EASi-KIDNEY™ (Gli studi sulla protezione del cuore e dei reni con BI 690517 in combinazione con Empagliflozin)
27 ottobre 2026 aggiornato da: Boehringer Ingelheim
Uno studio clinico multicentrico, internazionale, randomizzato, in doppio cieco, controllato con placebo sull'inibitore dell'aldosterone sintasi BI 690517 in combinazione con empagliflozin in pazienti con malattia renale cronica
This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study. The study is open to people who take other medicines called angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). People who already take empagliflozin or any other sodium-glucose cotransporter-2 inhibitor (SGLT2i) can also join. The study is also open to people who currently do not take any of these treatments. The purpose of this study is to find out whether a medicine called BI 690517 helps people with chronic kidney disease when taken in combination with a study medicine called empagliflozin. Worsening of kidney function increases the risk for kidney failure, cardiovascular disease, and heart failure hospitalisation.
After a run-in period, during which participants are confirmed to be receiving clinically appropriate renin-angiotensin system blockade and are established on empagliflozin, they are randomly assigned (by chance) to 1 of 2 groups. One group receives BI 690517 tablets, and the other group receives placebo tablets. Placebo tablets look like BI 690517 but do not contain any medicine. Participants take 1 study tablet once a day, in addition to empagliflozin, for the duration of the study.
The doctors document when participants experience worsening of their kidney disease, go to hospital due to heart failure, or die of cardiovascular problems during the study. The time to these events is compared between the 2 treatment groups to see whether the treatment works. The study continues until the required number of events have occurred which is about 3 to 4 years. During this time, participants visit the study site about 5 times within the first 6 months. Then they visit the study site every 6 months. At the visits, doctors regularly check participants' health, take blood and urine samples, measure blood pressure and weight, check kidney function, and take note of any unwanted effects.
Panoramica dello studio
Stato
Attivo, non reclutante
Condizioni
Intervento / Trattamento
Tipo di studio
Interventistico
Iscrizione (Effettivo)
8371
Fase
- Fase 3
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Luoghi di studio
-
-
-
Bariloche, Argentina, 8500
- Fundacion INTECNUS
-
Buenos Aires, Argentina, 1407
- Terapia Renal Domiciliaria
-
Buenos Aires, Argentina, B6000
- Centro de Salud Renal Junin SRL
-
Buenos Aires, Argentina, C1061AAE
- Dres. Iribarren & Asoc. Consultario
-
Buenos Aires, Argentina, C1430CKE
- Glenny Corp - Centro Medico Saavedra
-
CABA, Argentina, 1425
- CPSIC SRL - Cardiologia Palermo
-
Catamarca, Argentina, K4703AFI
- Sanatorio Pasteur S.A
-
Ciudad Autonoma Buenos Aires, Argentina, C1431FWO
- CEMIC
-
Lanús Este, Argentina, B1824KAJ
- CIMEL Chahin - Chahin S.A.
-
Mar del Plata, Argentina, B7612
- Centro Nefrologico del Mar
-
Rafaela, Argentina, S2300
- Mains Bleues
-
Rosario, Argentina, S2000GAP
- Hospital Privado de Rosario
-
Rosario, Argentina, S2013
- Sanatorio Parque S.A.
-
Salta, Argentina, A4400
- Instituto de Nefrourologia y Nutricion de Salta
-
San Juan, Argentina, J5400
- Clinica El Castaño
-
San Miguel de Tucumán, Argentina, 4000
- Centro de Investigaciones Medicas Tucuman
-
San Miguel de Tucumán, Argentina, 4000
- Centro Integral de Medicina Respiratoria - CIMER
-
Santa Fe, Argentina, 2000
- Instituto de Investigaciones Clinicas de Rosario
-
Villa Domínico, Argentina, B1872EEB
- CEREHA S.A.- Centro de Estudios Renales e Hipertension Arterial
-
-
-
-
-
New South Wales, Australia, 2019
- Macquarie University
-
New South Wales, Australia, 2145
- Westmead Hospital
-
-
New South Wales
-
Concord, New South Wales, Australia, 2139
- Concord Hospital
-
Gosford, New South Wales, Australia, 2250
- Renal Research, Gosford
-
Kingswood, New South Wales, Australia, 2747
- Nepean Hospital
-
Kogarah, New South Wales, Australia, 2217
- St George Hospital
-
Liverpool, New South Wales, Australia, 2170
- Liverpool Hospital
-
Port Macquarie, New South Wales, Australia, 2444
- Port Macquarie Base Hospital (PMBH)
-
-
Queensland
-
Pialba, Queensland, Australia, 4655
- Hervey Bay Hospital
-
Southport, Queensland, Australia, 4222
- Griffith University
-
Southport, Queensland, Australia, 4215
- AOVO Clinical Trials
-
Toowoomba, Queensland, Australia, 4350
- Toowoomba Hospital
-
-
South Australia
-
Bedford Park, South Australia, Australia, 5042
- Flinders Medical Centre
-
-
Victoria
-
Box Hill, Victoria, Australia, 3128
- Eastern Health-Box Hill Hospital
-
Heidelberg Heights, Victoria, Australia, 3081
- Austin Health
-
Melbourne, Victoria, Australia, 3004
- The Alfred Hospital
-
Melbourne, Victoria, Australia, 3065
- St Vincent's Hospital Melbourne
-
St Albans, Victoria, Australia, 3021
- Sunshine Hospital
-
-
-
-
-
Bruges, Belgio, 8000
- AZ Sint-Jan Brugge
-
Genk, Belgio, 3600
- Ziekenhuis Oost-Limburg
-
Jette, Belgio, 1090
- UZ Brussel
-
Liège, Belgio, 4000
- Centre Hospitalier Universitaire de Liège
-
-
-
-
-
Aracaju, Brasile, 49055-530
- Centro de Pesquisa Clínica do Coração
-
Belo Horizonte, Brasile, 30150-320
- Santa Casa de Belo Horizonte
-
Belo Horizonte, Brasile, 30220-330
- Centro de Pesquisa do Hospital Evangelico de Belo Horizonte
-
Botucatu, Brasile, 18618-686
- Universidade Estadual Paulista "Julio De Mesquita Filho"
-
Bragança Paulista, Brasile, 1291-6542
- Hospital Universitário São Francisco na Providência de Deus
-
Campinas, Brasile, 13073-350
- CEG - Centro de Endocrinologia Geloneze
-
Centro Linhares, Brasile, 29900010
- Instituto Cardiovascular de Linhares Ltda
-
Curitiba, Brasile, 80230-130
- PUC Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da PUC-PR
-
Fortaleza, Brasile, 60416-000
- Hospital Universitário Walter Cantidio - UFC
-
Fortaleza, Brasile, 60430-350
- Centro de Pesquisas em Diabetes e Doencas Metabolicas
-
Goiânia, Brasile, 74230-035
- Clínica CENDI Endocrinologia e Diabetes
-
Goiânia, Brasile, 74453200
- Hospital Ruy Azeredo
-
Joinville, Brasile, 89227-680
- Fundação Pró-Rim Joinville
-
Juiz de Fora, Brasile, 36033-318
- Galileo Medical Research Ltda
-
Maceió, Brasile, 57051-160
- Centro de Pesquisas Clínicas Dr. Marco Mota
-
Natal, Brasile, 59012300
- Hospital Universitário Onofre Lopes
-
Porto Alegre, Brasile, 90610-000
- Hospital Sao Lucas da PUCRS
-
Porto Alegre, Brasile, 90035-903
- Hospital de Clinicas de Porto Alegre
-
Porto Alegre, Brasile, 90560-032
- Hospitalar Moinhos de Vento
-
Recife, Brasile, 50070902
- IMIP Pernambuco
-
Recife, Brasile, 50720110
- AME Saúde
-
Recife, Brasile, 50740900
- Hospital das Clinicas da Universidade Federal de Pernambuco
-
Salvador, Brasile, 40110160
- Fundação Bahiana de Infectologia
-
São Bernardo do Campo, Brasile, 09715-090
- CEMEC - Centro Multidisciplinar de Estudos Clínicos
-
São José do Rio Preto, Brasile, 15090-000
- Hospital de Base
-
São José dos Campos, Brasile, 12230-001
- CIPES - Centro Internacional de Pesquisa Clínica
-
São Paulo, Brasile, 0402-9001
- Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo
-
São Paulo, Brasile, 04023900
- Fundacao Oswaldo Ramos (Hospital do Rim)
-
São Paulo, Brasile, 05403-000
- Hospital das Clinicas da Faculdade de Medicina da USP
-
Teresina, Brasile, 64049550
- Hospital Universitário da Universidade Federal do Piauí
-
Vitória, Brasile, 29043-260
- Hospital Universitário Cassiano Antônio Moraes
-
Votuporanga, Brasile, 15505-189
- Clínica Cardiológica
-
-
-
-
-
Montreal, Canada, H2X 0A9
- Centre hospitalier de l'Université de Montréal (CHUM)
-
Québec, Canada, G1V 4T3
- Diex Recherche Québec
-
Québec, Canada, G1R 2J6
- CHU de Quebec-Universite Laval Research Centre
-
-
Alberta
-
Edmonton, Alberta, Canada, T6G 2P4
- University of Alberta Hospital (University of Alberta)
-
-
British Columbia
-
Kamloops, British Columbia, Canada, V2C 2T1
- Royal Inland Hospital
-
Kelowna, British Columbia, Canada, V1Y 1T2
- Kelowna General Hospital
-
Prince George, British Columbia, Canada, V2M 1S2
- Northern Health
-
Surrey, British Columbia, Canada, V3W 1J8
- Fraser Health
-
Vancouver, British Columbia, Canada, V5Z 1M9
- Vancouver General Hospital
-
Vancouver, British Columbia, Canada, V1Y 1S1
- St. Paul's Hospital (Vancouver)
-
-
Montréal
-
Québec, Montréal, Canada, H4J 1C5
- CIUSSS Nord de l'île de Montreal
-
-
Nova Scotia
-
Halifax, Nova Scotia, Canada, B3H 1V7
- Centre for Clinical Research
-
-
Ontario
-
Brampton, Ontario, Canada, L6S 0C6
- Centricity Research (Brampton)
-
Concord, Ontario, Canada, L4K 4M2
- Centricity Research (Vaughan)
-
Kingston, Ontario, Canada, K7L 3N6
- Queen's University
-
London, Ontario, Canada, N6A 5W9
- London Regional Cancer Program - London Health Sciences Ctr.
-
Oshawa, Ontario, Canada, L1G 2B9
- Lakeridge Health Oshawa
-
Ottawa, Ontario, Canada, K1H 7W9
- The Ottawa Hospital
-
Toronto, Ontario, Canada, M5G 2N2
- Toronto General Hospital
-
Toronto, Ontario, Canada, M4G 3E8
- Sunnybrook Health Sciences Centre
-
Toronto, Ontario, Canada, M5C2T2
- St. Michael's Hospital
-
-
Quebec
-
Montreal, Quebec, Canada, H3G 1A4
- McGill University Health Centre (MUHC)
-
Montreal, Quebec, Canada, H1T 2M4
- CIUSSS de l'Est-de-l'Île-de-Montréal
-
Sherbrooke, Quebec, Canada, J1H 5N4
- CIUSSS de l Estrie-CHUS
-
-
-
-
-
Anshan, Cina, 114000
- Ansteel Group General Hospital
-
Beijing, Cina, 100029
- Beijing AnZhen Hospital, Capital Medical University
-
Beijing, Cina, 100029
- Peking University Third Hospital
-
Beijing, Cina, 100037
- Fuwai Hospital, CAMS&PUMC
-
Changzhi, Cina, 046000
- Heping Hospital Affiliated to Changzhi Medical College
-
Chaoyang, Cina, 122000
- The Second Hospital of Chaoyang
-
Chengdu, Cina, 610041
- Affiliated Hospital of Chengdu University
-
Chengdu, Cina, 610041
- West China Fourth Hospital of Sichuan University
-
Chifeng, Cina, 024000
- Affiliated Hospital of Chifeng University
-
Chongqing, Cina, 402160
- The Affiliated Yongchuan Hospital of Chongqing Medical University
-
Foshan, Cina, 528500
- Gaoming People's Hospital
-
Fuyang, Cina, 236400
- Linquan County People's Hospital
-
Gaozhou, Cina, 525200
- Gaozhou People's Hospital
-
Guangzhou, Cina, 510180
- Guangzhou First People's Hospital
-
Guangzhou, Cina, 510240
- Guangzhou Red Cross Hospital
-
Guangzhou, Cina, 510665
- The Third Affiliated Hospital of Southern Medical University
-
Guangzhou, Cina, 510925
- The Fifth Affiliated Hospital of Southern Medical University
-
Guangzhou, Cina, 528200
- Guangdong Provincial Hospital of Chinese Medicine
-
Haikou, Cina, 570311
- Hainan General Hospital
-
Hanghzhou, Cina, 310022
- Shulan(Hanghzhou) Hospital
-
Hangzhou, Cina, 310030
- Zhejiang Hospital
-
Harbin, Cina, 150001
- The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
-
Harbin, Cina, 150066
- The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
-
Hefei, Cina, 230011
- The Second People's Hospital of Hefei
-
Hohot, Cina, 010010
- International Mongolian Hospital of Inner Mongolia
-
Huangshi, Cina, 435000
- Huangshi Central Hospital
-
Jingzhou, Cina, 434020
- Jingzhou Central Hospital
-
Jiyuan, Cina, 454650
- Henan Jiyuan People's Hospital
-
Liuzhou, Cina, 545006
- Liuzhou People's Hospital
-
Luoyang, Cina, 471002
- Luoyang Third People's Hospital
-
Luoyang, Cina, 471000
- Oriental Hospital
-
Luoyang, Cina, 471009
- Luoyang Central Hospital
-
Luoyang, Cina, 471900
- Luoyang Yanshi People's Hospital
-
Meishan, Cina, 620010
- Meishan People's Hospital
-
Nanchang, Cina, 330000
- Jiangxi Branch Hospital of Xiangya Hospital of Central South University
-
Qingdao, Cina, 266034
- Qingdao Cardiovascular Hospital
-
Shanghai, Cina, 200072
- Shanghai Tenth People's Hospital
-
Shantou, Cina, 515041
- Second Hospital Affiliated to Shantou Medical University
-
Shantou, Cina, 515031
- Shantou Central Hospital
-
Shaoguan, Cina, 512000
- Shaoguan First People's Hospital
-
Shaoxing, Cina, 312000
- Shaoxing Second Hospital
-
Shenzhen, Cina, 518052
- Shenzhen Nanshan People's Hospital
-
Shenzhen, Cina, 518107
- The Seventh Affiliated Hospital, Sun Yat-sen University
-
Shijiazhuang, Cina, 050011
- Shijiazhuang People's Hospital
-
Songyuan, Cina, 138000
- Songyuan Jilin Oilfield Hospital
-
Taizhou, Cina, 317000
- Taizhou Hospital of Zhejiang Province
-
Tianjin, Cina, 300140
- The Fourth Central Hospital of Tianjin
-
Wuhan, Cina, 430000
- Wuhan Fourth Hospital
-
Wuhan, Cina, 430015
- Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine
-
Xiamen, Cina, 361006
- Xiamen Cardiovascular Hospital Xiamen University
-
Xinxiang, Cina, 453000
- Xinxiang Central Hospital
-
Xinxiang, Cina, 453100
- The First Affiliated Hospital of Xinxiang Medical University
-
Zhangjiakou, Cina, 075000
- The First Affiliated Hospital of Hebei North University
-
Zhengzhou, Cina, 450053
- The Ninth People's Hospital of Zhengzhou
-
Zhuhai, Cina, 519000
- Zhuhai People's Hospital
-
Zhumadian, Cina, 463000
- Zhumadian Central Hospital
-
Zhuzhou, Cina, 412000
- Zhuzhou Central Hospital
-
Zhuzhou, Cina, 412007
- Zhuzhou Central Hospital
-
Ürümqi, Cina, 830054
- The First Affiliated Hospital of Xinjiang Medical University
-
-
-
-
-
Ansan-si, Corea del Sud, 15355
- Korea University Ansan Hospital
-
Busan, Corea del Sud, 49241
- Pusan National University Hospital
-
Cheonan-si, Corea del Sud, 31151
- Soon Chun Hyang University Hospital Cheonan
-
Cheongju-si, Corea del Sud, 28644
- Chungbuk National University Hospital
-
Daegu, Corea del Sud, 41944
- Kyungpook National University Hospital
-
Deagu, Corea del Sud, 42601
- Keimyung University Dongsan Hospital
-
Goyang-si, Corea del Sud, 10380
- Inje University Ilsan Paik Hospital
-
Guri-si, Corea del Sud, 11923
- Hanyang University Guri Hospital
-
Gwangmyeong, Corea del Sud, 14353
- Chung-Ang University Gwangmyeong Hospital
-
Incheon, Corea del Sud, 21431
- The Catholic University of Korea, Incheon St. Mary's Hospital
-
Seongnam-si, Corea del Sud, 13496
- CHA Bundang Medical Center
-
Seoul, Corea del Sud, 03080
- Seoul National University Hospital
-
Seoul, Corea del Sud, 03722
- Severance Hospital
-
Seoul, Corea del Sud, 06273
- Gangnam Severance Hospital
-
Seoul, Corea del Sud, 08308
- Korea University Guro Hospital
-
Seoul, Corea del Sud, 07345
- The Catholic University of Korea, Yeouido St.Mary's Hospital
-
Seoul, Corea del Sud, 07061
- SMG-SNU Boramae Medical Center
-
Wŏnju, Corea del Sud, 26426
- Yonsei University Wonju Severance Christian Hospital
-
-
-
-
-
Aalborg, Danimarca, 9000
- Aalborg Universitetsshospital
-
Copenhagen, Danimarca, 2100
- Rigshospitalet, København
-
Herlev, Danimarca, 2730
- Herlev and Gentofte Hospital
-
Herlev, Danimarca, 2730
- Steno Diabetes Center Copenhagen
-
Kolding, Danimarca, 6000
- Kolding Hospital
-
Odense, Danimarca, 5000
- Odense University Hospital
-
Roskilde, Danimarca, 4000
- Zealand University Hospita; Roskilde
-
-
-
-
-
Aachen, Germania, 52074
- Universitätsklinikum Aachen, AöR
-
Bad Kreuznach, Germania, 55543
- KfH-Nierenzentrum Bad Kreuznach
-
Bad Nenndorf, Germania, 31542
- Nephrologische Gemeinschaftspraxis Bad Nenndorf
-
Bad Oeynhausen, Germania, 32545
- Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen
-
Berlin, Germania, 10249
- Vivantes Klinikum im Friedrichshain
-
Berlin, Germania, 12627
- Praxis für Nierenkrankheiten und Dialyse Helle Mitte
-
Bonn, Germania, 53127
- Universitätsklinikum Bonn AöR
-
Braunschweig, Germania, 38126
- Städtisches Klinikum Braunschweig gGmbH
-
Cloppenburg, Germania, 49661
- St.-Josefs-Hospital Cloppenburg
-
Coburg, Germania, 96450
- KfH Nierenzentrum Coburg
-
Dortmund, Germania, 44137
- Klinikum Dortmund gGmbH
-
Düsseldorf, Germania, 40225
- Universitätsklinikum Düsseldorf
-
Elsenfeld, Germania, 63820
- Dialysezentrum Elsenfeld
-
Frankfurt, Germania, 60596
- ClinPhenomics CVC GmbH
-
Frankfurt am Main, Germania, 60596
- Universitätsklinikum Frankfurt
-
Frankfurt am Main, Germania, 60431
- Agaplesion Markus Krankenhaus
-
Freiburg im Breisgau, Germania, 79100
- Nierenzentrum Freiburg
-
Giessen, Germania, 35392
- Universitätsklinikum Gießen und Marburg GmbH
-
Greifswald, Germania, 17489
- Universitätsmedizin Greifswald
-
Halle, Germania, 06097
- Universitätsklinikum Halle (Saale) AöR
-
Hamburg, Germania, 20246
- Universitätsklinikum Hamburg, Eppendorf
-
Hanover, Germania, 30625
- Medizinische Hochschule Hannover
-
Hanover, Germania, 30625
- Zentrum Für Nieren Hochdruck und Stoffwechselerkrankungen
-
Heilbronn, Germania, 74076
- BAG für Nephrologie und Dialyse
-
Herne, Germania, 44625
- Ruhr-Universität Bochum
-
Homburg, Germania, 66421
- Universität des Saarlandes
-
Jena, Germania, 07747
- Universitätsklinikum Jena
-
Kiel, Germania, 24105
- Universitätsklinikum Schleswig-Holstein, Campus Kiel
-
Konstanz, Germania, 78464
- Klinikum Konstanz
-
Kronach, Germania, 96317
- KfH-Nierenzentrum Kronach
-
Landshut, Germania, 84036
- Dr. Vehling-Kaiser MVZ GmbH
-
Leipzig, Germania, 04129
- KfH Nierenzentrum Leipzig
-
Lingen, Germania, 49808
- Nephrologisches Zentrum Emsland
-
Magdeburg, Germania, 39120
- Otto-von-Guericke-Universität Magdeburg
-
Mainz, Germania, 55131
- Universitätsmedizin der Johannes Gutenberg-Universität Mainz
-
München, Germania, 81675
- Klinikum rechts der Isar der Technischen Universität München
-
München, Germania, 80336
- Klinikum der Universität München - Campus Innenstadt
-
Neckarsulm, Germania, 74172
- Dialysezentrum Neckarsulm
-
Neuruppin, Germania, 16816
- Universitätsklinikum Ruppin-Brandenburg
-
Nuremberg, Germania, 90471
- Klinikum Nürnberg
-
Rostock, Germania, 18057
- Universitätsmedizin Rostock
-
Rotenburg (Wümme), Germania, 27356
- Dialysezentrum Rotenburg
-
Schweinfurt, Germania, 97421
- MVZ Dialysezentrum Schweinfurt
-
Solingen, Germania, 42653
- Städtisches Klinikum Solingen gGmbH
-
Springe, Germania, 31832
- Nephrologische Gemeinschaftspraxis Springe
-
Stuttgart, Germania, 70376
- Robert-Bosch-Krankenhaus GmbH
-
Traunstein, Germania, 83278
- KfH-Nierenzentrum Traunstein
-
Trier, Germania, 54292
- Medizinisches Versorgungszentrum der Barmherzigen Brüder Trier gGmbH
-
Villingen-Schwenningen, Germania, 78052
- Nephrologisches Zentrum Villingen-Schwenningen
-
Wiesbaden, Germania, 65191
- Nierenzentrum Wiesbaden
-
Wuppertal, Germania, 42283
- Helios Universitätsklinikum Wuppertal
-
Würzburg, Germania, 97078
- Universitätsklinikum Würzburg AÖR
-
-
-
-
-
Asahikawa-Shi, Giappone, 078-8510
- Asahikawa Medical University Hospital
-
Chiba, Giappone, 260-8677
- Chiba University Hospital
-
Chuo-Shi, Giappone, 409-3898
- University of Yamanashi Hospital
-
Fukuoka, Giappone, 812-8582
- Kyushu University Hospital
-
Isehara, Giappone, 259-1193
- Tokai University Hospital
-
Izumo, Giappone, 693-8501
- Shimane University Hospital
-
Kurashiki-Shi, Giappone, 701-0192
- Kawasaki Medical School Hospital
-
Kurume, Giappone, 830-0011
- Kurume University Hospital
-
Kyoto, Giappone, 606-8507
- Kyoto University Hospital
-
Nagakute, Giappone, 480-1195
- Aichi Medical University Hospital
-
Nagoya, Giappone, 466-8560
- Nagoya University Hospital
-
Nagoya, Giappone, 455-8530
- Chubu Rosai Hospital
-
Okayama, Giappone, 700-8558
- Okayama University Hospital
-
Osaka, Giappone, 553-0003
- Kansai Electric Power Hospital
-
Sendai, Giappone, 980-8547
- Tohoku University Hospital
-
Tokyo, Giappone, 160-8582
- Keio University Hospital
-
Tokyo, Giappone, 105-8470
- Toranomon Hospital
-
Tokyo, Giappone, 104-8560
- St. Luke's International Hospital
-
Tokyo, Giappone, 173-8606
- Teikyo University Hospital
-
Tokyo, Giappone, 113-8431
- Juntendo University Hospital
-
Tokyo, Giappone, 113-8655
- The University of Tokyo Hospital
-
Tokyo, Giappone, 162-8655
- National Center for Global Health and Medicine
-
Tokyo, Chuo-ku, Giappone, 103-0027
- Tokyo-Eki Center-building Clinic
-
Yokohama, Giappone, 236-0004
- Yokohama City University Hospital
-
Ōtsu, Giappone, 520-2192
- Shiga University of Medical Science Hospital
-
-
-
-
-
Bangalore, India, 560034
- St John's Medical College
-
Bangalore, India, 560017
- Manipal Hospitals, Old Airport Road
-
Bangalore, India, 560076
- Apollo Hospital - Bangalore
-
Bathinda, India, 151001
- All India Institute of Medical Sciences, Bathinda
-
Bhubaneswar, India, 751005
- Apollo Hospitals - Bhubaneswar
-
Bhubaneswar, India, 751019
- All India Institute of Medical Sciences Bhubaneswar
-
Bilāspur, India, 174001
- All India Institute of Medical Sciences, Bilaspur
-
Chandigarh, India, 160012
- Post Graduate Institute of Medical Education and Research
-
Chennai, India, 600006
- Apollo Hospital - Chennai
-
Chennai, India, 600095
- Apollo Speciality Hospitals, Vanagaram
-
Dwārka, India, 110075
- Aakash Healthcare Super Speciality Hospital
-
Faridabad, India, 121002
- Accord Superspeciality Hospital
-
Faridabad, India, 121002
- Amrita Hospital Faridabad
-
Guhugram, India, 122011
- Marengo Asia Hospitals, Guhugram
-
Guntur, India, 522001
- Vedenta Hospitals
-
Gurugram, India, 122001
- Artemis Hospital
-
Hubli, India, 580021
- Karnataka Institute of Medical Sciences, Hubli
-
Hyderabad, India, 500082
- Nizam's Institute of Medical Sciences
-
Hyderabad, India, 500012
- Osmania Medical College & Hospital
-
Hyderabad, India, 500033
- Apollo Hospitals Jubilee Hills
-
Hyderabad, India, 500058
- Apollo DRDO Hospital
-
Jalandhar, India, 144012
- Fortis Hospital, Jalandhar
-
Jodhpur, India, 342005
- All India Institute of Medical Sciences, Jodhpur
-
Kochi, India, 682041
- Amrita Institute of Medical Sciences and Research Centre
-
Kolkata, India, 700014
- Nil Ratan Sircar Medical College & Hospital
-
Kolkata, India
- Manipal Hospitals, EM Bypass
-
Kozhikode, India, 673009
- IQRAA International hospital & research centre.
-
Lucknow, India, 226003
- King George's Medical University
-
Lucknow, India, 226014
- Sanjay Gandhi Post Graduate Institute of Medical Sciences
-
Lucknow, India, 226010
- Dr Ram Manohar Lohia Institute of Medical Sciences
-
Madurai, India, 625107
- Meenakshi Mission Hospital & Research Centre
-
Madurai, K.K. Nagar, India, 625020
- Apollo Speciality Hospital
-
Mangaluru, India, 575001
- Kasturba Medical College and Hospital
-
Mysore, India, 570023
- Apollo BGS Hospital
-
Mānesar, India, 122052
- Fortis Hospital, Manesar
-
Nadiād, India, 387001
- Muljibhai Patel Urological Hospital
-
New Delhi, India, 110029
- All India Institute of Medical Sciences
-
New Delhi, India, 110026
- Maharaja Agrasen Hospital
-
New Delhi, India, 110017
- Max Super Specialty Hospital, Saket
-
New Delhi, India, 110025
- Epitome Kidney Urology Institute and Lions Hospital
-
New Delhi, India, 110070
- Fortis Flt. Lt. Rajan Dhall Hospital
-
New Delhi, India, 110075
- Venkateshwar Hospital
-
Patna, India, 800014
- Indira Gandhi Institute of Medical Sciences
-
Puducherry, India, 605006
- Jawaharlal Institute of Postgraduate Medical Education
-
Raipur, India, 492099
- All India Institute of Medical Sciences
-
Raipur, India, 492001
- DKS Post Graduate Institute & Research Center, Raipur (C.G)
-
Ranchi, India, 834001
- Raj Hospitals
-
Ranchi, India, 834004
- Paras HEC, Ranchi
-
Rohtak, India, 124001
- Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
-
Secunderabad, India, 500003
- Yashoda Hospitals - Secunderabad
-
Trivandrum, India, 695029
- Kimshealth
-
Vadodara, India, 390021
- Aman Hospital & Research Center
-
Vellore, India, 632517
- Christian Medical College, Vellore
-
Visakhapatnam, India, 530040
- Apollo Hospitals Health City
-
-
-
-
-
Alessandria, Italia, 15121
- Ospedale SS. Antonio e Biagio e C. Arrigo - AOUAL
-
Asti, Italia, 14100
- Asti-Ospedale Cardinal Massaia
-
Bari, Italia, 70124
- Azienda Universitaria Ospedaliera Consorziale Policlinico Bari
-
Bergamo, Italia, 24127
- ASST Papa Giovanni XXIII
-
Bologna, Italia, 40138
- Policlinico S. Orsola-Malpighi
-
Cagliari, Italia, 09100
- Azienda Ospedaliera ARNAS G. Brotzu
-
Chieri, Italia, 10023
- Chieri-Ospedale Maggiore
-
Chieti, Italia, 66100
- Ospedale SS Annunziata
-
Cuneo, Italia, 12100
- A.S.O. S. Croce e Carle
-
Florence, Italia, 50134
- A. O. Universitaria Careggi
-
Florence, Italia, 50124
- Firenze-Ospedale San Giovanni di Dio
-
Genova, Italia, 16132
- Azienda Ospedaliera San Martino
-
Imola, Italia, 40026
- Ospedale di Imola S. Maria della Scaletta
-
Milan, Italia, 20132
- Ospedale San Raffaele S.r.l.
-
Milan, Italia, 20142
- Asst Santi Paolo E Carlo
-
Monza, Italia, 20900
- Fondazione IRCCS San Gerardo dei Tintori
-
Novara, Italia, 28100
- Ospedale Maggiore della Carità
-
Padova, Italia, 35128
- Azienda Ospedaliera di Padova
-
Parma, Italia, 43126
- Azienda Ospedaliera Unversitaria di Parma
-
Pavia, Italia, 27100
- Fondazione Salvatore Maugeri
-
Perugia, Italia, 06129
- Azienda Ospedaliera di Perugia
-
Pisa, Italia, 56126
- Azienda Ospedaliera Universitaria Pisana
-
Prato, Italia, 59100
- Prato-Ospedale Santo Stefano
-
Roma, Italia, 00189
- Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
-
San Fermo della Battaglia, Italia, 22020
- Azienda Socio Sanitaria Territoriale Lariana
-
San Giovanni Rotondo (Foggia), Italia, 71013
- IRCCS Ospedale "Casa Sollievo della Sofferenza"
-
Savona, Italia, 17100
- Azienda Socio Sanitaria Ligure 2
-
Sesto San Giovanni, Italia, 20099
- IRCCS MultiMedica
-
Todi, Italia, 06059
- Todi-Nuovo Ospedale Media Valle del Tevere
-
Turin, Italia, 0100
- Torino-Ospedale Oftalmico
-
Verbania, Italia, 28922
- Ospedale Castelli - Verbania
-
Vicenza, Italia, 36100
- Ospedale San Bortolo
-
-
-
-
-
Ampang, Malaysia, 68000
- Hospital Ampang
-
Batu Caves, Malaysia, 68100
- Hospital Selayang
-
Batu Pahat, Malaysia, 83000
- Hospital Sultanah Nora Ismail
-
George Town, Malaysia, 10990
- Hospital Pulau Pinang-Pulau Pinang-21953
-
Ipoh, Malaysia, 30450
- Hospital Raja Permaisuri Bainun
-
Johor Bahru, Malaysia, 80100
- Hospital Sultanah Aminah
-
Johor Bahru, Malaysia, 81100
- Hospital Sultan Ismail
-
Kajang, Malaysia, 43000
- Hospital Sultan Idris Shah Serdang
-
Kajang, Selangor, Malaysia, 43000
- Hospital Kajang
-
Klang, Malaysia, 41200
- Hospital Tengku Ampuan Rahimah
-
Kota Bharu, Malaysia, 15586
- Hospital Raja Perempuan Zainab II
-
Kota Kinabalu, Malaysia, 88586
- Hospital Queen Elizabeth
-
Kuala Lumpur, Malaysia, 50586
- Hospital Kuala Lumpur
-
Kuala Lumpur, Malaysia, 59100
- University Malaya Medical Centre
-
Kuala Pilah, Malaysia, 72000
- Hospital Tuanku Ampuan Najihah
-
Kuantan, Malaysia, 25100
- Hospital Tengku Ampuan Afzan
-
Kuching, Malaysia, 93586
- Hospital Umum Sarawak
-
Kulim, Malaysia, 09090
- Hospital Kulim
-
Malacca, Malaysia, 75400
- Hospital Melaka
-
Muar town, Malaysia, 84000
- Hospital Pakar Sultanah Fatimah
-
Perai, Malaysia, 13700
- Hospital Seberang Jaya
-
Serdang, Malaysia, 43400
- Hospital Sultan Abdul Aziz Shah
-
Seremban, Malaysia, 70300
- Hospital Tuanku Ja'afar
-
Taiping, Malaysia
- Hospital Taiping
-
Teluk Intan, Malaysia, 36000
- Hospital Teluk Intan
-
Temerluh, Malaysia, 28000
- Hospital Sultan Haji Ahmad Shah
-
-
-
-
-
Aguascalientes, Messico, 20259
- Centenario Hospital Miguel Hidalgo
-
Cuernavaca, Messico, 62250
- Instituto de Diabetes, Obesidad y Nutrición S.C.
-
Culiacán, Messico, CP 80020
- Neurociencias Estudios Clinicos S.C.
-
Durango, Messico, 34000
- Instituto de investigación aplicado a la neurociencia
-
Guadalajara, Messico, 44670
- Unidad de Investigación Clinica y Atencion Medica HEPA SC
-
Guadalajara, Messico, 44340
- Centro de Investigacion Clinica y Medicina Traslacional (CIMeT)
-
Guadalajara, Messico, 44340
- Centro Medico Nacional de Occidente/ Centro De Investigacion Biomedica De Occidente
-
Mexico City, Messico, 03100
- Health Pharma Professional Research S.A. de C.V.
-
Mexico City, Messico, 03650
- Soluciones Terapéuticas Médico Quirúrgicas S. de R.L. de C.V.
-
Mexico City, Messico, 07760
- Hospital Juárez de México
-
Monterrey, Messico, 64460
- Hospital Universitario Dr Jose Eleuterio Gonzalez
-
Monterrey, Messico, 64310
- Iecsi S.C.
-
Monterrey, Messico, CP 64040
- Renall Monterrey
-
Morelia, Messico, 58260
- Centro de Investigación Clínica Chapultepec S.A. de C.V.
-
Mérida, Messico, 97070
- Medical Care & Research SA de CV
-
Mérida, Messico, 97125
- Merida Investigación Clínica
-
Tlajomulco de Zúñiga, Messico, 45653
- IMSS Regional General Hospital 180
-
Tlalpan, Messico, 14080
- Instituto Nacional de Cardiologia Ignacio Chavez
-
Veracruz, Messico, 91900
- FAICIC S de RL de C.V.
-
Veracruz, Messico, 91910
- Sociedad de Metabolismo y Corazón S.C.
-
-
-
-
-
Auckland, Nuova Zelanda, 1023
- Auckland City Hospital
-
Auckland, Nuova Zelanda, 2025
- Middlemore Hospital
-
Auckland, Takapuna, Nuova Zelanda, 0620
- North Shore Hospital
-
New Plymouth, Nuova Zelanda, 4310
- Taranaki Base Hospital
-
-
Northland
-
Whangarei, Northland, Nuova Zelanda, 0110
- Whangarei Hospital
-
-
Otago
-
Dunedin, Otago, Nuova Zelanda, 9016
- Dunedin Hospital
-
-
Waikato Region
-
Hamilton, Waikato Region, Nuova Zelanda, 3240
- Waikato Hospital
-
-
-
-
-
Aveiro, Portogallo, 3814-501
- ULS da Região de Aveiro
-
Braga, Portogallo, 4710-243
- Centro Clínico Académico de Braga (2CA-Braga)
-
Carnaxide, Portogallo, 2790-134
- CHLO, EPE - Hospital de Santa Cruz
-
Castelo Branco, Portogallo, 6000-085
- Unidade Local de Saúde de Castelo Branco, E.P.E
-
Coimbra, Portogallo, 3004-561
- CHUC - Centro Hospitalar e Universitario de Coimbra, EPE
-
Faro, Portogallo, 8000-386
- Unidade Local de Saúde do Algarve, E.P.E
-
Funchal, Portogallo, 9004-514
- SESARAM
-
Lisbon, Portogallo, 1069-166
- ULS de São José
-
Lisbon, Portogallo, 1649-035
- Unidade Local de Saúde Santa Maria
-
Loures, Portogallo, 2674-514
- Hospital Beatriz Ângelo
-
Porto, Portogallo, 4200-319
- Centro Hospitalar Universitário São João,EPE
-
Senhora da Hora, Portogallo, 4464-513
- Unidade Local de Saúde de Matosinhos
-
Setúbal, Portogallo, 2910-549
- Unidade Local De Saude Da Arrabida E.P.E.
-
Viseu, Portogallo, 3504-509
- Unidade Local De Saude De Viseu Dao-Lafoes E.P.E.
-
-
-
-
-
Antrim, Regno Unito, BT41 2RL
- Antrim Area Hospital
-
Basildon, Regno Unito, SS16 5NL
- Basildon Hospital
-
Belfast, Regno Unito, BT16 1RH
- Ulster Hospital
-
Belfast, Regno Unito, BT9 7AB
- Beltfast City Hospital
-
Birmingham, Regno Unito, B15 2WB
- Queen Elizabeth Hospital Birmingham
-
Birmingham, Regno Unito, B11 4AN
- Fernley Medical Centre
-
Birmingham, Regno Unito, B19 1TT
- Burbury Medical Centre
-
Birmingham, Regno Unito, B31 3HB
- West Heath Surgery
-
Birmingham, Regno Unito, B32 2TJ
- Ridgacre House Surgery
-
Blackburn, Regno Unito, BB2 1AX
- Oakenhurst Medical Practice
-
Brighton, Regno Unito, BN2 1ES
- Royal County Sussex Hospital
-
Bristol, Regno Unito, BS10 5NB
- Southmead Hospital
-
Bristol, Regno Unito, BS11 0QE
- Pioneer Ridingleaze
-
Bristol, Regno Unito, BS2 0AN
- Lawrence Hill Health Centre
-
Bristol, Regno Unito, BS34 5TF
- Coniston Medical Practice
-
Bury St Edmunds, Regno Unito, IP33 2QZ
- West Suffolk Hospital
-
Chelmsford, Regno Unito, CM1 7ET
- Broomfield Hospital
-
Chippenham, Regno Unito, SN14 6GT
- Hathaway Medical Centre
-
Clevedon, Regno Unito, BS21 6DG
- Clevedon Medical Centre
-
Cosham, Regno Unito, PO6 3LY
- Queen Alexandra Hospital
-
County Down, Regno Unito, BT35 8DR
- Daisy Hill Hospital
-
Coventry, Regno Unito, CV2 2DX
- University Hospital Coventry
-
Cramlington, Regno Unito, NE23 6US
- The Village Surgery
-
Darlington, Regno Unito, DL3 6HZ
- Orchard Court Surgery
-
Dartford, Regno Unito, DA2 8DA
- Darent Valley Hospital
-
Dorchester, Regno Unito, DT1 2JY
- Dorset County Hospital
-
Dudley, Regno Unito, DY1 2HQ
- Russells Hall Hospital
-
Durham, Regno Unito, DH1 3JX
- University Health Centre
-
Fulwood, Regno Unito, PR2 9HT
- Highland Clinical Research Facility
-
Gillingham, Regno Unito, ME7 2BU
- Woodlands Family Practice
-
Gloucester, Regno Unito, GL1 3NN
- Gloucestershire Royal Hospital
-
Great Yarmouth, Regno Unito, NR31 6LA
- James Paget University Hospital
-
Guisborough, Regno Unito, TS14 7DJ
- The Garth Surgery
-
Hereford, Regno Unito, HR1 2BN
- Hereford County Hospital
-
Ipswich, Regno Unito, IP4 5PD
- Ipswich Hospital (UK)
-
Kings Lynn, Regno Unito, PE30 4ET
- The Queen Elizabeth Hospital
-
Leeds, Regno Unito, LS26 9AA
- Pinfold Surgery
-
Leominster, Regno Unito, HR6 8HD
- Ryeland Surgery
-
Little Horton Lane, Regno Unito, BD5 0NA
- St Luke's Hospital
-
Liverpool, Regno Unito, L9 7AL
- Aintree University Hospital
-
London, Regno Unito, SE1 9RT
- Guy's Hospital
-
London, Regno Unito, SE5 9RS
- King's College Hospital
-
London, Regno Unito, SW17 0QT
- St George's Hospital
-
London, Regno Unito, W12 0HS
- Hammersmith Hospital
-
London, Regno Unito, N18 1QX
- North Middlesex University Hospital
-
London, Regno Unito, W6 7HY
- Richford Gate Medical Practice
-
Londonderry, Regno Unito, BT47 6SB
- Altnagelvin Area Hospital
-
Metropolitan Borough of Wirral, Regno Unito, CH49 5PE
- Arrowe Park Hospital
-
Middlesbrough, Regno Unito, TS5 6HA
- Linthorpe Surgery
-
Norfolk, Regno Unito, NR4 7UY
- Norfolk and Norwich University Hospital
-
Northampton, Regno Unito, NN1 5BD
- Northampton General Hospital
-
Oxford, Regno Unito, OX3 7LE
- Churchill Hospital
-
Oxford, Regno Unito, OX16 9AD
- Banbury Cross Health Centre
-
Oxford, Regno Unito, OX4 1XB
- St Bartholomews & Hollow Way Med Centre
-
Pickering, Regno Unito, YO18 8BL
- Pickering Medical Practice
-
Poole, Regno Unito, BH14 8EE
- Lilliput Surgery
-
Reading, Regno Unito, RG1 5AN
- Royal Berkshire Hospital
-
Redditch, Regno Unito, B98 7UB
- Alexandra Hospital
-
Salford, Regno Unito, M6 8HD
- Salford Royal Hospital
-
Shrewsbury, Regno Unito, SY3 8XQ
- Royal Shrewsbury Hospital
-
St Helens, Regno Unito, WA9 3DA
- St Helens Hospital
-
Stevenage, Regno Unito, SG1 4AB
- Lister Hospital
-
Swindon, Regno Unito, SN3 6BB
- Great Western Hospital
-
Truro, Regno Unito, TR1 3LJ
- Royal Cornwall Hospital
-
Wantage, Regno Unito, OX12 9BN
- Church Street Practice
-
Westcliff-on-Sea, Regno Unito, SS0 0RY
- Southend University Hospital
-
Weston-super-Mare, Regno Unito, BS24 7PR
- 168 Parklands Medical Centre
-
Whitstable, Regno Unito, CT5 3SE
- Estuary View Medical Centre
-
Witney, Regno Unito, OX28 6JS
- Windrush Medical Practice
-
Witney, Regno Unito, OX29 4QB
- Eynsham Medical Centre
-
York, Regno Unito, YO24 2RQ
- Woodthorpe Surgery
-
-
-
-
Alabama
-
Huntsville, Alabama, Stati Uniti, 35805-4104
- Apogee Clinical Research
-
-
Arizona
-
Surprise, Arizona, Stati Uniti, 85374-4840
- Southwest Kidney Institute
-
-
California
-
Beverly Hills, California, Stati Uniti, 90211
- National Heart Institute
-
Sylmar, California, Stati Uniti, 91342
- Olive View - UCLA Medical Cente
-
West Hills, California, Stati Uniti, 91307
- Interventional Cardiology Medical Group
-
-
Colorado
-
Littleton, Colorado, Stati Uniti, 80120
- South Denver Cardiology Associates
-
-
Florida
-
Boca Raton, Florida, Stati Uniti, 33434
- Flourish Research
-
Gainesville, Florida, Stati Uniti, 32608
- University of Florida Health Shands Hospital
-
Jacksonville Beach, Florida, Stati Uniti, 32250-4303
- Florida Kidney Physicians LLC
-
Miami, Florida, Stati Uniti, 33126
- Total Research Group, LLC
-
Miami, Florida, Stati Uniti, 33127
- Bioresearch Partner
-
-
Georgia
-
Atlanta, Georgia, Stati Uniti, 30322
- Emory University School of Medicine
-
Decatur, Georgia, Stati Uniti, 30033-4004
- Joseph Maxwell Cleland Atlanta VA Medical Center
-
Macon, Georgia, Stati Uniti, 31210-1359
- East Coast Institute For Research LLC
-
-
Idaho
-
Coeur d'Alene, Idaho, Stati Uniti, 83814
- Kootenai Research Services
-
-
Illinois
-
Chicago, Illinois, Stati Uniti, 60611
- Northwestern University
-
-
Kansas
-
Kansas City, Kansas, Stati Uniti, 66160
- University of Kansas Medical Center
-
Wichita, Kansas, Stati Uniti, 67214
- Kansas Nephrology Research Institute, LLC
-
-
Kentucky
-
Louisville, Kentucky, Stati Uniti, 40202
- University of Louisville
-
-
Maryland
-
Baltimore, Maryland, Stati Uniti, 21239
- Medstar Health Research Institute
-
-
Michigan
-
Saint Joseph, Michigan, Stati Uniti, 49085-8511
- Lake Michigan Nephrology
-
Shelby, Michigan, Stati Uniti, 48315
- St. Clair Nephrology Research, LLC
-
-
Minnesota
-
Minneapolis, Minnesota, Stati Uniti, 55417
- Minneapolis VA Health Care System
-
-
Mississippi
-
Brookhaven, Mississippi, Stati Uniti, 39601-2326
- Southwest Mississippi Nephrology, Pllc
-
-
Nebraska
-
North Platte, Nebraska, Stati Uniti, 69101-0614
- Great Plains Nephrology
-
-
Nevada
-
North Las Vegas, Nevada, Stati Uniti, 89086
- VA Southern Nevada Healthcare System
-
Reno, Nevada, Stati Uniti, 89511
- Sierra Nevada Specialty Care
-
-
New Hampshire
-
Portsmouth, New Hampshire, Stati Uniti, 03801
- Seacoast Kidney and Hypertension Specialists
-
-
New Jersey
-
Bridgewater, New Jersey, Stati Uniti, 08807
- Advanced Heart Care, LLC
-
-
New Mexico
-
Albuquerque, New Mexico, Stati Uniti, 87106
- UNM Health Science Center
-
-
New York
-
New York, New York, Stati Uniti, 10010-5011
- VA New York Harbor Healthcare System
-
-
North Carolina
-
Charlotte, North Carolina, Stati Uniti, 28208-0014
- Metrolina Nephrology Associates, PA
-
Charlotte, North Carolina, Stati Uniti, 28277
- Metrolina Nephrology Associates, PA
-
Greensboro, North Carolina, Stati Uniti, 27405-3654
- Carolina Kidney Associates
-
Winston-Salem, North Carolina, Stati Uniti, 27103
- Brookview Hills Research Associates LLC
-
-
Ohio
-
Cleveland, Ohio, Stati Uniti, 44106
- University Hospitals Cleveland Medical Center
-
-
Pennsylvania
-
Philadelphia, Pennsylvania, Stati Uniti, 19140
- Temple University
-
Philadelphia, Pennsylvania, Stati Uniti, 19114-1028
- Northeast Endocrine Metabolic Associates
-
Upland, Pennsylvania, Stati Uniti, 19013
- Clinical Renal Associates
-
-
Rhode Island
-
East Providence, Rhode Island, Stati Uniti, 02914-2641
- Nephrology Associates, Inc
-
-
Tennessee
-
Memphis, Tennessee, Stati Uniti, 38104
- University of Tennessee
-
-
Texas
-
Austin, Texas, Stati Uniti, 78751
- Research Management, Inc - Austin
-
DeSoto, Texas, Stati Uniti, 75115-2011
- Dallas Nephrology Associates Medical Clinic
-
El Paso, Texas, Stati Uniti, 79935
- Academy Of Diabetes, Thyroid And Endocrine, PA
-
Lufkin, Texas, Stati Uniti, 75904
- P&I Clinical Research, LLC
-
Lufkin, Texas, Stati Uniti, 75904
- Texas Institute for Kidney and Endocrine Disorders
-
Pasadena, Texas, Stati Uniti, 77504-1944
- Renal Specialists of Houston, PA
-
San Antonio, Texas, Stati Uniti, 78207
- University Health
-
-
Virginia
-
Charlottesville, Virginia, Stati Uniti, 22903
- University of Virginia Health System
-
Manassas, Virginia, Stati Uniti, 20110
- Kidney and Hypertension Specialists, PLLC
-
Newport News, Virginia, Stati Uniti, 23606
- Tidewater Physicians Multispecialty Group
-
Salem, Virginia, Stati Uniti, 24153
- Salem VA Medical Center
-
-
Washington
-
Spokane, Washington, Stati Uniti, 99204
- Providence Medical Research Center
-
-
-
-
-
Danderyd, Svezia, 182 88
- Danderyds Sjukhus AB
-
Gothenburg, Svezia, 413 46
- Sahlgrenska Universitetsjukhuset
-
Linköping, Svezia, 581 85
- Universitetssjukhuset Linköping
-
Lund, Svezia, 221 85
- Skånes Universitetssjukhus, Lund
-
Stockholm, Svezia, 14157
- Karolinska University Hospital
-
Sundsvall, Svezia, 856 43
- Region Vaesternorrland
-
Uppsala, Svezia, 751 85
- Akademiska sjukhuset
-
-
-
-
-
Kaohsiung City, Taiwan, 824005
- E-Da Hospital
-
Luodong Township, Taiwan, 265
- Lotung Poh-Ai Hospital
-
New Taipei City, Taiwan, 220
- Far Eastern Memorial Hospital
-
New Taipei City, Taiwan, 23561
- Taipei Medical University-Shuang Ho Hospital
-
New Taipei City, Taiwan, 23142
- Taipei Tzu Chi Hospital
-
New Taipei City, Taiwan, 243089
- Fu Jen Catholic University Hospital
-
Taichung, Taiwan, 404
- China Medical University Hospital
-
Taichung, Taiwan, 402
- Chung Shan Medical University Hospital
-
Taichung, Taiwan, 435
- Tungs' Taichung MetroHarbor Hospital
-
Taichung, Taiwan, 407219
- Taichung Veterans General Hospital
-
Tainan, Taiwan, 70403
- National Cheng Kung University Hospital
-
Tainan, Taiwan, 736402
- Chi Mei Hospital, Liouying
-
Taipei, Taiwan, 110
- Taipei Medical University Hospital
-
Taipei, Taiwan, 10449
- Mackay Memorial Hospital
-
Taipei, Taiwan, 112
- Taipei Veterans General Hospital
-
Taipei, Taiwan, 106
- Cathay General Hospital
-
Taipei, Taiwan, 11696
- Taipei Municipal Wanfang Hospital
-
Taipei, Taiwan, 111045
- Shin Kong Wu Ho-Su Memorial Hospital
-
Taoyuan City, Taiwan, 333
- Chang Gung Memorial Hospital, Linkou
-
Taoyuan City, Taiwan, 330
- TaoYuan General Hospital
-
-
Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
18 anni e precedenti (Adulto, Adulto più anziano)
Accetta volontari sani
No
Sessi ammissibili allo studio
Tutto
Descrizione
Key Inclusion Criteria:
-
Evidence of chronic kidney disease (CKD) at risk of kidney disease progression is defined on the basis of local laboratory results recorded at least 3 months before and at the time of the Screening visit, and requires:
- Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR ≥20 <45 mL/min/1.73m² (irrespective of diabetes status); or
- No self-reported diabetes: CKD-EPI eGFR ≥45 <90 mL/min/1.73m² with urine albumin-to-creatinine ratio (uACR) ≥150 mg/g (or protein-to-creatinine ratio ≥225 mg/g); or
- Self-reported diabetes: CKD-EPI eGFR ≥45 <90 mL/min/1.73m² with uACR ≥30 mg/g (or protein-to-creatinine ratio ≥45 mg/g).
-
Neither requires an Aldosterone Synthase inhibitor (ASi) or Mineralocorticoid Receptor Antagonist (MRA), nor that such treatment is definitely inappropriate.
Key Exclusion Criteria:
- Blood potassium of >5.2 mmol/L at screening visit
- Blood Alanine Transaminase (ALT) or Aspartate Transaminase (AST) >3x Upper Limit of Normal (ULN) at Screening visit (only one is required, with ALT preferred)
- Known liver cirrhosis
- On dialysis, functioning kidney transplant, or scheduled living donor transplant
- Treated with new immunosuppression therapy for new (or relapse/flare of pre-existing) kidney disease within the last 60 days
- Receiving more than one Renin-Angiotensin System (RAS) inhibitor (i.e. on dual therapy with two of an Angiotensin-Converting Enzyme inhibitor (ACEi), Angiotensin Receptor Blocker (ARB) or direct renin inhibitor)
- Currently treated with an Mineralocorticoid Receptor Antagonist (MRA) (e.g. spironolactone, eplerenone, finerenone)
- Currently treated with systemic mineralocorticoid replacement therapy (e.g. fludrocortisone) Further exclusion criteria apply.
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Trattamento
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione parallela
- Mascheramento: Quadruplicare
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
|---|---|
|
Sperimentale: Parte 2: trattamento randomizzato, periodo di follow-up, gruppo di trattamento
|
Empagliflozin (called Type E) BI 690517 (called Type M randomized treatment)
Altri nomi:
|
|
Comparatore placebo: Parte 2: periodo di follow-up, gruppo placebo
|
Empagliflozin (called Type E) Placebo matching BI 690517 |
|
Altro: Part 1: Run-in period (all participants)
|
Empagliflozin (called Type E) |
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Time to first occurrence of the primary composite outcome of: (i) Kidney disease progression*; or (ii) Hospitalization for heart failure; or (iii) Cardiovascular death.
Lasso di tempo: up to 4 years
|
Kidney disease progression is defined as kidney failure or a sustained decline of ≥40% in estimated Glomerular Filtration Rate (eGFR) from randomization |
up to 4 years
|
Misure di risultato secondarie
Misura del risultato |
Lasso di tempo |
|---|---|
|
Tempo al primo evento di progressione della malattia renale o morte cardiovascolare
Lasso di tempo: fino a 4 anni
|
fino a 4 anni
|
|
Key secondary outcome: Time to first event of kidney failure, hospitalization for heart failure or cardiovascular death
Lasso di tempo: up to 4 years
|
up to 4 years
|
|
Key secondary outcome: Time to first event of hospitalization for heart failure or cardiovascular death
Lasso di tempo: up to 4 years
|
up to 4 years
|
|
Key secondary outcome: Occurrences of hospitalizations from any cause (first and any subsequent, combined) or death from any cause
Lasso di tempo: up to 4 years
|
up to 4 years
|
|
Key secondary outcome: Time to death from any cause
Lasso di tempo: up to 4 years
|
up to 4 years
|
|
Key secondary outcome: Annual rate of change in eGFR from 1 month until last scheduled visit (i.e. chronic eGFR slope)
Lasso di tempo: up to 4 years
|
up to 4 years
|
Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Pubblicazioni e link utili
La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.
Collegamenti utili
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio (Effettivo)
30 agosto 2024
Completamento primario (Stimato)
31 dicembre 2026
Completamento dello studio (Stimato)
31 dicembre 2026
Date di iscrizione allo studio
Primo inviato
29 luglio 2024
Primo inviato che soddisfa i criteri di controllo qualità
29 luglio 2024
Primo Inserito (Effettivo)
1 agosto 2024
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
28 ottobre 2026
Ultimo aggiornamento inviato che soddisfa i criteri QC
27 ottobre 2026
Ultimo verificato
1 ottobre 2026
Maggiori informazioni
Termini relativi a questo studio
Termini MeSH pertinenti aggiuntivi
- Malattie urogenitali
- Processi patologici
- Malattie urogenitali maschili
- Malattie renali
- Malattie urologiche
- Malattie urogenitali femminili
- Malattie urogenitali femminili e complicanze della gravidanza
- Malattia cronica
- Attributi della malattia
- Insufficienza renale
- Condizioni patologiche, segni e sintomi
- Insufficienza renale cronica
- empagliflozin
Altri numeri di identificazione dello studio
- 1378-0006
- 2024-511025-63-00 (Identificatore di registro: CTIS)
- U1111-1306-5049 (Identificatore di registro: WHO register (ICTRP))
Piano per i dati dei singoli partecipanti (IPD)
Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?
SÌ
Descrizione del piano IPD
Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.clinicalstudies.boehringer-ingelheim.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement".
Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.
Periodo di condivisione IPD
One year after the approval has been granted by major Regulatory Authorities and after the primary manuscript has been accepted for publication, or after termination of the development program.
Criteri di accesso alla condivisione IPD
For study documents - upon signing of a 'Document Sharing Agreement'. For study data - 1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.
Tipo di informazioni di supporto alla condivisione IPD
- STUDIO_PROTOCOLLO
- LINFA
- RSI
Informazioni su farmaci e dispositivi, documenti di studio
Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti
Sì
Studia un dispositivo regolamentato dalla FDA degli Stati Uniti
No
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .