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Multimodal Imaging Based on Pathological and Genomic Characteristics

2022年3月20日 更新者：Affiliated Hospital to Academy of Military Medical Sciences

A New Multimodal Imaging Technique Based on Pathological and Genomic Characteristics of Gastrointestinal Mucosa

Mitochondrial DNA mutations in normal gastric tissue, early gastric cancer and advanced gastric cancer were identified by single cell sequencing, and the origin of gastric stem cells was traced and new molecular markers were found. At the same time, organize industry-university-research-medical inspection joint research, aiming at the advanced layout of new structural and functional imaging technologies, combined with some new imaging technologies, such as holography, fluorescence, etc., to explore and develop a new composite endoscopic imaging technology that is advanced, original and suitable for China's national conditions, in order to develop a prototype of multimodal structural and functional imaging digestive endoscope without contrast agent.

研究概览

地位

招聘中

条件

干预/治疗

详细说明

In this study, on the basis of previous work, aiming at the visualization of key molecular functions of gastric cancer, a full-chain digestive endoscopic diagnosis system was constructed by using cross-scale medical imaging technology. Mitochondrial DNA mutations in normal gastric tissue, early gastric cancer and advanced gastric cancer were identified by single cell sequencing, and the origin of gastric stem cells was traced and new molecular markers were found. The tissue characteristics are analyzed by the full spectrum imaging device, and the location, distribution and aggregation of key molecules on the cell membrane are observed by the high resolution imaging device, so as to develop an imaging probe with high labeling efficiency and biosafety, and to explore its clinical application to realize the information fusion of structural and functional imaging in the evolution and diagnosis and treatment of gastrointestinal tumors. The structural heterogeneity and molecular heterogeneity of gastrointestinal tumors are clarified from the macro-micro levels, and the full-scale imaging system with the most comprehensive visualization and resolution ability is established from multi-information dimensions and multi-imaging scales.

研究类型

观察性的

注册 (预期的)

200

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

研究联系人备份

学习地点

  • 中国
    • Beijing
      • Beijing、Beijing、中国、100853
        • 招聘中
        • The First Medical Center of Chinese PLA General Hospital
        • 接触：
        • 首席研究员：
          • Yan Liu

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年 至 80年 (成人、年长者)

接受健康志愿者

是的

有资格学习的性别

全部

取样方法

概率样本

研究人群

People diagnosed or suspected of one of the following common digestive mucosal diseases: gastritis, gastric cancer, colorectal polyps, colorectal cancer

描述

Inclusion Criteria:

  1. Diagnosis or suspected diagnosis of one of the following common digestive mucosal diseases: gastritis, gastric cancer, colorectal polyps, bowel cancer
  2. Written informed consent

Exclusion Criteria:

  1. Patients with cardiovascular and cerebrovascular diseases, or patients with severe impairment of liver, kidney and hematopoietic system
  2. Mental patients
  3. Hemorrhagic diseases
  4. Platelet count < 50 × 10 ^ 9 / L
  5. Allergic constitution
  6. unable to tolerate or cooperate with endoscopy
  7. Patients with serious complications, such as intestinal obstruction, intestinal perforation, toxic colonic dilatation, colorectal cancer, etc.
  8. Pregnant or lactating women

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

队列和干预

团体/队列
干预/治疗
Study Group
Study on the genomic and molecular pathological characteristics of gastrointestinal mucosal lesions
其他：Patients diagnosed as gastrointestinal mucosal lesions
Patients diagnosed as gastritis, gastric cancer, intestinal polyps and colorectal cancer
Control Group
Study on the genomic and molecular pathological characteristics of normal gastrointestinal mucosa

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Single cell sequencing and identification of mitochondrial DNA variation in gastrointestinal lesions
大体时间：1 month
Single cell sequencing and identification of mitochondrial DNA mutations in gastrointestinal lesions were carried out to trace the clonal origin of cells and look for molecular markers
1 month
To explore the multimodal imaging technique for the diagnosis of gastrointestinal mucosal lesions
大体时间：1 month
The tissue characteristics are analyzed by the full spectrum imaging device, the location, distribution and aggregation of key molecules on the cell membrane are observed by the high resolution imaging device, the imaging probe with high labeling efficiency and biosafety is developed, and the clinical application is discussed. in order to realize the information fusion of structural and functional imaging in the process of gastrointestinal tumor evolution and diagnosis and treatment.
1 month

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Affiliated Hospital to Academy of Military Medical Sciences

调查人员

  • 首席研究员：Yan Liu, MD、Beijing 302 Hospital

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2022年3月21日

初级完成 (预期的)

2022年6月1日

研究完成 (预期的)

2024年7月1日

研究注册日期

首次提交

2022年1月5日

首先提交符合 QC 标准的

2022年1月5日

首次发布 (实际的)

2022年1月19日

研究记录更新

最后更新发布 (实际的)

2022年4月1日

上次提交的符合 QC 标准的更新

2022年3月20日

最后验证

2022年3月1日

更多信息

与本研究相关的术语

关键字

其他研究编号

  • Multi-imaging

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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