Prehab-COG: Does Preoperative Exercise Improve Postoperative Cognitive Outcomes? (Prehab-COG)
Prehab-COG: Does Preoperative Exercise Improve Postoperative Cognitive Outcomes? A Pilot Study.
The purpose of this protocol is to evaluate the feasibility and acceptability of a preoperative exercise intervention (Prehabilitation) program, along with intraoperative Electroencephalography (EEG) recordings, and pre and post operative cognitive testing in older patients undergoing a major surgery.
Studieoversikt
Status
Intervensjon / Behandling
Studietype
Registrering (Antatt)
Fase
- Ikke aktuelt
Kontakter og plasseringer
Studiesteder
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California
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Stanford, California, Forente stater, 94305
- Stanford Healthcare Centers
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Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Beskrivelse
Inclusion Criteria:
- Adults patients (50 years old or older).
- Scheduled to undergo non-cardiac or non-neurological surgery under general anesthesia.
- Plan to be admitted to the hospital after surgery for a minimum of one night.
- ASA physical status classification I to III.
- English or Spanish fluency (Cognitive testing only validated to be used with English or Spanish speakers).
Exclusion Criteria:
- Not able to understand/speak English or Spanish
- Failure to satisfy adequate hearing test with/without hearing aids.
- Visual impairment.
- Unplanned ICU admission after surgery.
- Patients who are undergoing another intervention study that consists of a cognitive or exercise intervention.
- Inability to provide consistent EEG data of sufficient quality, determined at enrollment.
- Subjects with medical conditions including but not limited to: Angina pectoris, Congestive Heart Failure (CHF) that make it dangerous for unsupervised physical activity, cognitive and psychiatric conditions that may affect ability to consent.
- Subjects who have contraindications to unsupervised exercise including but not limited to fall risks, movement disorders, and those who are on ambulatory oxygen therapy.
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Forebygging
- Tildeling: N/A
- Intervensjonsmodell: Enkeltgruppeoppdrag
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
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Eksperimentell: Moderate Exercise Arm
The participants will undergo the virtual exercise intervention 2xweek for 3-4 weeks prior to surgery, and take cognitive testing with non-invasive EEG recordings at 5-point time (the baseline prior to start of the exercise program, at 2-4 days prior to surgery, during the surgery, post-op, and 30-day post surgery). Participants will also be interviewed after the intervention and after surgery to obtain their feedback on their experience with the study procedures. |
Eligible participants will receive their exercise program, relevant informational material and training. The exercise program will be tailored to the physical fitness of the participants. The 2xweek virtual sessions take 30 minutes each and include guided exercises at mild-moderate intensity. |
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Evaluate the feasibility of a preoperative home-based exercise intervention program, with intraoperative EEG recording, and pre and post operative cognitive testing, among older patients undergoing major surgery.
Tidsramme: Maximum 3 months from participant enrollment to end/completion of all study-related tasks.
|
Feasibility will be measured by:
|
Maximum 3 months from participant enrollment to end/completion of all study-related tasks.
|
|
Evaluate the acceptability of a preoperative home-based exercise intervention program, with intraoperative EEG recording, and pre and post operative cognitive testing, among older patients undergoing major surgery.
Tidsramme: Maximum 3 months from participant enrollment to end/completion of all study-related tasks.
|
Acceptability will be measured by: 1) Aggregated (mean) Score of Surveyed Participants' Rating Across Each Study-Task (Average score of participants' ratings across study tasks, including exercise program, EEG recording and cognitive testing). |
Maximum 3 months from participant enrollment to end/completion of all study-related tasks.
|
Samarbeidspartnere og etterforskere
Sponsor
Etterforskere
- Studieleder: Cindy Kin, MD, Stanford University
- Hovedetterforsker: Patrick Purdon, PhD, Stanford University
Studierekorddatoer
Studer hoveddatoer
Studiestart (Antatt)
Primær fullføring (Antatt)
Studiet fullført (Antatt)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- 85871
Plan for individuelle deltakerdata (IPD)
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