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Quadriceps Tendon vs Peroneus Longus Tendon in ACL Reconstruction

23 juni 2026 uppdaterad av: Muzaffer Agir, Acibadem University

A Prospective Randomized Clinical Trial Comparing Quadriceps Tendon and Peroneus Longus Tendon Autografts in Anterior Cruciate Ligament Reconstruction: Clinical, Functional, and Gait Analysis Outcomes

This prospective randomized clinical trial aims to compare quadriceps tendon and peroneus longus tendon autografts in anterior cruciate ligament reconstruction. Patients with anterior cruciate ligament injury undergoing primary reconstruction surgery will be randomly assigned to one of the two graft groups. Clinical examination findings, return-to-sport outcomes, ankle muscle strength, ankle-related functional scores, and gait analysis parameters will be evaluated at 6 months and 12 months postoperatively. The study aims to investigate both knee-related functional outcomes and donor site morbidity associated with graft harvesting techniques.

Studieöversikt

Status

Rekrytering

Betingelser

Intervention / Behandling

Detaljerad beskrivning

Anterior cruciate ligament (ACL) reconstruction is one of the most commonly performed orthopedic procedures for restoring knee stability and enabling return to sports activities after ACL injury. Various autograft options have been described for ACL reconstruction, including hamstring tendon, bone-patellar tendon-bone, quadriceps tendon, and more recently, peroneus longus tendon grafts. Each graft option has unique biomechanical characteristics, advantages, and potential donor site morbidities.

Quadriceps tendon autografts have gained increasing popularity because of their adequate graft diameter, favorable biomechanical properties, and relatively low donor site complications. Peroneus longus tendon autografts have also emerged as a promising alternative graft source with satisfactory clinical outcomes and sufficient graft size. However, concerns remain regarding donor site morbidity, particularly potential effects on ankle muscle strength and ankle function following peroneus longus tendon harvesting.

This prospective randomized study aims to compare quadriceps tendon and peroneus longus tendon autografts in patients undergoing primary ACL reconstruction. Patients will be randomly assigned into two groups according to graft type. Clinical evaluations, functional knee scores, return-to-sport outcomes, ankle muscle strength assessments, ankle-related functional scores, and gait analysis parameters will be assessed during postoperative follow-up.

Follow-up evaluations will be performed at 6 months and 12 months after surgery. The findings of this study are expected to contribute to graft selection strategies in ACL reconstruction by providing comparative data regarding clinical outcomes, functional recovery, gait characteristics, and donor site morbidity.

Studietyp

Interventionell

Inskrivning (Beräknad)

60

Fas

  • Inte tillämpbar

Kontakter och platser

Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.

Studieorter

  • Turkiet (Türkiye)
    • Besiktas
      • Istanbul, Besiktas, Turkiet (Türkiye), 34349
        • Rekrytering
        • Acibadem Fulya Hospital, Sport Medicine Center
        • Kontakt:

Deltagandekriterier

Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.

Urvalskriterier

Åldrar som är berättigade till studier

  • Vuxen

Tar emot friska volontärer

Nej

Beskrivning

Inclusion Criteria:

  • Patients diagnosed with anterior cruciate ligament rupture
  • Patients scheduled for primary anterior cruciate ligament reconstruction
  • Age between 18 and 50 years
  • Ability to provide informed consent
  • Willingness to comply with postoperative rehabilitation and follow-up evaluations

Exclusion Criteria:

  • Previous ligament reconstruction surgery on the affected knee
  • Multi-ligament knee injuries requiring additional ligament reconstruction
  • Severe osteoarthritis of the knee
  • Revision anterior cruciate ligament reconstruction
  • Neuromuscular disorders affecting lower extremity function
  • Active infection
  • Inability to comply with follow-up protocol

Studieplan

Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.

Hur är studien utformad?

Designdetaljer

  • Primärt syfte: Behandling
  • Tilldelning: Randomiserad
  • Interventionsmodell: Parallellt uppdrag
  • Maskning: Ingen (Open Label)

Vapen och interventioner

Deltagargrupp / Arm
Intervention / Behandling
Experimentell: Quadriceps Tendon Autograft
Patients undergoing anterior cruciate ligament reconstruction using quadriceps tendon autograft.
Procedur: Anterior Cruciate Ligament Reconstruction Using Quadriceps Tendon Autograft
Anterior cruciate ligament reconstruction performed using quadriceps tendon autograft.
Experimentell: Peroneus Longus Tendon Autograft
Patients undergoing anterior cruciate ligament reconstruction using peroneus longus tendon autograft.
Procedur: Anterior Cruciate Ligament Reconstruction Using Peroneus Longus Tendon Autograft
Anterior cruciate ligament reconstruction performed using peroneus longus tendon autograft.

Vad mäter studien?

Primära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
International Knee Documentation Committee (IKDC) Subjective Knee Score
Tidsram: 12 months postoperatively
Comparison of postoperative subjective knee function between quadriceps tendon and peroneus longus tendon autograft groups using the International Knee Documentation Committee (IKDC) subjective knee evaluation form.
12 months postoperatively

Sekundära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
Return to Sport Rate
Tidsram: Assessment of return to pre-injury level of sports activity following anterior cruciate ligament reconstruction.
6 and 12 months postoperatively
Assessment of return to pre-injury level of sports activity following anterior cruciate ligament reconstruction.
Ankle Plantar Flexion Strength
Tidsram: 6 and 12 months postoperatively
Isokinetic ankle plantar flexion strength will be evaluated using an isokinetic dynamometer. Peak torque (Nm) during plantar flexion will be recorded and compared between study groups.
6 and 12 months postoperatively
Ankle Dorsiflexion Strength
Tidsram: 6 and 12 months postoperatively
Isokinetic ankle dorsiflexion strength will be evaluated using an isokinetic dynamometer. Peak torque (Nm) during dorsiflexion will be recorded and compared between study groups.
6 and 12 months postoperatively
Ankle Inversion Strength
Tidsram: 6 and 12 months postoperatively
Isokinetic ankle inversion strength will be evaluated using an isokinetic dynamometer. Peak torque (Nm) during inversion will be recorded and compared between study groups.
6 and 12 months postoperatively
Ankle Eversion Strength
Tidsram: 6 and 12 months postoperatively
Isokinetic ankle eversion strength will be evaluated using an isokinetic dynamometer. Peak torque (Nm) during eversion will be recorded and compared between study groups.
6 and 12 months postoperatively
Ankle Rotational Strength
Tidsram: 6 and 12 months postoperatively
Isokinetic ankle rotational strength will be evaluated using an isokinetic dynamometer. Peak torque (Nm) during rotational movements will be recorded and compared between study groups.
6 and 12 months postoperatively
Ground Reaction Force
Tidsram: 6 and 12 months postoperatively
Lower extremity biomechanical performance will be assessed using the VALD ForceDecks dual force plate system. Ground reaction force (N) during standardized standing and functional testing tasks will be recorded and compared between study groups.
6 and 12 months postoperatively
Force Asymmetry
Tidsram: 6 and 12 months postoperatively
Lower extremity biomechanical performance will be assessed using the VALD ForceDecks dual force plate system. Force asymmetry (%) during standardized standing and functional testing tasks will be recorded and compared between study groups.
6 and 12 months postoperatively
Weight Distribution
Tidsram: 6 and 12 months postoperatively
Lower extremity biomechanical performance will be assessed using the VALD ForceDecks dual force plate system. Weight distribution (%) during standardized standing and functional testing tasks will be recorded and compared between study groups.
6 and 12 months postoperatively

Samarbetspartners och utredare

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Sponsor

Acibadem University

Studieavstämningsdatum

Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.

Studera stora datum

Studiestart (Faktisk)

1 maj 2026

Primärt slutförande (Beräknad)

1 maj 2027

Avslutad studie (Beräknad)

1 december 2027

Studieregistreringsdatum

Först inskickad

12 juni 2026

Först inskickad som uppfyllde QC-kriterierna

23 juni 2026

Första postat (Faktisk)

26 juni 2026

Uppdateringar av studier

Senaste uppdatering publicerad (Faktisk)

26 juni 2026

Senaste inskickade uppdateringen som uppfyllde QC-kriterierna

23 juni 2026

Senast verifierad

1 april 2026

Mer information

Termer relaterade till denna studie

Nyckelord

Ytterligare relevanta MeSH-villkor

Andra studie-ID-nummer

  • Quadriceps vs PL

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