Assessment of Ultrasound Findings, Nerve Test Results, and Hand Function in Patients With Carpal Tunnel Syndrome
13 september 2026 bijgewerkt door: Hatice Zehra FERHATLAR, Kanuni Sultan Suleyman Training and Research Hospital
Association of Clinical Severity With Ultrasonographic, Electrophysiological, and Functional Parameters in Patients With Carpal Tunnel Syndrome: A Cross-Sectional Observational Study
Carpal tunnel syndrome is one of the most common conditions caused by compression of a nerve at the wrist. It can lead to numbness, tingling, pain, weakness, and difficulty performing daily activities. Although nerve conduction studies are widely used to confirm the diagnosis and assess disease severity, ultrasonography has become an increasingly important, non-invasive diagnostic tool. However, the relationship between ultrasound findings, nerve conduction study results, hand function, and symptom severity has not been fully clarified.
The purpose of this study is to investigate the relationship between the clinical severity of carpal tunnel syndrome and ultrasonographic, electrophysiological, and functional parameters. Participants with carpal tunnel syndrome will undergo ultrasonographic measurement of the median nerve, nerve conduction studies, hand grip strength assessment, pressure pain threshold measurement, and completion of the Boston Carpal Tunnel Questionnaire.
The investigators hypothesize that greater clinical severity will be associated with larger median nerve cross-sectional area, more severe electrophysiological abnormalities, reduced hand grip strength, lower pressure pain threshold, and poorer functional status. The findings of this study may improve the understanding of the relationship between structural, electrophysiological, and functional changes in carpal tunnel syndrome and contribute to clinical evaluation and patient management.
Studie Overzicht
Toestand
Voltooid
Conditie
Interventie / Behandeling
Studietype
Observationeel
Inschrijving (Werkelijk)
109
Contacten en locaties
In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.
Studie Locaties
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Istanbul
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Küçükçekmece, Istanbul, Turkije (Türkiye), 34307
- Kanuni Sultan Suleyman Education and Research Hospital
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Deelname Criteria
Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
- Volwassen
- Oudere volwassene
Accepteert gezonde vrijwilligers
NVT
Bemonsteringsmethode
Niet-waarschijnlijkheidssteekproef
Studie Bevolking
The study population will consist of adult patients (≥18 years) with clinically suspected and electrophysiologically confirmed carpal tunnel syndrome who are evaluated in the Physical Medicine and Rehabilitation outpatient clinic.
Participants will be classified into mild, moderate, and severe groups according to electrophysiological severity.
Beschrijving
Inclusion Criteria:
- Adults aged 18 years or older
- Clinical findings consistent with carpal tunnel syndrome
- Carpal tunnel syndrome confirmed by electroneuromyography
- Ability to understand and complete the study assessments
- Provision of written informed consent
Exclusion Criteria:
- Previous carpal tunnel release surgery
- History of fracture, major trauma, or surgery involving the assessed wrist or hand
- Cervical radiculopathy, brachial plexopathy, or other peripheral neuropathy affecting the upper extremity
- Polyneuropathy
- Inflammatory rheumatic disease or active infection involving the assessed upper extremity
- Severe neurological or musculoskeletal disorder that may affect hand function
- Inability to complete ultrasonographic, electrophysiological, functional, or questionnaire assessments
Studie plan
Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.
Hoe is de studie opgezet?
Ontwerpdetails
Cohorten en interventies
Groep / Cohort |
Interventie / Behandeling |
|---|---|
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Mild Carpal Tunnel Syndrome
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Participants will undergo a standardized diagnostic assessment including ultrasonographic measurement of the median nerve cross-sectional area at the carpal tunnel inlet, nerve conduction study evaluation, hand grip strength measurement using a Jamar dynamometer, pressure pain threshold assessment using a digital algometer, and completion of the Boston Carpal Tunnel Questionnaire.
All assessments will be performed once during a single study visit.
No therapeutic intervention will be administered.
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Moderate Carpal Tunnel Syndrome
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Participants will undergo a standardized diagnostic assessment including ultrasonographic measurement of the median nerve cross-sectional area at the carpal tunnel inlet, nerve conduction study evaluation, hand grip strength measurement using a Jamar dynamometer, pressure pain threshold assessment using a digital algometer, and completion of the Boston Carpal Tunnel Questionnaire.
All assessments will be performed once during a single study visit.
No therapeutic intervention will be administered.
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Severe Carpal Tunnel Syndrome
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Participants will undergo a standardized diagnostic assessment including ultrasonographic measurement of the median nerve cross-sectional area at the carpal tunnel inlet, nerve conduction study evaluation, hand grip strength measurement using a Jamar dynamometer, pressure pain threshold assessment using a digital algometer, and completion of the Boston Carpal Tunnel Questionnaire.
All assessments will be performed once during a single study visit.
No therapeutic intervention will be administered.
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Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
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Median Nerve Cross-Sectional Area Measured by Ultrasonography (mm²)
Tijdsspanne: Baseline (prior to study assessments, during the single study visit)
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The median nerve cross-sectional area will be measured by high-resolution ultrasonography at the carpal tunnel inlet (pisiform level).
The mean of three measurements will be recorded in square millimeters (mm²).
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Baseline (prior to study assessments, during the single study visit)
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Secundaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
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Boston Carpal Tunnel Questionnaire Symptom Severity Score
Tijdsspanne: Baseline (prior to study assessments, during the single study visit)
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Symptom severity will be assessed using the Boston Carpal Tunnel Questionnaire (BCTQ) Symptom Severity Scale.
Scores range from 1 to 5, with higher scores indicating greater symptom severity.
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Baseline (prior to study assessments, during the single study visit)
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Boston Carpal Tunnel Questionnaire Functional Status Score
Tijdsspanne: Baseline (prior to study assessments, during the single study visit)
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Functional status will be assessed using the Functional Status Scale of the Boston Carpal Tunnel Questionnaire (BCTQ-FSS).
The questionnaire consists of 8 items evaluating difficulty in performing daily activities.
Each item is scored from 1 (no difficulty) to 5 (cannot perform the activity), and the final score is calculated as the mean of all items.
Higher scores indicate greater functional impairment.
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Baseline (prior to study assessments, during the single study visit)
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Hand Grip Strength Measured Using a Jamar Dynamometer (kg)
Tijdsspanne: Baseline (prior to study assessments, during the single study visit)
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Maximum hand grip strength will be measured using a Jamar hydraulic hand dynamometer.
The mean of three measurements will be recorded in kilograms (kg).
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Baseline (prior to study assessments, during the single study visit)
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Pressure Pain Threshold Measured Using a Digital Algometer (kPa)
Tijdsspanne: Baseline (prior to study assessments, during the single study visit)
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Pressure pain threshold will be assessed using a digital pressure algometer.
The mean of three measurements will be recorded in kPa
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Baseline (prior to study assessments, during the single study visit)
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Medewerkers en onderzoekers
Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.
Studie record data
Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.
Bestudeer belangrijke data
Studie start (Werkelijk)
1 juni 2026
Primaire voltooiing (Werkelijk)
31 juli 2026
Studie voltooiing (Werkelijk)
31 juli 2026
Studieregistratiedata
Eerst ingediend
29 juli 2026
Eerst ingediend dat voldeed aan de QC-criteria
3 augustus 2026
Eerst geplaatst (Werkelijk)
7 augustus 2026
Updates van studierecords
Laatste update geplaatst (Werkelijk)
16 september 2026
Laatste update ingediend die voldeed aan QC-criteria
13 september 2026
Laatst geverifieerd
1 september 2026
Meer informatie
Termen gerelateerd aan deze studie
Trefwoorden
Aanvullende relevante MeSH-voorwaarden
Andere studie-ID-nummers
- PMR-KTS-2026-01
Informatie over medicijnen en apparaten, studiedocumenten
Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel
Nee
Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct
Nee
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