1-1-12 Wash-in for Desflurane Low Flow Anesthesia
We propose a new wash-in technique for desflurane low flow anesthesia with fresh gas flow of O2:N2O 1:1 L/min with desfluraene 12%.
The objective of this study is to identify time to achieve alveolar concentration of desflurane at1, 2, 3, 4, 5 and 6%.
研究概览
详细说明
The benefits of low flow anesthesia are economic, less pollution, more heat and humidity preservation but it requires appropriate wash-in phase. The current wash-in protocols are complicated and time consuming. We propose a new 1-1-12 desflurane wash-in protocol which is more simple and predictable.
The objective of this study is to identify time to achieve alveolar concentration of desflurane at 1, 2, 3, 4, 5 and 6% with 1-1-12 wash-in protocol.
All patients will receive iv propofol 2 mg/kg as induction agent and succinyl choline 1.5 mg/kg for intubation. Then the ventilation will be controlled to achieve end-tidal CO2 30-35 mmHg with O2:N2O 1:1 L/min with desflurane 12%. Time to achieve alveolar concentration of desflurane at 1, 2, 3, 4, 5 and 6% will be recorded and analyzed. After that, the concentration of desflurane and anesthetic technique will be adjusted to requirement of anesthesiologist.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Khon Kaen、泰国、40002
- Srinagarind Hospital
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- ASA classification I-II
- age 18-64 years
Exclusion Criteria:
- BMI > 35
- contraindicated for N2O
- with pulmonary or cardiac disease
学习计划
研究是如何设计的？
设计细节
- 观测模型：队列
- 时间观点：预期
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
1-1-12 wash-in
wash-in using O2:N2O 1:1 L/min with desflurane 12%
|
wash-in phase during start of low flow anesthesia
|
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
Time (in second) to achieve alveolar concentration of desflurane 1, 2, 3, 4, 5 and 6%
大体时间：participants will be followed until alveolar concentration of desflurane reaches 6%, as expected of 15 minutes
|
participants will be followed until alveolar concentration of desflurane reaches 6%, as expected of 15 minutes
|
次要结果测量
结果测量 |
大体时间 |
|---|---|
|
Heart rate
大体时间：participants will be followed until alveolar concentration of desflurane reaches 6%, as expected of 15 minutes
|
participants will be followed until alveolar concentration of desflurane reaches 6%, as expected of 15 minutes
|
合作者和调查者
调查人员
- 首席研究员：Thepakorn Sathitkarnmanee, MD、Faculty of Medicine, Khon Kaen University
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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