Prognostic Biomarkers in Tumor Tissue Samples From Young Patients With Neuroblastoma
Observational - Expression of Ubiquitin Carboxyl-Terminal Hydrolase 1 (UCHL1) in Neuroblastoma Cancer Stem Cells and Its Relationship to Patient Prognosis
研究概览
详细说明
PRIMARY OBJECTIVES:
I. Determine whether ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) expression is an indirect cancer stem cell marker in pediatric patients with neuroblastoma. Correlate UCHL1 expression with staging information and patient's outcome.
Study Subtype: Observational Observational Study Model: Case-control Time Perspective: Retrospective Biospecimen Retention: None Retained Biospecimen Description: Tissue Study Population Description: Tissue microarray samples from patients with Neuroblastoma supplied by the COG Biopathology Center Sampling Method: Probability
OUTLINE:
Archived tissue microarray samples are analyzed for ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) expression by UCHL1 monoclonal antibody and peroxidase technique. Results are then compared with patients' clinical data, including age at diagnosis, race, date of diagnosis, histology, stage and location at diagnosis, presence of cancer predisposition, date of completion of treatment, surgery performed, type of chemotherapy received, history of recurrence, and status (alive with disease, alive without disease, dead), if available.
研究类型
注册 (实际的)
联系人和位置
学习地点
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California
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Monrovia、California、美国、91006-3776
- Children's Oncology Group
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参与标准
资格标准
适合学习的年龄
- 孩子
- 成人
- 年长者
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Diagnosed with neuroblastoma
- Tissue microarrays containing normal and neuroblastoma samples provided by the Children's Oncology Group (COG) Biopathology Center
学习计划
研究是如何设计的?
设计细节
- 观测模型:病例对照
- 时间观点:追溯
队列和干预
团体/队列 |
干预/治疗 |
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Biomarker analysis
Archived tissue microarray samples are analyzed for ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) expression by UCHL1 monoclonal antibody and peroxidase technique.
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相关研究
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
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Association between test result (percent cells with positive UCHL1 staining dichotomized into high and low categories) and International Neuroblastoma Staging System (INSS) stage
大体时间:Baseline
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Baseline
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次要结果测量
结果测量 |
大体时间 |
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Relationship between UCHL1 expression and tumor histology, and MYCN amplification
大体时间:Baseline
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Baseline
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合作者和调查者
调查人员
- 首席研究员:Aaron Sugalski, MD、Children's Oncology Group
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- ANBL11B3
- U10CA098543 (美国 NIH 拨款/合同)
- NCI-2011-02856 (注册表标识符:CTRP (Clinical Trial Reporting Program))
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