Changes in Spontaneous Ventilation in Response to Changes in Extracorporeal Carbon Dioxide Removal
In physiological conditions, spontaneous ventilation is controlled by blood carbon dioxide (and pH) levels. In healthy animals, extracorporeal carbon dioxide removal leads to hypoventilation or apnea (Kolobow et al., 1977). During acute respiratory insufficiency, extracorporeal carbon dioxide removal may be used to control spontaneous ventilation, limiting risks of lung damage and relieving dyspnea (Crotti et al., 2012). However, little is known about how spontaneous ventilation changes in response to changes in extracorporeal carbon dioxide removal during acute respiratory insufficiency, especially in humans.
Aim of this study is to monitor changes in spontaneous ventilation in awake patients treated with extracorporeal gas exchange support because of acute respiratory insufficiency, in response to changes in extracorporeal carbon dioxide removal.
研究概览
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
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-
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Milan、意大利、20122
- 招聘中
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
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首席研究员：
- Stefania Crotti, MD
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Acute Respiratory Insufficiency
- Extracorporeal gas exchange support
- The patient is spontaneously breathing (including assisted ventilation)
Exclusion Criteria:
- age below 18 yrs
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：非随机化
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：Acute Respiratory Distress Syndrome
Acute hypoxemia, bilateral pulmonary infiltrates and no evidence of primary left atrial hypertension
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实验性的：Chronic Obstructive Pulmonary Disease
Acute-on-Chronic Respiratory Insufficiency (patients with Chronic Obstructive Pulmonary Disease)
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实验性的：Bridge to Lung Transplant
Acute-on-Chronic Respiratory Insufficiency (patients awaiting lung transplant)
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Spontaneous ventilation
大体时间：30-60 minutes after changing extracorporeal carbon dioxide removal
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Extracorporeal carbon dioxide removal will be increased or decreased changing the gas flow to the extracorporeal membrane lung.
Actual extracorporeal carbon dioxide removal will be measured.
Spontaneous respiratory rate, tidal volume, minute ventilation, esophageal pressure swings and comfort of the patient will be recorded 30-60 minutes after changing extracorporeal carbon dioxide removal.
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30-60 minutes after changing extracorporeal carbon dioxide removal
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合作者和调查者
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.