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AI-Based Prediction of Root Coverage Outcome From Intraoral Photographs

16 de agosto de 2026 atualizado por: Marmara University

Development and Internal Validation of a Deep Learning Model Predicting the Outcome of Root Coverage Surgery From Preoperative Intraoral Photographs: A Prospective Observational Cohort Study

This study evaluates whether the outcome of root coverage surgery can be predicted from a preoperative intraoral photograph. Adults with Cairo RT1,RT2 or RT3 gingival recessions treated with a coronally advanced flap and a connective tissue graft are followed for six months. Standardised photographs and clinical measurements are obtained before surgery and at each follow-up visit. A deep learning model is developed to predict the surgical outcome from the preoperative photograph and baseline clinical variables, and its performance is compared with the outcome measured clinically at six months. The model does not influence treatment decisions.

Visão geral do estudo

Descrição detalhada

Whether an exposed root surface can be completely covered is the central question in planning mucogingival surgery. The Cairo classification is the current diagnostic standard for that judgement, but assignment of the recession type varies between examiners and prediction of the individual surgical outcome remains largely subjective. In this cohort, consecutive systemically healthy adults with Cairo RT1,RT2 or RT3 gingival recessions are treated by a single operator with a coronally advanced flap combined with a subepithelial connective tissue graft. Recession depth, keratinised tissue width and gingival thickness are recorded at baseline and at three and six months.

Standardised intraoral photographs are obtained at each time point under fixed conditions. A deep learning model is developed to predict the six-month outcome from the preoperative photograph together with baseline clinical variables. Model performance is assessed by discrimination, calibration and prediction error, using the clinical measurement at six months as the reference standard. A secondary analysis examines whether the recession type assigned automatically from the photograph agrees with the type assigned by the examining periodontist. The model is developed and validated internally within this cohort; no external validation set is available. Its output is not shown to the operator and does not influence treatment. Reporting follows the TRIPOD recommendations for prediction model studies.

Tipo de estudo

Observacional

Inscrição (Estimado)

36

Contactos e Locais

Esta seção fornece os detalhes de contato para aqueles que conduzem o estudo e informações sobre onde este estudo está sendo realizado.

Contato de estudo

Locais de estudo

    • Istanbul
      • Istanbul, Istanbul, Turquia (Türkiye), 34854
        • Recrutamento
        • Marmara University Faculty of Dentistry Department of Periodontology
        • Contato:

Critérios de participação

Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.

Critérios de elegibilidade

Idades elegíveis para estudo

  • Adulto
  • Adulto mais velho

Aceita Voluntários Saudáveis

Sim

Método de amostragem

Amostra Não Probabilística

População do estudo

The study population consists of systemically healthy adult patients (aged 18-65) presenting to the Department of Periodontology at Marmara University with esthetic concerns or dentin hypersensitivity associated with gingival recession. The cohort includes individuals diagnosed with Cairo Class RT1 or RT2 (Miller Class I or II) gingival recession defects who are scheduled to undergo mucogingival root coverage surgery.

Descrição

Inclusion Criteria:

  • Systemically healthy patients (ASA I or II status) with no contraindications for periodontal surgery.
  • Adult patients aged 18 to 65 years.
  • Presence of isolated or multiple gingival recessions classified as Cairo RT1, RT2 or RT3 in the maxilla or mandible.
  • Patients with good oral hygiene standards, defined as a Full Mouth Plaque Score (FMPS) and Full Mouth Bleeding Score (FMBS) of < 20% at baseline.
  • Presence of an identifiable Cemento-Enamel Junction (CEJ) (Crucial for AI segmentation).

Exclusion Criteria:

  • Patients with uncontrolled diabetes, immune system disorders, or pregnant/lactating women.
  • Teeth with cervical restorations or abrasions that obscure the CEJ.
  • Malpositioned or rotated teeth that would distort the photographic angle for AI analysis.

Plano de estudo

Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.

Como o estudo é projetado?

Detalhes do projeto

Coortes e Intervenções

Grupo / Coorte
Intervenção / Tratamento
Root coverage surgery cohort
Systemically healthy adults aged 18 to 65 years with Cairo RT1,RT2 pr RT3 gingival recessions, treated with a coronally advanced flap combined with a subepithelial connective tissue graft by a single operator and followed for six months. All participants received the same surgical technique; no comparison group was formed and no participant was assigned to a treatment for the purposes of this study. Standardised intraoral photographs and clinical measurements were obtained before surgery and at three and six months.
A coronally advanced flap is raised over the recession defect and a subepithelial connective tissue graft harvested from the palate is positioned beneath it, after which the flap is sutured coronal to the cemento-enamel junction. Graft thickness, length and width are recorded for each treated site. The procedure was performed as routine clinical care and was not assigned for research purposes.
Preoperative intraoral photographs and baseline clinical variables are analysed by a deep learning model that predicts the outcome of root coverage surgery. The model output is not used in clinical decision making and does not influence treatment; it is compared retrospectively with the outcome measured by the treating periodontist at six months. The same photographs are also used to assign the recession type automatically, which is compared with the clinical assignment.

O que o estudo está medindo?

Medidas de resultados primários

Medida de resultado
Descrição da medida
Prazo
Accuracy of the model in predicting root coverage at six months
Prazo: 6 months
Difference between the root coverage predicted by a model based on preoperative intraoral photographs and baseline clinical characteristics, and the root coverage observed at six months. Root coverage is expressed as the percentage of the baseline recession depth that is covered, calculated as [(baseline recession depth - six-month recession depth) / baseline recession depth] × 100, from probing measurements made by the treating periodontist from the cemento-enamel junction to the gingival margin. Predictive accuracy is summarised as the mean absolute error in percentage points across all treated sites.
6 months

Medidas de resultados secundários

Medida de resultado
Descrição da medida
Prazo
Sensitivity and specificity of the model at the selected decision threshold
Prazo: 6 months
Proportion of sites correctly identified by the model among those that achieved the outcome (sensitivity) and among those that did not (specificity), evaluated at the operating point selected on the receiver operating characteristic curve. Both proportions are reported with 95% confidence intervals. The reference standard is the clinical measurement made at six months by the treating periodontist, using a periodontal probe from the cemento-enamel junction to the gingival margin.
6 months

Outras medidas de resultado

Medida de resultado
Descrição da medida
Prazo
Calibration of the model
Prazo: 6 months
Agreement between the probability predicted by the model and the frequency observed in the cohort, assessed by the calibration slope and intercept and displayed as a calibration plot. Discrimination indicates whether the model ranks sites correctly; calibration indicates whether the predicted probabilities are numerically correct, and the two are reported separately because a model may rank well while producing miscalibrated probabilities. The reference standard is the clinical measurement made at six months.
6 months
Agreement between the model-assigned and the clinician-assigned recession type
Prazo: Baseline
Proportion of treated sites at which the recession type assigned by the model from the preoperative photograph matches the type assigned by the examining periodontist, reported together with quadratic weighted kappa. The reference standard is the clinical assignment recorded at baseline according to the criteria of Cairo et al.
Baseline

Colaboradores e Investigadores

É aqui que você encontrará pessoas e organizações envolvidas com este estudo.

Patrocinador

Investigadores

  • Investigador principal: Leyla Kuru, Professor, Marmara University Faculty of Dentistry Department of Periodontology

Datas de registro do estudo

Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados ​​pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.

Datas Principais do Estudo

Início do estudo (Real)

17 de setembro de 2025

Conclusão Primária (Estimado)

17 de setembro de 2026

Conclusão do estudo (Estimado)

17 de setembro de 2027

Datas de inscrição no estudo

Enviado pela primeira vez

16 de agosto de 2026

Enviado pela primeira vez que atendeu aos critérios de CQ

16 de agosto de 2026

Primeira postagem (Real)

20 de agosto de 2026

Atualizações de registro de estudo

Última Atualização Postada (Real)

20 de agosto de 2026

Última atualização enviada que atendeu aos critérios de controle de qualidade

16 de agosto de 2026

Última verificação

1 de agosto de 2026

Mais Informações

Termos relacionados a este estudo

Informações sobre medicamentos e dispositivos, documentos de estudo

Estuda um medicamento regulamentado pela FDA dos EUA

Não

Estuda um produto de dispositivo regulamentado pela FDA dos EUA

Não

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