Pharmacokinetics (PK) of Ertapenem Intravenous (IV) Bolus Versus Standard Infusion

实验性的：Ertapenem 1 gram intravenous (IV) 5 minute bolus

Participants received ertapenem 1 gram every 24 hours for 3 doses with each dose infused as a 5 minute IV bolus.

药品：ertapenem

1 gram IV bolus every 24 hours (q24h) for 3 days

药品：ertapenem

1 gram 30 minute infusion q24h for 3 days

有源比较器：Ertapenem 1 gram IV 30 minute infusion

Participants received ertapenem 1 gram every 24 hours for 3 doses with each dose infused as a 30 minute infusion (i.e., the standard dose).

药品：ertapenem

1 gram IV bolus every 24 hours (q24h) for 3 days

药品：ertapenem

1 gram 30 minute infusion q24h for 3 days

Maximum Observed Plasma Concentration (Cmax) at Steady-State (After 3rd Dose)

Cmax is measured at 5 minutes after the beginning of the infusion for the 5 minute IV bolus dosage regimen and at 30 minutes after the beginning of the infusion for the 30 minute infusion dosage regimen.

Area Under the Curve From 48 to 72 Hours [AUC(48-72)]

AUC(48-72) is the 24 hour area under the concentration versus time curve after the 3rd dose of ertapenem, which is selected to measure approximate AUC at steady-state.

Number of Participants With Adverse Events as a Measure of Safety and Tolerability

The following laboratory assessments will be make before and after participation in the study to determine if objective changes occurred: blood pressure, pulse rate, temperature, complete blood count with differential, platelet count, blood urea nitrogen, serum creatinine, liver function panel [aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase], total bilirubin, and urinalysis with microscopy. Monitoring of other pathologic or unintended changes in structure (signs),or function (symptoms) of the body associated with participation in the study will occur.

Probability of Target Attainment (PTA)

After simulating 5000 patients receiving each dosing regimen, the probability of achieving free drug concentrations above an MIC of 0.25 mcg/mL and 0.5mcg/mL for at least 40% of the dosing interval (40% fT>MIC) is calculated at each MIC dilution.