Effect of Protein Composition on Gastric Emptying
Effect of the Protein Composition on the Gastric Emptying Rate in Children With Cerebral Paresis
研究概览
详细说明
Several factors in nutrition are known to affect gastric emptying rate, such as energy content, temperature, viscosity etc. In infants the protein composition affects gastric emptying. Children with cerebral pasly commonly have foregut dysmotility - with nausea, vomiting, feeding intolerance and gastroesophageal reflux. Tube feedings, usually based on cows milk are commonly used.
Our hypothesis is that the source and thus protein composition of feeding affects gastric emptying rate and electrofysiology.
Using four different tube feedings, standardized for content of fat, glucose and calories, we will measure gastric emptying rate using C13 octanoic acid as well as electrogastrography will be recorded. The protein modules are derived from casein, whey/casein mixture, hydrolyzed whey and aminoacids. Children with cerebral paresis and gastrostomy will be included. Each serves as his / her own control.
The primary endpoint is gastric emptying rate, the secondary endpoint electrogastrography.
研究类型
注册
阶段
- 不适用
联系人和位置
学习地点
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Oslo、挪威、0407
- Ullevaal University Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria: Cerebral paresis, user of tube feedings through gastrostomy -
Exclusion Criteria: Use of valproic acid (interferes with breath test). Age >16 y.
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学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：非随机化
- 介入模型：交叉作业
- 屏蔽：双倍的
研究衡量的是什么？
主要结果指标
结果测量 |
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Gastric emptying, measured by octanoic acid breath test.
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次要结果测量
结果测量 |
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Electrogastrography
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合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
研究完成
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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