Evaluation of Breathing Effort in Spontaneously Breathing Subjects
Problems of Measurement and Evaluation of Breathing Effort in Spontaneously Breathing Subjects
The aim of the research project is to evaluate the breathing effort using the Work of Breathing (WoB) and Pressure-Time Product (PTP) parameters, depending on the increasing flow resistance. The research project is concerned with assessing the increased (imposed) breathing effort using the Work of Breathing (iWoB) and the Pressure-Time Product (iPTP).
The main hypothesis tested is the differential effect of flow resistance on iWoB and iPTP parameters in spontaneous breathing of healthy probands.
研究概览
详细说明
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
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Czech Republic
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Kladno、Czech Republic、捷克语、27201
- 招聘中
- Department of Biomedical Technology Faculty of Biomedical Engineering Czech Technical University in Prague
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接触：
- Karel Roubík, Prof.
- 电话号码：+420 603 479 901
- 邮箱：roubik@fbmi.cvut.cz
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接触：
- Anna Miltová
- 电话号码：+420 774 670 233
- 邮箱：anna.miltova@fbmi.cvut.cz
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Healthy males and females > 18 and < 40 years old
- Signed informed consent has been obtained
Exclusion Criteria:
- Respiratory disease
- Pregnancy
- Cardiovascular disease
- Diabetes mellitus
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：Breathing through a system with adjustable flow resistance
During the experiment, the volunteers will breathe through ten adjustable flow resistances and their work of breathing will be measured.
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The proband will breathe through the adjustable flow resistance within the experiment, to which a standard D-lite Flow sensor will be connected, and the airway pressure, flow, minute consumption, oxygen and carbon dioxide, tidal volume, oxygen saturation of peripheral blood and oxygen and carbon dioxide concentrations in both inspired and expired air will be recorded using the Datex-Ohmeda S/5 Patient Monitor vital signs monitor. The proband will breathe through the flow resistors in a randomized order, and pre-defined three-minute pauses will be maintained between measurements with different flow resistance values. Each measurement will take approximately two minutes and will be measured on ten different flow resistances. |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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iWoB
大体时间：through study completion, an average of 1 year
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imposed work of breathing in J/s/L
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through study completion, an average of 1 year
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iPTP
大体时间：through study completion, an average of 1 year
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imposed pressure time product in Pa.s/L
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through study completion, an average of 1 year
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合作者和调查者
调查人员
- 研究主任：Karel Roubik, Prof.、Czech Technical University in Prague, Fac. of Biomedical Engineering
出版物和有用的链接
一般刊物
- Bellani G, Pesenti A. Assessing effort and work of breathing. Curr Opin Crit Care. 2014 Jun;20(3):352-8. doi: 10.1097/MCC.0000000000000089.
- Collett PW, Perry C, Engel LA. Pressure-time product, flow, and oxygen cost of resistive breathing in humans. J Appl Physiol (1985). 1985 Apr;58(4):1263-72. doi: 10.1152/jappl.1985.58.4.1263.
- de Vries H, Jonkman A, Shi ZH, Spoelstra-de Man A, Heunks L. Assessing breathing effort in mechanical ventilation: physiology and clinical implications. Ann Transl Med. 2018 Oct;6(19):387. doi: 10.21037/atm.2018.05.53.
- Dodd DS, Kelly S, Collett PW, Engel LA. Pressure-time product, work rate, and endurance during resistive breathing in humans. J Appl Physiol (1985). 1988 Apr;64(4):1397-404. doi: 10.1152/jappl.1988.64.4.1397.
- Cabello B, Mancebo J. Work of breathing. Intensive Care Med. 2006 Sep;32(9):1311-4. doi: 10.1007/s00134-006-0278-3. Epub 2006 Jul 13. No abstract available.
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- iWoBvsiPTP
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
IPD 计划说明
药物和器械信息、研究文件
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研究美国 FDA 监管的设备产品
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