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A Working Memory Training to Decrease Rumination in Depressed and Anxious Individuals

2014年4月18日更新者：Ingmar Franken、Erasmus Medical Center

A Working Memory Training to Decrease Rumination in Depressed and Anxious Individuals: A Double-blind Randomized Controlled Trial

Dysfunctioning executive functioning, including working memory (WM), is related to rumination. Findings show that working memory capacity (WMC) can be increased by training. The current study explored by means of a double-blind randomized controlled trial whether an adaptive WM training could reduce rumination, anxiety and depression in a sample of 98 depressed and anxious individuals.

研究概览

地位

完全的

条件

干预/治疗

研究类型

介入性

注册 (实际的)

阶段

不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

荷兰
- Zuid Holland
  - Rotterdam、Zuid Holland、荷兰、3000 DR
    - Erasmus University Rotterdam

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年至 67年 (成人、年长者)

接受健康志愿者

不

有资格学习的性别

全部

描述

Inclusion Criteria:

Major depression diagnosis
Anxiety diagnosis

Exclusion Criteria:

Current psychosis
Substance abuse

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

主要用途：治疗
分配：随机化
介入模型：并行分配
屏蔽：双倍的

手臂数量

武器和干预

参与者组/臂	干预/治疗
实验性的：工作记忆训练	行为的：工作记忆训练
安慰剂比较：Placebo working memory training	行为的：安慰剂训练

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
Change in Ruminative Response Scale (RRS) score from pre to post training and after two months (follow up 2) 大体时间：Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)	Dutch version; Raes, Hermans, & Eelen, 2003) measures the frequency of self-reported rumination behavior, with answer options ranging from 1 (never) to 4 (always). The total score of the 22 items was used in the analyses.	Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)

次要结果测量

结果测量	措施说明	大体时间
Change in Beck Depression Inventory Second Edition (BDI-II) score from pre to post training and after two months (follow up 2) 大体时间：Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)	The Beck Depression Inventory - II (BDI-II; Beck, Steer, & Brown, 1996; Dutch version: Van der Does, 2002) measures the severity of depression symptoms of the last two weeks.	Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)
Change in State-Trait Anxiety Inventory (STAI) score from pre to post training and after two months (follow up 2) 大体时间：Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)	The State-Trait Anxiety Inventory (STAI; Spielberger, Gorsuch, Lushene, Vagg, & Jacobs, 1983, Dutch version; Van der Ploeg, Defares, & Spielberger, 1979) measures self-reported anxiety, divided in state anxiety and trait anxiety.	Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)

其他结果措施

结果测量	措施说明	大体时间
The change in Internal Shift Task (IST) score from pre to post training and to follow up (two months after post) 大体时间：Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)	The Internal Shift Task (IST; De Lissnyder et al., 2012) measures the ability to shift attention between items stored in WM.	Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)
The change in Digit Span score from pre to post training and to follow up (two months after post) 大体时间：Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)	The Digit Span (Lumley & Calhoun, 1934), which consist of two parts: the forward and backward span, with 14 trials each. The forward Digit Span is a frequently used measure for short term memory, an important subcomponent of the memory system (Shipstead et al., 2012) and the backward version measures WM.	Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)
The change in Reading Span partial-credit unit score from pre to post training and to follow up (two months after post) 大体时间：Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)	The Reading Span (Daneman & Carpenter, 1980), the third WMC assessment, measures the processing and storage functions of the WM (Shipstead et al., 2012).	Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Erasmus Medical Center

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2011年8月1日

初级完成 (实际的)

2011年12月1日

研究注册日期

首次提交

2014年4月8日

首先提交符合 QC 标准的

2014年4月18日

首次发布 (估计)

2014年4月22日

研究记录更新

最后更新发布 (估计)

2014年4月22日

上次提交的符合 QC 标准的更新

2014年4月18日

最后验证

2014年4月1日

A Working Memory Training to Decrease Rumination in Depressed and Anxious Individuals