Timing of Rocuronium After Induction With Propofol on Temporal Summation of Pain
2020年9月11日 更新者：Cheol Lee、Wonkwang University Hospital
The Impact of the Timing of Rocuronium After Induction With Propofol on Temporal Summation of Pain in Gynecologic Laparoscopic Surgery-prospective and Controlled Study.
Temporal summation of pain, which is defined as the perception of increasingly greater pain evoked by repetitive painful stimuli, is highly variable between individuals.
This study aimed to determine the impact of the timing of rocuronium after induction with propofol on temporal summation of pain in gynecologic laparoscopic surgery.
研究概览
地位
完全的
条件
研究类型
介入性
注册 (实际的)
100
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
-
-
Jeonbuk
-
Iksan、Jeonbuk、大韩民国、570-711
- WonwangUH
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
19年 至 60年 (成人)
接受健康志愿者
不
有资格学习的性别
女性
描述
Inclusion Criteria:
- Elective gynecologic laparoscopic surgery
- American Society of Anesthesiologists' physical status class) I-II
Exclusion Criteria:
- Menopause (to exclude the hormonal effect on pain)
- Patients who had muscular, cardiovascular, hepatic or kidney disorders and patients with a history of medication who would affect muscle relaxants were excluded from this study.
- Patients with difficult venous access on forearm, a known allergy to propofol or rocuronium, chronic pain, pregnancy, and those who had received analgesics or sedatives within the previous 24 hours, were excluded from the study.
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：预防
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：单身的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
其他：group PRi
received immediate injection of rocuronium after propofol administration,
|
The difference of the timing was rocuronium was administered immediately after propofol injection or when BIS score became below 60 after propofol administration.
|
|
其他：group PRd
rocuronium injection when bispectral index score became below 60 after propofol administration
|
The difference of the timing was rocuronium was administered immediately after propofol injection or when BIS score became below 60 after propofol administration.
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
the grade of rocuronium induced withdrawal movement.
大体时间：during anesthesia induction
|
withdrawal movements were graded by the investigator according to the following scale:
|
during anesthesia induction
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
visual analog scale (VAS) for injection pain
大体时间：during anesthesia induction
|
check VAS for pain after propofol administration.
visual analog scale with 100 mm for pain after surgery.
0 = no pain, 100 = the worst pain
|
during anesthesia induction
|
|
VAS for pain
大体时间：at 1 hour, 24 hours and 48 hours
|
check VAS with 100 mm for pain after surgery.
0 = no pain, 100 = the worst pain
|
at 1 hour, 24 hours and 48 hours
|
|
Patient controlled analgesia (PCA) Opioid consumption
大体时间：at 24 and 48 hours
|
check the volume of PCA Opioid consumption (ml) (PCA) pump containing fentanyl (800 ug), ketorolac (150 mg), and ramosetron (0.6 mg) in a total volume of 150 mL of saline was set to deliver a basal infusion of 2 mL/h and bolus doses of 0.5 mL, with a 15-min lockout period for postoperative analgesia.
|
at 24 and 48 hours
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 研究主任：Cheol Lee, M.D,Ph.D、Department of Anesthesiology and Pain Medicine
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Cheng JC, Erpelding N, Kucyi A, DeSouza DD, Davis KD. Individual Differences in Temporal Summation of Pain Reflect Pronociceptive and Antinociceptive Brain Structure and Function. J Neurosci. 2015 Jul 1;35(26):9689-700. doi: 10.1523/JNEUROSCI.5039-14.2015.
- Ayoglu H, Altunkaya H, Ozer Y, Yapakci O, Cukdar G, Ozkocak I. Does dexmedetomidine reduce the injection pain due to propofol and rocuronium? Eur J Anaesthesiol. 2007 Jun;24(6):541-5. doi: 10.1017/S0265021506002250. Epub 2007 Jan 23.
- Hwang SM, Cho SH, Lim SY, et al. The efficacy of BIS monitoring for the preventing of withdrawal movement on the intravenous injection of rocuronium. Korean J Anesthesiol 2005;49:293-7.
- Lim BG, Lee IO, Kim YS, Won YJ, Kim H, Kong MH. The utility of bispectral index monitoring for prevention of rocuronium-induced withdrawal movement in children: A randomized controlled trial. Medicine (Baltimore). 2017 Jan;96(2):e5871. doi: 10.1097/MD.0000000000005871.
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2020年5月1日
初级完成 (实际的)
2020年5月30日
研究完成 (实际的)
2020年9月4日
研究注册日期
首次提交
2020年9月7日
首先提交符合 QC 标准的
2020年9月7日
首次发布 (实际的)
2020年9月14日
研究记录更新
最后更新发布 (实际的)
2020年9月16日
上次提交的符合 QC 标准的更新
2020年9月11日
最后验证
2020年9月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.