Thrombopoietin Levels and Platelet Transfusion in Neonates
Thrombopoietin Levels Following Platelet Transfusion in Neonates With Thrombocytopenia
研究概览
地位
条件
详细说明
Thrombocytopenia, defined as a platelet count < 150,000/mm3, is a very common hematologic problem in the neonatal period. Multiple etiologies are known to be associated with thrombocytopenia in neonates. Thrombopoietin (TPO) is known to be the central regulator of megakaryocyte and platelet production in adults and infants. However, the role of TPO in neonatal platelet regulation is not well understood. TPO levels have been shown to be higher in neonates with thrombocytopenia, with a decrease in TPO after resolution of the thrombocytopenia. The response of TPO levels in neonates after platelet transfusion has never been studied. In addition, the optimal volume of platelet transfusions has never been studied in neonates. This study will evaluate the response to 2 different volumes of platelet transfusion.
We hypothesize that a decrease in plasma TPO levels will be seen following a platelet transfusion in a population of neonates with thrombocytopenia. We also hypothesize that a platelet transfusion of 15 mL/kg will result in a greater rise in platelet count than a transfusion pf 10 mL/kg of platelets.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Delaware
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Newark、Delaware、美国、19718
- Christiana Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Preterm infants with thrombocytopenia
- Decision made by medical team to transfuse with platelets
Exclusion Criteria:
- Infants with major congenital malformations
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
|---|
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1
10 mL/kg platelet transfusion
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2
15 mL / kg platelet transfusion
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Reduction in TPO levels following platelet transfusion
大体时间：Within 36 hours of transfusion
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Within 36 hours of transfusion
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次要结果测量
结果测量 |
大体时间 |
|---|---|
|
Platelet rise following platelet transfusion in 10 mL/kg versus 15 mL/kg.
大体时间：Within 36 hours after platelet transfusion
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Within 36 hours after platelet transfusion
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合作者和调查者
调查人员
- 首席研究员：David A. Paul, MD、Christiana Hospital
- 首席研究员：Alex Kline, MD、Christiana Hospital
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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