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EASi-KIDNEY™ (estudos de proteção cardíaca e renal com BI 690517 em combinação com empagliflozina)

27 de outubro de 2026 atualizado por: Boehringer Ingelheim

Um ensaio clínico multicêntrico, internacional, randomizado, duplo-cego e controlado por placebo do inibidor da aldosterona sintase BI 690517 em combinação com empagliflozina em pacientes com doença renal crônica

This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study. The study is open to people who take other medicines called angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). People who already take empagliflozin or any other sodium-glucose cotransporter-2 inhibitor (SGLT2i) can also join. The study is also open to people who currently do not take any of these treatments. The purpose of this study is to find out whether a medicine called BI 690517 helps people with chronic kidney disease when taken in combination with a study medicine called empagliflozin. Worsening of kidney function increases the risk for kidney failure, cardiovascular disease, and heart failure hospitalisation.

After a run-in period, during which participants are confirmed to be receiving clinically appropriate renin-angiotensin system blockade and are established on empagliflozin, they are randomly assigned (by chance) to 1 of 2 groups. One group receives BI 690517 tablets, and the other group receives placebo tablets. Placebo tablets look like BI 690517 but do not contain any medicine. Participants take 1 study tablet once a day, in addition to empagliflozin, for the duration of the study.

The doctors document when participants experience worsening of their kidney disease, go to hospital due to heart failure, or die of cardiovascular problems during the study. The time to these events is compared between the 2 treatment groups to see whether the treatment works. The study continues until the required number of events have occurred which is about 3 to 4 years. During this time, participants visit the study site about 5 times within the first 6 months. Then they visit the study site every 6 months. At the visits, doctors regularly check participants' health, take blood and urine samples, measure blood pressure and weight, check kidney function, and take note of any unwanted effects.

Visão geral do estudo

Status

Ativo, não recrutando

Condições

Intervenção / Tratamento

Tipo de estudo

Intervencional

Inscrição (Real)

8371

Estágio

  • Fase 3

Contactos e Locais

Esta seção fornece os detalhes de contato para aqueles que conduzem o estudo e informações sobre onde este estudo está sendo realizado.

Locais de estudo

  • Alemanha
      • Aachen, Alemanha, 52074
        • Universitätsklinikum Aachen, AöR
      • Bad Kreuznach, Alemanha, 55543
        • KfH-Nierenzentrum Bad Kreuznach
      • Bad Nenndorf, Alemanha, 31542
        • Nephrologische Gemeinschaftspraxis Bad Nenndorf
      • Bad Oeynhausen, Alemanha, 32545
        • Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen
      • Berlin, Alemanha, 10249
        • Vivantes Klinikum im Friedrichshain
      • Berlin, Alemanha, 12627
        • Praxis für Nierenkrankheiten und Dialyse Helle Mitte
      • Bonn, Alemanha, 53127
        • Universitätsklinikum Bonn AöR
      • Braunschweig, Alemanha, 38126
        • Städtisches Klinikum Braunschweig gGmbH
      • Cloppenburg, Alemanha, 49661
        • St.-Josefs-Hospital Cloppenburg
      • Coburg, Alemanha, 96450
        • KfH Nierenzentrum Coburg
      • Dortmund, Alemanha, 44137
        • Klinikum Dortmund gGmbH
      • Düsseldorf, Alemanha, 40225
        • Universitätsklinikum Düsseldorf
      • Elsenfeld, Alemanha, 63820
        • Dialysezentrum Elsenfeld
      • Frankfurt, Alemanha, 60596
        • ClinPhenomics CVC GmbH
      • Frankfurt am Main, Alemanha, 60596
        • Universitätsklinikum Frankfurt
      • Frankfurt am Main, Alemanha, 60431
        • Agaplesion Markus Krankenhaus
      • Freiburg im Breisgau, Alemanha, 79100
        • Nierenzentrum Freiburg
      • Giessen, Alemanha, 35392
        • Universitätsklinikum Gießen und Marburg GmbH
      • Greifswald, Alemanha, 17489
        • Universitätsmedizin Greifswald
      • Halle, Alemanha, 06097
        • Universitätsklinikum Halle (Saale) AöR
      • Hamburg, Alemanha, 20246
        • Universitätsklinikum Hamburg, Eppendorf
      • Hanover, Alemanha, 30625
        • Medizinische Hochschule Hannover
      • Hanover, Alemanha, 30625
        • Zentrum Für Nieren Hochdruck und Stoffwechselerkrankungen
      • Heilbronn, Alemanha, 74076
        • BAG für Nephrologie und Dialyse
      • Herne, Alemanha, 44625
        • Ruhr-Universität Bochum
      • Homburg, Alemanha, 66421
        • Universität des Saarlandes
      • Jena, Alemanha, 07747
        • Universitätsklinikum Jena
      • Kiel, Alemanha, 24105
        • Universitätsklinikum Schleswig-Holstein, Campus Kiel
      • Konstanz, Alemanha, 78464
        • Klinikum Konstanz
      • Kronach, Alemanha, 96317
        • KfH-Nierenzentrum Kronach
      • Landshut, Alemanha, 84036
        • Dr. Vehling-Kaiser MVZ GmbH
      • Leipzig, Alemanha, 04129
        • KfH Nierenzentrum Leipzig
      • Lingen, Alemanha, 49808
        • Nephrologisches Zentrum Emsland
      • Magdeburg, Alemanha, 39120
        • Otto-von-Guericke-Universität Magdeburg
      • Mainz, Alemanha, 55131
        • Universitätsmedizin der Johannes Gutenberg-Universität Mainz
      • München, Alemanha, 81675
        • Klinikum rechts der Isar der Technischen Universität München
      • München, Alemanha, 80336
        • Klinikum der Universität München - Campus Innenstadt
      • Neckarsulm, Alemanha, 74172
        • Dialysezentrum Neckarsulm
      • Neuruppin, Alemanha, 16816
        • Universitätsklinikum Ruppin-Brandenburg
      • Nuremberg, Alemanha, 90471
        • Klinikum Nürnberg
      • Rostock, Alemanha, 18057
        • Universitätsmedizin Rostock
      • Rotenburg (Wümme), Alemanha, 27356
        • Dialysezentrum Rotenburg
      • Schweinfurt, Alemanha, 97421
        • MVZ Dialysezentrum Schweinfurt
      • Solingen, Alemanha, 42653
        • Städtisches Klinikum Solingen gGmbH
      • Springe, Alemanha, 31832
        • Nephrologische Gemeinschaftspraxis Springe
      • Stuttgart, Alemanha, 70376
        • Robert-Bosch-Krankenhaus GmbH
      • Traunstein, Alemanha, 83278
        • KfH-Nierenzentrum Traunstein
      • Trier, Alemanha, 54292
        • Medizinisches Versorgungszentrum der Barmherzigen Brüder Trier gGmbH
      • Villingen-Schwenningen, Alemanha, 78052
        • Nephrologisches Zentrum Villingen-Schwenningen
      • Wiesbaden, Alemanha, 65191
        • Nierenzentrum Wiesbaden
      • Wuppertal, Alemanha, 42283
        • Helios Universitätsklinikum Wuppertal
      • Würzburg, Alemanha, 97078
        • Universitätsklinikum Würzburg AÖR
  • Argentina
      • Bariloche, Argentina, 8500
        • Fundacion INTECNUS
      • Buenos Aires, Argentina, 1407
        • Terapia Renal Domiciliaria
      • Buenos Aires, Argentina, B6000
        • Centro de Salud Renal Junin SRL
      • Buenos Aires, Argentina, C1061AAE
        • Dres. Iribarren & Asoc. Consultario
      • Buenos Aires, Argentina, C1430CKE
        • Glenny Corp - Centro Medico Saavedra
      • CABA, Argentina, 1425
        • CPSIC SRL - Cardiologia Palermo
      • Catamarca, Argentina, K4703AFI
        • Sanatorio Pasteur S.A
      • Ciudad Autonoma Buenos Aires, Argentina, C1431FWO
        • CEMIC
      • Lanús Este, Argentina, B1824KAJ
        • CIMEL Chahin - Chahin S.A.
      • Mar del Plata, Argentina, B7612
        • Centro Nefrologico del Mar
      • Rafaela, Argentina, S2300
        • Mains Bleues
      • Rosario, Argentina, S2000GAP
        • Hospital Privado de Rosario
      • Rosario, Argentina, S2013
        • Sanatorio Parque S.A.
      • Salta, Argentina, A4400
        • Instituto de Nefrourologia y Nutricion de Salta
      • San Juan, Argentina, J5400
        • Clinica El Castaño
      • San Miguel de Tucumán, Argentina, 4000
        • Centro de Investigaciones Medicas Tucuman
      • San Miguel de Tucumán, Argentina, 4000
        • Centro Integral de Medicina Respiratoria - CIMER
      • Santa Fe, Argentina, 2000
        • Instituto de Investigaciones Clinicas de Rosario
      • Villa Domínico, Argentina, B1872EEB
        • CEREHA S.A.- Centro de Estudios Renales e Hipertension Arterial
  • Austrália
      • New South Wales, Austrália, 2019
        • Macquarie University
      • New South Wales, Austrália, 2145
        • Westmead Hospital
    • New South Wales
      • Concord, New South Wales, Austrália, 2139
        • Concord Hospital
      • Gosford, New South Wales, Austrália, 2250
        • Renal Research, Gosford
      • Kingswood, New South Wales, Austrália, 2747
        • Nepean Hospital
      • Kogarah, New South Wales, Austrália, 2217
        • St George Hospital
      • Liverpool, New South Wales, Austrália, 2170
        • Liverpool Hospital
      • Port Macquarie, New South Wales, Austrália, 2444
        • Port Macquarie Base Hospital (PMBH)
    • Queensland
      • Pialba, Queensland, Austrália, 4655
        • Hervey Bay Hospital
      • Southport, Queensland, Austrália, 4222
        • Griffith University
      • Southport, Queensland, Austrália, 4215
        • AOVO Clinical Trials
      • Toowoomba, Queensland, Austrália, 4350
        • Toowoomba Hospital
    • South Australia
      • Bedford Park, South Australia, Austrália, 5042
        • Flinders Medical Centre
    • Victoria
      • Box Hill, Victoria, Austrália, 3128
        • Eastern Health-Box Hill Hospital
      • Heidelberg Heights, Victoria, Austrália, 3081
        • Austin Health
      • Melbourne, Victoria, Austrália, 3004
        • The Alfred Hospital
      • Melbourne, Victoria, Austrália, 3065
        • St Vincent's Hospital Melbourne
      • St Albans, Victoria, Austrália, 3021
        • Sunshine Hospital
  • Brasil
      • Aracaju, Brasil, 49055-530
        • Centro de Pesquisa Clínica do Coração
      • Belo Horizonte, Brasil, 30150-320
        • Santa Casa de Belo Horizonte
      • Belo Horizonte, Brasil, 30220-330
        • Centro de Pesquisa do Hospital Evangelico de Belo Horizonte
      • Botucatu, Brasil, 18618-686
        • Universidade Estadual Paulista "Julio De Mesquita Filho"
      • Bragança Paulista, Brasil, 1291-6542
        • Hospital Universitário São Francisco na Providência de Deus
      • Campinas, Brasil, 13073-350
        • CEG - Centro de Endocrinologia Geloneze
      • Centro Linhares, Brasil, 29900010
        • Instituto Cardiovascular de Linhares Ltda
      • Curitiba, Brasil, 80230-130
        • PUC Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da PUC-PR
      • Fortaleza, Brasil, 60416-000
        • Hospital Universitário Walter Cantidio - UFC
      • Fortaleza, Brasil, 60430-350
        • Centro de Pesquisas em Diabetes e Doencas Metabolicas
      • Goiânia, Brasil, 74230-035
        • Clínica CENDI Endocrinologia e Diabetes
      • Goiânia, Brasil, 74453200
        • Hospital Ruy Azeredo
      • Joinville, Brasil, 89227-680
        • Fundação Pró-Rim Joinville
      • Juiz de Fora, Brasil, 36033-318
        • Galileo Medical Research Ltda
      • Maceió, Brasil, 57051-160
        • Centro de Pesquisas Clínicas Dr. Marco Mota
      • Natal, Brasil, 59012300
        • Hospital Universitário Onofre Lopes
      • Porto Alegre, Brasil, 90610-000
        • Hospital Sao Lucas da PUCRS
      • Porto Alegre, Brasil, 90035-903
        • Hospital de Clinicas de Porto Alegre
      • Porto Alegre, Brasil, 90560-032
        • Hospitalar Moinhos de Vento
      • Recife, Brasil, 50070902
        • IMIP Pernambuco
      • Recife, Brasil, 50720110
        • AME Saúde
      • Recife, Brasil, 50740900
        • Hospital das Clinicas da Universidade Federal de Pernambuco
      • Salvador, Brasil, 40110160
        • Fundação Bahiana de Infectologia
      • São Bernardo do Campo, Brasil, 09715-090
        • CEMEC - Centro Multidisciplinar de Estudos Clínicos
      • São José do Rio Preto, Brasil, 15090-000
        • Hospital de Base
      • São José dos Campos, Brasil, 12230-001
        • CIPES - Centro Internacional de Pesquisa Clínica
      • São Paulo, Brasil, 0402-9001
        • Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo
      • São Paulo, Brasil, 04023900
        • Fundacao Oswaldo Ramos (Hospital do Rim)
      • São Paulo, Brasil, 05403-000
        • Hospital das Clinicas da Faculdade de Medicina da USP
      • Teresina, Brasil, 64049550
        • Hospital Universitário da Universidade Federal do Piauí
      • Vitória, Brasil, 29043-260
        • Hospital Universitário Cassiano Antônio Moraes
      • Votuporanga, Brasil, 15505-189
        • Clínica Cardiológica
  • Bélgica
      • Bruges, Bélgica, 8000
        • AZ Sint-Jan Brugge
      • Genk, Bélgica, 3600
        • Ziekenhuis Oost-Limburg
      • Jette, Bélgica, 1090
        • UZ Brussel
      • Liège, Bélgica, 4000
        • Centre Hospitalier Universitaire de Liège
  • Canadá
      • Montreal, Canadá, H2X 0A9
        • Centre hospitalier de l'Université de Montréal (CHUM)
      • Québec, Canadá, G1V 4T3
        • Diex Recherche Québec
      • Québec, Canadá, G1R 2J6
        • CHU de Quebec-Universite Laval Research Centre
    • Alberta
      • Edmonton, Alberta, Canadá, T6G 2P4
        • University of Alberta Hospital (University of Alberta)
    • British Columbia
      • Kamloops, British Columbia, Canadá, V2C 2T1
        • Royal Inland Hospital
      • Kelowna, British Columbia, Canadá, V1Y 1T2
        • Kelowna General Hospital
      • Prince George, British Columbia, Canadá, V2M 1S2
        • Northern Health
      • Surrey, British Columbia, Canadá, V3W 1J8
        • Fraser Health
      • Vancouver, British Columbia, Canadá, V5Z 1M9
        • Vancouver General Hospital
      • Vancouver, British Columbia, Canadá, V1Y 1S1
        • St. Paul's Hospital (Vancouver)
    • Montréal
      • Québec, Montréal, Canadá, H4J 1C5
        • CIUSSS Nord de l'île de Montreal
    • Nova Scotia
      • Halifax, Nova Scotia, Canadá, B3H 1V7
        • Centre for Clinical Research
    • Ontario
      • Brampton, Ontario, Canadá, L6S 0C6
        • Centricity Research (Brampton)
      • Concord, Ontario, Canadá, L4K 4M2
        • Centricity Research (Vaughan)
      • Kingston, Ontario, Canadá, K7L 3N6
        • Queen's University
      • London, Ontario, Canadá, N6A 5W9
        • London Regional Cancer Program - London Health Sciences Ctr.
      • Oshawa, Ontario, Canadá, L1G 2B9
        • Lakeridge Health Oshawa
      • Ottawa, Ontario, Canadá, K1H 7W9
        • The Ottawa Hospital
      • Toronto, Ontario, Canadá, M5G 2N2
        • Toronto General Hospital
      • Toronto, Ontario, Canadá, M4G 3E8
        • Sunnybrook Health Sciences Centre
      • Toronto, Ontario, Canadá, M5C2T2
        • St. Michael's Hospital
    • Quebec
      • Montreal, Quebec, Canadá, H3G 1A4
        • McGill University Health Centre (MUHC)
      • Montreal, Quebec, Canadá, H1T 2M4
        • CIUSSS de l'Est-de-l'Île-de-Montréal
      • Sherbrooke, Quebec, Canadá, J1H 5N4
        • CIUSSS de l Estrie-CHUS
  • China
      • Anshan, China, 114000
        • Ansteel Group General Hospital
      • Beijing, China, 100029
        • Beijing AnZhen Hospital, Capital Medical University
      • Beijing, China, 100029
        • Peking University Third Hospital
      • Beijing, China, 100037
        • Fuwai Hospital, CAMS&PUMC
      • Changzhi, China, 046000
        • Heping Hospital Affiliated to Changzhi Medical College
      • Chaoyang, China, 122000
        • The Second Hospital of Chaoyang
      • Chengdu, China, 610041
        • Affiliated Hospital of Chengdu University
      • Chengdu, China, 610041
        • West China Fourth Hospital of Sichuan University
      • Chifeng, China, 024000
        • Affiliated Hospital of Chifeng University
      • Chongqing, China, 402160
        • The Affiliated Yongchuan Hospital of Chongqing Medical University
      • Foshan, China, 528500
        • Gaoming People's Hospital
      • Fuyang, China, 236400
        • Linquan County People's Hospital
      • Gaozhou, China, 525200
        • Gaozhou People's Hospital
      • Guangzhou, China, 510180
        • Guangzhou First People's Hospital
      • Guangzhou, China, 510240
        • Guangzhou Red Cross Hospital
      • Guangzhou, China, 510665
        • The Third Affiliated Hospital of Southern Medical University
      • Guangzhou, China, 510925
        • The Fifth Affiliated Hospital of Southern Medical University
      • Guangzhou, China, 528200
        • Guangdong Provincial Hospital of Chinese Medicine
      • Haikou, China, 570311
        • Hainan General Hospital
      • Hanghzhou, China, 310022
        • Shulan(Hanghzhou) Hospital
      • Hangzhou, China, 310030
        • Zhejiang Hospital
      • Harbin, China, 150001
        • The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
      • Harbin, China, 150066
        • The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
      • Hefei, China, 230011
        • The Second People's Hospital of Hefei
      • Hohot, China, 010010
        • International Mongolian Hospital of Inner Mongolia
      • Huangshi, China, 435000
        • Huangshi Central Hospital
      • Jingzhou, China, 434020
        • Jingzhou Central Hospital
      • Jiyuan, China, 454650
        • Henan Jiyuan People's Hospital
      • Liuzhou, China, 545006
        • Liuzhou People's Hospital
      • Luoyang, China, 471002
        • Luoyang Third People's Hospital
      • Luoyang, China, 471000
        • Oriental Hospital
      • Luoyang, China, 471009
        • Luoyang Central Hospital
      • Luoyang, China, 471900
        • Luoyang Yanshi People's Hospital
      • Meishan, China, 620010
        • Meishan People's Hospital
      • Nanchang, China, 330000
        • Jiangxi Branch Hospital of Xiangya Hospital of Central South University
      • Qingdao, China, 266034
        • Qingdao Cardiovascular Hospital
      • Shanghai, China, 200072
        • Shanghai Tenth People's Hospital
      • Shantou, China, 515041
        • Second Hospital Affiliated to Shantou Medical University
      • Shantou, China, 515031
        • Shantou Central Hospital
      • Shaoguan, China, 512000
        • Shaoguan First People's Hospital
      • Shaoxing, China, 312000
        • Shaoxing Second Hospital
      • Shenzhen, China, 518052
        • Shenzhen Nanshan People's Hospital
      • Shenzhen, China, 518107
        • The Seventh Affiliated Hospital, Sun Yat-sen University
      • Shijiazhuang, China, 050011
        • Shijiazhuang People's Hospital
      • Songyuan, China, 138000
        • Songyuan Jilin Oilfield Hospital
      • Taizhou, China, 317000
        • Taizhou Hospital of Zhejiang Province
      • Tianjin, China, 300140
        • The Fourth Central Hospital of Tianjin
      • Wuhan, China, 430000
        • Wuhan Fourth Hospital
      • Wuhan, China, 430015
        • Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine
      • Xiamen, China, 361006
        • Xiamen Cardiovascular Hospital Xiamen University
      • Xinxiang, China, 453000
        • Xinxiang Central Hospital
      • Xinxiang, China, 453100
        • The First Affiliated Hospital of Xinxiang Medical University
      • Zhangjiakou, China, 075000
        • The First Affiliated Hospital of Hebei North University
      • Zhengzhou, China, 450053
        • The Ninth People's Hospital of Zhengzhou
      • Zhuhai, China, 519000
        • Zhuhai People's Hospital
      • Zhumadian, China, 463000
        • Zhumadian Central Hospital
      • Zhuzhou, China, 412000
        • Zhuzhou Central Hospital
      • Zhuzhou, China, 412007
        • Zhuzhou Central Hospital
      • Ürümqi, China, 830054
        • The First Affiliated Hospital of Xinjiang Medical University
  • Coréia do Sul
      • Ansan-si, Coréia do Sul, 15355
        • Korea University Ansan Hospital
      • Busan, Coréia do Sul, 49241
        • Pusan National University Hospital
      • Cheonan-si, Coréia do Sul, 31151
        • Soon Chun Hyang University Hospital Cheonan
      • Cheongju-si, Coréia do Sul, 28644
        • Chungbuk National University Hospital
      • Daegu, Coréia do Sul, 41944
        • Kyungpook National University Hospital
      • Deagu, Coréia do Sul, 42601
        • Keimyung University Dongsan Hospital
      • Goyang-si, Coréia do Sul, 10380
        • Inje University Ilsan Paik Hospital
      • Guri-si, Coréia do Sul, 11923
        • Hanyang University Guri Hospital
      • Gwangmyeong, Coréia do Sul, 14353
        • Chung-Ang University Gwangmyeong Hospital
      • Incheon, Coréia do Sul, 21431
        • The Catholic University of Korea, Incheon St. Mary's Hospital
      • Seongnam-si, Coréia do Sul, 13496
        • CHA Bundang Medical Center
      • Seoul, Coréia do Sul, 03080
        • Seoul National University Hospital
      • Seoul, Coréia do Sul, 03722
        • Severance Hospital
      • Seoul, Coréia do Sul, 06273
        • Gangnam Severance Hospital
      • Seoul, Coréia do Sul, 08308
        • Korea University Guro Hospital
      • Seoul, Coréia do Sul, 07345
        • The Catholic University of Korea, Yeouido St.Mary's Hospital
      • Seoul, Coréia do Sul, 07061
        • SMG-SNU Boramae Medical Center
      • Wŏnju, Coréia do Sul, 26426
        • Yonsei University Wonju Severance Christian Hospital
  • Dinamarca
      • Aalborg, Dinamarca, 9000
        • Aalborg Universitetsshospital
      • Copenhagen, Dinamarca, 2100
        • Rigshospitalet, København
      • Herlev, Dinamarca, 2730
        • Herlev and Gentofte Hospital
      • Herlev, Dinamarca, 2730
        • Steno Diabetes Center Copenhagen
      • Kolding, Dinamarca, 6000
        • Kolding Hospital
      • Odense, Dinamarca, 5000
        • Odense University Hospital
      • Roskilde, Dinamarca, 4000
        • Zealand University Hospita; Roskilde
  • Estados Unidos
    • Alabama
      • Huntsville, Alabama, Estados Unidos, 35805-4104
        • Apogee Clinical Research
    • Arizona
      • Surprise, Arizona, Estados Unidos, 85374-4840
        • Southwest Kidney Institute
    • California
      • Beverly Hills, California, Estados Unidos, 90211
        • National Heart Institute
      • Sylmar, California, Estados Unidos, 91342
        • Olive View - UCLA Medical Cente
      • West Hills, California, Estados Unidos, 91307
        • Interventional Cardiology Medical Group
    • Colorado
      • Littleton, Colorado, Estados Unidos, 80120
        • South Denver Cardiology Associates
    • Florida
      • Boca Raton, Florida, Estados Unidos, 33434
        • Flourish Research
      • Gainesville, Florida, Estados Unidos, 32608
        • University of Florida Health Shands Hospital
      • Jacksonville Beach, Florida, Estados Unidos, 32250-4303
        • Florida Kidney Physicians LLC
      • Miami, Florida, Estados Unidos, 33126
        • Total Research Group, LLC
      • Miami, Florida, Estados Unidos, 33127
        • Bioresearch Partner
    • Georgia
      • Atlanta, Georgia, Estados Unidos, 30322
        • Emory University School of Medicine
      • Decatur, Georgia, Estados Unidos, 30033-4004
        • Joseph Maxwell Cleland Atlanta VA Medical Center
      • Macon, Georgia, Estados Unidos, 31210-1359
        • East Coast Institute For Research LLC
    • Idaho
      • Coeur d'Alene, Idaho, Estados Unidos, 83814
        • Kootenai Research Services
    • Illinois
      • Chicago, Illinois, Estados Unidos, 60611
        • Northwestern University
    • Kansas
      • Kansas City, Kansas, Estados Unidos, 66160
        • University of Kansas Medical Center
      • Wichita, Kansas, Estados Unidos, 67214
        • Kansas Nephrology Research Institute, LLC
    • Kentucky
      • Louisville, Kentucky, Estados Unidos, 40202
        • University of Louisville
    • Maryland
      • Baltimore, Maryland, Estados Unidos, 21239
        • Medstar Health Research Institute
    • Michigan
      • Saint Joseph, Michigan, Estados Unidos, 49085-8511
        • Lake Michigan Nephrology
      • Shelby, Michigan, Estados Unidos, 48315
        • St. Clair Nephrology Research, LLC
    • Minnesota
      • Minneapolis, Minnesota, Estados Unidos, 55417
        • Minneapolis VA Health Care System
    • Mississippi
      • Brookhaven, Mississippi, Estados Unidos, 39601-2326
        • Southwest Mississippi Nephrology, Pllc
    • Nebraska
      • North Platte, Nebraska, Estados Unidos, 69101-0614
        • Great Plains Nephrology
    • Nevada
      • North Las Vegas, Nevada, Estados Unidos, 89086
        • VA Southern Nevada Healthcare System
      • Reno, Nevada, Estados Unidos, 89511
        • Sierra Nevada Specialty Care
    • New Hampshire
      • Portsmouth, New Hampshire, Estados Unidos, 03801
        • Seacoast Kidney and Hypertension Specialists
    • New Jersey
      • Bridgewater, New Jersey, Estados Unidos, 08807
        • Advanced Heart Care, LLC
    • New Mexico
      • Albuquerque, New Mexico, Estados Unidos, 87106
        • UNM Health Science Center
    • New York
      • New York, New York, Estados Unidos, 10010-5011
        • VA New York Harbor Healthcare System
    • North Carolina
      • Charlotte, North Carolina, Estados Unidos, 28208-0014
        • Metrolina Nephrology Associates, PA
      • Charlotte, North Carolina, Estados Unidos, 28277
        • Metrolina Nephrology Associates, PA
      • Greensboro, North Carolina, Estados Unidos, 27405-3654
        • Carolina Kidney Associates
      • Winston-Salem, North Carolina, Estados Unidos, 27103
        • Brookview Hills Research Associates LLC
    • Ohio
      • Cleveland, Ohio, Estados Unidos, 44106
        • University Hospitals Cleveland Medical Center
    • Pennsylvania
      • Philadelphia, Pennsylvania, Estados Unidos, 19140
        • Temple University
      • Philadelphia, Pennsylvania, Estados Unidos, 19114-1028
        • Northeast Endocrine Metabolic Associates
      • Upland, Pennsylvania, Estados Unidos, 19013
        • Clinical Renal Associates
    • Rhode Island
      • East Providence, Rhode Island, Estados Unidos, 02914-2641
        • Nephrology Associates, Inc
    • Tennessee
      • Memphis, Tennessee, Estados Unidos, 38104
        • University of Tennessee
    • Texas
      • Austin, Texas, Estados Unidos, 78751
        • Research Management, Inc - Austin
      • DeSoto, Texas, Estados Unidos, 75115-2011
        • Dallas Nephrology Associates Medical Clinic
      • El Paso, Texas, Estados Unidos, 79935
        • Academy Of Diabetes, Thyroid And Endocrine, PA
      • Lufkin, Texas, Estados Unidos, 75904
        • P&I Clinical Research, LLC
      • Lufkin, Texas, Estados Unidos, 75904
        • Texas Institute for Kidney and Endocrine Disorders
      • Pasadena, Texas, Estados Unidos, 77504-1944
        • Renal Specialists of Houston, PA
      • San Antonio, Texas, Estados Unidos, 78207
        • University Health
    • Virginia
      • Charlottesville, Virginia, Estados Unidos, 22903
        • University of Virginia Health System
      • Manassas, Virginia, Estados Unidos, 20110
        • Kidney and Hypertension Specialists, PLLC
      • Newport News, Virginia, Estados Unidos, 23606
        • Tidewater Physicians Multispecialty Group
      • Salem, Virginia, Estados Unidos, 24153
        • Salem VA Medical Center
    • Washington
      • Spokane, Washington, Estados Unidos, 99204
        • Providence Medical Research Center
  • Itália
      • Alessandria, Itália, 15121
        • Ospedale SS. Antonio e Biagio e C. Arrigo - AOUAL
      • Asti, Itália, 14100
        • Asti-Ospedale Cardinal Massaia
      • Bari, Itália, 70124
        • Azienda Universitaria Ospedaliera Consorziale Policlinico Bari
      • Bergamo, Itália, 24127
        • ASST Papa Giovanni XXIII
      • Bologna, Itália, 40138
        • Policlinico S. Orsola-Malpighi
      • Cagliari, Itália, 09100
        • Azienda Ospedaliera ARNAS G. Brotzu
      • Chieri, Itália, 10023
        • Chieri-Ospedale Maggiore
      • Chieti, Itália, 66100
        • Ospedale SS Annunziata
      • Cuneo, Itália, 12100
        • A.S.O. S. Croce e Carle
      • Florence, Itália, 50134
        • A. O. Universitaria Careggi
      • Florence, Itália, 50124
        • Firenze-Ospedale San Giovanni di Dio
      • Genova, Itália, 16132
        • Azienda Ospedaliera San Martino
      • Imola, Itália, 40026
        • Ospedale di Imola S. Maria della Scaletta
      • Milan, Itália, 20132
        • Ospedale San Raffaele S.r.l.
      • Milan, Itália, 20142
        • Asst Santi Paolo E Carlo
      • Monza, Itália, 20900
        • Fondazione IRCCS San Gerardo dei Tintori
      • Novara, Itália, 28100
        • Ospedale Maggiore della Carità
      • Padova, Itália, 35128
        • Azienda Ospedaliera di Padova
      • Parma, Itália, 43126
        • Azienda Ospedaliera Unversitaria di Parma
      • Pavia, Itália, 27100
        • Fondazione Salvatore Maugeri
      • Perugia, Itália, 06129
        • Azienda Ospedaliera di Perugia
      • Pisa, Itália, 56126
        • Azienda Ospedaliera Universitaria Pisana
      • Prato, Itália, 59100
        • Prato-Ospedale Santo Stefano
      • Roma, Itália, 00189
        • Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
      • San Fermo della Battaglia, Itália, 22020
        • Azienda Socio Sanitaria Territoriale Lariana
      • San Giovanni Rotondo (Foggia), Itália, 71013
        • IRCCS Ospedale "Casa Sollievo della Sofferenza"
      • Savona, Itália, 17100
        • Azienda Socio Sanitaria Ligure 2
      • Sesto San Giovanni, Itália, 20099
        • IRCCS MultiMedica
      • Todi, Itália, 06059
        • Todi-Nuovo Ospedale Media Valle del Tevere
      • Turin, Itália, 0100
        • Torino-Ospedale Oftalmico
      • Verbania, Itália, 28922
        • Ospedale Castelli - Verbania
      • Vicenza, Itália, 36100
        • Ospedale San Bortolo
  • Japão
      • Asahikawa-Shi, Japão, 078-8510
        • Asahikawa Medical University Hospital
      • Chiba, Japão, 260-8677
        • Chiba University Hospital
      • Chuo-Shi, Japão, 409-3898
        • University of Yamanashi Hospital
      • Fukuoka, Japão, 812-8582
        • Kyushu University Hospital
      • Isehara, Japão, 259-1193
        • Tokai University Hospital
      • Izumo, Japão, 693-8501
        • Shimane University Hospital
      • Kurashiki-Shi, Japão, 701-0192
        • Kawasaki Medical School Hospital
      • Kurume, Japão, 830-0011
        • Kurume University Hospital
      • Kyoto, Japão, 606-8507
        • Kyoto University Hospital
      • Nagakute, Japão, 480-1195
        • Aichi Medical University Hospital
      • Nagoya, Japão, 466-8560
        • Nagoya University Hospital
      • Nagoya, Japão, 455-8530
        • Chubu Rosai Hospital
      • Okayama, Japão, 700-8558
        • Okayama University Hospital
      • Osaka, Japão, 553-0003
        • Kansai Electric Power Hospital
      • Sendai, Japão, 980-8547
        • Tohoku University Hospital
      • Tokyo, Japão, 160-8582
        • Keio University Hospital
      • Tokyo, Japão, 105-8470
        • Toranomon Hospital
      • Tokyo, Japão, 104-8560
        • St. Luke's International Hospital
      • Tokyo, Japão, 173-8606
        • Teikyo University Hospital
      • Tokyo, Japão, 113-8431
        • Juntendo University Hospital
      • Tokyo, Japão, 113-8655
        • The University of Tokyo Hospital
      • Tokyo, Japão, 162-8655
        • National Center for Global Health and Medicine
      • Tokyo, Chuo-ku, Japão, 103-0027
        • Tokyo-Eki Center-building Clinic
      • Yokohama, Japão, 236-0004
        • Yokohama City University Hospital
      • Ōtsu, Japão, 520-2192
        • Shiga University of Medical Science Hospital
  • Malásia
      • Ampang, Malásia, 68000
        • Hospital Ampang
      • Batu Caves, Malásia, 68100
        • Hospital Selayang
      • Batu Pahat, Malásia, 83000
        • Hospital Sultanah Nora Ismail
      • George Town, Malásia, 10990
        • Hospital Pulau Pinang-Pulau Pinang-21953
      • Ipoh, Malásia, 30450
        • Hospital Raja Permaisuri Bainun
      • Johor Bahru, Malásia, 80100
        • Hospital Sultanah Aminah
      • Johor Bahru, Malásia, 81100
        • Hospital Sultan Ismail
      • Kajang, Malásia, 43000
        • Hospital Sultan Idris Shah Serdang
      • Kajang, Selangor, Malásia, 43000
        • Hospital Kajang
      • Klang, Malásia, 41200
        • Hospital Tengku Ampuan Rahimah
      • Kota Bharu, Malásia, 15586
        • Hospital Raja Perempuan Zainab II
      • Kota Kinabalu, Malásia, 88586
        • Hospital Queen Elizabeth
      • Kuala Lumpur, Malásia, 50586
        • Hospital Kuala Lumpur
      • Kuala Lumpur, Malásia, 59100
        • University Malaya Medical Centre
      • Kuala Pilah, Malásia, 72000
        • Hospital Tuanku Ampuan Najihah
      • Kuantan, Malásia, 25100
        • Hospital Tengku Ampuan Afzan
      • Kuching, Malásia, 93586
        • Hospital Umum Sarawak
      • Kulim, Malásia, 09090
        • Hospital Kulim
      • Malacca, Malásia, 75400
        • Hospital Melaka
      • Muar town, Malásia, 84000
        • Hospital Pakar Sultanah Fatimah
      • Perai, Malásia, 13700
        • Hospital Seberang Jaya
      • Serdang, Malásia, 43400
        • Hospital Sultan Abdul Aziz Shah
      • Seremban, Malásia, 70300
        • Hospital Tuanku Ja'afar
      • Taiping, Malásia
        • Hospital Taiping
      • Teluk Intan, Malásia, 36000
        • Hospital Teluk Intan
      • Temerluh, Malásia, 28000
        • Hospital Sultan Haji Ahmad Shah
  • México
      • Aguascalientes, México, 20259
        • Centenario Hospital Miguel Hidalgo
      • Cuernavaca, México, 62250
        • Instituto de Diabetes, Obesidad y Nutrición S.C.
      • Culiacán, México, CP 80020
        • Neurociencias Estudios Clinicos S.C.
      • Durango, México, 34000
        • Instituto de investigación aplicado a la neurociencia
      • Guadalajara, México, 44670
        • Unidad de Investigación Clinica y Atencion Medica HEPA SC
      • Guadalajara, México, 44340
        • Centro de Investigacion Clinica y Medicina Traslacional (CIMeT)
      • Guadalajara, México, 44340
        • Centro Medico Nacional de Occidente/ Centro De Investigacion Biomedica De Occidente
      • Mexico City, México, 03100
        • Health Pharma Professional Research S.A. de C.V.
      • Mexico City, México, 03650
        • Soluciones Terapéuticas Médico Quirúrgicas S. de R.L. de C.V.
      • Mexico City, México, 07760
        • Hospital Juárez de México
      • Monterrey, México, 64460
        • Hospital Universitario Dr Jose Eleuterio Gonzalez
      • Monterrey, México, 64310
        • Iecsi S.C.
      • Monterrey, México, CP 64040
        • Renall Monterrey
      • Morelia, México, 58260
        • Centro de Investigación Clínica Chapultepec S.A. de C.V.
      • Mérida, México, 97070
        • Medical Care & Research SA de CV
      • Mérida, México, 97125
        • Merida Investigación Clínica
      • Tlajomulco de Zúñiga, México, 45653
        • IMSS Regional General Hospital 180
      • Tlalpan, México, 14080
        • Instituto Nacional de Cardiologia Ignacio Chavez
      • Veracruz, México, 91900
        • FAICIC S de RL de C.V.
      • Veracruz, México, 91910
        • Sociedad de Metabolismo y Corazón S.C.
  • Nova Zelândia
      • Auckland, Nova Zelândia, 1023
        • Auckland City Hospital
      • Auckland, Nova Zelândia, 2025
        • Middlemore Hospital
      • Auckland, Takapuna, Nova Zelândia, 0620
        • North Shore Hospital
      • New Plymouth, Nova Zelândia, 4310
        • Taranaki Base Hospital
    • Northland
      • Whangarei, Northland, Nova Zelândia, 0110
        • Whangarei Hospital
    • Otago
      • Dunedin, Otago, Nova Zelândia, 9016
        • Dunedin Hospital
    • Waikato Region
      • Hamilton, Waikato Region, Nova Zelândia, 3240
        • Waikato Hospital
  • Portugal
      • Aveiro, Portugal, 3814-501
        • ULS da Região de Aveiro
      • Braga, Portugal, 4710-243
        • Centro Clínico Académico de Braga (2CA-Braga)
      • Carnaxide, Portugal, 2790-134
        • CHLO, EPE - Hospital de Santa Cruz
      • Castelo Branco, Portugal, 6000-085
        • Unidade Local de Saúde de Castelo Branco, E.P.E
      • Coimbra, Portugal, 3004-561
        • CHUC - Centro Hospitalar e Universitario de Coimbra, EPE
      • Faro, Portugal, 8000-386
        • Unidade Local de Saúde do Algarve, E.P.E
      • Funchal, Portugal, 9004-514
        • SESARAM
      • Lisbon, Portugal, 1069-166
        • ULS de São José
      • Lisbon, Portugal, 1649-035
        • Unidade Local de Saúde Santa Maria
      • Loures, Portugal, 2674-514
        • Hospital Beatriz Ângelo
      • Porto, Portugal, 4200-319
        • Centro Hospitalar Universitário São João,EPE
      • Senhora da Hora, Portugal, 4464-513
        • Unidade Local de Saúde de Matosinhos
      • Setúbal, Portugal, 2910-549
        • Unidade Local De Saude Da Arrabida E.P.E.
      • Viseu, Portugal, 3504-509
        • Unidade Local De Saude De Viseu Dao-Lafoes E.P.E.
  • Reino Unido
      • Antrim, Reino Unido, BT41 2RL
        • Antrim Area Hospital
      • Basildon, Reino Unido, SS16 5NL
        • Basildon Hospital
      • Belfast, Reino Unido, BT16 1RH
        • Ulster Hospital
      • Belfast, Reino Unido, BT9 7AB
        • Beltfast City Hospital
      • Birmingham, Reino Unido, B15 2WB
        • Queen Elizabeth Hospital Birmingham
      • Birmingham, Reino Unido, B11 4AN
        • Fernley Medical Centre
      • Birmingham, Reino Unido, B19 1TT
        • Burbury Medical Centre
      • Birmingham, Reino Unido, B31 3HB
        • West Heath Surgery
      • Birmingham, Reino Unido, B32 2TJ
        • Ridgacre House Surgery
      • Blackburn, Reino Unido, BB2 1AX
        • Oakenhurst Medical Practice
      • Brighton, Reino Unido, BN2 1ES
        • Royal County Sussex Hospital
      • Bristol, Reino Unido, BS10 5NB
        • Southmead Hospital
      • Bristol, Reino Unido, BS11 0QE
        • Pioneer Ridingleaze
      • Bristol, Reino Unido, BS2 0AN
        • Lawrence Hill Health Centre
      • Bristol, Reino Unido, BS34 5TF
        • Coniston Medical Practice
      • Bury St Edmunds, Reino Unido, IP33 2QZ
        • West Suffolk Hospital
      • Chelmsford, Reino Unido, CM1 7ET
        • Broomfield Hospital
      • Chippenham, Reino Unido, SN14 6GT
        • Hathaway Medical Centre
      • Clevedon, Reino Unido, BS21 6DG
        • Clevedon Medical Centre
      • Cosham, Reino Unido, PO6 3LY
        • Queen Alexandra Hospital
      • County Down, Reino Unido, BT35 8DR
        • Daisy Hill Hospital
      • Coventry, Reino Unido, CV2 2DX
        • University Hospital Coventry
      • Cramlington, Reino Unido, NE23 6US
        • The Village Surgery
      • Darlington, Reino Unido, DL3 6HZ
        • Orchard Court Surgery
      • Dartford, Reino Unido, DA2 8DA
        • Darent Valley Hospital
      • Dorchester, Reino Unido, DT1 2JY
        • Dorset County Hospital
      • Dudley, Reino Unido, DY1 2HQ
        • Russells Hall Hospital
      • Durham, Reino Unido, DH1 3JX
        • University Health Centre
      • Fulwood, Reino Unido, PR2 9HT
        • Highland Clinical Research Facility
      • Gillingham, Reino Unido, ME7 2BU
        • Woodlands Family Practice
      • Gloucester, Reino Unido, GL1 3NN
        • Gloucestershire Royal Hospital
      • Great Yarmouth, Reino Unido, NR31 6LA
        • James Paget University Hospital
      • Guisborough, Reino Unido, TS14 7DJ
        • The Garth Surgery
      • Hereford, Reino Unido, HR1 2BN
        • Hereford County Hospital
      • Ipswich, Reino Unido, IP4 5PD
        • Ipswich Hospital (UK)
      • Kings Lynn, Reino Unido, PE30 4ET
        • The Queen Elizabeth Hospital
      • Leeds, Reino Unido, LS26 9AA
        • Pinfold Surgery
      • Leominster, Reino Unido, HR6 8HD
        • Ryeland Surgery
      • Little Horton Lane, Reino Unido, BD5 0NA
        • St Luke's Hospital
      • Liverpool, Reino Unido, L9 7AL
        • Aintree University Hospital
      • London, Reino Unido, SE1 9RT
        • Guy's Hospital
      • London, Reino Unido, SE5 9RS
        • King's College Hospital
      • London, Reino Unido, SW17 0QT
        • St George's Hospital
      • London, Reino Unido, W12 0HS
        • Hammersmith Hospital
      • London, Reino Unido, N18 1QX
        • North Middlesex University Hospital
      • London, Reino Unido, W6 7HY
        • Richford Gate Medical Practice
      • Londonderry, Reino Unido, BT47 6SB
        • Altnagelvin Area Hospital
      • Metropolitan Borough of Wirral, Reino Unido, CH49 5PE
        • Arrowe Park Hospital
      • Middlesbrough, Reino Unido, TS5 6HA
        • Linthorpe Surgery
      • Norfolk, Reino Unido, NR4 7UY
        • Norfolk and Norwich University Hospital
      • Northampton, Reino Unido, NN1 5BD
        • Northampton General Hospital
      • Oxford, Reino Unido, OX3 7LE
        • Churchill Hospital
      • Oxford, Reino Unido, OX16 9AD
        • Banbury Cross Health Centre
      • Oxford, Reino Unido, OX4 1XB
        • St Bartholomews & Hollow Way Med Centre
      • Pickering, Reino Unido, YO18 8BL
        • Pickering Medical Practice
      • Poole, Reino Unido, BH14 8EE
        • Lilliput Surgery
      • Reading, Reino Unido, RG1 5AN
        • Royal Berkshire Hospital
      • Redditch, Reino Unido, B98 7UB
        • Alexandra Hospital
      • Salford, Reino Unido, M6 8HD
        • Salford Royal Hospital
      • Shrewsbury, Reino Unido, SY3 8XQ
        • Royal Shrewsbury Hospital
      • St Helens, Reino Unido, WA9 3DA
        • St Helens Hospital
      • Stevenage, Reino Unido, SG1 4AB
        • Lister Hospital
      • Swindon, Reino Unido, SN3 6BB
        • Great Western Hospital
      • Truro, Reino Unido, TR1 3LJ
        • Royal Cornwall Hospital
      • Wantage, Reino Unido, OX12 9BN
        • Church Street Practice
      • Westcliff-on-Sea, Reino Unido, SS0 0RY
        • Southend University Hospital
      • Weston-super-Mare, Reino Unido, BS24 7PR
        • 168 Parklands Medical Centre
      • Whitstable, Reino Unido, CT5 3SE
        • Estuary View Medical Centre
      • Witney, Reino Unido, OX28 6JS
        • Windrush Medical Practice
      • Witney, Reino Unido, OX29 4QB
        • Eynsham Medical Centre
      • York, Reino Unido, YO24 2RQ
        • Woodthorpe Surgery
  • Suécia
      • Danderyd, Suécia, 182 88
        • Danderyds Sjukhus AB
      • Gothenburg, Suécia, 413 46
        • Sahlgrenska Universitetsjukhuset
      • Linköping, Suécia, 581 85
        • Universitetssjukhuset Linköping
      • Lund, Suécia, 221 85
        • Skånes Universitetssjukhus, Lund
      • Stockholm, Suécia, 14157
        • Karolinska University Hospital
      • Sundsvall, Suécia, 856 43
        • Region Vaesternorrland
      • Uppsala, Suécia, 751 85
        • Akademiska sjukhuset
  • Taiwan
      • Kaohsiung City, Taiwan, 824005
        • E-Da Hospital
      • Luodong Township, Taiwan, 265
        • Lotung Poh-Ai Hospital
      • New Taipei City, Taiwan, 220
        • Far Eastern Memorial Hospital
      • New Taipei City, Taiwan, 23561
        • Taipei Medical University-Shuang Ho Hospital
      • New Taipei City, Taiwan, 23142
        • Taipei Tzu Chi Hospital
      • New Taipei City, Taiwan, 243089
        • Fu Jen Catholic University Hospital
      • Taichung, Taiwan, 404
        • China Medical University Hospital
      • Taichung, Taiwan, 402
        • Chung Shan Medical University Hospital
      • Taichung, Taiwan, 435
        • Tungs' Taichung MetroHarbor Hospital
      • Taichung, Taiwan, 407219
        • Taichung Veterans General Hospital
      • Tainan, Taiwan, 70403
        • National Cheng Kung University Hospital
      • Tainan, Taiwan, 736402
        • Chi Mei Hospital, Liouying
      • Taipei, Taiwan, 110
        • Taipei Medical University Hospital
      • Taipei, Taiwan, 10449
        • Mackay Memorial Hospital
      • Taipei, Taiwan, 112
        • Taipei Veterans General Hospital
      • Taipei, Taiwan, 106
        • Cathay General Hospital
      • Taipei, Taiwan, 11696
        • Taipei Municipal Wanfang Hospital
      • Taipei, Taiwan, 111045
        • Shin Kong Wu Ho-Su Memorial Hospital
      • Taoyuan City, Taiwan, 333
        • Chang Gung Memorial Hospital, Linkou
      • Taoyuan City, Taiwan, 330
        • TaoYuan General Hospital
  • Índia
      • Bangalore, Índia, 560034
        • St John's Medical College
      • Bangalore, Índia, 560017
        • Manipal Hospitals, Old Airport Road
      • Bangalore, Índia, 560076
        • Apollo Hospital - Bangalore
      • Bathinda, Índia, 151001
        • All India Institute of Medical Sciences, Bathinda
      • Bhubaneswar, Índia, 751005
        • Apollo Hospitals - Bhubaneswar
      • Bhubaneswar, Índia, 751019
        • All India Institute of Medical Sciences Bhubaneswar
      • Bilāspur, Índia, 174001
        • All India Institute of Medical Sciences, Bilaspur
      • Chandigarh, Índia, 160012
        • Post Graduate Institute of Medical Education and Research
      • Chennai, Índia, 600006
        • Apollo Hospital - Chennai
      • Chennai, Índia, 600095
        • Apollo Speciality Hospitals, Vanagaram
      • Dwārka, Índia, 110075
        • Aakash Healthcare Super Speciality Hospital
      • Faridabad, Índia, 121002
        • Accord Superspeciality Hospital
      • Faridabad, Índia, 121002
        • Amrita Hospital Faridabad
      • Guhugram, Índia, 122011
        • Marengo Asia Hospitals, Guhugram
      • Guntur, Índia, 522001
        • Vedenta Hospitals
      • Gurugram, Índia, 122001
        • Artemis Hospital
      • Hubli, Índia, 580021
        • Karnataka Institute of Medical Sciences, Hubli
      • Hyderabad, Índia, 500082
        • Nizam's Institute of Medical Sciences
      • Hyderabad, Índia, 500012
        • Osmania Medical College & Hospital
      • Hyderabad, Índia, 500033
        • Apollo Hospitals Jubilee Hills
      • Hyderabad, Índia, 500058
        • Apollo DRDO Hospital
      • Jalandhar, Índia, 144012
        • Fortis Hospital, Jalandhar
      • Jodhpur, Índia, 342005
        • All India Institute of Medical Sciences, Jodhpur
      • Kochi, Índia, 682041
        • Amrita Institute of Medical Sciences and Research Centre
      • Kolkata, Índia, 700014
        • Nil Ratan Sircar Medical College & Hospital
      • Kolkata, Índia
        • Manipal Hospitals, EM Bypass
      • Kozhikode, Índia, 673009
        • IQRAA International hospital & research centre.
      • Lucknow, Índia, 226003
        • King George's Medical University
      • Lucknow, Índia, 226014
        • Sanjay Gandhi Post Graduate Institute of Medical Sciences
      • Lucknow, Índia, 226010
        • Dr Ram Manohar Lohia Institute of Medical Sciences
      • Madurai, Índia, 625107
        • Meenakshi Mission Hospital & Research Centre
      • Madurai, K.K. Nagar, Índia, 625020
        • Apollo Speciality Hospital
      • Mangaluru, Índia, 575001
        • Kasturba Medical College and Hospital
      • Mysore, Índia, 570023
        • Apollo BGS Hospital
      • Mānesar, Índia, 122052
        • Fortis Hospital, Manesar
      • Nadiād, Índia, 387001
        • Muljibhai Patel Urological Hospital
      • New Delhi, Índia, 110029
        • All India Institute of Medical Sciences
      • New Delhi, Índia, 110026
        • Maharaja Agrasen Hospital
      • New Delhi, Índia, 110017
        • Max Super Specialty Hospital, Saket
      • New Delhi, Índia, 110025
        • Epitome Kidney Urology Institute and Lions Hospital
      • New Delhi, Índia, 110070
        • Fortis Flt. Lt. Rajan Dhall Hospital
      • New Delhi, Índia, 110075
        • Venkateshwar Hospital
      • Patna, Índia, 800014
        • Indira Gandhi Institute of Medical Sciences
      • Puducherry, Índia, 605006
        • Jawaharlal Institute of Postgraduate Medical Education
      • Raipur, Índia, 492099
        • All India Institute of Medical Sciences
      • Raipur, Índia, 492001
        • DKS Post Graduate Institute & Research Center, Raipur (C.G)
      • Ranchi, Índia, 834001
        • Raj Hospitals
      • Ranchi, Índia, 834004
        • Paras HEC, Ranchi
      • Rohtak, Índia, 124001
        • Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
      • Secunderabad, Índia, 500003
        • Yashoda Hospitals - Secunderabad
      • Trivandrum, Índia, 695029
        • Kimshealth
      • Vadodara, Índia, 390021
        • Aman Hospital & Research Center
      • Vellore, Índia, 632517
        • Christian Medical College, Vellore
      • Visakhapatnam, Índia, 530040
        • Apollo Hospitals Health City

Critérios de participação

Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.

Critérios de elegibilidade

Idades elegíveis para estudo

18 anos e mais velhos (Adulto, Adulto mais velho)

Aceita Voluntários Saudáveis

Não

Gêneros Elegíveis para o Estudo

Tudo

Descrição

Key Inclusion Criteria:

  • Evidence of chronic kidney disease (CKD) at risk of kidney disease progression is defined on the basis of local laboratory results recorded at least 3 months before and at the time of the Screening visit, and requires:

    1. Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR ≥20 <45 mL/min/1.73m² (irrespective of diabetes status); or
    2. No self-reported diabetes: CKD-EPI eGFR ≥45 <90 mL/min/1.73m² with urine albumin-to-creatinine ratio (uACR) ≥150 mg/g (or protein-to-creatinine ratio ≥225 mg/g); or
    3. Self-reported diabetes: CKD-EPI eGFR ≥45 <90 mL/min/1.73m² with uACR ≥30 mg/g (or protein-to-creatinine ratio ≥45 mg/g).

  • Neither requires an Aldosterone Synthase inhibitor (ASi) or Mineralocorticoid Receptor Antagonist (MRA), nor that such treatment is definitely inappropriate.

Key Exclusion Criteria:

  • Blood potassium of >5.2 mmol/L at screening visit
  • Blood Alanine Transaminase (ALT) or Aspartate Transaminase (AST) >3x Upper Limit of Normal (ULN) at Screening visit (only one is required, with ALT preferred)
  • Known liver cirrhosis
  • On dialysis, functioning kidney transplant, or scheduled living donor transplant
  • Treated with new immunosuppression therapy for new (or relapse/flare of pre-existing) kidney disease within the last 60 days
  • Receiving more than one Renin-Angiotensin System (RAS) inhibitor (i.e. on dual therapy with two of an Angiotensin-Converting Enzyme inhibitor (ACEi), Angiotensin Receptor Blocker (ARB) or direct renin inhibitor)
  • Currently treated with an Mineralocorticoid Receptor Antagonist (MRA) (e.g. spironolactone, eplerenone, finerenone)
  • Currently treated with systemic mineralocorticoid replacement therapy (e.g. fludrocortisone) Further exclusion criteria apply.

Plano de estudo

Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.

Como o estudo é projetado?

Detalhes do projeto

  • Finalidade Principal: Tratamento
  • Alocação: Randomizado
  • Modelo Intervencional: Atribuição Paralela
  • Mascaramento: Quadruplicar

Armas e Intervenções

Grupo de Participantes / Braço
Intervenção / Tratamento
Experimental: Parte 2: Tratamento randomizado, período de acompanhamento, grupo de tratamento
Medicamento: Empagliflozin

Empagliflozin (called Type E)

Medicamento: BI 690517

BI 690517 (called Type M randomized treatment)

Outros nomes:
  • Vicadrostato
Comparador de Placebo: Parte 2: Período de acompanhamento, grupo placebo
Medicamento: Empagliflozin

Empagliflozin (called Type E)

Medicamento: Placebo matching BI 690517

Placebo matching BI 690517
Outro: Part 1: Run-in period (all participants)
  • Participant will receive empagliflozin (called Type E) together with study tablets (called Type F) prior to later randomisation to the main study treatment (Type M).
  • This run-in period allows empagliflozin to be established and have its effects on kidney function before randomisation, and to make sure participant can tolerate empagliflozin long-term. Participants will not routinely know whether type F treatment is active or inactive so that participants can become familiar with taking main study tablet (Type M) after randomization.
Medicamento: Empagliflozin

Empagliflozin (called Type E)

O que o estudo está medindo?

Medidas de resultados primários

Medida de resultado
Descrição da medida
Prazo
Time to first occurrence of the primary composite outcome of: (i) Kidney disease progression*; or (ii) Hospitalization for heart failure; or (iii) Cardiovascular death.
Prazo: up to 4 years

Kidney disease progression is defined as kidney failure or a sustained decline of ≥40% in estimated Glomerular Filtration Rate (eGFR) from randomization
up to 4 years

Medidas de resultados secundários

Medida de resultado
Prazo
Tempo até o primeiro evento de progressão da doença renal ou morte cardiovascular
Prazo: até 4 anos
até 4 anos
Key secondary outcome: Time to first event of kidney failure, hospitalization for heart failure or cardiovascular death
Prazo: up to 4 years
up to 4 years
Key secondary outcome: Time to first event of hospitalization for heart failure or cardiovascular death
Prazo: up to 4 years
up to 4 years
Key secondary outcome: Occurrences of hospitalizations from any cause (first and any subsequent, combined) or death from any cause
Prazo: up to 4 years
up to 4 years
Key secondary outcome: Time to death from any cause
Prazo: up to 4 years
up to 4 years
Key secondary outcome: Annual rate of change in eGFR from 1 month until last scheduled visit (i.e. chronic eGFR slope)
Prazo: up to 4 years
up to 4 years

Colaboradores e Investigadores

É aqui que você encontrará pessoas e organizações envolvidas com este estudo.

Patrocinador

Boehringer Ingelheim

Publicações e links úteis

A pessoa responsável por inserir informações sobre o estudo fornece voluntariamente essas publicações. Estes podem ser sobre qualquer coisa relacionada ao estudo.

Links úteis

Datas de registro do estudo

Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados ​​pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.

Datas Principais do Estudo

Início do estudo (Real)

30 de agosto de 2024

Conclusão Primária (Estimado)

31 de dezembro de 2026

Conclusão do estudo (Estimado)

31 de dezembro de 2026

Datas de inscrição no estudo

Enviado pela primeira vez

29 de julho de 2024

Enviado pela primeira vez que atendeu aos critérios de CQ

29 de julho de 2024

Primeira postagem (Real)

1 de agosto de 2024

Atualizações de registro de estudo

Última Atualização Postada (Real)

28 de outubro de 2026

Última atualização enviada que atendeu aos critérios de controle de qualidade

27 de outubro de 2026

Última verificação

1 de outubro de 2026

Mais Informações

Termos relacionados a este estudo

Termos MeSH relevantes adicionais

Outros números de identificação do estudo

  • 1378-0006
  • 2024-511025-63-00 (Identificador de registro: CTIS)
  • U1111-1306-5049 (Identificador de registro: WHO register (ICTRP))

Plano para dados de participantes individuais (IPD)

Planeja compartilhar dados de participantes individuais (IPD)?

SIM

Descrição do plano IPD

Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.clinicalstudies.boehringer-ingelheim.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement".

Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.

Prazo de Compartilhamento de IPD

One year after the approval has been granted by major Regulatory Authorities and after the primary manuscript has been accepted for publication, or after termination of the development program.

Critérios de acesso de compartilhamento IPD

For study documents - upon signing of a 'Document Sharing Agreement'. For study data - 1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.

Tipo de informação de suporte de compartilhamento de IPD

  • PROTOCOLO DE ESTUDO
  • SEIVA
  • CSR

Informações sobre medicamentos e dispositivos, documentos de estudo

Estuda um medicamento regulamentado pela FDA dos EUA

Sim

Estuda um produto de dispositivo regulamentado pela FDA dos EUA

Não

Essas informações foram obtidas diretamente do site clinicaltrials.gov sem nenhuma alteração. Se você tiver alguma solicitação para alterar, remover ou atualizar os detalhes do seu estudo, entre em contato com register@clinicaltrials.gov. Assim que uma alteração for implementada em clinicaltrials.gov, ela também será atualizada automaticamente em nosso site .

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