Antimicrobial Stewardship Through MRSA Diagnosis in Emergency Department (ED) Patients With Abscesses
A Randomized Clinical Trial Comparing Use of Rapid Molecular Testing for Staphylococcus Aureus for Patients With Cutaneous Abscesses in the Emergency Department With Standard of Care.
研究概览
详细说明
Our objective was to determine whether real-time availability of rapid molecular results of Staphylococcus aureus would impact emergency department clinician antimicrobial selection for adults with cutaneous abscesses.
We performed a prospective, randomized controlled trial in two urban emergency departments comparing a rapid molecular test with standard of care culture-based testing. Follow-up telephone calls were made at between 2 and 7 days, 1 month, and 3 months after discharge.
Patients at least 18 years old presenting with a chief complaint of abscess, cellulitis, or insect bite and receiving incision and drainage were eligible. Seven hundred seventy-eight people were assessed for eligibility and 252 met eligibility criteria.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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-
District of Columbia
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Washington, D.C.、District of Columbia、美国、20037
- The George Washington University
-
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Maryland
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Baltimore、Maryland、美国
- Johns Hopkins University
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- adults 18 years or older with community onset abscess
Exclusion Criteria:
- previous treatment for same abscess in past 14 days
- postoperative infection
- inability to provide informed consent
学习计划
研究是如何设计的？
设计细节
- 主要用途：卫生服务研究
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：Xpert MRSA/SA SSTI
use of the Xpert MRSA/SSTI diagnostic assay
|
Use of Xpert MRSA/SA SSTI assay
|
|
有源比较器：Standard culture
performance of standard bacterial culture of abscess material
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Number of Participants With Antibiotic Usage at the Time of the ED Visit
大体时间：Baseline
|
Number of Participants with Antibiotic Usage at the time of the ED visit (narrow spectrum, broad spectrum, or none) will be recorded at the time of the ED visit
|
Baseline
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Participant Clinical Improvement Post-treatment at One Week
大体时间：2 to 7 days
|
clinical improvement (decreasing erythema, pain, swelling, drainage, and presence or absence of fever) will be documented at 2-7 day phone follow up and 1 and 3 months
|
2 to 7 days
|
|
Clinical Outcome at One or Three Months
大体时间：3 months
|
Recurrence of abscess within a three month time period
|
3 months
|
合作者和调查者
调查人员
- 首席研究员：Larissa S May, MD、The George Washington University
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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