Chongqing Medical University
        • Contact:
      • Fuyang, China, 236400
        • Recruiting
        • Linquan County People's Hospital
        • Contact:
      • Gaozhou, China, 525200
        • Recruiting
        • Gaozhou People's Hospital
        • Contact:
      • Guangzhou, China, 510180
        • Recruiting
        • Guangzhou First People's Hospital
        • Contact:
      • Guangzhou, China, 510240
        • Recruiting
        • Guangzhou Red Cross Hospital
        • Contact:
      • Guangzhou, China, 528200
        • Recruiting
        • Guangdong Provincial Hospital of Chinese Medicine
        • Contact:
      • Guangzhou, China, 510665
        • Recruiting
        • The Third Affiliated Hospital of Southern Medical University
        • Contact:
      • Guangzhou, China, 510925
        • Recruiting
        • The Fifth Affiliated Hospital of Southern Medical University
        • Contact:
      • Haikou, China, 570311
        • Recruiting
        • Hainan General Hospital
        • Contact:
      • Hanghzhou, China, 310022
        • Recruiting
        • Shulan(Hanghzhou) Hospital
        • Contact:
      • Hangzhou, China, 310030
      • Harbin, China, 150001
        • Recruiting
        • The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
        • Contact:
      • Harbin, China, 150066
        • Recruiting
        • The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
        • Contact:
      • Hefei, China, 230011
        • Recruiting
        • The Second People's Hospital of Hefei
        • Contact:
      • Hohot, China, 010010
        • Recruiting
        • International Mongolian Hospital of Inner Mongolia
        • Contact:
      • Huangshi, China, 435000
        • Recruiting
        • Huangshi Central Hospital
        • Contact:
      • Jingzhou, China, 434020
        • Recruiting
        • Jingzhou Central Hospital
        • Contact:
      • Jiyuan, China, 454650
        • Recruiting
        • Henan Jiyuan People's Hospital
        • Contact:
      • Liuzhou, China, 545006
        • Recruiting
        • Liuzhou people's Hospital
        • Contact:
      • Luoyang, China, 471002
        • Recruiting
        • Luoyang Third People's Hospital
        • Contact:
      • Luoyang, China, 471009
        • Recruiting
        • Luoyang Central Hospital
        • Contact:
      • Luoyang, China, 471900
        • Recruiting
        • Luoyang Yanshi People's Hospital
        • Contact:
      • Luoyang, China, 471000
      • Nanchang, China, 330000
        • Recruiting
        • Jiangxi Branch Hospital of Xiangya Hospital of Central South University
        • Contact:
      • Qingdao, China, 266034
        • Recruiting
        • Qingdao Cardiovascular Hospital
        • Contact:
      • Shanghai, China, 200072
        • Recruiting
        • Shanghai Tenth People's Hospital
        • Contact:
      • Shantou, China, 515041
        • Recruiting
        • Second Hospital Affiliated to Shantou Medical University
        • Contact:
      • Shantou, China, 515031
        • Recruiting
        • Shantou Central Hospital
        • Contact:
      • Shaoguan, China, 512000
        • Recruiting
        • Shaoguan First People's Hospital
        • Contact:
      • Shaoxing, China, 312000
        • Recruiting
        • Shaoxing Second Hospital
        • Contact:
      • Shenzhen, China, 518052
        • Recruiting
        • Shenzhen Nanshan People's Hospital
        • Contact:
      • Songyuan, China, 138000
        • Recruiting
        • Songyuan Jilin Oilfield Hospital
        • Contact:
      • Taizhou, China, 317000
        • Recruiting
        • Taizhou Hospital of Zhejiang Province
        • Contact:
      • Tianjin, China, 300140
        • Recruiting
        • The Fourth Central Hospital of Tianjin
        • Contact:
      • Wuhan, China, 430015
        • Recruiting
        • Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine
        • Contact:
      • Wuhan, China, 430000
        • Recruiting
        • Wuhan Fourth Hospital
        • Contact:
      • Xiamen, China, 361006
        • Recruiting
        • Xiamen Cardiovascular Hospital Xiamen University
        • Contact:
      • Xinxiang, China, 453000
        • Recruiting
        • Xinxiang Central Hospital
        • Contact:
      • Xinxiang, China, 453100
        • Recruiting
        • The First Affiliated Hospital of Xinxiang Medical University
        • Contact:
      • Zhangjiakou, China, 075000
        • Recruiting
        • The First Affiliated Hospital of Hebei North University
        • Contact:
      • Zhengzhou, China, 450053
        • Recruiting
        • The Ninth People's Hospital of Zhengzhou
        • Contact:
      • Zhuhai, China, 519000
        • Recruiting
        • Zhuhai People's Hospital
        • Contact:
      • Zhumadian, China, 463000
        • Recruiting
        • Zhumadian Central Hospital
        • Contact:
      • Zhuzhou, China, 412007
        • Recruiting
        • ZhuZhou Central Hospital
        • Contact:
      • Zhuzhou, China, 412000
        • Recruiting
        • ZhuZhou Central Hospital
        • Contact:
      • Ürümqi, China, 830054
        • Recruiting
        • The first affiliated hospital of Xinjiang medical university
        • Contact:
  • Denmark
      • Aalborg, Denmark, 9000
      • Copenhagen, Denmark, 2100
      • Herlev, Denmark, 2730
      • Herlev, Denmark, 2730
        • Recruiting
        • Steno Diabetes Center Copenhagen
        • Contact:
      • Kolding, Denmark, 6000
      • Odense, Denmark, 5000
      • Roskilde, Denmark, 4000
        • Recruiting
        • Zealand University Hospita; Roskilde
        • Contact:
  • Germany
      • Aachen, Germany, 52074
      • Bad Kreuznach, Germany, 55543
      • Bad Nenndorf, Germany, 31542
        • Recruiting
        • Nephrologische Gemeinschaftspraxis Bad Nenndorf
        • Contact:
      • Bad Oeynhausen, Germany, 32545
        • Recruiting
        • Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen
        • Contact:
      • Berlin, Germany, 12627
        • Recruiting
        • Praxis für Nierenkrankheiten und Dialyse Helle Mitte
        • Contact:
      • Bonn, Germany, 53127
      • Braunschweig, Germany, 38126
      • Coburg, Germany, 96450
      • Dortmund, Germany, 44137
      • Düsseldorf, Germany, 40225
      • Elsenfeld, Germany, 63820
      • Frankfurt, Germany, 60596
      • Frankfurt am Main, Germany, 60431
      • Frankfurt am Main, Germany, 60596
      • Freiburg im Breisgau, Germany, 79100
      • Giessen, Germany, 35392
        • Recruiting
        • Universitätsklinikum Gießen und Marburg GmbH
        • Contact:
      • Greifswald, Germany, 17489
      • Halle, Germany, 06097
      • Hamburg, Germany, 20246
      • Hanover, Germany, 30625
      • Hanover, Germany, 30625
        • Recruiting
        • Zentrum Für Nieren Hochdruck und Stoffwechselerkrankungen
        • Contact:
      • Heilbronn, Germany, 74076
      • Herne, Germany, 44625
      • Homburg, Germany, 66421
      • Jena, Germany, 07747
      • Kiel, Germany, 24105
        • Recruiting
        • Universitätsklinikum Schleswig-Holstein, Campus Kiel
        • Contact:
      • Konstanz, Germany, 78464
      • Kronach, Germany, 96317
      • Landshut, Germany, 84036
      • Leipzig, Germany, 04129
      • Lingen, Germany, 49808
      • Magdeburg, Germany, 39120
      • Mainz, Germany, 55131
        • Recruiting
        • Universitätsmedizin der Johannes Gutenberg-Universität Mainz
        • Contact:
      • München, Germany, 80336
        • Recruiting
        • Klinikum der Universität München - Campus Innenstadt
        • Contact:
      • München, Germany, 81675
        • Recruiting
        • Klinikum rechts der Isar der Technischen Universität München
        • Contact:
      • Neckarsulm, Germany, 74172
      • Neuruppin, Germany, 16816
      • Nuremberg, Germany, 90471
      • Rostock, Germany, 18057
      • Rotenburg (Wümme), Germany, 27356
      • Schweinfurt, Germany, 97421
      • Solingen, Germany, 42653
      • Springe, Germany, 31832
      • Stuttgart, Germany, 70376
      • Traunstein, Germany, 83278
      • Trier, Germany, 54292
        • Recruiting
        • Medizinisches Versorgungszentrum der Barmherzigen Brüder Trier gGmbH
        • Contact:
      • Villingen-Schwenningen, Germany, 78052
        • Recruiting
        • Nephrologisches Zentrum Villingen-Schwenningen
        • Contact:
      • Wiesbaden, Germany, 65191
      • Wuppertal, Germany, 42283
      • Würzburg, Germany, 97078
  • India
      • Bangalore, India, 560034
        • Recruiting
        • St John's Medical College
        • Contact:
      • Bangalore, India, 560076
        • Recruiting
        • Apollo Hospital - Bangalore
        • Contact:
      • Bangalore, India, 560017
        • Recruiting
        • Manipal Hospitals, Old Airport Road
        • Contact:
      • Bathinda, India, 151001
        • Recruiting
        • All India Institute of Medical Sciences, Bathinda
        • Contact:
      • Bhubaneswar, India, 751019
        • Recruiting
        • All India Institute of Medical Sciences Bhubaneswar
        • Contact:
      • Bhubaneswar, India, 751005
        • Recruiting
        • Apollo Hospitals - Bhubaneswar
        • Contact:
      • Bilāspur, India, 174001
        • Recruiting
        • All India Institute of Medical Sciences, Bilaspur
        • Contact:
      • Chandigarh, India, 160012
        • Recruiting
        • Post Graduate Institute of Medical Education and Research
        • Contact:
      • Chennai, India, 600006
        • Recruiting
        • Apollo Hospital - Chennai
        • Contact:
      • Chennai, India, 600095
        • Recruiting
        • Apollo Speciality Hospitals, Vanagaram
        • Contact:
      • Dwārka, India, 110075
        • Recruiting
        • Aakash Healthcare Super Speciality Hospital
        • Contact:
      • Faridabad, India, 121002
        • Recruiting
        • Accord Superspeciality Hospital
        • Contact:
      • Faridabad, India, 121002
        • Recruiting
        • Amrita Hospital Faridabad
        • Contact:
      • Guhugram, India, 122011
        • Recruiting
        • Marengo Asia Hospitals, Guhugram
        • Contact:
      • Guntur, India, 522001
        • Recruiting
        • Vedenta Hospitals
        • Contact:
      • Gurugram, India, 122001
      • Hubli, India, 580021
        • Recruiting
        • Karnataka Institute of Medical Sciences, Hubli
        • Contact:
      • Hyderabad, India, 500012
        • Recruiting
        • Osmania Medical College & Hospital
        • Contact:
      • Hyderabad, India, 500033
        • Recruiting
        • Apollo Hospitals Jubilee Hills
        • Contact:
      • Hyderabad, India, 500058
        • Recruiting
        • Apollo DRDO Hospital
        • Contact:
      • Jalandhar, India, 144012
        • Recruiting
        • Fortis Hospital, Jalandhar
        • Contact:
      • Jodhpur, India, 342005
        • Recruiting
        • All India Institute of Medical Sciences, Jodhpur
        • Contact:
      • Kochi, India, 682041
        • Recruiting
        • Amrita Institute of Medical Sciences and Research Centre
        • Contact:
      • Kolkata, India, 700014
        • Recruiting
        • Nil Ratan Sircar Medical College & Hospital
        • Contact:
      • Kolkata, India
        • Recruiting
        • Manipal Hospitals, EM Bypass
        • Contact:
      • Kozhikode, India, 673009
        • Recruiting
        • IQRAA International hospital & research centre.
        • Contact:
      • Lucknow, India, 226003
        • Recruiting
        • King George's Medical University
        • Contact:
      • Lucknow, India, 226010
        • Recruiting
        • Dr Ram Manohar Lohia Institute of Medical Sciences
        • Contact:
      • Lucknow, India, 226014
        • Recruiting
        • Sanjay Gandhi Post Graduate Institute of Medical Sciences
        • Contact:
      • Madurai, India, 625107
        • Recruiting
        • Meenakshi Mission Hospital & Research Centre
        • Contact:
      • Madurai, K.K. Nagar, India, 625020
        • Recruiting
        • Apollo Speciality Hospital
        • Contact:
      • Mangaluru, India, 575001
        • Recruiting
        • Kasturba Medical College and Hospital
        • Contact:
      • Mysore, India, 570023
        • Recruiting
        • Apollo BGS Hospital
        • Contact:
      • Nadiād, India, 387001
        • Recruiting
        • Muljibhai Patel Urological Hospital
        • Contact:
      • New Delhi, India, 110029
        • Recruiting
        • All India Institute of Medical Sciences
        • Contact:
      • New Delhi, India, 110026
        • Recruiting
        • Maharaja Agrasen Hospital
        • Contact:
      • New Delhi, India, 110025
        • Recruiting
        • Epitome Kidney Urology Institute and Lions Hospital
        • Contact:
      • New Delhi, India, 110017
        • Recruiting
        • Max Super Specialty Hospital, Saket
        • Contact:
      • New Delhi, India, 110070
        • Recruiting
        • Fortis Flt. Lt. Rajan Dhall Hospital
        • Contact:
      • New Delhi, India, 110075
        • Recruiting
        • Venkateshwar Hospital
        • Contact:
      • Patna, India, 800014
        • Recruiting
        • Indira Gandhi Institute of Medical Sciences
        • Contact:
      • Puducherry, India, 605006
        • Recruiting
        • Jawaharlal Institute of Postgraduate Medical Education
        • Contact:
      • Raipur, India, 492099
        • Recruiting
        • All India Institute of Medical Sciences
        • Contact:
      • Ranchi, India, 834004
        • Recruiting
        • Paras HEC, Ranchi
        • Contact:
      • Rohtak, India, 124001
        • Recruiting
        • Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
        • Contact:
      • Secunderabad, India, 500003
        • Recruiting
        • Yashoda Hospitals - Secunderabad
        • Contact:
      • Trivandrum, India, 695029
      • Vellore, India, 632517
        • Recruiting
        • Christian Medical College, Vellore
        • Contact:
      • Visakhapatnam, India, 530040
        • Recruiting
        • Apollo Hospitals Health City
        • Contact:
  • Italy
      • Alessandria, Italy, 15121
        • Recruiting
        • Ospedale SS. Antonio e Biagio e C. Arrigo - AOUAL
        • Contact:
      • Asti, Italy, 14100
        • Recruiting
        • Asti-Ospedale Cardinal Massaia
        • Contact:
      • Bari, Italy, 70124
        • Recruiting
        • Azienda Universitaria Ospedaliera Consorziale Policlinico Bari
        • Contact:
      • Bergamo, Italy, 24127
      • Bologna, Italy, 40138
        • Recruiting
        • Policlinico S. Orsola-Malpighi
        • Contact:
      • Cagliari, Italy, 09100
        • Recruiting
        • Azienda Ospedaliera ARNAS G. Brotzu
        • Contact:
      • Chieri, Italy, 10023
      • Chieti, Italy, 66100
      • Cuneo, Italy, 12100
      • Florence, Italy, 50124
        • Recruiting
        • Firenze-Ospedale San Giovanni di Dio
        • Contact:
      • Florence, Italy, 50134
        • Recruiting
        • A. O. Universitaria Careggi
        • Contact:
      • Genova, Italy, 16132
        • Recruiting
        • Azienda Ospedaliera San Martino
        • Contact:
      • Imola, Italy, 40026
        • Recruiting
        • Ospedale di Imola S. Maria della Scaletta
        • Contact:
      • Milan, Italy, 20142
      • Milan, Italy, 20132
        • Recruiting
        • Ospedale San Raffaele S.r.l.
        • Contact:
      • Monza, Italy, 20900
        • Recruiting
        • Fondazione IRCCS San Gerardo dei Tintori
        • Contact:
      • Novara, Italy, 28100
        • Recruiting
        • Ospedale Maggiore Della Carita
        • Contact:
      • Padova, Italy, 35128
        • Recruiting
        • Azienda Ospedaliera di Padova
        • Contact:
      • Parma, Italy, 43126
        • Recruiting
        • Azienda Ospedaliera Unversitaria di Parma
        • Contact:
      • Pavia, Italy, 27100
        • Recruiting
        • Fondazione Salvatore Maugeri
        • Contact:
      • Perugia, Italy, 06129
        • Recruiting
        • Azienda Ospedaliera di Perugia
        • Contact:
      • Pisa, Italy, 56126
        • Recruiting
        • Azienda Ospedaliera Universitaria Pisana
        • Contact:
      • Prato, Italy, 59100
        • Recruiting
        • Prato-Ospedale Santo Stefano
        • Contact:
      • Roma, Italy, 00189
        • Recruiting
        • Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
        • Contact:
      • San Fermo della Battaglia, Italy, 22020
        • Recruiting
        • Ospedale Sant'Anna di San Fermo della Battaglia
        • Contact:
      • San Giovanni Rotondo (Foggia), Italy, 71013
        • Recruiting
        • IRCCS Ospedale "Casa Sollievo della Sofferenza"
        • Contact:
      • Savona, Italy, 17100
        • Recruiting
        • Azienda Sociosanitaria Ligure 2
        • Contact:
      • Sesto San Giovanni, Italy, 20099
      • Todi, Italy, 06059
        • Recruiting
        • Todi-Nuovo Ospedale Media Valle del Tevere
        • Contact:
      • Turin, Italy, 0100
        • Recruiting
        • Torino-Ospedale Oftalmico
        • Contact:
      • Verbania, Italy, 28922
        • Recruiting
        • Ospedale Castelli - Verbania
        • Contact:
      • Vicenza, Italy, 36100
  • Japan
      • Asahikawa-Shi, Japan, 078-8510
        • Recruiting
        • Asahikawa Medical University Hospital
        • Contact:
      • Chiba, Japan, 260-8677
        • Recruiting
        • Chiba University Hospital
        • Contact:
      • Chuo-Shi, Japan, 409-3898
        • Recruiting
        • University of Yamanashi Hospital
        • Contact:
      • Fukuoka, Japan, 812-8582
        • Recruiting
        • Kyushu University Hospital
        • Contact:
      • Isehara, Japan, 259-1193
        • Recruiting
        • Tokai University Hospital
        • Contact:
      • Izumo, Japan, 693-8501
        • Recruiting
        • Shimane University Hospital
        • Contact:
      • Kurashiki-Shi, Japan, 701-0192
        • Recruiting
        • Kawasaki Medical School Hospital
        • Contact:
      • Kurume, Japan, 830-0011
        • Recruiting
        • Kurume University Hospital
        • Contact:
      • Kyoto, Japan, 606-8507
        • Recruiting
        • Kyoto University Hospital
        • Contact:
      • Nagakute, Japan, 480-1195
        • Recruiting
        • Aichi Medical University Hospital
        • Contact:
      • Nagoya, Japan, 466-8560
        • Recruiting
        • Nagoya University Hospital
        • Contact:
      • Nagoya, Japan, 455-8530
      • Okayama, Japan, 700-8558
        • Recruiting
        • Okayama University Hospital
        • Contact:
      • Osaka, Japan, 553-0003
        • Recruiting
        • Kansai Electric Power Hospital
        • Contact:
      • Sendai, Japan, 980-8547
        • Recruiting
        • Tohoku University Hospital
        • Contact:
      • Tokyo, Japan, 113-8655
        • Recruiting
        • The University of Tokyo Hospital
        • Contact:
      • Tokyo, Japan, 113-8431
        • Recruiting
        • Juntendo University Hospital
        • Contact:
      • Tokyo, Japan, 104-8560
        • Recruiting
        • St. Luke's International Hospital
        • Contact:
      • Tokyo, Japan, 162-8655
        • Recruiting
        • National Center for Global Health and Medicine
        • Contact:
      • Tokyo, Japan, 105-8470
      • Tokyo, Japan, 160-8582
        • Recruiting
        • Keio University Hospital
        • Contact:
      • Tokyo, Japan, 173-8606
        • Recruiting
        • Teikyo University Hospital
        • Contact:
      • Tokyo, Chuo-ku, Japan, 103-0027
        • Recruiting
        • Tokyo-Eki Center-building Clinic
        • Contact:
      • Yokohama, Japan, 236-0004
        • Recruiting
        • Yokohama City University Hospital
        • Contact:
      • Ōtsu, Japan, 520-2192
        • Recruiting
        • Shiga University of Medical Science Hospital
        • Contact:
  • Malaysia
      • Ampang, Malaysia, 68000
      • Batu Caves, Malaysia, 68100
      • Batu Pahat, Malaysia, 83000
      • George Town, Malaysia, 10990
        • Recruiting
        • Hospital Pulau Pinang-Pulau Pinang-21953
        • Contact:
      • Ipoh, Malaysia, 30450
      • Johor Bahru, Malaysia, 81100
      • Johor Bahru, Malaysia, 80100
      • Kajang, Malaysia, 43000
        • Recruiting
        • Hospital Sultan Idris Shah Serdang
        • Contact:
      • Kajang, Selangor, Malaysia, 43000
      • Klang, Malaysia, 41200
      • Kota Bharu, Malaysia, 15586
        • Recruiting
        • Hospital Raja Perempuan Zainab Ii
        • Contact:
      • Kota Kinabalu, Malaysia, 88586
      • Kuala Lumpur, Malaysia, 59100
        • Recruiting
        • University Malaya Medical Centre
        • Contact:
      • Kuala Lumpur, Malaysia, 50586
      • Kuala Pilah, Malaysia, 72000
      • Kuantan, Malaysia, 25100
      • Kuching, Malaysia, 93586
      • Kulim, Malaysia, 09090
      • Malacca, Malaysia, 75400
      • Muar town, Malaysia, 84000
      • Perai, Malaysia, 13700
      • Serdang, Malaysia, 43400
      • Seremban, Malaysia, 70300
      • Taiping, Malaysia
      • Teluk Intan, Malaysia, 36000
      • Temerluh, Malaysia, 28000
  • Mexico
      • Aguascalientes, Mexico, 20259
        • Recruiting
        • Centenario Hospital Miguel Hidalgo
        • Contact:
      • Durango, Mexico, 34000
        • Recruiting
        • Instituto de investigación aplicado a la neurociencia
        • Contact:
      • Guadalajara, Mexico, 44670
        • Recruiting
        • Unidad de Investigación Clinica y Atencion Medica HEPA SC
        • Contact:
      • Guadalajara, Mexico, 44340
        • Recruiting
        • Centro de Investigacion Clinica y Medicina Traslacional (CIMeT)
        • Contact:
      • Guadalajara, Mexico, 44340
        • Recruiting
        • Centro Medico Nacional de Occidente/ Centro De Investigacion Biomedica De Occidente
        • Contact:
      • Mexico City, Mexico, 07760
        • Recruiting
        • Hospital Juarez de Mexico
        • Contact:
      • Mexico City, Mexico, 03100
        • Recruiting
        • Health Pharma Professional Research S.A. de C.V.
        • Contact:
      • Mexico City, Mexico, 03650
        • Recruiting
        • Soluciones Terapéuticas Médico Quirúrgicas S. de R.L. de C.V.
        • Contact:
      • Monterrey, Mexico, 64310
      • Monterrey, Mexico, 64460
        • Recruiting
        • Hospital Universitario Dr Jose Eleuterio Gonzalez
        • Contact:
      • Morelia, Mexico, 58260
        • Recruiting
        • Centro de Investigacion Clinica Chapultepec S.A. de C.V.
        • Contact:
      • Mérida, Mexico, 97125
        • Recruiting
        • Merida Investigación Clínica
        • Contact:
      • Tlajomulco de Zúñiga, Mexico, 45653
        • Recruiting
        • IMSS Regional General Hospital 180
        • Contact:
      • Tlalpan, Mexico, 14080
        • Recruiting
        • Instituto Nacional de Cardiologia Ignacio Chavez
        • Contact:
      • Veracruz, Mexico, 91900
        • Recruiting
        • FAICIC S de RL de C.V.
        • Contact:
  • New Zealand
      • Auckland, New Zealand, 1023
      • Auckland, New Zealand, 2025
      • Auckland, Takapuna, New Zealand, 0620
      • New Plymouth, New Zealand, 4310
    • Northland
      • Whangarei, Northland, New Zealand, 0110
    • Otago
      • Dunedin, Otago, New Zealand, 9016
    • Waikato Region
      • Hamilton, Waikato Region, New Zealand, 3240
  • Portugal
      • Aveiro, Portugal, 3814-501
      • Carnaxide, Portugal, 2790-134
        • Recruiting
        • CHLO, EPE - Hospital de Santa Cruz
        • Contact:
      • Coimbra, Portugal, 3004-561
        • Recruiting
        • CHUC - Centro Hospitalar e Universitario de Coimbra, EPE
        • Contact:
      • Faro, Portugal, 8000-386
        • Recruiting
        • Unidade Local de Saúde do Algarve, E.P.E
        • Contact:
      • Funchal, Portugal, 9004-514
      • Lisbon, Portugal, 1649-035
        • Recruiting
        • Unidade Local de Saúde Santa Maria
        • Contact:
      • Lisbon, Portugal, 1069-166
      • Loures, Portugal, 2674-514
      • Porto, Portugal, 4200-319
        • Recruiting
        • Centro Hospitalar Universitário São João,EPE
        • Contact:
      • Senhora da Hora, Portugal, 4464-513
        • Recruiting
        • Unidade Local de Saúde de Matosinhos
        • Contact:
      • Setúbal, Portugal, 2910-549
        • Recruiting
        • Unidade Local De Saude Da Arrabida E.P.E.
        • Contact:
  • South Korea
      • Ansan-si, South Korea, 15355
        • Recruiting
        • Korea University Ansan Hospital
        • Contact:
      • Busan, South Korea, 49241
        • Recruiting
        • Pusan National University Hospital
        • Contact:
      • Cheonan-si, South Korea, 31151
        • Recruiting
        • Soon Chun Hyang University Hospital Cheonan
        • Contact:
      • Cheongju-si, South Korea, 28644
        • Recruiting
        • Chungbuk National University Hospital
        • Contact:
      • Daegu, South Korea, 41944
        • Recruiting
        • Kyungpook National University Hospital
        • Contact:
      • Deagu, South Korea, 42601
        • Recruiting
        • Keimyung University Dongsan Hospital
        • Contact:
      • Goyang-si, South Korea, 10380
        • Recruiting
        • Inje University Ilsan Paik Hospital
        • Contact:
      • Guri-si, South Korea, 11923
        • Recruiting
        • Hanyang University Guri Hospital
        • Contact:
      • Gwangmyeong, South Korea, 14353
        • Recruiting
        • Chung-Ang University Gwangmyeong Hospital
        • Contact:
      • Incheon, South Korea, 21431
        • Recruiting
        • The Catholic University of Korea, Incheon St. Mary's Hospital
        • Contact:
      • Seongnam-si, South Korea, 13496
        • Recruiting
        • CHA Bundang Medical Center
        • Contact:
      • Seoul, South Korea, 03080
        • Recruiting
        • Seoul National University Hospital
        • Contact:
      • Seoul, South Korea, 07061
        • Recruiting
        • SMG-SNU Boramae Medical Center
        • Contact:
      • Seoul, South Korea, 03722
      • Seoul, South Korea, 08308
        • Recruiting
        • Korea University Guro Hospital
        • Contact:
      • Seoul, South Korea, 06273
        • Recruiting
        • Gangnam Severance Hospital
        • Contact:
      • Seoul, South Korea, 07345
        • Recruiting
        • The Catholic University of Korea, Yeouido St.Mary's Hospital
        • Contact:
      • Wŏnju, South Korea, 26426
        • Recruiting
        • Yonsei University Wonju Severance Christian Hospital
        • Contact:
  • Sweden
      • Danderyd, Sweden, 182 88
      • Gothenburg, Sweden, 413 46
        • Recruiting
        • Sahlgrenska Universitetsjukhuset
        • Contact:
      • Linköping, Sweden, 581 85
        • Recruiting
        • Universitetssjukhuset Linköping
        • Contact:
      • Stockholm, Sweden, 14157
        • Recruiting
        • Karolinska University Hospital
        • Contact:
      • Sundsvall, Sweden, 856 43
      • Uppsala, Sweden, 751 85
  • Taiwan
      • Kaohsiung City, Taiwan, 824005
      • Luodong Township, Taiwan, 265
      • New Taipei City, Taiwan, 220
        • Recruiting
        • Far Eastern Memorial Hospital
        • Contact:
      • New Taipei City, Taiwan, 23561
        • Recruiting
        • Taipei Medical University-Shuang Ho Hospital
        • Contact:
      • New Taipei City, Taiwan, 23142
      • New Taipei City, Taiwan, 243089
        • Recruiting
        • Fu Jen Catholic University Hospital
        • Contact:
      • Taichung, Taiwan, 435
        • Recruiting
        • Tungs' Taichung MetroHarbor Hospital
        • Contact:
      • Taichung, Taiwan, 402
        • Recruiting
        • Chung Shan Medical University Hospital
        • Contact:
      • Taichung, Taiwan, 404
        • Recruiting
        • China Medical University Hospital
        • Contact:
      • Taichung, Taiwan, 407219
        • Recruiting
        • Taichung Veterans General Hospital
        • Contact:
      • Tainan, Taiwan, 70403
        • Recruiting
        • National Cheng Kung University Hospital
        • Contact:
      • Tainan, Taiwan, 736402
        • Recruiting
        • Chi Mei Hospital, Liouying
        • Contact:
      • Taipei, Taiwan, 10449
        • Recruiting
        • Mackay Memorial Hospital
        • Contact:
      • Taipei, Taiwan, 112
        • Recruiting
        • Taipei Veterans General Hospital
        • Contact:
      • Taipei, Taiwan, 111045
        • Recruiting
        • Shin Kong Wu Ho-Su Memorial Hospital
        • Contact:
      • Taipei, Taiwan, 110
        • Recruiting
        • Taipei Medical University Hospital
        • Contact:
      • Taipei, Taiwan, 106
      • Taipei, Taiwan, 11696
        • Recruiting
        • Taipei Municipal Wanfang Hospital
        • Contact:
      • Taoyuan City, Taiwan, 333
        • Recruiting
        • Chang Gung Memorial Hospital, Linkou
        • Contact:
      • Taoyuan City, Taiwan, 330
        • Recruiting
        • TaoYuan General Hospital
        • Contact:
  • United Kingdom
      • Antrim, United Kingdom, BT41 2RL
      • Basildon, United Kingdom, SS16 5NL
      • Belfast, United Kingdom, BT16 1RH
      • Belfast, United Kingdom, BT9 7AB
      • Birmingham, United Kingdom, B32 2TJ
      • Birmingham, United Kingdom, B15 2WB
      • Blackburn, United Kingdom, BB2 1AX
      • Brighton, United Kingdom, BN2 1ES
      • Bristol, United Kingdom, BS10 5NB
      • Bristol, United Kingdom, BS34 5TF
      • Bristol, United Kingdom, BS11 0QE
      • Bury St Edmunds, United Kingdom, IP33 2QZ
      • Chelmsford, United Kingdom, CM1 7ET
      • Chippenham, United Kingdom, SN14 6GT
      • Clevedon, United Kingdom, BS21 6DG
      • Cosham, United Kingdom, PO6 3LY
      • County Down, United Kingdom, BT35 8DR
      • Coventry, United Kingdom, CV2 2DX
      • Darlington, United Kingdom, DL3 6HZ
      • Dartford, United Kingdom, DA2 8DA
      • Dorchester, United Kingdom, DT1 2JY
      • Dudley, United Kingdom, DY1 2HQ
      • Durham, United Kingdom, DH1 3JX
      • Fulwood, United Kingdom, PR2 9HT
      • Gillingham, United Kingdom, ME7 2BU
      • Gloucester, United Kingdom, GL1 3NN
      • Great Yarmouth, United Kingdom, NR31 6LA
      • Guisborough, United Kingdom, TS14 7DJ
      • Hereford, United Kingdom, HR1 2BN
      • Ipswich, United Kingdom, IP4 5PD
      • Kings Lynn, United Kingdom, PE30 4ET
      • Leeds, United Kingdom, LS26 9AA
      • Leominster, United Kingdom, HR6 8HD
      • Little Horton Lane, United Kingdom, BD5 0NA
      • Liverpool, United Kingdom, L9 7AL
      • London, United Kingdom, N18 1QX
      • London, United Kingdom, W12 0HS
      • London, United Kingdom, SE5 9RS
      • London, United Kingdom, SE1 9RT
      • London, United Kingdom, SW17 0QT
      • London, United Kingdom, W6 7HY
      • Londonderry, United Kingdom, BT47 6SB
      • Metropolitan Borough of Wirral, United Kingdom, CH49 5PE
      • Middlesbrough, United Kingdom, TS5 6HA
      • Norfolk, United Kingdom, NR4 7UY
      • Northampton, United Kingdom, NN1 5BD
      • Oxford, United Kingdom, OX3 7LE
      • Oxford, United Kingdom, OX16 9AD
      • Oxford, United Kingdom, OX4 1XB
      • Pickering, United Kingdom, YO18 8BL
      • Poole, United Kingdom, BH14 8EE
      • Reading, United Kingdom, RG1 5AN
      • Redditch, United Kingdom, B98 7UB
      • Shrewsbury, United Kingdom, SY3 8XQ
      • Stevenage, United Kingdom, SG1 4AB
      • Swindon, United Kingdom, SN3 6BB
      • Truro, United Kingdom, TR1 3LJ
      • Wantage, United Kingdom, OX12 9BN
      • Westcliff-on-Sea, United Kingdom, SS0 0RY
      • Weston-super-Mare, United Kingdom, BS24 7PR
      • Whitstable, United Kingdom, CT5 3SE
      • Witney, United Kingdom, OX29 4QB
      • York, United Kingdom, YO24 2RQ
  • United States
    • Alabama
      • Huntsville, Alabama, United States, 35805-4104
    • Arizona
      • Surprise, Arizona, United States, 85374-4840
    • California
      • Beverly Hills, California, United States, 90211
    • Florida
      • Gainesville, Florida, United States, 32608
      • Jacksonville Beach, Florida, United States, 32250-4303
      • Miami, Florida, United States, 33126
    • Georgia
      • Atlanta, Georgia, United States, 30322
      • Decatur, Georgia, United States, 30033-4004
        • Recruiting
        • Joseph Maxwell Cleland Atlanta VA Medical Center
        • Contact:
      • Macon, Georgia, United States, 31210-1359
    • Idaho
      • Coeur d'Alene, Idaho, United States, 83814
    • Illinois
      • Chicago, Illinois, United States, 60611
    • Kansas
      • Kansas City, Kansas, United States, 66160
      • Wichita, Kansas, United States, 67214
    • Kentucky
      • Louisville, Kentucky, United States, 40202
    • Maryland
      • Baltimore, Maryland, United States, 21239
    • Michigan
      • Saint Joseph, Michigan, United States, 49085-8511
      • Shelby, Michigan, United States, 48315
    • Minnesota
      • Minneapolis, Minnesota, United States, 55417
    • Mississippi
      • Brookhaven, Mississippi, United States, 39601-2326
    • Nebraska
      • North Platte, Nebraska, United States, 69101-0614
    • Nevada
      • North Las Vegas, Nevada, United States, 89086
      • Reno, Nevada, United States, 89511
    • New Hampshire
      • Portsmouth, New Hampshire, United States, 03801
    • New Mexico
      • Albuquerque, New Mexico, United States, 87106
    • North Carolina
      • Charlotte, North Carolina, United States, 28208-0014
      • Charlotte, North Carolina, United States, 28277
      • Greensboro, North Carolina, United States, 27405-3654
      • Winston-Salem, North Carolina, United States, 27103
    • Ohio
      • Cleveland, Ohio, United States, 44106
    • Pennsylvania
      • Philadelphia, Pennsylvania, United States, 19140
      • Philadelphia, Pennsylvania, United States, 19114-1028
      • Upland, Pennsylvania, United States, 19013
    • Rhode Island
      • East Providence, Rhode Island, United States, 02914-2641
    • Tennessee
      • Memphis, Tennessee, United States, 38104
    • Texas
      • Austin, Texas, United States, 78751
      • DeSoto, Texas, United States, 75115-2011
      • El Paso, Texas, United States, 79935
        • Recruiting
        • Academy Of Diabetes, Thyroid And Endocrine, PA
        • Contact:
      • Lufkin, Texas, United States, 75904
        • Recruiting
        • Texas Institute for Kidney and Endocrine Disorders
        • Contact:
      • Lufkin, Texas, United States, 75904
      • Pasadena, Texas, United States, 77504-1944
    • Virginia
      • Charlottesville, Virginia, United States, 22903
      • Manassas, Virginia, United States, 20110
      • Newport News, Virginia, United States, 23606
      • Salem, Virginia, United States, 24153
    • Washington
      • Spokane, Washington, United States, 99204

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Key Inclusion Criteria:

  • Evidence of chronic kidney disease (CKD) at risk of kidney disease progression is defined on the basis of local laboratory results recorded at least 3 months before and at the time of the Screening visit, and requires:

    1. Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR ≥20 <45 mL/min/1.73m² (irrespective of diabetes status); or
    2. No self-reported diabetes: CKD-EPI eGFR ≥45 <90 mL/min/1.73m² with urine albumin-to-creatinine ratio (uACR) ≥150 mg/g (or protein-to-creatinine ratio ≥225 mg/g); or
    3. Self-reported diabetes: CKD-EPI eGFR ≥45 <90 mL/min/1.73m² with uACR ≥30 mg/g (or protein-to-creatinine ratio ≥45 mg/g).
  • Neither requires an Aldosterone Synthase inhibitor (ASi) or Mineralocorticoid Receptor Antagonist (MRA), nor that such treatment is definitely inappropriate.

Key Exclusion Criteria:

  • Blood potassium of >5.2 mmol/L at screening visit
  • Blood Alanine Transaminase (ALT) or Aspartate Transaminase (AST) >3x Upper Limit of Normal (ULN) at Screening visit (only one is required, with ALT preferred)
  • Known liver cirrhosis
  • On dialysis, functioning kidney transplant, or scheduled living donor transplant
  • Treated with new immunosuppression therapy for new (or relapse/flare of pre-existing) kidney disease within the last 60 days
  • Receiving more than one Renin-Angiotensin System (RAS) inhibitor (i.e. on dual therapy with two of an Angiotensin-Converting Enzyme inhibitor (ACEi), Angiotensin Receptor Blocker (ARB) or direct renin inhibitor)
  • Currently treated with an Mineralocorticoid Receptor Antagonist (MRA) (e.g. spironolactone, eplerenone, finerenone)
  • Currently treated with systemic mineralocorticoid replacement therapy (e.g. fludrocortisone) Further exclusion criteria apply.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Part 2: Randomized treatment, follow-up period, treatment group
Drug: Empagliflozin
Empagliflozin (called Type E)
Drug: BI 690517
BI 690517 (called Type M randomized treatment)
Other Names:
  • Vicadrostat
Placebo Comparator: Part 2: Follow-up period, placebo group
Drug: Placebo matching BI 690517
Placebo matching BI 690517
Drug: Empagliflozin
Empagliflozin (called Type E)
Other: Part 1: Run-in period (all participants)
  • Participant will receive empagliflozin (called Type E) together with study tablets (called Type F) prior to later randomisation to the main study treatment (Type M).
  • This run-in period allows empagliflozin to be established and have its effects on kidney function before randomisation, and to make sure participant can tolerate empagliflozin long-term. Participants will not routinely know whether type F treatment is active or inactive so that participants can become familiar with taking main study tablet (Type M) after randomization.
Drug: Empagliflozin
Empagliflozin (called Type E)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Time to first occurrence of the primary composite outcome of: (i) Kidney disease progression*; or (ii) Hospitalization for heart failure; or (iii) Cardiovascular death.
Time Frame: up to 4 years
Kidney disease progression is defined as kidney failure or a sustained decline of ≥40% in estimated Glomerular Filtration Rate (eGFR) from randomization
up to 4 years

Secondary Outcome Measures

Outcome Measure
Time Frame
Time to first event of kidney disease progression or cardiovascular death
Time Frame: up to 4 years
up to 4 years
Key secondary outcome: Time to first event of kidney failure, hospitalization for heart failure or cardiovascular death
Time Frame: up to 4 years
up to 4 years
Key secondary outcome: Time to first event of hospitalization for heart failure or cardiovascular death
Time Frame: up to 4 years
up to 4 years
Key secondary outcome: Occurrences of hospitalizations from any cause (first and any subsequent, combined) or death from any cause
Time Frame: up to 4 years
up to 4 years
Key secondary outcome: Time to death from any cause
Time Frame: up to 4 years
up to 4 years
Key secondary outcome: Annual rate of change in eGFR from 1 month until last scheduled visit (i.e. chronic eGFR slope)
Time Frame: up to 4 years
up to 4 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Boehringer Ingelheim

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 30, 2024

Primary Completion (Estimated)

August 30, 2028

Study Completion (Estimated)

August 30, 2028

Study Registration Dates

First Submitted

July 29, 2024

First Submitted That Met QC Criteria

July 29, 2024

First Posted (Actual)

August 1, 2024

Study Record Updates

Last Update Posted (Actual)

August 21, 2026

Last Update Submitted That Met QC Criteria

August 20, 2026

Last Verified

August 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 1378-0006
  • 2024-511025-63-00 (Registry Identifier: CTIS)
  • U1111-1306-5049 (Registry Identifier: WHO register (ICTRP))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.clinicalstudies.boehringer-ingelheim.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement".

Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.

IPD Sharing Time Frame

One year after the approval has been granted by major Regulatory Authorities and after the primary manuscript has been accepted for publication, or after termination of the development program.

IPD Sharing Access Criteria

For study documents - upon signing of a 'Document Sharing Agreement'. For study data - 1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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