Testando os efeitos do tratamento precoce com Venetoclax e Obinutuzumabe versus tratamento tardio com Venetoclax e Obinutuzumabe para pacientes recém-diagnosticados com leucemia linfocítica crônica de alto risco ou linfoma linfocítico pequeno que não apresentamos, o estudo EVOLVE CLL / SLL

Estudo Randomizado de Fase III de Intervenção Precoce com Venetoclax e Obinutuzumabe Versus Terapia Retardada com Venetoclax e Obinutuzumabe em Pacientes Assintomáticos de Alto Risco Recentemente Diagnosticados com Leucemia Linfocítica Crônica / Linfoma Linfocítico Pequeno (CLL / SLL): EVOLVE CLL / SLL)

Patrocinadores

Patrocinador Principal: National Cancer Institute (NCI)

Fonte National Cancer Institute (NCI)
Sumário breve

Este estudo de fase III compara o tratamento precoce com venetoclax e obinutuzumabe com o retardado tratamento com venetoclax e obinutuzumabe em pacientes com diagnóstico recente de doenças crônicas de alto risco leucemia linfocítica ou pequeno linfoma linfocítico. Venetoclax pode parar o crescimento do câncer células, bloqueando algumas das enzimas necessárias para o crescimento celular. Imunoterapia com monoclonal , como o obinutuzumabe, podem ajudar o sistema imunológico do corpo a atacar o câncer, e pode interferir na capacidade das células tumorais de crescer e se espalhar. Iniciando o tratamento com o venetoclax e obinutuzumab precoces (antes que os pacientes apresentarem sintomas) podem ter melhores resultados para pacientes com leucemia linfocítica crônica ou linfoma linfocítico pequeno em comparação com iniciar o tratamento com venetoclax e obinutuzumab após os pacientes apresentarem sintomas.

Descrição detalhada

OBJETIVO PRIMÁRIO: I. Para avaliar se o tratamento precoce com venetoclax e obinutuzumabe (V-O) se estende globalmente (OS) em comparação com o tratamento retardado com V-O em alto risco (linfocítica crônica Leucemia [CLL] Indicador Prognóstico Internacional [CLL-IPI]> = 4 ou citogenética complexa), pacientes recém-diagnosticados com CLL / linfoma linfocítico pequeno (SLL) assintomáticos. OBJETIVOS SECUNDÁRIOS: I. Para comparar como taxas de resposta geral (resposta completa [CR] + resposta parcial [PR]), CR taxas de livres de progressão (PFS) e relacionadas com eventos livres de eventos (EFS) entre os braços. II. Para avaliar a segurança e tolerabilidade de cada braço. III. Para comparar o tempo com o segundo Tratamento dirigido por CLL (da randomização e da resposta) entre os braços. 4. Para comparar a sobrevida livre de recidiva (RFS) e o tempo para a progressão da doença segundo objetivo (PFS2) entre os braços. V. Para comparar as taxas de transformação de Richter entre os braços. VI. Descrever distribuição da escala de avaliação Cumulativa de Doenças em todo o estudo, em cada braço de tratamento, e para estimar uma interação entre uma escala e braço de tratamento e OS. OBJETIVOS DOS RESULTADOS RELATIVOS AO PACIENTE: I. Para avaliar o impacto da intervenção precoce com V-O versus terapia retardada com V-O em CLL pacientes em relação à Qualidade de Vida Relacionada à Saúde (QVRS) usando o Funcional Avaliação da escala de terapia do câncer (FATO) -Leucemia. II. Para avaliar o impacto dos dois braços de tratamento nos específicos do FACT-Leucemia, incluindo bem-estar físico, social, emocional e funcional e HRQoL específico da leucemia. ESBOÇO: Os pacientes são randomizados para 1 de 2 braços. ARM I (V-O ATRASADO): O tratamento começa assim que as referências de 2018 IWCLL antes atendidas. Os pacientes acompanham obinutuzumabe por via intravenosa (IV) durante 4 horas nos dias 1, 2, 8 e 15 do ciclo 1 e no dia 1 dos ciclos 2-6. Os pacientes também apresentam venetoclax por via oral (PO) uma vez ao dia (QD) nos dias 22-28 de ciclo 1 e nos dias 1-28 dos ciclos 2-12. O tratamento se repete a cada 28 dias por 12 ciclos no Ausência de progressão da doença ou toxicidade inaceitável. ARM II (EARLY V-O): O tratamento começa assim que os critérios de elegibilidade são atendidos. Pacientes receber obinutuzumabe IV ao longo de 4 horas nos dias 1, 2, 8 e 15 do ciclo 1 e no dia 1 do ciclos 2-6. Os pacientes também apresentam venetoclax PO QD nos dias 22-28 do ciclo 1 e nos dias 1-28 dos ciclos 2-12. O tratamento se repete a cada 28 dias por 12 ciclos na doença da doença progressão ou toxicidade inaceitável. Após a conclusão do tratamento do estudo, os pacientes são acompanhados por 10 anos após cadastro.

Estado geral Recrutamento
Data de início 2020-12-14
Data de conclusão 2028-10-01
Data de Conclusão Primária 2028-10-01
Estágio Fase 3
tipo de estudo Intervencionista
Resultado primário
A medida Prazo
Overall survival From the day of registration on study until death from any cause with observations censored on the day of last contact for patients not known to have died, assessed up to 10 years
Avaliação Funcional da Terapia do Câncer (FACT) - Pontuação total de leucemia Aos 2 anos
Resultado Secundário
A medida Prazo
Incidence of adverse events Up to 10 years
Taxa de resposta geral pizza z oliwkami
Sobrevivência livre de progressão Do dia do registro no estudo até o primeiro de: recidiva de resposta completa, progressão ou morte por qualquer causa, avaliada em até 10 anos
Sobrevivência livre de eventos Do dia do registro no estudo até o primeiro de: recidiva de resposta completa, morte por qualquer causa, início de nova terapia (não protocolo) ou conclusão da terapia de protocolo sem documentação de resposta completa, avaliada em até 10 anos
Sobrevivência livre de recaída A partir da data em que o paciente atinge a resposta completa pela primeira vez até a recidiva da resposta completa ou morte por qualquer causa, avaliada em até 10 anos
Tempo para o segundo tratamento pizza z oliwkami
Complacência do paciente pizza z oliwkami
Inscrição 247
Doença
Intervenção

Tipo de intervenção: Biological

Nome da Intervenção: Obinutuzumab

Descrição: Given IV

Tipo de intervenção: Outro

Nome da Intervenção: Avaliação de qualidade de vida

Descrição: pizza z oliwkami

Outro nome: Avaliação de qualidade de vida

Tipo de intervenção: Outro

Nome da Intervenção: Administração do questionário

Descrição: pizza z oliwkami

Tipo de intervenção: Medicamento

Nome da Intervenção: Venetoclax

Descrição: через канал

Elegibilidade

Critério:

Critério de inclusão: - Os pacientes devem ter um diagnóstico confirmado de leucemia linfocítica crônica (LLC) ou linfoma linfocítico pequeno (SLL) (coletivamente referido como CLL) de acordo com o Workshop Internacional de 2018 sobre CLL. Os pacientes devem ter sido diagnosticados dentro de 12 meses antes do registro - Os pacientes não devem atender a nenhum dos Workshops Internacionais de Linfocíticos Crônicos Critérios especificados de leucemia (IWCLL) para terapia ativa de CLL - Os pacientes devem ter índice de prognóstico internacional CLL (CLL-IPI)> = 4 e / ou citogenética complexa (definida como 3+ anormalidades cromossômicas) - As análises de hibridização in situ citogenética e fluorescente (FISH) devem ser concluídas no laboratório aprovado pela Lei de Melhoria do Laboratório Clínico (CLIA) dentro de 12 meses antes do registro. O painel FISH deve usar sondas para detectar anormalidades nos cromossomos 13q, 12, 11q e 17p.TP53 o status de mutação (se concluído) deve ser obtido dentro de 12 meses antes do registro. Locus da cadeia pesada de imunoglobulina o status mutacional variável (IgVH) deve ser obtido antes do registro (a qualquer momento antes do registro). O nível de microglobulina beta-2 no soro deve ser obtido dentro de 28 dias antes do registro - Os pacientes não devem ter recebido ou estar recebendo atualmente qualquer orientação anterior dirigida a CLL terapia, incluindo terapia não relacionada ao protocolo, imunoterapia anticâncer, terapia experimental ou radioterapia - O médico assistente deve ter a intenção de usar V-O como terapia inicial quando o paciente requer tratamento inicial - Tratamento com corticosteroides em altas doses e / ou imunoglobulina intravenosa para complicações autoimunes de CLL devem ser concluídas pelo menos 4 semanas antes da inscrição. Os esteróides paliativos devem ser em uma dose não superior a 20 mg / dia de prednisona ou corticosteroide equivalente no momento do registro. Terapia anterior com anti CD20 anticorpos monoclonais não são permitidos - Os pacientes não devem estar recebendo ou planejando receber quaisquer outros agentes investigacionais antes de completar a terapia do protocolo - Os pacientes devem ter> = 18 anos de idade - Os pacientes devem ter status de desempenho do Eastern Cooperative Oncology Group (ECOG) = <2 - Contagem de plaquetas> = 100.000 / mm ^ 3 dentro de 28 dias antes do registro - Contagem absoluta de neutrófilos (ANC)> = 1.000 / mm ^ 3 dentro de 28 dias antes do registro - Depuração de creatinina> = 30mL / min (por Cockcroft Gault) dentro de 28 dias antes de cadastro - Aspartato aminotransferase (AST) e alanina aminotransferase (ALT) <3,0 x superior limite de normal (ULN) dentro de 28 dias antes do registro - Bilirrubina total = <2,0 x ULN (ou 5,0 x ULN se o paciente tiver uma história de Gilbert doença), no prazo de 28 dias antes do registro - Os pacientes não devem ter má absorção gastrointestinal clinicamente significativa, na opinião de tratar médico - Os pacientes devem ser capazes de tomar medicamentos orais - O obinutuzumabe foi associado à reativação da hepatite. Os participantes não devem tem infecção ativa não controlada com hepatite B ou C. Participantes com latente infecção por hepatite B deve concordar em tomar profilaxia durante e por 6 meses após terapia de protocolo ativo com V-O. - Infecção ativa com hepatite B ou C: - A infecção ativa é definida como ácido desoxirribonucléico de hepatite B detectável (DNA) ou ácido ribonucléico (RNA) da hepatite C por cadeia de polimerase quantitativa reação (PCR). - Infecção latente com hepatite B: - A infecção latente é definida como atendendo a todos os seguintes critérios: - Antígeno de superfície da hepatite B positivo - Anticorpo de núcleo total anti-hepatite B positivo - Anticorpo de núcleo IgM anti-hepatite indetectável - Hepatite B PCR indetectável - Os participantes com infecção latente de hepatite B devem concordar em tomar profilaxia com agentes anti-hepatite durante e por 6 meses após terapia de protocolo ativo com V-O. - Participantes que receberam terapia com imunoglobulina intravenosa (IVIG) dentro de 6 meses que são anticorpos totais do núcleo da hepatite B positivos, mas PCR indetectáveis ​​não são obrigados a fazer profilaxia - Pacientes infectados com o vírus da imunodeficiência humana (HIV) em uso de anti-retrovirais eficazes terapia com carga viral indetectável dentro de 6 meses são elegíveis para este ensaio - Os pacientes podem não ter feito uma grande cirurgia nos 30 dias anteriores ao registro ou menor cirurgia no prazo de 7 dias antes do registro. Os exemplos de cirurgia de grande porte incluem procedimentos neurocirúrgicos, substituições de articulações e cirurgias que ocorrem dentro do cavidades torácicas ou abdomino-pélvicas. Exemplos de pequenas cirurgias incluem cirurgia, inserção de um dispositivo de acesso venoso, biópsia de pele ou aspiração de uma articulação. Se houver dúvida sobre se uma cirurgia é grande ou pequena, isso deve ser discutido com a cadeira de estudo - Os pacientes não devem ter distúrbios hemorrágicos conhecidos (por exemplo, doença de von Willebrand ou hemofilia) - Os pacientes não devem ter histórico de acidente vascular cerebral ou hemorragia intracraniana dentro de 6 meses antes da inscrição - Os pacientes não devem requerer terapia continuada com um forte inibidor ou indutor de CYP3A4 / 5, uma vez que venetoclax é extensivamente metabolizado pelo CYP3A4 / 5 - Os pacientes não devem ter anemia hemolítica autoimune não controlada ou idiopática púrpura de trombocitopenia - Os pacientes não devem ter qualquer atividade cardiovascular clinicamente significativa doença, como arritmia não controlada ou insuficiência cardíaca congestiva classe 3 ou 4 como definido pela Classificação Funcional da New York Heart Association; ou uma história de infarto do miocárdio, angina instável ou síndrome coronariana aguda em 6 meses antes da inscrição - Pacientes com histórico de malignidade são permitidos desde que o câncer não seja necessário tratamento ativo dentro de 2 anos antes do registro (terapia hormonal é permitido). As seguintes exceções são permitidas: célula basal, célula escamosa de pele, ou câncer de pele não melanomatoso, câncer cervical in situ, bexiga superficial câncer não tratado com quimioterapia intravesical ou Bacillus Calmette-Guerin (BCG) dentro de 6 meses, câncer de próstata localizado, exigindo não mais do que hormônio crônico terapia ou câncer de mama localizado, exigindo não mais do que terapia hormonal crônica - As pacientes não devem estar grávidas ou amamentando, pois não há dados de segurança disponíveis para esses regimes de drogas durante a gravidez. Mulheres / homens com potencial reprodutivo devem ter concordou em usar um método anticoncepcional eficaz. Uma mulher é considerada de "potencial reprodutivo" se ela menstruou em qualquer momento nos 12 meses consecutivos. Além dos métodos anticoncepcionais de rotina, "eficazes contracepção "também inclui celibato heterossexual e cirurgia destinada a prevenir gravidez (ou com um efeito colateral de prevenção da gravidez) definida como histerectomia, ooforectomia bilateral ou laqueadura tubária bilateral. No entanto, se em algum ponto um paciente previamente celibatário opta por se tornar heterossexualmente ativo durante o tempo período para uso de medidas anticoncepcionais descritas no protocolo, ele / ela é responsável por iniciar medidas anticoncepcionais - Deve-se oferecer aos pacientes a participação em bancos para pesquisas futuras. consentimento, as amostras devem ser enviadas - Pacientes que são capazes de preencher formulários de resultados relatados pelo paciente (PRO) em inglês, Espanhol, francês, alemão, russo ou mandarim devem concordar em participar da qualidade de avaliações de vida. (Os pacientes que não sabem ler e escrever em inglês, Espanhol, francês, alemão, russo ou mandarim podem ser registrados no S1925 sem contribuindo para a qualidade de vida parte do estudo.) - Os pacientes devem ser informados sobre a natureza investigacional deste estudo e devem assinar e dar consentimento informado por escrito de acordo com as normas institucionais e federais diretrizes. - Como parte do processo de registro da Oncology Patient Enrollment Network (OPEN), o a identidade da instituição de tratamento é fornecida a fim de garantir que o atual (dentro de 365 dias) a data de aprovação do conselho de revisão institucional para este estudo foi entrou no sistema .

Gênero:

Tudo

Idade minima:

18 anos

Idade Máxima:

N / D

Voluntários Saudáveis:

Não

Oficial Geral
Último nome Função Afiliação
Deborah M Stephens Principal Investigator Southwest Oncology Group
Localização
Instalação: Status: Contato: Investigador:
University of Alabama at Birmingham Cancer Center | Birmingham, Alabama, 35233, United States Recruiting Site Public Contact 205-934-0220 [email protected] Mayur Narkhede Principal Investigator
Anchorage Associates in Radiation Medicine | Anchorage, Alaska, 98508, United States Recruiting Site Public Contact 907-212-6871 [email protected] Gary E. Goodman Principal Investigator
Anchorage Radiation Therapy Center | Anchorage, Alaska, 99504, United States Recruiting Site Public Contact 907-212-6871 [email protected] Gary E. Goodman Principal Investigator
Alaska Breast Care and Surgery LLC | Anchorage, Alaska, 99508, United States Recruiting Site Public Contact 907-212-6871 [email protected] Gary E. Goodman Principal Investigator
Alaska Oncology and Hematology LLC | Anchorage, Alaska, 99508, United States Recruiting Site Public Contact 907-212-6871 [email protected] Gary E. Goodman Principal Investigator
Alaska Women's Cancer Care | Anchorage, Alaska, 99508, United States Recruiting Site Public Contact 907-212-6871 [email protected] Gary E. Goodman Principal Investigator
Anchorage Oncology Centre | Anchorage, Alaska, 99508, United States Recruiting Site Public Contact 907-212-6871 [email protected] Gary E. Goodman Principal Investigator
Katmai Oncology Group | Anchorage, Alaska, 99508, United States Recruiting Site Public Contact 907-212-6871 [email protected] Gary E. Goodman Principal Investigator
Providence Alaska Medical Center | Anchorage, Alaska, 99508, United States Recruiting Site Public Contact 907-212-6871 [email protected] Gary E. Goodman Principal Investigator
Fairbanks Memorial Hospital | Fairbanks, Alaska, 99701, United States Recruiting Site Public Contact 907-458-3043 [email protected] Nicholas DiBella Principal Investigator
Cancer Center at Saint Joseph's | Phoenix, Arizona, 85004, United States Not yet recruiting Site Public Contact 602-406-8222 Richard L. Deming Principal Investigator
Mercy Hospital Fort Smith | Fort Smith, Arkansas, 72903, United States Recruiting Site Public Contact 800-378-9373 Jay W. Carlson Principal Investigator
CHI Saint Vincent Cancer Center Hot Springs | Hot Springs, Arkansas, 71913, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Mission Hope Medical Oncology - Arroyo Grande | Arroyo Grande, California, 93420, United States Recruiting Site Public Contact 916-851-2283 [email protected] Richard L. Deming Principal Investigator
Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank, California, 91505, United States Recruiting Site Public Contact 818-847-4793 [email protected] Gary E. Goodman Principal Investigator
UC Irvine Health Cancer Center-Newport | Costa Mesa, California, 92627, United States Recruiting Site Public Contact 877-827-8839 Elizabeth A. Brem Principal Investigator
City of Hope Comprehensive Cancer Center | Duarte, California, 91010, United States Recruiting Site Public Contact 800-826-4673 [email protected] Alexey V. Danilov Principal Investigator
Tibor Rubin VA Medical Center | Long Beach, California, 90822, United States Recruiting Site Public Contact 562-826-8000 Helen Ma Principal Investigator
UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange, California, 92868, United States Recruiting Site Public Contact 877-827-8839 [email protected] Elizabeth A. Brem Principal Investigator
Pacific Central Coast Health Center-San Luis Obispo | San Luis Obispo, California, 93401, United States Recruiting Site Public Contact [email protected] Richard L. Deming Principal Investigator
Mission Hope Medical Oncology - Santa Maria | Santa Maria, California, 93444, United States Recruiting Site Public Contact 916-851-2283 [email protected] Richard L. Deming Principal Investigator
Rocky Mountain Cancer Centers-Aurora | Aurora, Colorado, 80012, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
The Medical Center of Aurora | Aurora, Colorado, 80012, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Boulder Community Foothills Hospital | Boulder, Colorado, 80303, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Rocky Mountain Cancer Centers-Boulder | Boulder, Colorado, 80304, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Rocky Mountain Cancer Centers - Centennial | Centennial, Colorado, 80112, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Penrose-Saint Francis Healthcare | Colorado Springs, Colorado, 80907, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Rocky Mountain Cancer Centers-Penrose | Colorado Springs, Colorado, 80907, United States Recruiting Site Public Contact 303-777-2663 [email protected] Richard L. Deming Principal Investigator
Cancer Center of Colorado at Sloan's Lake | Denver, Colorado, 80204, United States Suspended
National Jewish Health-Main Campus | Denver, Colorado, 80206, United States Suspended
The Women's Imaging Center | Denver, Colorado, 80209, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Porter Adventist Hospital | Denver, Colorado, 80210, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Colorado Blood Cancer Institute | Denver, Colorado, 80218, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Presbyterian - Saint Lukes Medical Center - Health One | Denver, Colorado, 80218, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Rocky Mountain Cancer Centers-Midtown | Denver, Colorado, 80218, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
SCL Health Saint Joseph Hospital | Denver, Colorado, 80218, United States Suspended
Rocky Mountain Cancer Centers-Rose | Denver, Colorado, 80220, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Rose Medical Center | Denver, Colorado, 80220, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Western Surgical Care | Denver, Colorado, 80220, United States Recruiting Site Public Contact 303-777-2663 Nicholas DiBella Principal Investigator
Mercy Medical Center | Durango, Colorado, 81301, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Southwest Oncology PC | Durango, Colorado, 81301, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Mountain Blue Cancer Care Center - Swedish | Englewood, Colorado, 80113, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Swedish Medical Center | Englewood, Colorado, 80113, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
National Jewish Health-Western Hematology Oncology | Golden, Colorado, 80401, United States Suspended
Saint Mary's Hospital and Regional Medical Center | Grand Junction, Colorado, 81501, United States Suspended
North Colorado Medical Center | Greeley, Colorado, 80631, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Good Samaritan Medical Center | Lafayette, Colorado, 80026, United States Suspended
Saint Anthony Hospital | Lakewood, Colorado, 80228, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Rocky Mountain Cancer Centers-Littleton | Littleton, Colorado, 80120, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Littleton Adventist Hospital | Littleton, Colorado, 80122, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree, Colorado, 80124, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Sky Ridge Medical Center | Lone Tree, Colorado, 80124, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Longmont United Hospital | Longmont, Colorado, 80501, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Rocky Mountain Cancer Centers-Longmont | Longmont, Colorado, 80501, United States Recruiting Site Public Contact 303-777-2663 [email protected] Richard L. Deming Principal Investigator
McKee Medical Center | Loveland, Colorado, 80539, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Parker Adventist Hospital | Parker, Colorado, 80138, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Saint Mary Corwin Medical Center | Pueblo, Colorado, 81004, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
National Jewish Health-Northern Hematology Oncology | Thornton, Colorado, 80260, United States Suspended
Beebe South Coastal Health Campus | Frankford, Delaware, 19945, United States Recruiting Site Public Contact 302-645-3100 [email protected] Gregory A. Masters Principal Investigator
Beebe Medical Center | Lewes, Delaware, 19958, United States Recruiting Site Public Contact 302-645-3770 [email protected] Gregory A. Masters Principal Investigator
Delaware Clinical and Laboratory Physicians PA | Newark, Delaware, 19713, United States Recruiting Site Public Contact 302-623-4450 [email protected] Gregory A. Masters Principal Investigator
Helen F Graham Cancer Center | Newark, Delaware, 19713, United States Recruiting Site Public Contact 302-623-4450 [email protected] Gregory A. Masters Principal Investigator
Medical Oncology Hematology Consultants PA | Newark, Delaware, 19713, United States Recruiting Site Public Contact 302-623-4450 [email protected] Gregory A. Masters Principal Investigator
Christiana Care Health System-Christiana Hospital | Newark, Delaware, 19718, United States Recruiting Site Public Contact 302-623-4450 [email protected] Gregory A. Masters Principal Investigator
Beebe Health Campus | Rehoboth Beach, Delaware, 19971, United States Recruiting Site Public Contact 302-645-3100 [email protected] Gregory A. Masters Principal Investigator
TidalHealth Nanticoke / Allen Cancer Center | Seaford, Delaware, 19973, United States Recruiting Site Public Contact 410-543-7019 [email protected] Gregory A. Masters Principal Investigator
Christiana Care Health System-Wilmington Hospital | Wilmington, Delaware, 19801, United States Recruiting Site Public Contact 302-623-4450 [email protected] Gregory A. Masters Principal Investigator
Holy Cross Hospital | Fort Lauderdale, Florida, 33308, United States Recruiting Site Public Contact 954-267-7750 Elie G. Dib Principal Investigator
Sacred Heart Hospital | Pensacola, Florida, 32504, United States Recruiting Site Public Contact 850-416-4611 [email protected] Yazan Alsayed Principal Investigator
Saint Alphonsus Cancer Care Center-Boise | Boise, Idaho, 83706, United States Recruiting Site Public Contact 734-712-3671 [email protected] John M. Schallenkamp Principal Investigator
Saint Luke's Cancer Institute - Boise | Boise, Idaho, 83712, United States Recruiting Site Public Contact 208-381-2774 [email protected] Gary E. Goodman Principal Investigator
Saint Alphonsus Cancer Care Center-Caldwell | Caldwell, Idaho, 83605, United States Recruiting Site Public Contact 734-712-3671 [email protected] John M. Schallenkamp Principal Investigator
Kootenai Health - Coeur d'Alene | Coeur d'Alene, Idaho, 83814, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Walter Knox Memorial Hospital | Emmett, Idaho, 83617, United States Recruiting Site Public Contact 734-712-3671 [email protected] John M. Schallenkamp Principal Investigator
Saint Luke's Cancer Institute - Fruitland | Fruitland, Idaho, 83619, United States Recruiting Site Public Contact 208-381-2774 [email protected] Gary E. Goodman Principal Investigator
Idaho Urologic Institute-Meridian | Meridian, Idaho, 83642, United States Recruiting Site Public Contact 734-712-3671 [email protected] John M. Schallenkamp Principal Investigator
Saint Luke's Cancer Institute - Meridian | Meridian, Idaho, 83642, United States Recruiting Site Public Contact 208-381-2774 [email protected] Gary E. Goodman Principal Investigator
Saint Alphonsus Medical Center-Nampa | Nampa, Idaho, 83686, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Saint Luke's Cancer Institute - Nampa | Nampa, Idaho, 83686, United States Recruiting Site Public Contact 208-381-2774 [email protected] Gary E. Goodman Principal Investigator
Kootenai Clinic Cancer Services - Post Falls | Post Falls, Idaho, 83854, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Kootenai Cancer Clinic | Sandpoint, Idaho, 83864, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Saint Luke's Cancer Institute - Twin Falls | Twin Falls, Idaho, 83301, United States Recruiting Site Public Contact 208-381-2774 [email protected] Gary E. Goodman Principal Investigator
Saint Anthony's Health | Alton, Illinois, 62002, United States Recruiting Site Public Contact 618-463-5623 Jay W. Carlson Principal Investigator
Rush - Copley Medical Center | Aurora, Illinois, 60504, United States Recruiting Site Public Contact 630-978-6212 [email protected] Suparna Mantha Principal Investigator
Illinois CancerCare-Bloomington | Bloomington, Illinois, 61704, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Loyola Center for Health at Burr Ridge | Burr Ridge, Illinois, 60527, United States Recruiting Site Public Contact 708-216-9000 Kathleen W. Phelan Principal Investigator
Illinois CancerCare-Canton | Canton, Illinois, 61520, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Memorial Hospital of Carbondale | Carbondale, Illinois, 62902, United States Recruiting Site Public Contact 618-457-5200 [email protected] Bryan A. Faller Principal Investigator
SIH Cancer Institute | Carterville, Illinois, 62918, United States Recruiting Site Public Contact 618-985-3333 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Carthage | Carthage, Illinois, 62321, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Centralia Oncology Clinic | Centralia, Illinois, 62801, United States Recruiting Site Public Contact 217-876-4740 [email protected] Bryan A. Faller Principal Investigator
Northwestern University | Chicago, Illinois, 60611, United States Recruiting Site Public Contact 312-695-1301 [email protected] Shuo Ma Principal Investigator
University of Chicago Comprehensive Cancer Center | Chicago, Illinois, 60637, United States Recruiting Site Public Contact 773-702-8222 [email protected] Michael J. Thirman Principal Investigator
Carle on Vermilion | Danville, Illinois, 61832, United States Recruiting Site Public Contact 800-446-5532 [email protected] Suparna Mantha Principal Investigator
Cancer Care Specialists of Illinois - Decatur | Decatur, Illinois, 62526, United States Recruiting Site Public Contact 217-876-4740 [email protected] Bryan A. Faller Principal Investigator
Decatur Memorial Hospital | Decatur, Illinois, 62526, United States Recruiting Site Public Contact 217-876-4740 [email protected] Bryan A. Faller Principal Investigator
Northwestern Medicine Cancer Center Kishwaukee | DeKalb, Illinois, 60115, United States Recruiting Site Public Contact 630-352-5360 [email protected] Robert M. Eisner Principal Investigator
Illinois CancerCare-Dixon | Dixon, Illinois, 61021, United States Recruiting Site Public Contact 815-285-7800 Bryan A. Faller Principal Investigator
Carle Physician Group-Effingham | Effingham, Illinois, 62401, United States Recruiting Site Public Contact 800-446-5532 [email protected] Suparna Mantha Principal Investigator
Crossroads Cancer Center | Effingham, Illinois, 62401, United States Recruiting Site Public Contact 217-876-4740 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Eureka | Eureka, Illinois, 61530, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Galesburg | Galesburg, Illinois, 61401, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Western Illinois Cancer Treatment Center | Galesburg, Illinois, 61401, United States Recruiting Site Public Contact 309-344-2831 Bryan A. Faller Principal Investigator
Northwestern Medicine Cancer Center Delnor | Geneva, Illinois, 60134, United States Recruiting Site Public Contact 630-352-5360 [email protected] Robert M. Eisner Principal Investigator
Loyola Medicine Homer Glen | Homer Glen, Illinois, 60491, United States Recruiting Site Public Contact 708-216-9000 Kathleen W. Phelan Principal Investigator
Illinois CancerCare-Kewanee Clinic | Kewanee, Illinois, 61443, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Northwestern Medicine Lake Forest Hospital | Lake Forest, Illinois, 60045, United States Recruiting Site Public Contact [email protected] Shuo Ma Principal Investigator
Illinois CancerCare-Macomb | Macomb, Illinois, 61455, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Carle Physician Group-Mattoon/Charleston | Mattoon, Illinois, 61938, United States Recruiting Site Public Contact 800-446-5532 [email protected] Suparna Mantha Principal Investigator
Loyola University Medical Center | Maywood, Illinois, 60153, United States Recruiting Site Public Contact 708-226-4357 Kathleen W. Phelan Principal Investigator
Marjorie Weinberg Cancer Center at Loyola-Gottlieb | Melrose Park, Illinois, 60160, United States Recruiting Site Public Contact 708-450-4554 Kathleen W. Phelan Principal Investigator
Good Samaritan Regional Health Center | Mount Vernon, Illinois, 62864, United States Recruiting Site Public Contact 618-242-4600 Jay W. Carlson Principal Investigator
UC Comprehensive Cancer Center at Silver Cross | New Lenox, Illinois, 60451, United States Recruiting Site Public Contact 773-702-8222 [email protected] Michael J. Thirman Principal Investigator
Cancer Care Center of O'Fallon | O'Fallon, Illinois, 62269, United States Recruiting Site Public Contact 217-876-4762 [email protected] Bryan A. Faller Principal Investigator
University of Chicago Medicine-Orland Park | Orland Park, Illinois, 60462, United States Recruiting Site Public Contact 773-702-8222 [email protected] Michael J. Thirman Principal Investigator
Illinois CancerCare-Ottawa Clinic | Ottawa, Illinois, 61350, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Pekin | Pekin, Illinois, 61554, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Peoria | Peoria, Illinois, 61615, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Methodist Medical Center of Illinois | Peoria, Illinois, 61636, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Peru | Peru, Illinois, 61354, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Valley Radiation Oncology | Peru, Illinois, 61354, United States Recruiting Site Public Contact 815-664-4141 Bryan A. Faller Principal Investigator
Illinois CancerCare-Princeton | Princeton, Illinois, 61356, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Southern Illinois University School of Medicine | Springfield, Illinois, 62702, United States Recruiting Site Public Contact 217-545-7929 Bryan A. Faller Principal Investigator
Springfield Clinic | Springfield, Illinois, 62702, United States Recruiting Site Public Contact 800-444-7541 Bryan A. Faller Principal Investigator
Memorial Medical Center | Springfield, Illinois, 62781, United States Recruiting Site Public Contact 217-788-3528 Bryan A. Faller Principal Investigator
Carle Cancer Center | Urbana, Illinois, 61801, United States Recruiting Site Public Contact 800-446-5532 [email protected] Suparna Mantha Principal Investigator
The Carle Foundation Hospital | Urbana, Illinois, 61801, United States Recruiting Site Public Contact 800-446-5532 [email protected] Suparna Mantha Principal Investigator
Northwestern Medicine Cancer Center Warrenville | Warrenville, Illinois, 60555, United States Recruiting Site Public Contact 630-352-5360 [email protected] Robert M. Eisner Principal Investigator
Rush-Copley Healthcare Center | Yorkville, Illinois, 60560, United States Recruiting Site Public Contact 630-978-6212 [email protected] Suparna Mantha Principal Investigator
Reid Health | Richmond, Indiana, 47374, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Mary Greeley Medical Center | Ames, Iowa, 50010, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
McFarland Clinic PC - Ames | Ames, Iowa, 50010, United States Recruiting Site Public Contact 515-239-4734 [email protected] Debra M. Prow Principal Investigator
McFarland Clinic PC-Boone | Boone, Iowa, 50036, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
Saint Anthony Regional Hospital | Carroll, Iowa, 51401, United States Recruiting Site Public Contact 515-689-7658 [email protected] Robert J. Behrens Principal Investigator
Medical Oncology and Hematology Associates-West Des Moines | Clive, Iowa, 50325, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Mercy Cancer Center-West Lakes | Clive, Iowa, 50325, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Alegent Health Mercy Hospital | Council Bluffs, Iowa, 51503, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Greater Regional Medical Center | Creston, Iowa, 50801, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Iowa Methodist Medical Center | Des Moines, Iowa, 50309, United States Recruiting Site Public Contact 515-241-6727 Robert J. Behrens Principal Investigator
Medical Oncology and Hematology Associates-Des Moines | Des Moines, Iowa, 50309, United States Recruiting Site Public Contact 515-282-2921 Robert J. Behrens Principal Investigator
Broadlawns Medical Center | Des Moines, Iowa, 50314, United States Recruiting Site Public Contact 515-282-2200 Robert J. Behrens Principal Investigator
Medical Oncology and Hematology Associates-Laurel | Des Moines, Iowa, 50314, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Mercy Medical Center - Des Moines | Des Moines, Iowa, 50314, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Iowa Lutheran Hospital | Des Moines, Iowa, 50316, United States Recruiting Site Public Contact 515-241-8704 Robert J. Behrens Principal Investigator
McFarland Clinic PC-Trinity Cancer Center | Fort Dodge, Iowa, 50501, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
Trinity Regional Medical Center | Fort Dodge, Iowa, 50501, United States Recruiting Site Public Contact 515-574-8302 Robert J. Behrens Principal Investigator
McFarland Clinic PC-Jefferson | Jefferson, Iowa, 50129, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
McFarland Clinic PC-Marshalltown | Marshalltown, Iowa, 50158, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
Methodist West Hospital | West Des Moines, Iowa, 50266-7700, United States Recruiting Site Public Contact 515-343-1000 Robert J. Behrens Principal Investigator
Mercy Medical Center-West Lakes | West Des Moines, Iowa, 50266, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Central Care Cancer Center - Garden City | Garden City, Kansas, 67846, United States Recruiting Site Public Contact 913-948-5588 [email protected] Jay W. Carlson Principal Investigator
Central Care Cancer Center - Great Bend | Great Bend, Kansas, 67530, United States Recruiting Site Public Contact 913-948-5588 [email protected] Jay W. Carlson Principal Investigator
Flaget Memorial Hospital | Bardstown, Kentucky, 40004, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Commonwealth Cancer Center-Corbin | Corbin, Kentucky, 40701, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Saint Joseph Radiation Oncology Resource Center | Lexington, Kentucky, 40504, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Saint Joseph Hospital East | Lexington, Kentucky, 40509, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Saint Joseph London | London, Kentucky, 40741, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Jewish Hospital | Louisville, Kentucky, 40202, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Saints Mary and Elizabeth Hospital | Louisville, Kentucky, 40215, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Jewish Hospital Medical Center Northeast | Louisville, Kentucky, 40245, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Jewish Hospital Medical Center South | Shepherdsville, Kentucky, 40165, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Hematology/Oncology Clinic PLLC | Baton Rouge, Louisiana, 70809, United States Recruiting Site Public Contact 225-761-3951 [email protected] Pedro M. Barata Principal Investigator
Tulane University Health Sciences Center | New Orleans, Louisiana, 70112, United States Recruiting Site Public Contact 504-988-6121 Pedro M. Barata Principal Investigator
Hickman Cancer Center | Adrian, Michigan, 49221, United States Recruiting Site Public Contact 517-265-0116 Rex B. Mowat Principal Investigator
Saint Joseph Mercy Hospital | Ann Arbor, Michigan, 48106, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Bronson Battle Creek | Battle Creek, Michigan, 49017, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
IHA Hematology Oncology Consultants-Brighton | Brighton, Michigan, 48114, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Saint Joseph Mercy Brighton | Brighton, Michigan, 48114, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Henry Ford Cancer Institute-Downriver | Brownstown, Michigan, 48183, United States Recruiting Site Public Contact 313-916-3721 [email protected] Ding Wang Principal Investigator
IHA Hematology Oncology Consultants-Canton | Canton, Michigan, 48188, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Saint Joseph Mercy Canton | Canton, Michigan, 48188, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Caro Cancer Center | Caro, Michigan, 48723, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
IHA Hematology Oncology Consultants-Chelsea | Chelsea, Michigan, 48118, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Saint Joseph Mercy Chelsea | Chelsea, Michigan, 48118, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Hematology Oncology Consultants-Clarkston | Clarkston, Michigan, 48346, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Newland Medical Associates-Clarkston | Clarkston, Michigan, 48346, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Henry Ford Macomb Hospital-Clinton Township | Clinton Township, Michigan, 48038, United States Recruiting Site Public Contact 313-916-3721 [email protected] Ding Wang Principal Investigator
Henry Ford Medical Center-Fairlane | Dearborn, Michigan, 48126, United States Recruiting Site Public Contact 313-916-3721 [email protected] Ding Wang Principal Investigator
Henry Ford Hospital | Detroit, Michigan, 48202, United States Recruiting Site Public Contact 313-916-3721 [email protected] Ding Wang Principal Investigator
Ascension Saint John Hospital | Detroit, Michigan, 48236, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Great Lakes Cancer Management Specialists-Doctors Park | East China Township, Michigan, 48054, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Genesee Cancer and Blood Disease Treatment Center | Flint, Michigan, 48503, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Genesee Hematology Oncology PC | Flint, Michigan, 48503, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Genesys Hurley Cancer Institute | Flint, Michigan, 48503, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Hurley Medical Center | Flint, Michigan, 48503, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids, Michigan, 49503, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Mercy Health Saint Mary's | Grand Rapids, Michigan, 49503, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Spectrum Health at Butterworth Campus | Grand Rapids, Michigan, 49503, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Academic Hematology Oncology Specialists | Grosse Pointe Woods, Michigan, 48236, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods, Michigan, 48236, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Michigan Breast Specialists-Grosse Pointe Woods | Grosse Pointe Woods, Michigan, 48236, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Allegiance Health | Jackson, Michigan, 49201, United States Recruiting Site Public Contact 313-916-3721 [email protected] Ding Wang Principal Investigator
Bronson Methodist Hospital | Kalamazoo, Michigan, 49007, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
West Michigan Cancer Center | Kalamazoo, Michigan, 49007, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Borgess Medical Center | Kalamazoo, Michigan, 49048, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Sparrow Hospital | Lansing, Michigan, 48912, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Hope Cancer Clinic | Livonia, Michigan, 48154, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Saint Mary Mercy Hospital | Livonia, Michigan, 48154, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Great Lakes Cancer Management Specialists-Macomb Medical Campus | Macomb, Michigan, 48044, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Michigan Breast Specialists-Macomb Township | Macomb, Michigan, 48044, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Saint Mary's Oncology/Hematology Associates of Marlette | Marlette, Michigan, 48453, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Toledo Clinic Cancer Centers-Monroe | Monroe, Michigan, 48162, United States Recruiting Site Public Contact 800-444-3561 Rex B. Mowat Principal Investigator
Mercy Health Mercy Campus | Muskegon, Michigan, 49444, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Lakeland Hospital Niles | Niles, Michigan, 49120, United States Recruiting Site Public Contact 616-391-1230 Kathleen J. Yost Principal Investigator
Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores, Michigan, 49444, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Henry Ford Medical Center-Columbus | Novi, Michigan, 48377, United States Recruiting Site Public Contact 313-916-3721 [email protected] Ding Wang Principal Investigator
21st Century Oncology-Pontiac | Pontiac, Michigan, 48341, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Hope Cancer Center | Pontiac, Michigan, 48341, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Newland Medical Associates-Pontiac | Pontiac, Michigan, 48341, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Saint Joseph Mercy Oakland | Pontiac, Michigan, 48341, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Spectrum Health Reed City Hospital | Reed City, Michigan, 49677, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Ascension Saint Mary's Hospital | Saginaw, Michigan, 48601, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Oncology Hematology Associates of Saginaw Valley PC | Saginaw, Michigan, 48604, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Lakeland Medical Center Saint Joseph | Saint Joseph, Michigan, 49085, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Marie Yeager Cancer Center | Saint Joseph, Michigan, 49085, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Henry Ford Macomb Health Center - Shelby Township | Shelby, Michigan, 48315, United States Recruiting Site Public Contact 313-916-1784 [email protected] Ding Wang Principal Investigator
Bhadresh Nayak MD PC-Sterling Heights | Sterling Heights, Michigan, 48312, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Ascension Saint Joseph Hospital | Tawas City, Michigan, 48764, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Munson Medical Center | Traverse City, Michigan, 49684, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Advanced Breast Care Center PLLC | Warren, Michigan, 48088, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Great Lakes Cancer Management Specialists-Macomb Professional Building | Warren, Michigan, 48093, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Macomb Hematology Oncology PC | Warren, Michigan, 48093, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Michigan Breast Specialists-Warren | Warren, Michigan, 48093, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Saint John Macomb-Oakland Hospital | Warren, Michigan, 48093, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Henry Ford West Bloomfield Hospital | West Bloomfield, Michigan, 48322, United States Recruiting Site Public Contact 313-916-3721 [email protected] Ding Wang Principal Investigator
Saint Mary's Oncology/Hematology Associates of West Branch | West Branch, Michigan, 48661, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Metro Health Hospital | Wyoming, Michigan, 49519, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Huron Gastroenterology PC | Ypsilanti, Michigan, 48106, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
IHA Hematology Oncology Consultants-Ann Arbor | Ypsilanti, Michigan, 48197, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Fairview Ridges Hospital | Burnsville, Minnesota, 55337, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Minnesota Oncology - Burnsville | Burnsville, Minnesota, 55337, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Cambridge Medical Center | Cambridge, Minnesota, 55008, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Mercy Hospital | Coon Rapids, Minnesota, 55433, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Fairview Southdale Hospital | Edina, Minnesota, 55435, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Unity Hospital | Fridley, Minnesota, 55432, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Fairview Clinics and Surgery Center Maple Grove | Maple Grove, Minnesota, 55369, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Minnesota Oncology Hematology PA-Maplewood | Maplewood, Minnesota, 55109, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Saint John's Hospital - Healtheast | Maplewood, Minnesota, 55109, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Abbott-Northwestern Hospital | Minneapolis, Minnesota, 55407, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Hennepin County Medical Center | Minneapolis, Minnesota, 55415, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Minneapolis VA Medical Center | Minneapolis, Minnesota, 55417, United States Recruiting Site Public Contact 612-467-2800 Sharon D. Luikart Principal Investigator
Health Partners Inc | Minneapolis, Minnesota, 55454, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Monticello Cancer Center | Monticello, Minnesota, 55362, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
New Ulm Medical Center | New Ulm, Minnesota, 56073, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Fairview Northland Medical Center | Princeton, Minnesota, 55371, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
North Memorial Medical Health Center | Robbinsdale, Minnesota, 55422, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Park Nicollet Clinic - Saint Louis Park | Saint Louis Park, Minnesota, 55416, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Regions Hospital | Saint Paul, Minnesota, 55101, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
United Hospital | Saint Paul, Minnesota, 55102, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Saint Francis Regional Medical Center | Shakopee, Minnesota, 55379, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Lakeview Hospital | Stillwater, Minnesota, 55082, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Ridgeview Medical Center | Waconia, Minnesota, 55387, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Rice Memorial Hospital | Willmar, Minnesota, 56201, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Minnesota Oncology Hematology PA-Woodbury | Woodbury, Minnesota, 55125, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Fairview Lakes Medical Center | Wyoming, Minnesota, 55092, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Saint Louis Cancer and Breast Institute-Ballwin | Ballwin, Missouri, 63011, United States Recruiting Site Public Contact 314-251-7058 Jay W. Carlson Principal Investigator
Central Care Cancer Center - Bolivar | Bolivar, Missouri, 65613, United States Recruiting Site Public Contact 913-948-5588 [email protected] Jay W. Carlson Principal Investigator
Saint Francis Medical Center | Cape Girardeau, Missouri, 63703, United States Recruiting Site Public Contact 573-334-2230 [email protected] Bryan A. Faller Principal Investigator
Southeast Cancer Center | Cape Girardeau, Missouri, 63703, United States Recruiting Site Public Contact 573-651-5550 Bryan A. Faller Principal Investigator
Saint Luke's Hospital | Chesterfield, Missouri, 63017, United States Recruiting Site Public Contact 314-205-6936 Joseph Sokhn Principal Investigator
Siteman Cancer Center at West County Hospital | Creve Coeur, Missouri, 63141, United States Recruiting Site Public Contact 800-600-3606 [email protected] Brad S. Kahl Principal Investigator
Parkland Health Center - Farmington | Farmington, Missouri, 63640, United States Recruiting Site Public Contact 314-996-5569 Bryan A. Faller Principal Investigator
Capital Region Southwest Campus | Jefferson City, Missouri, 65109, United States Recruiting Site Public Contact 573-632-4814 [email protected] Bryan A. Faller Principal Investigator
Freeman Health System | Joplin, Missouri, 64804, United States Recruiting Site Public Contact 417-347-4030 [email protected] Jay W. Carlson Principal Investigator
Mercy Hospital Joplin | Joplin, Missouri, 64804, United States Recruiting Site Public Contact 417-556-3074 [email protected] Jay W. Carlson Principal Investigator
Delbert Day Cancer Institute at PCRMC | Rolla, Missouri, 65401, United States Recruiting Site Public Contact 573-458-8776 [email protected] Jay W. Carlson Principal Investigator
Mercy Clinic-Rolla-Cancer and Hematology | Rolla, Missouri, 65401, United States Recruiting Site Public Contact 573-458-6379 Jay W. Carlson Principal Investigator
Heartland Regional Medical Center | Saint Joseph, Missouri, 64506, United States Recruiting Site Public Contact 816-271-7937 [email protected] Jay W. Carlson Principal Investigator
Saint Louis Cancer and Breast Institute-South City | Saint Louis, Missouri, 63109, United States Recruiting Site Public Contact 314-353-1870 Jay W. Carlson Principal Investigator
Washington University School of Medicine | Saint Louis, Missouri, 63110, United States Recruiting Site Public Contact 800-600-3606 [email protected] Brad S. Kahl Principal Investigator
Mercy Hospital South | Saint Louis, Missouri, 63128, United States Recruiting Site Public Contact [email protected] Jay W. Carlson Principal Investigator
Siteman Cancer Center-South County | Saint Louis, Missouri, 63129, United States Recruiting Site Public Contact 800-600-3606 [email protected] Brad S. Kahl Principal Investigator
Missouri Baptist Medical Center | Saint Louis, Missouri, 63131, United States Recruiting Site Public Contact 314-996-5569 Bryan A. Faller Principal Investigator
Siteman Cancer Center at Christian Hospital | Saint Louis, Missouri, 63136, United States Recruiting Site Public Contact 800-600-3606 [email protected] Brad S. Kahl Principal Investigator
Mercy Hospital Saint Louis | Saint Louis, Missouri, 63141, United States Recruiting Site Public Contact 314-251-7066 Jay W. Carlson Principal Investigator
Siteman Cancer Center at Saint Peters Hospital | Saint Peters, Missouri, 63376, United States Recruiting Site Public Contact 800-600-3606 [email protected] Brad S. Kahl Principal Investigator
Sainte Genevieve County Memorial Hospital | Sainte Genevieve, Missouri, 63670, United States Recruiting Site Public Contact 314-996-5569 Bryan A. Faller Principal Investigator
Mercy Hospital Springfield | Springfield, Missouri, 65804, United States Recruiting Site Public Contact 417-269-4520 Jay W. Carlson Principal Investigator
CoxHealth South Hospital | Springfield, Missouri, 65807, United States Recruiting Site Public Contact 417-269-4520 Jay W. Carlson Principal Investigator
Missouri Baptist Sullivan Hospital | Sullivan, Missouri, 63080, United States Recruiting Site Public Contact 314-996-5569 Bryan A. Faller Principal Investigator
Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills, Missouri, 63127, United States Recruiting Site Public Contact 314-996-5569 Bryan A. Faller Principal Investigator
Mercy Hospital Washington | Washington, Missouri, 63090, United States Recruiting Site Public Contact 636-390-1600 Jay W. Carlson Principal Investigator
Community Hospital of Anaconda | Anaconda, Montana, 59711, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Billings Clinic Cancer Center | Billings, Montana, 59101, United States Recruiting Site Public Contact 800-996-2663 [email protected] John M. Schallenkamp Principal Investigator
Saint Vincent Healthcare | Billings, Montana, 59101, United States Suspended
Saint Vincent Frontier Cancer Center | Billings, Montana, 59102, United States Suspended
Bozeman Deaconess Hospital | Bozeman, Montana, 59715, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Benefis Healthcare- Sletten Cancer Institute | Great Falls, Montana, 59405, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Great Falls Clinic | Great Falls, Montana, 59405, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Kalispell Regional Medical Center | Kalispell, Montana, 59901, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Saint Patrick Hospital - Community Hospital | Missoula, Montana, 59802, United States Recruiting Site Public Contact 406-327-3118 [email protected] Gary E. Goodman Principal Investigator
Community Medical Hospital | Missoula, Montana, 59804, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
CHI Health Saint Francis | Grand Island, Nebraska, 68803, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
CHI Health Good Samaritan | Kearney, Nebraska, 68847, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Saint Elizabeth Regional Medical Center | Lincoln, Nebraska, 68510, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Alegent Health Immanuel Medical Center | Omaha, Nebraska, 68122, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Alegent Health Bergan Mercy Medical Center | Omaha, Nebraska, 68124, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Alegent Health Lakeside Hospital | Omaha, Nebraska, 68130, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Creighton University Medical Center | Omaha, Nebraska, 68131, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Midlands Community Hospital | Papillion, Nebraska, 68046, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Memorial Sloan Kettering Basking Ridge | Basking Ridge, New Jersey, 07920, United States Recruiting Site Public Contact 212-639-7592 Lindsey E. Roeker Principal Investigator
Memorial Sloan Kettering Monmouth | Middletown, New Jersey, 07748, United States Recruiting Site Public Contact 212-639-7592 Lindsey E. Roeker Principal Investigator
Memorial Sloan Kettering Bergen | Montvale, New Jersey, 07645, United States Recruiting Site Public Contact 212-639-7592 Lindsey E. Roeker Principal Investigator
Hematology Oncology Associates of Central New York-Auburn | Auburn, New York, 13021, United States Recruiting Site Public Contact 315-472-7504 Jeffrey J. Kirshner Principal Investigator
Memorial Sloan Kettering Commack | Commack, New York, 11725, United States Recruiting Site Public Contact 212-639-7592 Lindsey E. Roeker Principal Investigator
Hematology Oncology Associates of Central New York-East Syracuse | East Syracuse, New York, 13057, United States Recruiting Site Public Contact 315-472-7504 Jeffrey J. Kirshner Principal Investigator
Glens Falls Hospital | Glens Falls, New York, 12801, United States Recruiting Site Public Contact 518-926-6700 Christopher R. Mason Principal Investigator
Memorial Sloan Kettering Westchester | Harrison, New York, 10604, United States Recruiting Site Public Contact 212-639-7592 Lindsey E. Roeker Principal Investigator
Memorial Sloan Kettering Cancer Center | New York, New York, 10065, United States Recruiting Site Public Contact 212-639-7592 Lindsey E. Roeker Principal Investigator
Rochester General Hospital | Rochester, New York, 14621, United States Recruiting Site Public Contact 585-922-3536 [email protected] Rachel J. David Principal Investigator
University of Rochester | Rochester, New York, 14642, United States Recruiting Site Public Contact 585-275-5830 Paul M. Barr Principal Investigator
Hematology Oncology Associates of Central New York-Onondaga Hill | Syracuse, New York, 13215, United States Recruiting Site Public Contact 315-472-7504 Jeffrey J. Kirshner Principal Investigator
Memorial Sloan Kettering Nassau | Uniondale, New York, 11553, United States Recruiting Site Public Contact 212-639-7592 Lindsey E. Roeker Principal Investigator
Southeastern Medical Oncology Center-Clinton | Clinton, North Carolina, 28328, United States Recruiting Site Public Contact 919-587-9084 [email protected] Samer S. Kasbari Principal Investigator
Southeastern Medical Oncology Center-Goldsboro | Goldsboro, North Carolina, 27534, United States Recruiting Site Public Contact 919-587-9084 [email protected] Samer S. Kasbari Principal Investigator
Southeastern Medical Oncology Center-Jacksonville | Jacksonville, North Carolina, 28546, United States Recruiting Site Public Contact 910-587-9084 [email protected] Samer S. Kasbari Principal Investigator
Vidant Oncology-Kenansville | Kenansville, North Carolina, 28349, United States Recruiting Site Public Contact 252-559-2201 [email protected] Misbah U. Qadir Principal Investigator
Vidant Oncology-Kinston | Kinston, North Carolina, 28501, United States Recruiting Site Public Contact 252-559-2201 [email protected] Misbah U. Qadir Principal Investigator
Vidant Oncology-Richlands | Richlands, North Carolina, 28574, United States Recruiting Site Public Contact 252-559-2201 [email protected] Misbah U. Qadir Principal Investigator
Indu and Raj Soin Medical Center | Beavercreek, Ohio, 45431, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Strecker Cancer Center-Belpre | Belpre, Ohio, 45714, United States Recruiting Site Public Contact 800-523-3977 [email protected] Timothy D. Moore Principal Investigator
Saint Elizabeth Boardman Hospital | Boardman, Ohio, 44512, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Cleveland Clinic Mercy Hospital | Canton, Ohio, 44708, United States Recruiting Site Public Contact 888-293-4673 Mitchell Haut Principal Investigator
Mercy Hematology and Oncology Associates Inc | Canton, Ohio, 44708, United States Recruiting Site Public Contact 330-453-9993 Mitchell Haut Principal Investigator
Dayton Physicians LLC-Miami Valley South | Centerville, Ohio, 45459, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Miami Valley Hospital South | Centerville, Ohio, 45459, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Adena Regional Medical Center | Chillicothe, Ohio, 45601, United States Recruiting Site Public Contact 877-779-7585 [email protected] Timothy D. Moore Principal Investigator
Good Samaritan Hospital - Cincinnati | Cincinnati, Ohio, 45220, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Oncology Hematology Care Inc-Kenwood | Cincinnati, Ohio, 45236, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Bethesda North Hospital | Cincinnati, Ohio, 45242, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
TriHealth Cancer Institute-Westside | Cincinnati, Ohio, 45247, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
TriHealth Cancer Institute-Anderson | Cincinnati, Ohio, 45255, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Cleveland Clinic Foundation | Cleveland, Ohio, 44195, United States Recruiting Site Public Contact 866-223-8100 [email protected] Brian T. Hill Principal Investigator
Ohio State University Comprehensive Cancer Center | Columbus, Ohio, 43210, United States Recruiting Site Public Contact 800-293-5066 [email protected] Seema A. Bhat Principal Investigator
Mount Carmel East Hospital | Columbus, Ohio, 43213, United States Recruiting Site Public Contact 614-488-2118 [email protected] Timothy D. Moore Principal Investigator
Columbus Oncology and Hematology Associates Inc | Columbus, Ohio, 43214, United States Recruiting Site Public Contact 614-488-2118 [email protected] Timothy D. Moore Principal Investigator
Riverside Methodist Hospital | Columbus, Ohio, 43214, United States Recruiting Site Public Contact 614-566-4475 [email protected] Timothy D. Moore Principal Investigator
Grant Medical Center | Columbus, Ohio, 43215, United States Recruiting Site Public Contact 614-566-4475 [email protected] Timothy D. Moore Principal Investigator
The Mark H Zangmeister Center | Columbus, Ohio, 43219, United States Recruiting Site Public Contact 614-488-2118 [email protected] Timothy D. Moore Principal Investigator
Mount Carmel Health Center West | Columbus, Ohio, 43222, United States Recruiting Site Public Contact 614-234-5433 [email protected] Timothy D. Moore Principal Investigator
Doctors Hospital | Columbus, Ohio, 43228, United States Recruiting Site Public Contact 614-566-3275 [email protected] Timothy D. Moore Principal Investigator
Miami Valley Hospital | Dayton, Ohio, 45409, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Dayton Physician LLC-Miami Valley Hospital North | Dayton, Ohio, 45415, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Miami Valley Hospital North | Dayton, Ohio, 45415, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Delaware Health Center-Grady Cancer Center | Delaware, Ohio, 43015, United States Recruiting Site Public Contact 740-615-0227 [email protected] Timothy D. Moore Principal Investigator
Grady Memorial Hospital | Delaware, Ohio, 43015, United States Recruiting Site Public Contact 740-615-2403 [email protected] Timothy D. Moore Principal Investigator
Dublin Methodist Hospital | Dublin, Ohio, 43016, United States Recruiting Site Public Contact 800-752-9119 [email protected] Timothy D. Moore Principal Investigator
Armes Family Cancer Center | Findlay, Ohio, 45840, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Blanchard Valley Hospital | Findlay, Ohio, 45840, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Orion Cancer Care | Findlay, Ohio, 45840, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Atrium Medical Center-Middletown Regional Hospital | Franklin, Ohio, 45005-1066, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Dayton Physicians LLC-Atrium | Franklin, Ohio, 45005, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Central Ohio Breast and Endocrine Surgery | Gahanna, Ohio, 43230, United States Recruiting Site Public Contact 614-488-2745 [email protected] Timothy D. Moore Principal Investigator
Dayton Physicians LLC-Wayne | Greenville, Ohio, 45331, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Wayne Hospital | Greenville, Ohio, 45331, United States Suspended
Mount Carmel Grove City Hospital | Grove City, Ohio, 43123, United States Recruiting Site Public Contact 877-779-7585 [email protected] Timothy D. Moore Principal Investigator
Greater Dayton Cancer Center | Kettering, Ohio, 45409, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Kettering Medical Center | Kettering, Ohio, 45429, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Fairfield Medical Center | Lancaster, Ohio, 43130, United States Recruiting Site Public Contact 740-687-8863 [email protected] Timothy D. Moore Principal Investigator
Saint Rita's Medical Center | Lima, Ohio, 45801, United States Recruiting Site Public Contact 419-226-9617 Timothy D. Moore Principal Investigator
OhioHealth Mansfield Hospital | Mansfield, Ohio, 44903, United States Recruiting Site Public Contact 419-526-8018 [email protected] Timothy D. Moore Principal Investigator
Marietta Memorial Hospital | Marietta, Ohio, 45750, United States Recruiting Site Public Contact 800-523-3977 [email protected] Timothy D. Moore Principal Investigator
OhioHealth Marion General Hospital | Marion, Ohio, 43302, United States Recruiting Site Public Contact 614-488-2118 [email protected] Timothy D. Moore Principal Investigator
Knox Community Hospital | Mount Vernon, Ohio, 43050, United States Recruiting Site Public Contact 740-393-9000 [email protected] Timothy D. Moore Principal Investigator
Licking Memorial Hospital | Newark, Ohio, 43055, United States Recruiting Site Public Contact 740-348-4000 [email protected] Timothy D. Moore Principal Investigator
Newark Radiation Oncology | Newark, Ohio, 43055, United States Recruiting Site Public Contact 614-488-2118 [email protected] Timothy D. Moore Principal Investigator
Mercy Health Perrysburg Cancer Center | Perrysburg, Ohio, 43551, United States Recruiting Site Public Contact 614-488-2118 [email protected] Timothy D. Moore Principal Investigator
Southern Ohio Medical Center | Portsmouth, Ohio, 45662, United States Recruiting Site Public Contact 614-488-2118 [email protected] Timothy D. Moore Principal Investigator
Springfield Regional Cancer Center | Springfield, Ohio, 45504, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Springfield Regional Medical Center | Springfield, Ohio, 45505, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Saint Vincent Mercy Medical Center | Toledo, Ohio, 43608, United States Recruiting Site Public Contact 614-488-2118 [email protected] Timothy D. Moore Principal Investigator
Mercy Health - Saint Anne Hospital | Toledo, Ohio, 43623, United States Recruiting Site Public Contact 614-488-2118 [email protected] Timothy D. Moore Principal Investigator
Toledo Clinic Cancer Centers-Toledo | Toledo, Ohio, 43623, United States Recruiting Site Public Contact 800-444-3561 Rex B. Mowat Principal Investigator
Dayton Physicians LLC-Upper Valley | Troy, Ohio, 45373, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Upper Valley Medical Center | Troy, Ohio, 45373, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Saint Joseph Warren Hospital | Warren, Ohio, 44484, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Saint Ann's Hospital | Westerville, Ohio, 43081, United States Recruiting Site Public Contact 614-234-5433 [email protected] Timothy D. Moore Principal Investigator
Wright-Patterson Medical Center | Wright-Patterson Air Force Base, Ohio, 45433, United States Recruiting Site Public Contact 937-528-2900 [email protected] Ali Bukhari Principal Investigator
Saint Elizabeth Youngstown Hospital | Youngstown, Ohio, 44501, United States Recruiting Site Public Contact 937-528-2900 [email protected] Howard M. Gross Principal Investigator
Genesis Healthcare System Cancer Care Center | Zanesville, Ohio, 43701, United States Recruiting Site Public Contact 740-454-5232 [email protected] Timothy D. Moore Principal Investigator
University of Oklahoma Health Sciences Center | Oklahoma City, Oklahoma, 73104, United States Recruiting Site Public Contact 405-271-8777 [email protected] Mohamad Khawandanah Principal Investigator
Mercy Hospital Oklahoma City | Oklahoma City, Oklahoma, 73120, United States Recruiting Site Public Contact 405-752-3402 Jay W. Carlson Principal Investigator
Saint Alphonsus Medical Center-Baker City | Baker City, Oregon, 97814, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Saint Charles Health System | Bend, Oregon, 97701, United States Recruiting Site Public Contact 541-706-2909 [email protected] Gary E. Goodman Principal Investigator
Clackamas Radiation Oncology Center | Clackamas, Oregon, 97015, United States Recruiting Site Public Contact 503-215-2614 [email protected] Gary E. Goodman Principal Investigator
Providence Cancer Institute Clackamas Clinic | Clackamas, Oregon, 97015, United States Recruiting Site Public Contact 503-215-2614 [email protected]vidence.org Gary E. Goodman Principal Investigator
Bay Area Hospital | Coos Bay, Oregon, 97420, United States Recruiting Site Public Contact 541-269-8392 [email protected] Gary E. Goodman Principal Investigator
Providence Newberg Medical Center | Newberg, Oregon, 97132, United States Recruiting Site Public Contact 503-215-2614 [email protected] Gary E. Goodman Principal Investigator
Saint Alphonsus Medical Center-Ontario | Ontario, Oregon, 97914, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Providence Portland Medical Center | Portland, Oregon, 97213, United States Recruiting Site Public Contact 503-215-2614 [email protected] Gary E. Goodman Principal Investigator
Providence Saint Vincent Medical Center | Portland, Oregon, 97225, United States Recruiting Site Public Contact 503-215-2614 [email protected] Gary E. Goodman Principal Investigator
Saint Charles Health System-Redmond | Redmond, Oregon, 97756, United States Recruiting Site Public Contact 541-706-2909 Gary E. Goodman Principal Investigator
Lehigh Valley Hospital-Cedar Crest | Allentown, Pennsylvania, 18103, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Lehigh Valley Hospital - Muhlenberg | Bethlehem, Pennsylvania, 18017, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Christiana Care Health System-Concord Health Center | Chadds Ford, Pennsylvania, 19317, United States Recruiting Site Public Contact 302-623-4450 [email protected] Gregory A. Masters Principal Investigator
Pocono Medical Center | East Stroudsburg, Pennsylvania, 18301, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Lehigh Valley Hospital-Hazleton | Hazleton, Pennsylvania, 18201, United States Recruiting Site Public Contact 734-712-3671 [email protected] Elie G. Dib Principal Investigator
Wellmont Bristol Regional Medical Center | Bristol, Tennessee, 37620, United States Recruiting Site Public Contact 423-578-8538 [email protected] Asheesh Shipstone Principal Investigator
Regional Cancer Center at Indian Path Community Hospital | Kingsport, Tennessee, 37660, United States Recruiting Site Public Contact 423-578-8538 [email protected] Asheesh Shipstone Principal Investigator
Wellmont Holston Valley Hospital and Medical Center | Kingsport, Tennessee, 37660, United States Recruiting Site Public Contact 423-578-8538 [email protected] Asheesh Shipstone Principal Investigator
Saint Joseph Regional Cancer Center | Bryan, Texas, 77802, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Huntsman Cancer Institute/University of Utah | Salt Lake City, Utah, 84112, United States Recruiting Site Public Contact 888-424-2100 [email protected] Deborah M. Stephens Principal Investigator
Wellmont Medical Associates-Bristol | Bristol, Virginia, 24201, United States Recruiting Site Public Contact 423-578-8538 [email protected] Asheesh Shipstone Principal Investigator
Southwest VA Regional Cancer Center | Norton, Virginia, 24273, United States Recruiting Site Public Contact 423-578-8538 [email protected] Asheesh Shipstone Principal Investigator
Providence Regional Cancer System-Aberdeen | Aberdeen, Washington, 98520, United States Recruiting Site Public Contact 360-412-8958 [email protected] Gary E. Goodman Principal Investigator
PeaceHealth Saint Joseph Medical Center | Bellingham, Washington, 98225, United States Recruiting Site Public Contact 360-788-8238 [email protected] Gary E. Goodman Principal Investigator
Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton, Washington, 98310, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Harrison Medical Center | Bremerton, Washington, 98310, United States Recruiting Site Public Contact 888-825-3227 [email protected] Richard L. Deming Principal Investigator
Highline Medical Center-Main Campus | Burien, Washington, 98166, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Providence Regional Cancer System-Centralia | Centralia, Washington, 98531, United States Recruiting Site Public Contact 360-412-8958 [email protected] Gary E. Goodman Principal Investigator
Swedish Cancer Institute-Edmonds | Edmonds, Washington, 98026, United States Recruiting Site Public Contact 206-215-3086 [email protected] Gary E. Goodman Principal Investigator
Saint Elizabeth Hospital | Enumclaw, Washington, 98022, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Providence Regional Cancer Partnership | Everett, Washington, 98201, United States Recruiting Site Public Contact 425-261-3529 [email protected] Gary E. Goodman Principal Investigator
Saint Francis Hospital | Federal Way, Washington, 98003, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Swedish Cancer Institute-Issaquah | Issaquah, Washington, 98029, United States Recruiting Site Public Contact 206-215-3086 [email protected] Gary E. Goodman Principal Investigator
Kadlec Clinic Hematology and Oncology | Kennewick, Washington, 99336, United States Recruiting Site Public Contact 509-783-4637 [email protected] Gary E. Goodman Principal Investigator
Providence Regional Cancer System-Lacey | Lacey, Washington, 98503, United States Recruiting Site Public Contact 360-412-8958 [email protected] Gary E. Goodman Principal Investigator
Saint Clare Hospital | Lakewood, Washington, 98499, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
PeaceHealth Saint John Medical Center | Longview, Washington, 98632, United States Recruiting Site Public Contact 360-514-2016 [email protected] Gary E. Goodman Principal Investigator
Jefferson Healthcare | Port Townsend, Washington, 98368, United States Recruiting Site Public Contact 360-344-3091 Nicholas DiBella Principal Investigator
Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo, Washington, 98370, United States Suspended
Pacific Gynecology Specialists | Seattle, Washington, 98104, United States Recruiting Site Public Contact 206-215-3086 [email protected] Gary E. Goodman Principal Investigator
Swedish Medical Center-Ballard Campus | Seattle, Washington, 98107, United States Recruiting Site Public Contact 206-215-3086 [email protected] Gary E. Goodman Principal Investigator
Swedish Medical Center-First Hill | Seattle, Washington, 98122-4307, United States Recruiting Site Public Contact 206-215-3086 [email protected] Gary E. Goodman Principal Investigator
Swedish Medical Center-Cherry Hill | Seattle, Washington, 98122-5711, United States Recruiting Site Public Contact 206-215-3086 [email protected] Gary E. Goodman Principal Investigator
PeaceHealth United General Medical Center | Sedro-Woolley, Washington, 98284, United States Recruiting Site Public Contact 360-788-8238 [email protected] Gary E. Goodman Principal Investigator
Providence Regional Cancer System-Shelton | Shelton, Washington, 98584, United States Recruiting Site Public Contact 360-412-8958 [email protected] Gary E. Goodman Principal Investigator
Franciscan Research Center-Northwest Medical Plaza | Tacoma, Washington, 98405, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Northwest Medical Specialties PLLC | Tacoma, Washington, 98405, United States Suspended
PeaceHealth Southwest Medical Center | Vancouver, Washington, 98664, United States Recruiting Site Public Contact 360-514-3940 [email protected] Gary E. Goodman Principal Investigator
Providence Saint Mary Regional Cancer Center | Walla Walla, Washington, 99362, United States Recruiting Site Public Contact 509-897-5993 [email protected]rg Gary E. Goodman Principal Investigator
Providence Regional Cancer System-Yelm | Yelm, Washington, 98597, United States Recruiting Site Public Contact 360-412-8958 [email protected] Gary E. Goodman Principal Investigator
Marshfield Medical Center-EC Cancer Center | Eau Claire, Wisconsin, 54701, United States Recruiting Site Public Contact 800-782-8581 [email protected] Chady A. Leon Principal Investigator
Marshfield Medical Center-Marshfield | Marshfield, Wisconsin, 54449, United States Recruiting Site Public Contact 800-782-8581 [email protected] Chady A. Leon Principal Investigator
Marshfield Clinic-Minocqua Center | Minocqua, Wisconsin, 54548, United States Recruiting Site Public Contact 800-782-8581 [email protected] Chady A. Leon Principal Investigator
Cancer Center of Western Wisconsin | New Richmond, Wisconsin, 54017, United States Recruiting Site Public Contact 952-993-1517 [email protected] David M. King Principal Investigator
Marshfield Medical Center-Rice Lake | Rice Lake, Wisconsin, 54868, United States Recruiting Site Public Contact 800-782-8581 [email protected] Chady A. Leon Principal Investigator
Marshfield Clinic Stevens Point Center | Stevens Point, Wisconsin, 54482, United States Recruiting Site Public Contact 800-782-8581 [email protected] Chady A. Leon Principal Investigator
Marshfield Medical Center - Weston | Weston, Wisconsin, 54476, United States Recruiting Site Public Contact 800-782-8581 [email protected] Chady A. Leon Principal Investigator
Cheyenne Regional Medical Center-West | Cheyenne, Wyoming, 82001, United States Recruiting Site Public Contact 303-777-2663 [email protected] Nicholas DiBella Principal Investigator
Billings Clinic-Cody | Cody, Wyoming, 82414, United States Recruiting Site Public Contact 800-996-2663 [email protected] John M. Schallenkamp Principal Investigator
Welch Cancer Center | Sheridan, Wyoming, 82801, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Países de localização

United States

Data de Verificação

2020-12-01

Parte Responsável

Tipo: Patrocinador

Tem Acesso Expandido Mediterraans diëet
Número de armas 2
Grupo de Armas

Rótulo: Arm I (delayed V-O)

Tipo: Active Comparator

Descrição: Treatment begins once 2018 IWCLL indications are met. Patients receive obinutuzumab IV over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO QD on days 22-28 of cycle 1 and on days 1-28 of cycles 2-12. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity.

Rótulo: Braço II (V-O inicial)

Tipo: Experimental

Descrição: O tratamento começa assim que os critérios de elegibilidade são atendidos. Os pacientes recebem obinutuzumabe IV por 4 horas nos dias 1, 2, 8 e 15 do ciclo 1 e no dia 1 dos ciclos 2-6. Os pacientes também recebem venetoclax PO QD nos dias 22-28 do ciclo 1 e nos dias 1-28 dos ciclos 2-12. O tratamento se repete a cada 28 dias por 12 ciclos na ausência de progressão da doença ou toxicidade inaceitável.

Informações de design de estudo

Alocação: Randomizado

Modelo de Intervenção: Atribuição Paralela

Objetivo Primário: Tratamento

Mascaramento: Nenhum (rótulo aberto)

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