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Study of Prevalence of Colorectal Adenoma in 30- to 49-year-old Subjects With a Family History of Colorectal Cancer

2011年9月8日更新者：Jaeil Kim、Asan Medical Center

Prevalence of Colorectal Adenoma in 30- to 49-year-old Asymptomatic Subjects With a First Relative History of Colorectal Cancer

Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer are controversial. The aim of this study was to prospectively define the prevalence of colorectal adenoma 30- to 49-years-old asymptomatic subjects with a first relative history of colorectal cancer and to compare the data with controls.

Design: Single-center prospective study

研究概览

地位

未知

条件

结直肠肿瘤

详细说明

Colorectal cancer screening is recommended for average-risk persons beginning at age 50. A family history of colorectal cancer is recognized as a risk factor for colorectal adenoma. However, the strength of this association is uncertain. Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer have proved controversial. The conflicting recommendations are partly attributable to the lack of data about the prevalence of CRC and adenomas among 30- to 49-year-old individuals with a first relative history of colorectal cancer. This prospective study will quantify the prevalence of adenomas (any size) and advanced adenomas among 30- to 49-year-old individuals undergoing their first screening colonoscopy because of a first relative history of colorectal cancer and compare the data with controls(asymptomatic subjects without a first relative history of colorectal cancer).

研究类型

观察性的

注册 (预期的)

1000

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

大韩民国
- - Seoul、大韩民国、138-736
    - 招聘中
    - Asan Medical Center
    - 接触：
      
      Jaeil Kim, M.D
      
      电话号码：82230105673
      
      邮箱：pianojaeil@nate.com
    - 接触：
      
      Kyung-Jo Kim, M.D
      
      电话号码：82230103196
      
      邮箱：capsulendos@gmail.com

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

30年至 49年 (成人)

接受健康志愿者

不

有资格学习的性别

全部

取样方法

非概率样本

研究人群

30- to 49-year-old asymptomatic subjects undergoing first screening colonoscopy because of a first relative history of colorectal cancer

描述

Inclusion Criteria:

30- to 49-year-old asymptomatic subjects
First relative history of colorectal cancer

Exclusion Criteria:

previous colonoscopy for any reason
personal history of colorectal adenomas or CRC
history of familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer, or inflammatory bowel disease
documented history of occult GI bleeding, lower gastrointestinal tract bleeding not attributable to hemorrhoid, or
iron deficiency anemia
unexplained weight loss of >10% of the body weight in the 6 months before colonoscopy
incomplete examination of entire colon

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

观测模型：队列
时间观点：预期

团体/队列数

队列和干预

团体/队列
Family history 30- to 49-year-old asymptomatic subjects with a first relative history of colorectal cancer

研究衡量的是什么？

主要结果指标

结果测量	大体时间
prevalence of colorectal adenoma(any size) 大体时间：First screening colonoscopy	First screening colonoscopy

次要结果测量

结果测量	措施说明	大体时间
prevalence of advanced adenoma 大体时间：First screening colonoscopy	Any adenoma ≥10 mm Any villous component High-grade dysplasia	First screening colonoscopy

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Asan Medical Center

调查人员

研究主任：Kyung-Jo Kim, M.D、Department of Gastroenterology, Asan Medical Center

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2011年9月1日

初级完成 (预期的)

2014年9月1日

研究完成 (预期的)

2014年9月1日

研究注册日期

首次提交

2011年9月2日

首先提交符合 QC 标准的