EASi-KIDNEY™ (undersøgelserne af hjerte- og nyrebeskyttelse med BI 690517 i kombination med Empagliflozin)
27. oktober 2026 opdateret af: Boehringer Ingelheim
Et multicenter, internationalt, randomiseret, dobbeltblindt, placebokontrolleret klinisk forsøg med aldosteronsyntasehæmmeren BI 690517 i kombination med empagliflozin hos patienter med kronisk nyresygdom
This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study. The study is open to people who take other medicines called angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). People who already take empagliflozin or any other sodium-glucose cotransporter-2 inhibitor (SGLT2i) can also join. The study is also open to people who currently do not take any of these treatments. The purpose of this study is to find out whether a medicine called BI 690517 helps people with chronic kidney disease when taken in combination with a study medicine called empagliflozin. Worsening of kidney function increases the risk for kidney failure, cardiovascular disease, and heart failure hospitalisation.
After a run-in period, during which participants are confirmed to be receiving clinically appropriate renin-angiotensin system blockade and are established on empagliflozin, they are randomly assigned (by chance) to 1 of 2 groups. One group receives BI 690517 tablets, and the other group receives placebo tablets. Placebo tablets look like BI 690517 but do not contain any medicine. Participants take 1 study tablet once a day, in addition to empagliflozin, for the duration of the study.
The doctors document when participants experience worsening of their kidney disease, go to hospital due to heart failure, or die of cardiovascular problems during the study. The time to these events is compared between the 2 treatment groups to see whether the treatment works. The study continues until the required number of events have occurred which is about 3 to 4 years. During this time, participants visit the study site about 5 times within the first 6 months. Then they visit the study site every 6 months. At the visits, doctors regularly check participants' health, take blood and urine samples, measure blood pressure and weight, check kidney function, and take note of any unwanted effects.
Studieoversigt
Status
Aktiv, ikke rekrutterende
Betingelser
Intervention / Behandling
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
8371
Fase
- Fase 3
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Bariloche, Argentina, 8500
- Fundacion INTECNUS
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Buenos Aires, Argentina, 1407
- Terapia Renal Domiciliaria
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Buenos Aires, Argentina, B6000
- Centro de Salud Renal Junin SRL
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Buenos Aires, Argentina, C1061AAE
- Dres. Iribarren & Asoc. Consultario
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Buenos Aires, Argentina, C1430CKE
- Glenny Corp - Centro Medico Saavedra
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CABA, Argentina, 1425
- CPSIC SRL - Cardiologia Palermo
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Catamarca, Argentina, K4703AFI
- Sanatorio Pasteur S.A
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Ciudad Autonoma Buenos Aires, Argentina, C1431FWO
- CEMIC
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Lanús Este, Argentina, B1824KAJ
- CIMEL Chahin - Chahin S.A.
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Mar del Plata, Argentina, B7612
- Centro Nefrologico del Mar
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Rafaela, Argentina, S2300
- Mains Bleues
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Rosario, Argentina, S2000GAP
- Hospital Privado de Rosario
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Rosario, Argentina, S2013
- Sanatorio Parque S.A.
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Salta, Argentina, A4400
- Instituto de Nefrourologia y Nutricion de Salta
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San Juan, Argentina, J5400
- Clinica El Castaño
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San Miguel de Tucumán, Argentina, 4000
- Centro de Investigaciones Medicas Tucuman
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San Miguel de Tucumán, Argentina, 4000
- Centro Integral de Medicina Respiratoria - CIMER
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Santa Fe, Argentina, 2000
- Instituto de Investigaciones Clinicas de Rosario
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Villa Domínico, Argentina, B1872EEB
- CEREHA S.A.- Centro de Estudios Renales e Hipertension Arterial
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New South Wales, Australien, 2019
- Macquarie University
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New South Wales, Australien, 2145
- Westmead Hospital
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New South Wales
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Concord, New South Wales, Australien, 2139
- Concord Hospital
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Gosford, New South Wales, Australien, 2250
- Renal Research, Gosford
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Kingswood, New South Wales, Australien, 2747
- Nepean Hospital
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Kogarah, New South Wales, Australien, 2217
- St George Hospital
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Liverpool, New South Wales, Australien, 2170
- Liverpool Hospital
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Port Macquarie, New South Wales, Australien, 2444
- Port Macquarie Base Hospital (PMBH)
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Queensland
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Pialba, Queensland, Australien, 4655
- Hervey Bay Hospital
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Southport, Queensland, Australien, 4222
- Griffith University
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Southport, Queensland, Australien, 4215
- AOVO Clinical Trials
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Toowoomba, Queensland, Australien, 4350
- Toowoomba Hospital
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South Australia
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Bedford Park, South Australia, Australien, 5042
- Flinders Medical Centre
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Victoria
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Box Hill, Victoria, Australien, 3128
- Eastern Health-Box Hill Hospital
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Heidelberg Heights, Victoria, Australien, 3081
- Austin Health
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Melbourne, Victoria, Australien, 3004
- The Alfred Hospital
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Melbourne, Victoria, Australien, 3065
- St Vincent's Hospital Melbourne
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St Albans, Victoria, Australien, 3021
- Sunshine Hospital
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Bruges, Belgien, 8000
- AZ Sint-Jan Brugge
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Genk, Belgien, 3600
- Ziekenhuis Oost-Limburg
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Jette, Belgien, 1090
- UZ Brussel
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Liège, Belgien, 4000
- Centre Hospitalier Universitaire de Liège
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Aracaju, Brasilien, 49055-530
- Centro de Pesquisa Clínica do Coração
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Belo Horizonte, Brasilien, 30150-320
- Santa Casa de Belo Horizonte
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Belo Horizonte, Brasilien, 30220-330
- Centro de Pesquisa do Hospital Evangelico de Belo Horizonte
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Botucatu, Brasilien, 18618-686
- Universidade Estadual Paulista "Julio De Mesquita Filho"
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Bragança Paulista, Brasilien, 1291-6542
- Hospital Universitário São Francisco na Providência de Deus
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Campinas, Brasilien, 13073-350
- CEG - Centro de Endocrinologia Geloneze
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Centro Linhares, Brasilien, 29900010
- Instituto Cardiovascular de Linhares Ltda
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Curitiba, Brasilien, 80230-130
- PUC Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da PUC-PR
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Fortaleza, Brasilien, 60416-000
- Hospital Universitário Walter Cantidio - UFC
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Fortaleza, Brasilien, 60430-350
- Centro de Pesquisas em Diabetes e Doencas Metabolicas
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Goiânia, Brasilien, 74230-035
- Clínica CENDI Endocrinologia e Diabetes
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Goiânia, Brasilien, 74453200
- Hospital Ruy Azeredo
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Joinville, Brasilien, 89227-680
- Fundação Pró-Rim Joinville
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Juiz de Fora, Brasilien, 36033-318
- Galileo Medical Research Ltda
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Maceió, Brasilien, 57051-160
- Centro de Pesquisas Clínicas Dr. Marco Mota
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Natal, Brasilien, 59012300
- Hospital Universitário Onofre Lopes
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Porto Alegre, Brasilien, 90610-000
- Hospital Sao Lucas da PUCRS
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Porto Alegre, Brasilien, 90035-903
- Hospital de Clinicas de Porto Alegre
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Porto Alegre, Brasilien, 90560-032
- Hospitalar Moinhos de Vento
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Recife, Brasilien, 50070902
- IMIP Pernambuco
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Recife, Brasilien, 50720110
- AME Saúde
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Recife, Brasilien, 50740900
- Hospital das Clinicas da Universidade Federal de Pernambuco
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Salvador, Brasilien, 40110160
- Fundação Bahiana de Infectologia
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São Bernardo do Campo, Brasilien, 09715-090
- CEMEC - Centro Multidisciplinar de Estudos Clínicos
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São José do Rio Preto, Brasilien, 15090-000
- Hospital de Base
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São José dos Campos, Brasilien, 12230-001
- CIPES - Centro Internacional de Pesquisa Clínica
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São Paulo, Brasilien, 0402-9001
- Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo
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São Paulo, Brasilien, 04023900
- Fundacao Oswaldo Ramos (Hospital do Rim)
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São Paulo, Brasilien, 05403-000
- Hospital das Clinicas da Faculdade de Medicina da USP
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Teresina, Brasilien, 64049550
- Hospital Universitário da Universidade Federal do Piauí
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Vitória, Brasilien, 29043-260
- Hospital Universitário Cassiano Antônio Moraes
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Votuporanga, Brasilien, 15505-189
- Clínica Cardiológica
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Montreal, Canada, H2X 0A9
- Centre hospitalier de l'Université de Montréal (CHUM)
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Québec, Canada, G1V 4T3
- Diex Recherche Québec
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Québec, Canada, G1R 2J6
- CHU de Quebec-Universite Laval Research Centre
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Alberta
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Edmonton, Alberta, Canada, T6G 2P4
- University of Alberta Hospital (University of Alberta)
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British Columbia
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Kamloops, British Columbia, Canada, V2C 2T1
- Royal Inland Hospital
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Kelowna, British Columbia, Canada, V1Y 1T2
- Kelowna General Hospital
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Prince George, British Columbia, Canada, V2M 1S2
- Northern Health
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Surrey, British Columbia, Canada, V3W 1J8
- Fraser Health
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Vancouver, British Columbia, Canada, V5Z 1M9
- Vancouver General Hospital
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Vancouver, British Columbia, Canada, V1Y 1S1
- St. Paul's Hospital (Vancouver)
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Montréal
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Québec, Montréal, Canada, H4J 1C5
- CIUSSS Nord de l'île de Montreal
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Nova Scotia
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Halifax, Nova Scotia, Canada, B3H 1V7
- Centre for Clinical Research
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Ontario
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Brampton, Ontario, Canada, L6S 0C6
- Centricity Research (Brampton)
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Concord, Ontario, Canada, L4K 4M2
- Centricity Research (Vaughan)
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Kingston, Ontario, Canada, K7L 3N6
- Queen's University
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London, Ontario, Canada, N6A 5W9
- London Regional Cancer Program - London Health Sciences Ctr.
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Oshawa, Ontario, Canada, L1G 2B9
- Lakeridge Health Oshawa
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Ottawa, Ontario, Canada, K1H 7W9
- The Ottawa Hospital
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Toronto, Ontario, Canada, M5G 2N2
- Toronto General Hospital
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Toronto, Ontario, Canada, M4G 3E8
- Sunnybrook Health Sciences Centre
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Toronto, Ontario, Canada, M5C2T2
- St. Michael's Hospital
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Quebec
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Montreal, Quebec, Canada, H3G 1A4
- McGill University Health Centre (MUHC)
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Montreal, Quebec, Canada, H1T 2M4
- CIUSSS de l'Est-de-l'Île-de-Montréal
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Sherbrooke, Quebec, Canada, J1H 5N4
- CIUSSS de l Estrie-CHUS
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Aalborg, Danmark, 9000
- Aalborg Universitetsshospital
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Copenhagen, Danmark, 2100
- Rigshospitalet, København
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Herlev, Danmark, 2730
- Herlev and Gentofte Hospital
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Herlev, Danmark, 2730
- Steno Diabetes Center Copenhagen
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Kolding, Danmark, 6000
- Kolding Hospital
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Odense, Danmark, 5000
- Odense University Hospital
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Roskilde, Danmark, 4000
- Zealand University Hospita; Roskilde
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Antrim, Det Forenede Kongerige, BT41 2RL
- Antrim Area Hospital
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Basildon, Det Forenede Kongerige, SS16 5NL
- Basildon Hospital
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Belfast, Det Forenede Kongerige, BT16 1RH
- Ulster Hospital
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Belfast, Det Forenede Kongerige, BT9 7AB
- Beltfast City Hospital
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Birmingham, Det Forenede Kongerige, B15 2WB
- Queen Elizabeth Hospital Birmingham
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Birmingham, Det Forenede Kongerige, B11 4AN
- Fernley Medical Centre
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Birmingham, Det Forenede Kongerige, B19 1TT
- Burbury Medical Centre
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Birmingham, Det Forenede Kongerige, B31 3HB
- West Heath Surgery
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Birmingham, Det Forenede Kongerige, B32 2TJ
- Ridgacre House Surgery
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Blackburn, Det Forenede Kongerige, BB2 1AX
- Oakenhurst Medical Practice
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Brighton, Det Forenede Kongerige, BN2 1ES
- Royal County Sussex Hospital
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Bristol, Det Forenede Kongerige, BS10 5NB
- Southmead Hospital
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Bristol, Det Forenede Kongerige, BS11 0QE
- Pioneer Ridingleaze
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Bristol, Det Forenede Kongerige, BS2 0AN
- Lawrence Hill Health Centre
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Bristol, Det Forenede Kongerige, BS34 5TF
- Coniston Medical Practice
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Bury St Edmunds, Det Forenede Kongerige, IP33 2QZ
- West Suffolk Hospital
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Chelmsford, Det Forenede Kongerige, CM1 7ET
- Broomfield Hospital
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Chippenham, Det Forenede Kongerige, SN14 6GT
- Hathaway Medical Centre
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Clevedon, Det Forenede Kongerige, BS21 6DG
- Clevedon Medical Centre
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Cosham, Det Forenede Kongerige, PO6 3LY
- Queen Alexandra Hospital
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County Down, Det Forenede Kongerige, BT35 8DR
- Daisy Hill Hospital
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Coventry, Det Forenede Kongerige, CV2 2DX
- University Hospital Coventry
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Cramlington, Det Forenede Kongerige, NE23 6US
- The Village Surgery
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Darlington, Det Forenede Kongerige, DL3 6HZ
- Orchard Court Surgery
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Dartford, Det Forenede Kongerige, DA2 8DA
- Darent Valley Hospital
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Dorchester, Det Forenede Kongerige, DT1 2JY
- Dorset County Hospital
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Dudley, Det Forenede Kongerige, DY1 2HQ
- Russells Hall Hospital
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Durham, Det Forenede Kongerige, DH1 3JX
- University Health Centre
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Fulwood, Det Forenede Kongerige, PR2 9HT
- Highland Clinical Research Facility
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Gillingham, Det Forenede Kongerige, ME7 2BU
- Woodlands Family Practice
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Gloucester, Det Forenede Kongerige, GL1 3NN
- Gloucestershire Royal Hospital
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Great Yarmouth, Det Forenede Kongerige, NR31 6LA
- James Paget University Hospital
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Guisborough, Det Forenede Kongerige, TS14 7DJ
- The Garth Surgery
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Hereford, Det Forenede Kongerige, HR1 2BN
- Hereford County Hospital
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Ipswich, Det Forenede Kongerige, IP4 5PD
- Ipswich Hospital (UK)
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Kings Lynn, Det Forenede Kongerige, PE30 4ET
- The Queen Elizabeth Hospital
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Leeds, Det Forenede Kongerige, LS26 9AA
- Pinfold Surgery
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Leominster, Det Forenede Kongerige, HR6 8HD
- Ryeland Surgery
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Little Horton Lane, Det Forenede Kongerige, BD5 0NA
- St Luke's Hospital
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Liverpool, Det Forenede Kongerige, L9 7AL
- Aintree University Hospital
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London, Det Forenede Kongerige, SE1 9RT
- Guy's Hospital
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London, Det Forenede Kongerige, SE5 9RS
- King's College Hospital
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London, Det Forenede Kongerige, SW17 0QT
- St George's Hospital
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London, Det Forenede Kongerige, W12 0HS
- Hammersmith Hospital
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London, Det Forenede Kongerige, N18 1QX
- North Middlesex University Hospital
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London, Det Forenede Kongerige, W6 7HY
- Richford Gate Medical Practice
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Londonderry, Det Forenede Kongerige, BT47 6SB
- Altnagelvin Area Hospital
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Metropolitan Borough of Wirral, Det Forenede Kongerige, CH49 5PE
- Arrowe Park Hospital
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Middlesbrough, Det Forenede Kongerige, TS5 6HA
- Linthorpe Surgery
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Norfolk, Det Forenede Kongerige, NR4 7UY
- Norfolk and Norwich University Hospital
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Northampton, Det Forenede Kongerige, NN1 5BD
- Northampton General Hospital
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Oxford, Det Forenede Kongerige, OX3 7LE
- Churchill Hospital
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Oxford, Det Forenede Kongerige, OX16 9AD
- Banbury Cross Health Centre
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Oxford, Det Forenede Kongerige, OX4 1XB
- St Bartholomews & Hollow Way Med Centre
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Pickering, Det Forenede Kongerige, YO18 8BL
- Pickering Medical Practice
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Poole, Det Forenede Kongerige, BH14 8EE
- Lilliput Surgery
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Reading, Det Forenede Kongerige, RG1 5AN
- Royal Berkshire Hospital
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Redditch, Det Forenede Kongerige, B98 7UB
- Alexandra Hospital
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Salford, Det Forenede Kongerige, M6 8HD
- Salford Royal Hospital
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Shrewsbury, Det Forenede Kongerige, SY3 8XQ
- Royal Shrewsbury Hospital
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St Helens, Det Forenede Kongerige, WA9 3DA
- St Helens Hospital
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Stevenage, Det Forenede Kongerige, SG1 4AB
- Lister Hospital
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Swindon, Det Forenede Kongerige, SN3 6BB
- Great Western Hospital
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Truro, Det Forenede Kongerige, TR1 3LJ
- Royal Cornwall Hospital
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Wantage, Det Forenede Kongerige, OX12 9BN
- Church Street Practice
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Westcliff-on-Sea, Det Forenede Kongerige, SS0 0RY
- Southend University Hospital
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Weston-super-Mare, Det Forenede Kongerige, BS24 7PR
- 168 Parklands Medical Centre
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Whitstable, Det Forenede Kongerige, CT5 3SE
- Estuary View Medical Centre
-
Witney, Det Forenede Kongerige, OX28 6JS
- Windrush Medical Practice
-
Witney, Det Forenede Kongerige, OX29 4QB
- Eynsham Medical Centre
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York, Det Forenede Kongerige, YO24 2RQ
- Woodthorpe Surgery
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Alabama
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Huntsville, Alabama, Forenede Stater, 35805-4104
- Apogee Clinical Research
-
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Arizona
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Surprise, Arizona, Forenede Stater, 85374-4840
- Southwest Kidney Institute
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California
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Beverly Hills, California, Forenede Stater, 90211
- National Heart Institute
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Sylmar, California, Forenede Stater, 91342
- Olive View - UCLA Medical Cente
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West Hills, California, Forenede Stater, 91307
- Interventional Cardiology Medical Group
-
-
Colorado
-
Littleton, Colorado, Forenede Stater, 80120
- South Denver Cardiology Associates
-
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Florida
-
Boca Raton, Florida, Forenede Stater, 33434
- Flourish Research
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Gainesville, Florida, Forenede Stater, 32608
- University of Florida Health Shands Hospital
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Jacksonville Beach, Florida, Forenede Stater, 32250-4303
- Florida Kidney Physicians LLC
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Miami, Florida, Forenede Stater, 33126
- Total Research Group, LLC
-
Miami, Florida, Forenede Stater, 33127
- Bioresearch Partner
-
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Georgia
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Atlanta, Georgia, Forenede Stater, 30322
- Emory University School of Medicine
-
Decatur, Georgia, Forenede Stater, 30033-4004
- Joseph Maxwell Cleland Atlanta VA Medical Center
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Macon, Georgia, Forenede Stater, 31210-1359
- East Coast Institute For Research LLC
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Idaho
-
Coeur d'Alene, Idaho, Forenede Stater, 83814
- Kootenai Research Services
-
-
Illinois
-
Chicago, Illinois, Forenede Stater, 60611
- Northwestern University
-
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Kansas
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Kansas City, Kansas, Forenede Stater, 66160
- University of Kansas Medical Center
-
Wichita, Kansas, Forenede Stater, 67214
- Kansas Nephrology Research Institute, LLC
-
-
Kentucky
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Louisville, Kentucky, Forenede Stater, 40202
- University of Louisville
-
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Maryland
-
Baltimore, Maryland, Forenede Stater, 21239
- Medstar Health Research Institute
-
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Michigan
-
Saint Joseph, Michigan, Forenede Stater, 49085-8511
- Lake Michigan Nephrology
-
Shelby, Michigan, Forenede Stater, 48315
- St. Clair Nephrology Research, LLC
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Minnesota
-
Minneapolis, Minnesota, Forenede Stater, 55417
- Minneapolis VA Health Care System
-
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Mississippi
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Brookhaven, Mississippi, Forenede Stater, 39601-2326
- Southwest Mississippi Nephrology, Pllc
-
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Nebraska
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North Platte, Nebraska, Forenede Stater, 69101-0614
- Great Plains Nephrology
-
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Nevada
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North Las Vegas, Nevada, Forenede Stater, 89086
- VA Southern Nevada Healthcare System
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Reno, Nevada, Forenede Stater, 89511
- Sierra Nevada Specialty Care
-
-
New Hampshire
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Portsmouth, New Hampshire, Forenede Stater, 03801
- Seacoast Kidney and Hypertension Specialists
-
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New Jersey
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Bridgewater, New Jersey, Forenede Stater, 08807
- Advanced Heart Care, LLC
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87106
- UNM Health Science Center
-
-
New York
-
New York, New York, Forenede Stater, 10010-5011
- VA New York Harbor Healthcare System
-
-
North Carolina
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Charlotte, North Carolina, Forenede Stater, 28208-0014
- Metrolina Nephrology Associates, PA
-
Charlotte, North Carolina, Forenede Stater, 28277
- Metrolina Nephrology Associates, PA
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Greensboro, North Carolina, Forenede Stater, 27405-3654
- Carolina Kidney Associates
-
Winston-Salem, North Carolina, Forenede Stater, 27103
- Brookview Hills Research Associates LLC
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Ohio
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Cleveland, Ohio, Forenede Stater, 44106
- University Hospitals Cleveland Medical Center
-
-
Pennsylvania
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Philadelphia, Pennsylvania, Forenede Stater, 19140
- Temple University
-
Philadelphia, Pennsylvania, Forenede Stater, 19114-1028
- Northeast Endocrine Metabolic Associates
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Upland, Pennsylvania, Forenede Stater, 19013
- Clinical Renal Associates
-
-
Rhode Island
-
East Providence, Rhode Island, Forenede Stater, 02914-2641
- Nephrology Associates, Inc
-
-
Tennessee
-
Memphis, Tennessee, Forenede Stater, 38104
- University of Tennessee
-
-
Texas
-
Austin, Texas, Forenede Stater, 78751
- Research Management, Inc - Austin
-
DeSoto, Texas, Forenede Stater, 75115-2011
- Dallas Nephrology Associates Medical Clinic
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El Paso, Texas, Forenede Stater, 79935
- Academy Of Diabetes, Thyroid And Endocrine, PA
-
Lufkin, Texas, Forenede Stater, 75904
- P&I Clinical Research, LLC
-
Lufkin, Texas, Forenede Stater, 75904
- Texas Institute for Kidney and Endocrine Disorders
-
Pasadena, Texas, Forenede Stater, 77504-1944
- Renal Specialists of Houston, PA
-
San Antonio, Texas, Forenede Stater, 78207
- University Health
-
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Virginia
-
Charlottesville, Virginia, Forenede Stater, 22903
- University of Virginia Health System
-
Manassas, Virginia, Forenede Stater, 20110
- Kidney and Hypertension Specialists, PLLC
-
Newport News, Virginia, Forenede Stater, 23606
- Tidewater Physicians Multispecialty Group
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Salem, Virginia, Forenede Stater, 24153
- Salem VA Medical Center
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Washington
-
Spokane, Washington, Forenede Stater, 99204
- Providence Medical Research Center
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-
-
-
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Bangalore, Indien, 560034
- St John's Medical College
-
Bangalore, Indien, 560017
- Manipal Hospitals, Old Airport Road
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Bangalore, Indien, 560076
- Apollo Hospital - Bangalore
-
Bathinda, Indien, 151001
- All India Institute of Medical Sciences, Bathinda
-
Bhubaneswar, Indien, 751005
- Apollo Hospitals - Bhubaneswar
-
Bhubaneswar, Indien, 751019
- All India Institute of Medical Sciences Bhubaneswar
-
Bilāspur, Indien, 174001
- All India Institute of Medical Sciences, Bilaspur
-
Chandigarh, Indien, 160012
- Post Graduate Institute of Medical Education and Research
-
Chennai, Indien, 600006
- Apollo Hospital - Chennai
-
Chennai, Indien, 600095
- Apollo Speciality Hospitals, Vanagaram
-
Dwārka, Indien, 110075
- Aakash Healthcare Super Speciality Hospital
-
Faridabad, Indien, 121002
- Accord Superspeciality Hospital
-
Faridabad, Indien, 121002
- Amrita Hospital Faridabad
-
Guhugram, Indien, 122011
- Marengo Asia Hospitals, Guhugram
-
Guntur, Indien, 522001
- Vedenta Hospitals
-
Gurugram, Indien, 122001
- Artemis Hospital
-
Hubli, Indien, 580021
- Karnataka Institute of Medical Sciences, Hubli
-
Hyderabad, Indien, 500082
- Nizam's Institute of Medical Sciences
-
Hyderabad, Indien, 500012
- Osmania Medical College & Hospital
-
Hyderabad, Indien, 500033
- Apollo Hospitals Jubilee Hills
-
Hyderabad, Indien, 500058
- Apollo DRDO Hospital
-
Jalandhar, Indien, 144012
- Fortis Hospital, Jalandhar
-
Jodhpur, Indien, 342005
- All India Institute of Medical Sciences, Jodhpur
-
Kochi, Indien, 682041
- Amrita Institute of Medical Sciences and Research Centre
-
Kolkata, Indien, 700014
- Nil Ratan Sircar Medical College & Hospital
-
Kolkata, Indien
- Manipal Hospitals, EM Bypass
-
Kozhikode, Indien, 673009
- IQRAA International hospital & research centre.
-
Lucknow, Indien, 226003
- King George's Medical University
-
Lucknow, Indien, 226014
- Sanjay Gandhi Post Graduate Institute of Medical Sciences
-
Lucknow, Indien, 226010
- Dr Ram Manohar Lohia Institute of Medical Sciences
-
Madurai, Indien, 625107
- Meenakshi Mission Hospital & Research Centre
-
Madurai, K.K. Nagar, Indien, 625020
- Apollo Speciality Hospital
-
Mangaluru, Indien, 575001
- Kasturba Medical College and Hospital
-
Mysore, Indien, 570023
- Apollo BGS Hospital
-
Mānesar, Indien, 122052
- Fortis Hospital, Manesar
-
Nadiād, Indien, 387001
- Muljibhai Patel Urological Hospital
-
New Delhi, Indien, 110029
- All India Institute of Medical Sciences
-
New Delhi, Indien, 110026
- Maharaja Agrasen Hospital
-
New Delhi, Indien, 110017
- Max Super Specialty Hospital, Saket
-
New Delhi, Indien, 110025
- Epitome Kidney Urology Institute and Lions Hospital
-
New Delhi, Indien, 110070
- Fortis Flt. Lt. Rajan Dhall Hospital
-
New Delhi, Indien, 110075
- Venkateshwar Hospital
-
Patna, Indien, 800014
- Indira Gandhi Institute of Medical Sciences
-
Puducherry, Indien, 605006
- Jawaharlal Institute of Postgraduate Medical Education
-
Raipur, Indien, 492099
- All India Institute of Medical Sciences
-
Raipur, Indien, 492001
- DKS Post Graduate Institute & Research Center, Raipur (C.G)
-
Ranchi, Indien, 834001
- Raj Hospitals
-
Ranchi, Indien, 834004
- Paras HEC, Ranchi
-
Rohtak, Indien, 124001
- Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
-
Secunderabad, Indien, 500003
- Yashoda Hospitals - Secunderabad
-
Trivandrum, Indien, 695029
- Kimshealth
-
Vadodara, Indien, 390021
- Aman Hospital & Research Center
-
Vellore, Indien, 632517
- Christian Medical College, Vellore
-
Visakhapatnam, Indien, 530040
- Apollo Hospitals Health City
-
-
-
-
-
Alessandria, Italien, 15121
- Ospedale SS. Antonio e Biagio e C. Arrigo - AOUAL
-
Asti, Italien, 14100
- Asti-Ospedale Cardinal Massaia
-
Bari, Italien, 70124
- Azienda Universitaria Ospedaliera Consorziale Policlinico Bari
-
Bergamo, Italien, 24127
- ASST Papa Giovanni XXIII
-
Bologna, Italien, 40138
- Policlinico S. Orsola-Malpighi
-
Cagliari, Italien, 09100
- Azienda Ospedaliera ARNAS G. Brotzu
-
Chieri, Italien, 10023
- Chieri-Ospedale Maggiore
-
Chieti, Italien, 66100
- Ospedale SS Annunziata
-
Cuneo, Italien, 12100
- A.S.O. S. Croce e Carle
-
Florence, Italien, 50134
- A. O. Universitaria Careggi
-
Florence, Italien, 50124
- Firenze-Ospedale San Giovanni di Dio
-
Genova, Italien, 16132
- Azienda Ospedaliera San Martino
-
Imola, Italien, 40026
- Ospedale di Imola S. Maria della Scaletta
-
Milan, Italien, 20132
- Ospedale San Raffaele S.r.l.
-
Milan, Italien, 20142
- Asst Santi Paolo E Carlo
-
Monza, Italien, 20900
- Fondazione IRCCS San Gerardo dei Tintori
-
Novara, Italien, 28100
- Ospedale Maggiore della Carità
-
Padova, Italien, 35128
- Azienda Ospedaliera di Padova
-
Parma, Italien, 43126
- Azienda Ospedaliera Unversitaria di Parma
-
Pavia, Italien, 27100
- Fondazione Salvatore Maugeri
-
Perugia, Italien, 06129
- Azienda Ospedaliera di Perugia
-
Pisa, Italien, 56126
- Azienda Ospedaliera Universitaria Pisana
-
Prato, Italien, 59100
- Prato-Ospedale Santo Stefano
-
Roma, Italien, 00189
- Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
-
San Fermo della Battaglia, Italien, 22020
- Azienda Socio Sanitaria Territoriale Lariana
-
San Giovanni Rotondo (Foggia), Italien, 71013
- IRCCS Ospedale "Casa Sollievo della Sofferenza"
-
Savona, Italien, 17100
- Azienda Socio Sanitaria Ligure 2
-
Sesto San Giovanni, Italien, 20099
- IRCCS MultiMedica
-
Todi, Italien, 06059
- Todi-Nuovo Ospedale Media Valle del Tevere
-
Turin, Italien, 0100
- Torino-Ospedale Oftalmico
-
Verbania, Italien, 28922
- Ospedale Castelli - Verbania
-
Vicenza, Italien, 36100
- Ospedale San Bortolo
-
-
-
-
-
Asahikawa-Shi, Japan, 078-8510
- Asahikawa Medical University Hospital
-
Chiba, Japan, 260-8677
- Chiba University Hospital
-
Chuo-Shi, Japan, 409-3898
- University of Yamanashi Hospital
-
Fukuoka, Japan, 812-8582
- Kyushu University Hospital
-
Isehara, Japan, 259-1193
- Tokai University Hospital
-
Izumo, Japan, 693-8501
- Shimane University Hospital
-
Kurashiki-Shi, Japan, 701-0192
- Kawasaki Medical School Hospital
-
Kurume, Japan, 830-0011
- Kurume University Hospital
-
Kyoto, Japan, 606-8507
- Kyoto University Hospital
-
Nagakute, Japan, 480-1195
- Aichi Medical University Hospital
-
Nagoya, Japan, 466-8560
- Nagoya University Hospital
-
Nagoya, Japan, 455-8530
- Chubu Rosai Hospital
-
Okayama, Japan, 700-8558
- Okayama University Hospital
-
Osaka, Japan, 553-0003
- Kansai Electric Power Hospital
-
Sendai, Japan, 980-8547
- Tohoku University Hospital
-
Tokyo, Japan, 160-8582
- Keio University Hospital
-
Tokyo, Japan, 105-8470
- Toranomon Hospital
-
Tokyo, Japan, 104-8560
- St. Luke's International Hospital
-
Tokyo, Japan, 173-8606
- Teikyo University Hospital
-
Tokyo, Japan, 113-8431
- Juntendo University Hospital
-
Tokyo, Japan, 113-8655
- The University of Tokyo Hospital
-
Tokyo, Japan, 162-8655
- National Center for Global Health and Medicine
-
Tokyo, Chuo-ku, Japan, 103-0027
- Tokyo-Eki Center-building Clinic
-
Yokohama, Japan, 236-0004
- Yokohama City University Hospital
-
Ōtsu, Japan, 520-2192
- Shiga University of Medical Science Hospital
-
-
-
-
-
Anshan, Kina, 114000
- Ansteel Group General Hospital
-
Beijing, Kina, 100029
- Beijing AnZhen Hospital, Capital Medical University
-
Beijing, Kina, 100029
- Peking University Third Hospital
-
Beijing, Kina, 100037
- Fuwai Hospital, CAMS&PUMC
-
Changzhi, Kina, 046000
- Heping Hospital Affiliated to Changzhi Medical College
-
Chaoyang, Kina, 122000
- The Second Hospital of Chaoyang
-
Chengdu, Kina, 610041
- Affiliated Hospital of Chengdu University
-
Chengdu, Kina, 610041
- West China Fourth Hospital of Sichuan University
-
Chifeng, Kina, 024000
- Affiliated Hospital of Chifeng University
-
Chongqing, Kina, 402160
- The Affiliated Yongchuan Hospital of Chongqing Medical University
-
Foshan, Kina, 528500
- Gaoming People's Hospital
-
Fuyang, Kina, 236400
- Linquan County People's Hospital
-
Gaozhou, Kina, 525200
- Gaozhou People's Hospital
-
Guangzhou, Kina, 510180
- Guangzhou First People's Hospital
-
Guangzhou, Kina, 510240
- Guangzhou Red Cross Hospital
-
Guangzhou, Kina, 510665
- The Third Affiliated Hospital of Southern Medical University
-
Guangzhou, Kina, 510925
- The Fifth Affiliated Hospital of Southern Medical University
-
Guangzhou, Kina, 528200
- Guangdong Provincial Hospital of Chinese Medicine
-
Haikou, Kina, 570311
- Hainan General Hospital
-
Hanghzhou, Kina, 310022
- Shulan(Hanghzhou) Hospital
-
Hangzhou, Kina, 310030
- Zhejiang Hospital
-
Harbin, Kina, 150001
- The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
-
Harbin, Kina, 150066
- The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
-
Hefei, Kina, 230011
- The Second People's Hospital of Hefei
-
Hohot, Kina, 010010
- International Mongolian Hospital of Inner Mongolia
-
Huangshi, Kina, 435000
- Huangshi Central Hospital
-
Jingzhou, Kina, 434020
- Jingzhou Central Hospital
-
Jiyuan, Kina, 454650
- Henan Jiyuan People's Hospital
-
Liuzhou, Kina, 545006
- Liuzhou People's Hospital
-
Luoyang, Kina, 471002
- Luoyang Third People's Hospital
-
Luoyang, Kina, 471000
- Oriental Hospital
-
Luoyang, Kina, 471009
- Luoyang Central Hospital
-
Luoyang, Kina, 471900
- Luoyang Yanshi People's Hospital
-
Meishan, Kina, 620010
- Meishan People's Hospital
-
Nanchang, Kina, 330000
- Jiangxi Branch Hospital of Xiangya Hospital of Central South University
-
Qingdao, Kina, 266034
- Qingdao Cardiovascular Hospital
-
Shanghai, Kina, 200072
- Shanghai Tenth People's Hospital
-
Shantou, Kina, 515041
- Second Hospital Affiliated to Shantou Medical University
-
Shantou, Kina, 515031
- Shantou Central Hospital
-
Shaoguan, Kina, 512000
- Shaoguan First People's Hospital
-
Shaoxing, Kina, 312000
- Shaoxing Second Hospital
-
Shenzhen, Kina, 518052
- Shenzhen Nanshan People's Hospital
-
Shenzhen, Kina, 518107
- The Seventh Affiliated Hospital, Sun Yat-sen University
-
Shijiazhuang, Kina, 050011
- Shijiazhuang People's Hospital
-
Songyuan, Kina, 138000
- Songyuan Jilin Oilfield Hospital
-
Taizhou, Kina, 317000
- Taizhou Hospital of Zhejiang Province
-
Tianjin, Kina, 300140
- The Fourth Central Hospital of Tianjin
-
Wuhan, Kina, 430000
- Wuhan Fourth Hospital
-
Wuhan, Kina, 430015
- Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine
-
Xiamen, Kina, 361006
- Xiamen Cardiovascular Hospital Xiamen University
-
Xinxiang, Kina, 453000
- Xinxiang Central Hospital
-
Xinxiang, Kina, 453100
- The First Affiliated Hospital of Xinxiang Medical University
-
Zhangjiakou, Kina, 075000
- The First Affiliated Hospital of Hebei North University
-
Zhengzhou, Kina, 450053
- The Ninth People's Hospital of Zhengzhou
-
Zhuhai, Kina, 519000
- Zhuhai People's Hospital
-
Zhumadian, Kina, 463000
- Zhumadian Central Hospital
-
Zhuzhou, Kina, 412000
- Zhuzhou Central Hospital
-
Zhuzhou, Kina, 412007
- Zhuzhou Central Hospital
-
Ürümqi, Kina, 830054
- The First Affiliated Hospital of Xinjiang Medical University
-
-
-
-
-
Ampang, Malaysia, 68000
- Hospital Ampang
-
Batu Caves, Malaysia, 68100
- Hospital Selayang
-
Batu Pahat, Malaysia, 83000
- Hospital Sultanah Nora Ismail
-
George Town, Malaysia, 10990
- Hospital Pulau Pinang-Pulau Pinang-21953
-
Ipoh, Malaysia, 30450
- Hospital Raja Permaisuri Bainun
-
Johor Bahru, Malaysia, 80100
- Hospital Sultanah Aminah
-
Johor Bahru, Malaysia, 81100
- Hospital Sultan Ismail
-
Kajang, Malaysia, 43000
- Hospital Sultan Idris Shah Serdang
-
Kajang, Selangor, Malaysia, 43000
- Hospital Kajang
-
Klang, Malaysia, 41200
- Hospital Tengku Ampuan Rahimah
-
Kota Bharu, Malaysia, 15586
- Hospital Raja Perempuan Zainab II
-
Kota Kinabalu, Malaysia, 88586
- Hospital Queen Elizabeth
-
Kuala Lumpur, Malaysia, 50586
- Hospital Kuala Lumpur
-
Kuala Lumpur, Malaysia, 59100
- University Malaya Medical Centre
-
Kuala Pilah, Malaysia, 72000
- Hospital Tuanku Ampuan Najihah
-
Kuantan, Malaysia, 25100
- Hospital Tengku Ampuan Afzan
-
Kuching, Malaysia, 93586
- Hospital Umum Sarawak
-
Kulim, Malaysia, 09090
- Hospital Kulim
-
Malacca, Malaysia, 75400
- Hospital Melaka
-
Muar town, Malaysia, 84000
- Hospital Pakar Sultanah Fatimah
-
Perai, Malaysia, 13700
- Hospital Seberang Jaya
-
Serdang, Malaysia, 43400
- Hospital Sultan Abdul Aziz Shah
-
Seremban, Malaysia, 70300
- Hospital Tuanku Ja'afar
-
Taiping, Malaysia
- Hospital Taiping
-
Teluk Intan, Malaysia, 36000
- Hospital Teluk Intan
-
Temerluh, Malaysia, 28000
- Hospital Sultan Haji Ahmad Shah
-
-
-
-
-
Aguascalientes, Mexico, 20259
- Centenario Hospital Miguel Hidalgo
-
Cuernavaca, Mexico, 62250
- Instituto de Diabetes, Obesidad y Nutrición S.C.
-
Culiacán, Mexico, CP 80020
- Neurociencias Estudios Clinicos S.C.
-
Durango, Mexico, 34000
- Instituto de investigación aplicado a la neurociencia
-
Guadalajara, Mexico, 44670
- Unidad de Investigación Clinica y Atencion Medica HEPA SC
-
Guadalajara, Mexico, 44340
- Centro de Investigacion Clinica y Medicina Traslacional (CIMeT)
-
Guadalajara, Mexico, 44340
- Centro Medico Nacional de Occidente/ Centro De Investigacion Biomedica De Occidente
-
Mexico City, Mexico, 03100
- Health Pharma Professional Research S.A. de C.V.
-
Mexico City, Mexico, 03650
- Soluciones Terapéuticas Médico Quirúrgicas S. de R.L. de C.V.
-
Mexico City, Mexico, 07760
- Hospital Juárez de México
-
Monterrey, Mexico, 64460
- Hospital Universitario Dr Jose Eleuterio Gonzalez
-
Monterrey, Mexico, 64310
- Iecsi S.C.
-
Monterrey, Mexico, CP 64040
- Renall Monterrey
-
Morelia, Mexico, 58260
- Centro de Investigación Clínica Chapultepec S.A. de C.V.
-
Mérida, Mexico, 97070
- Medical Care & Research SA de CV
-
Mérida, Mexico, 97125
- Merida Investigación Clínica
-
Tlajomulco de Zúñiga, Mexico, 45653
- IMSS Regional General Hospital 180
-
Tlalpan, Mexico, 14080
- Instituto Nacional de Cardiologia Ignacio Chavez
-
Veracruz, Mexico, 91900
- FAICIC S de RL de C.V.
-
Veracruz, Mexico, 91910
- Sociedad de Metabolismo y Corazón S.C.
-
-
-
-
-
Auckland, New Zealand, 1023
- Auckland City Hospital
-
Auckland, New Zealand, 2025
- Middlemore Hospital
-
Auckland, Takapuna, New Zealand, 0620
- North Shore Hospital
-
New Plymouth, New Zealand, 4310
- Taranaki Base Hospital
-
-
Northland
-
Whangarei, Northland, New Zealand, 0110
- Whangarei Hospital
-
-
Otago
-
Dunedin, Otago, New Zealand, 9016
- Dunedin Hospital
-
-
Waikato Region
-
Hamilton, Waikato Region, New Zealand, 3240
- Waikato Hospital
-
-
-
-
-
Aveiro, Portugal, 3814-501
- ULS da Região de Aveiro
-
Braga, Portugal, 4710-243
- Centro Clínico Académico de Braga (2CA-Braga)
-
Carnaxide, Portugal, 2790-134
- CHLO, EPE - Hospital de Santa Cruz
-
Castelo Branco, Portugal, 6000-085
- Unidade Local de Saúde de Castelo Branco, E.P.E
-
Coimbra, Portugal, 3004-561
- CHUC - Centro Hospitalar e Universitario de Coimbra, EPE
-
Faro, Portugal, 8000-386
- Unidade Local de Saúde do Algarve, E.P.E
-
Funchal, Portugal, 9004-514
- SESARAM
-
Lisbon, Portugal, 1069-166
- ULS de São José
-
Lisbon, Portugal, 1649-035
- Unidade Local de Saúde Santa Maria
-
Loures, Portugal, 2674-514
- Hospital Beatriz Ângelo
-
Porto, Portugal, 4200-319
- Centro Hospitalar Universitário São João,EPE
-
Senhora da Hora, Portugal, 4464-513
- Unidade Local de Saúde de Matosinhos
-
Setúbal, Portugal, 2910-549
- Unidade Local De Saude Da Arrabida E.P.E.
-
Viseu, Portugal, 3504-509
- Unidade Local De Saude De Viseu Dao-Lafoes E.P.E.
-
-
-
-
-
Danderyd, Sverige, 182 88
- Danderyds Sjukhus AB
-
Gothenburg, Sverige, 413 46
- Sahlgrenska Universitetsjukhuset
-
Linköping, Sverige, 581 85
- Universitetssjukhuset Linköping
-
Lund, Sverige, 221 85
- Skånes Universitetssjukhus, Lund
-
Stockholm, Sverige, 14157
- Karolinska University Hospital
-
Sundsvall, Sverige, 856 43
- Region Vaesternorrland
-
Uppsala, Sverige, 751 85
- Akademiska sjukhuset
-
-
-
-
-
Ansan-si, Sydkorea, 15355
- Korea University Ansan Hospital
-
Busan, Sydkorea, 49241
- Pusan National University Hospital
-
Cheonan-si, Sydkorea, 31151
- Soon Chun Hyang University Hospital Cheonan
-
Cheongju-si, Sydkorea, 28644
- Chungbuk National University Hospital
-
Daegu, Sydkorea, 41944
- Kyungpook National University Hospital
-
Deagu, Sydkorea, 42601
- Keimyung University Dongsan Hospital
-
Goyang-si, Sydkorea, 10380
- Inje University Ilsan Paik Hospital
-
Guri-si, Sydkorea, 11923
- Hanyang University Guri Hospital
-
Gwangmyeong, Sydkorea, 14353
- Chung-Ang University Gwangmyeong Hospital
-
Incheon, Sydkorea, 21431
- The Catholic University of Korea, Incheon St. Mary's Hospital
-
Seongnam-si, Sydkorea, 13496
- CHA Bundang Medical Center
-
Seoul, Sydkorea, 03080
- Seoul National University Hospital
-
Seoul, Sydkorea, 03722
- Severance Hospital
-
Seoul, Sydkorea, 06273
- Gangnam Severance Hospital
-
Seoul, Sydkorea, 08308
- Korea University Guro Hospital
-
Seoul, Sydkorea, 07345
- The Catholic University of Korea, Yeouido St.Mary's Hospital
-
Seoul, Sydkorea, 07061
- SMG-SNU Boramae Medical Center
-
Wŏnju, Sydkorea, 26426
- Yonsei University Wonju Severance Christian Hospital
-
-
-
-
-
Kaohsiung City, Taiwan, 824005
- E-Da Hospital
-
Luodong Township, Taiwan, 265
- Lotung Poh-Ai Hospital
-
New Taipei City, Taiwan, 220
- Far Eastern Memorial Hospital
-
New Taipei City, Taiwan, 23561
- Taipei Medical University-Shuang Ho Hospital
-
New Taipei City, Taiwan, 23142
- Taipei Tzu Chi Hospital
-
New Taipei City, Taiwan, 243089
- Fu Jen Catholic University Hospital
-
Taichung, Taiwan, 404
- China Medical University Hospital
-
Taichung, Taiwan, 402
- Chung Shan Medical University Hospital
-
Taichung, Taiwan, 435
- Tungs' Taichung MetroHarbor Hospital
-
Taichung, Taiwan, 407219
- Taichung Veterans General Hospital
-
Tainan, Taiwan, 70403
- National Cheng Kung University Hospital
-
Tainan, Taiwan, 736402
- Chi Mei Hospital, Liouying
-
Taipei, Taiwan, 110
- Taipei Medical University Hospital
-
Taipei, Taiwan, 10449
- Mackay Memorial Hospital
-
Taipei, Taiwan, 112
- Taipei Veterans General Hospital
-
Taipei, Taiwan, 106
- Cathay General Hospital
-
Taipei, Taiwan, 11696
- Taipei Municipal Wanfang Hospital
-
Taipei, Taiwan, 111045
- Shin Kong Wu Ho-Su Memorial Hospital
-
Taoyuan City, Taiwan, 333
- Chang Gung Memorial Hospital, Linkou
-
Taoyuan City, Taiwan, 330
- TaoYuan General Hospital
-
-
-
-
-
Aachen, Tyskland, 52074
- Universitätsklinikum Aachen, AöR
-
Bad Kreuznach, Tyskland, 55543
- KfH-Nierenzentrum Bad Kreuznach
-
Bad Nenndorf, Tyskland, 31542
- Nephrologische Gemeinschaftspraxis Bad Nenndorf
-
Bad Oeynhausen, Tyskland, 32545
- Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen
-
Berlin, Tyskland, 10249
- Vivantes Klinikum im Friedrichshain
-
Berlin, Tyskland, 12627
- Praxis für Nierenkrankheiten und Dialyse Helle Mitte
-
Bonn, Tyskland, 53127
- Universitätsklinikum Bonn AöR
-
Braunschweig, Tyskland, 38126
- Städtisches Klinikum Braunschweig gGmbH
-
Cloppenburg, Tyskland, 49661
- St.-Josefs-Hospital Cloppenburg
-
Coburg, Tyskland, 96450
- KfH Nierenzentrum Coburg
-
Dortmund, Tyskland, 44137
- Klinikum Dortmund gGmbH
-
Düsseldorf, Tyskland, 40225
- Universitätsklinikum Düsseldorf
-
Elsenfeld, Tyskland, 63820
- Dialysezentrum Elsenfeld
-
Frankfurt, Tyskland, 60596
- ClinPhenomics CVC GmbH
-
Frankfurt am Main, Tyskland, 60596
- Universitätsklinikum Frankfurt
-
Frankfurt am Main, Tyskland, 60431
- Agaplesion Markus Krankenhaus
-
Freiburg im Breisgau, Tyskland, 79100
- Nierenzentrum Freiburg
-
Giessen, Tyskland, 35392
- Universitätsklinikum Gießen und Marburg GmbH
-
Greifswald, Tyskland, 17489
- Universitätsmedizin Greifswald
-
Halle, Tyskland, 06097
- Universitätsklinikum Halle (Saale) AöR
-
Hamburg, Tyskland, 20246
- Universitätsklinikum Hamburg, Eppendorf
-
Hanover, Tyskland, 30625
- Medizinische Hochschule Hannover
-
Hanover, Tyskland, 30625
- Zentrum Für Nieren Hochdruck und Stoffwechselerkrankungen
-
Heilbronn, Tyskland, 74076
- BAG für Nephrologie und Dialyse
-
Herne, Tyskland, 44625
- Ruhr-Universität Bochum
-
Homburg, Tyskland, 66421
- Universität des Saarlandes
-
Jena, Tyskland, 07747
- Universitätsklinikum Jena
-
Kiel, Tyskland, 24105
- Universitätsklinikum Schleswig-Holstein, Campus Kiel
-
Konstanz, Tyskland, 78464
- Klinikum Konstanz
-
Kronach, Tyskland, 96317
- KfH-Nierenzentrum Kronach
-
Landshut, Tyskland, 84036
- Dr. Vehling-Kaiser MVZ GmbH
-
Leipzig, Tyskland, 04129
- KfH Nierenzentrum Leipzig
-
Lingen, Tyskland, 49808
- Nephrologisches Zentrum Emsland
-
Magdeburg, Tyskland, 39120
- Otto-von-Guericke-Universität Magdeburg
-
Mainz, Tyskland, 55131
- Universitätsmedizin der Johannes Gutenberg-Universität Mainz
-
München, Tyskland, 81675
- Klinikum rechts der Isar der Technischen Universität München
-
München, Tyskland, 80336
- Klinikum der Universität München - Campus Innenstadt
-
Neckarsulm, Tyskland, 74172
- Dialysezentrum Neckarsulm
-
Neuruppin, Tyskland, 16816
- Universitätsklinikum Ruppin-Brandenburg
-
Nuremberg, Tyskland, 90471
- Klinikum Nürnberg
-
Rostock, Tyskland, 18057
- Universitätsmedizin Rostock
-
Rotenburg (Wümme), Tyskland, 27356
- Dialysezentrum Rotenburg
-
Schweinfurt, Tyskland, 97421
- MVZ Dialysezentrum Schweinfurt
-
Solingen, Tyskland, 42653
- Städtisches Klinikum Solingen gGmbH
-
Springe, Tyskland, 31832
- Nephrologische Gemeinschaftspraxis Springe
-
Stuttgart, Tyskland, 70376
- Robert-Bosch-Krankenhaus GmbH
-
Traunstein, Tyskland, 83278
- KfH-Nierenzentrum Traunstein
-
Trier, Tyskland, 54292
- Medizinisches Versorgungszentrum der Barmherzigen Brüder Trier gGmbH
-
Villingen-Schwenningen, Tyskland, 78052
- Nephrologisches Zentrum Villingen-Schwenningen
-
Wiesbaden, Tyskland, 65191
- Nierenzentrum Wiesbaden
-
Wuppertal, Tyskland, 42283
- Helios Universitätsklinikum Wuppertal
-
Würzburg, Tyskland, 97078
- Universitätsklinikum Würzburg AÖR
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Beskrivelse
Key Inclusion Criteria:
-
Evidence of chronic kidney disease (CKD) at risk of kidney disease progression is defined on the basis of local laboratory results recorded at least 3 months before and at the time of the Screening visit, and requires:
- Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR ≥20 <45 mL/min/1.73m² (irrespective of diabetes status); or
- No self-reported diabetes: CKD-EPI eGFR ≥45 <90 mL/min/1.73m² with urine albumin-to-creatinine ratio (uACR) ≥150 mg/g (or protein-to-creatinine ratio ≥225 mg/g); or
- Self-reported diabetes: CKD-EPI eGFR ≥45 <90 mL/min/1.73m² with uACR ≥30 mg/g (or protein-to-creatinine ratio ≥45 mg/g).
-
Neither requires an Aldosterone Synthase inhibitor (ASi) or Mineralocorticoid Receptor Antagonist (MRA), nor that such treatment is definitely inappropriate.
Key Exclusion Criteria:
- Blood potassium of >5.2 mmol/L at screening visit
- Blood Alanine Transaminase (ALT) or Aspartate Transaminase (AST) >3x Upper Limit of Normal (ULN) at Screening visit (only one is required, with ALT preferred)
- Known liver cirrhosis
- On dialysis, functioning kidney transplant, or scheduled living donor transplant
- Treated with new immunosuppression therapy for new (or relapse/flare of pre-existing) kidney disease within the last 60 days
- Receiving more than one Renin-Angiotensin System (RAS) inhibitor (i.e. on dual therapy with two of an Angiotensin-Converting Enzyme inhibitor (ACEi), Angiotensin Receptor Blocker (ARB) or direct renin inhibitor)
- Currently treated with an Mineralocorticoid Receptor Antagonist (MRA) (e.g. spironolactone, eplerenone, finerenone)
- Currently treated with systemic mineralocorticoid replacement therapy (e.g. fludrocortisone) Further exclusion criteria apply.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Firedobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: Del 2: Randomiseret behandling, opfølgningsperiode, behandlingsgruppe
|
Empagliflozin (called Type E) BI 690517 (called Type M randomized treatment)
Andre navne:
|
|
Placebo komparator: Del 2: Opfølgningsperiode, placebogruppe
|
Empagliflozin (called Type E) Placebo matching BI 690517 |
|
Andet: Part 1: Run-in period (all participants)
|
Empagliflozin (called Type E) |
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Time to first occurrence of the primary composite outcome of: (i) Kidney disease progression*; or (ii) Hospitalization for heart failure; or (iii) Cardiovascular death.
Tidsramme: up to 4 years
|
Kidney disease progression is defined as kidney failure or a sustained decline of ≥40% in estimated Glomerular Filtration Rate (eGFR) from randomization |
up to 4 years
|
Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Tid til den første hændelse af nyresygdomsprogression eller kardiovaskulær død
Tidsramme: op til 4 år
|
op til 4 år
|
|
Key secondary outcome: Time to first event of kidney failure, hospitalization for heart failure or cardiovascular death
Tidsramme: up to 4 years
|
up to 4 years
|
|
Key secondary outcome: Time to first event of hospitalization for heart failure or cardiovascular death
Tidsramme: up to 4 years
|
up to 4 years
|
|
Key secondary outcome: Occurrences of hospitalizations from any cause (first and any subsequent, combined) or death from any cause
Tidsramme: up to 4 years
|
up to 4 years
|
|
Key secondary outcome: Time to death from any cause
Tidsramme: up to 4 years
|
up to 4 years
|
|
Key secondary outcome: Annual rate of change in eGFR from 1 month until last scheduled visit (i.e. chronic eGFR slope)
Tidsramme: up to 4 years
|
up to 4 years
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Hjælpsomme links
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
30. august 2024
Primær færdiggørelse (Anslået)
31. december 2026
Studieafslutning (Anslået)
31. december 2026
Datoer for studieregistrering
Først indsendt
29. juli 2024
Først indsendt, der opfyldte QC-kriterier
29. juli 2024
Først opslået (Faktiske)
1. august 2024
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
28. oktober 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
27. oktober 2026
Sidst verificeret
1. oktober 2026
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Urogenitale sygdomme
- Patologiske processer
- Mandlige urogenitale sygdomme
- Nyresygdomme
- Urologiske sygdomme
- Urogenitale sygdomme hos kvinder
- Kvinders urogenitale sygdomme og graviditetskomplikationer
- Kronisk sygdom
- Sygdomsegenskaber
- Nyreinsufficiens
- Patologiske tilstande, tegn og symptomer
- Nyreinsufficiens, kronisk
- Empagliflozin
Andre undersøgelses-id-numre
- 1378-0006
- 2024-511025-63-00 (Registry Identifier: CTIS)
- U1111-1306-5049 (Registry Identifier: WHO register (ICTRP))
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
JA
IPD-planbeskrivelse
Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.clinicalstudies.boehringer-ingelheim.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement".
Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.
IPD-delingstidsramme
One year after the approval has been granted by major Regulatory Authorities and after the primary manuscript has been accepted for publication, or after termination of the development program.
IPD-delingsadgangskriterier
For study documents - upon signing of a 'Document Sharing Agreement'. For study data - 1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.
IPD-deling Understøttende informationstype
- STUDY_PROTOCOL
- SAP
- CSR
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Ja
Studerer et amerikansk FDA-reguleret enhedsprodukt
Ingen
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .