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Effects of Rosemary Essential Oil on Human Cognition (Rosmarinus)

2026年4月28日 更新者:Heloisa de Freitas Pacífico、Federal University of Paraíba

The Use of Rosmarinus Officinalis L. Essential Oil (Camphor and Cineol Chemotypes) in Cognition: a Randomized, Double-blind, Placebo-controlled Study

Aromatherapy is one of the complementary therapies that is carried out through essential oils. The essential oil of Rosmarinus Officinalis L. (rosemary) has been gaining attention in aromatherapy research, as studies have shown that the use of this oil is one of the promising non-pharmacological therapies for cognition. In this way, inhalation of rosemary essential oil is one of the forms of cognitive intervention across different age groups. The study will aim to analyze the effect of rosemary essential oil, with the following chemotypes: camphor and cineole, on the cognitive performance of adults. Significant differences are expected between the control (placebo) and experimental groups, given that studies in humans have already shown significant effects of rosemary essential oil on cognition. Considering the inclusion and exclusion criteria of the study, participants will be allocated to either the control or experimental group. Consequently, the application of the tests will be carried out neuropsychological tests for the pre-test evaluation, followed by aromatherapy (acute phase) and the reapplication of the tests (post-test phase 1). For 14 days, the participants will chronically use rosemary essential oil and at the end they will participate in the reapplication of the neuropsychological tests (post-test phase 2). For inferential analyses, the ANOVA test or its non-parametric equivalent will be used. In addition, linear regressions may be performed to verify how much the essential oil can predict the outcome of the study's dependent variables. Effect Size will also be calculated. Keywords: Chronic intervention; neuropsychology; aromatherapy.

研究概览

地位

主动,不招人

条件

干预/治疗

研究类型

介入性

注册 (实际的)

63

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。

学习地点

    • Paraíba
      • João Pessoa、Paraíba、巴西、58062-106
        • Helô

参与标准

研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

  • 成人

接受健康志愿者

是的

描述

  1. Inclusion Criteria:

    • 1a Healthy adults
    • 1b should be able to inhale the essential oil
  2. Exclusion Criteria:

    • 2a Neurodegenerative diseases
    • 2b Traumatic brain injury
    • 2c Brain tumors
    • 2d Multiple sclerosis
    • 2e Epileptic seizures
    • 2f Anxiety Disorder
    • 2g Depressive Disorders,
    • 2h Uncontrolled arterial hypertension,
    • 2i nutritional deficiency or thyroid disease.

学习计划

本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。

研究是如何设计的?

设计细节

  • 主要用途:其他
  • 分配:随机化
  • 介入模型:并行分配
  • 屏蔽:双倍的

武器和干预

参与者组/臂
干预/治疗
实验性的:essential oil of Rosmarinus officinalis 1
Inhalation of 2 drops of rosemary camphor essential oil for 5 minutes, once a day for 1 week consecutive on a cotton pad followed
oil essential
无干预:Placebo
Inhalation of 2 drops of sunflower essential oil for 5 minutes, once a day for 1 week consecutive on a cotton pad followed
有源比较器:essential oil of Rosmarinus officinalis 2
Inhalation of 2 drops of rosemary cineol essential oil for 5 minutes, for once a day for 1 week consecutive on a cotton pad followed
oil essential

研究衡量的是什么?

主要结果指标

结果测量
措施说明
大体时间
STROOP TEST
大体时间:Cognitive tests were administered at the following stages: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."
Unit of measurement: time (seconds)
Cognitive tests were administered at the following stages: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."
Subteste Digits of the Test WAIS-III - (Wechsler Adult Scale)
大体时间:Cognitive tests were administered at the following stages: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."

1a. Maximum raw score: 30

1b. Minimum raw score: 2

Cognitive tests were administered at the following stages: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."
Subtest Number and Letter Sequence of the WAIS-III Test - (Wechsler Adult Scale)
大体时间:Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."

1.0 Measurement Units: raw score 1a. Maximum raw score: 21

1b. Minimum raw score: 0

Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."
Tower of London
大体时间:Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."

1.0 Measurement Units: raw score 1a. Maximum raw score: 46

1b. Minimum raw score: 0

Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."
Token Test
大体时间:Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."

1.0 Measurement Units: raw score 1a. Maximum raw score: 36

1b. Minimum raw score: 0

Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."
Corsi Blocks
大体时间:Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."

1.0 Measurement Units: raw score 1a. Maximum raw score: 30

1b. Minimum raw score: 0

Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."
Hopkins Verbal Learning
大体时间:Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."

1.0 Measurement Units: raw score 1a. Maximum raw score: 0

1b. Minimum raw score: 36

Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2025年3月1日

初级完成 (估计的)

2026年12月1日

研究完成 (估计的)

2026年12月31日

研究注册日期

首次提交

2026年4月13日

首先提交符合 QC 标准的

2026年4月28日

首次发布 (实际的)

2026年5月1日

研究记录更新

最后更新发布 (实际的)

2026年5月1日

上次提交的符合 QC 标准的更新

2026年4月28日

最后验证

2026年4月1日

更多信息

与本研究相关的术语

其他研究编号

  • 80434324.0.0000.5188

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.

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