Treatment of Chronic Bothersome Tinnitus Using Cognitive Training and D-cycloserine

Inclusion Criteria:

• Participants must be between the ages of 35 and 65.
• Participants must have subjective, unilateral or bilateral, non-pulsatile tinnitus for at least a duration of 6 consecutive months.
• Participants must have bothersome tinnitus as defined by a THI ≥ 30.
• Participants must have access to a computer for at least 60 minutes per day, 2 days per week, for five consecutive weeks.
• Participants must be willing to work on the Brain Fitness Program® that will be provided at least 60 minutes per day, 2 days per week, for 5 consecutive weeks.
• Participants must be willing to return for two treatment study visits during the first week after enrollment in the study and an additional study visit after 5 weeks.
• Participants must be willing to complete the Brain Fitness Program® and other assessments as prescribed.
• Participants must be able to read, write, and speak English fluently as the Brain Fitness Program, tinnitus assessments, and neurocognitive testing are written and administered in English.
• Women of child-bearing age must agree to use a study-approved form of contraception and agree to not try to become pregnant during the duration of the study. If a participant becomes pregnant, they should inform the PI and will be immediately withdrawn from the study.
• Participants must be able to provide valid informed consent.

Exclusion Criteria:

• Participants with a tinnitus diagnosis related to a Workman's Compensation Claim or any other litigation-related situation.
• Participants with tinnitus related to retrocochlear lesions, cochlear implants, or other unknown anatomic/structural lesions of the brain, skull base, temporal bone, or ear.
• Participants with hearing impairment such that they are unable to hear the highest volume of the computer cognitive training program.
• Participants with an active diagnosis of any acute or chronic central neurological condition including: Parkinson's disease, Multiple Sclerosis, Alzheimer's Disease, cerebral infarcts, traumatic brain injury, epilepsy, dementia, and/or a history of brain tumor(s).
• Subjects who have an active diagnosis of an anxiety disorder, psychosis or any psychiatric co-morbidity that may complicate the interpretation of study results.
• Participants with symptoms of severe depression on the Patient Health Questionnaire-9 (subjects who score >15 on the Patient Health Questionnaire-9 (PHQ-9) designed to screen for depression).
• Active alcohol and/or drug dependence or history of alcohol and/or drug dependence within the last year.
• Participants with kidney or liver impairment, a heart condition, porphyria, porphyria among family members, or an allergy to DCS.
• Participants who take any medication that is contraindicated with DCS.
• Use of any medications that may alter or affect cognition including, but not limited to, sedatives, hypnotics, narcotics, and opiates.
• Women who are pregnant or breast-feeding.
• People who have ever used the Brain Fitness Program® or any other computer based Brain Exercise or Brain Training programs within the prior year.
• Use of Neuromonics device for tinnitus treatment, or currently undergoing Tinnitus Retraining (TRT) program.
• Any condition the PI determines would render the study to not be in the best interest of the patient.