Validation of a Remediation Method for Memory Impairments Through Motor Encoding in Patients With Alzheimer's Disease (ADACT)
2026年7月30日 更新者：Centre Hospitalier Universitaire de Saint Etienne
In France, over 1.5 million people suffer from mild cognitive impairment, often a precursor to Alzheimer's disease (AD), whose global prevalence could reach 153 million by 2050.
With no curative treatment available, maintaining patients' autonomy at home is essential to mitigate the negative effects of institutionalization and reduce economic costs.
Non-pharmacological approaches, such as cognitive training, have shown potential in stabilizing cognitive functions.
Research suggests that motor networks and procedural memory remain relatively preserved in early AD, and bodily engagement during encoding enhances memory.
For patients with motor impairments, motor imagery (MI) activates these networks without actual movement.
Additionally, dynamic visual cues, like videos, reduce cognitive load compared to static images.
This project aims to combine real action, MI, and dynamic visual supports to optimize memory.
By validating 120 videos of daily activities, it will assess the impact of action on recall, evaluate MI's effectiveness for patients with mobility limitations, and confirm the superiority of videos over static images.
The results could support the development of digital tools, such as serious games, to enhance patients' autonomy and address aging-related challenges.
研究概览
详细说明
In France, over 1.5 million people suffer from mild cognitive impairment, often a precursor to Alzheimer's disease (AD), whose global prevalence could reach 153 million by 2050.
With no curative treatment available, maintaining patients' autonomy at home is essential to mitigate the negative effects of institutionalization and reduce economic costs.
Non-pharmacological approaches, such as cognitive training, have shown potential in stabilizing cognitive functions.
Research suggests that motor networks and procedural memory remain relatively preserved in early AD, and bodily engagement during encoding enhances memory.
For patients with motor impairments, motor imagery (MI) activates these networks without actual movement.
Additionally, dynamic visual cues, like videos, reduce cognitive load compared to static images.
This project aims to combine real action, MI, and dynamic visual supports to optimize memory.
By validating 120 videos of daily activities, it will assess the impact of action on recall, evaluate MI's effectiveness for patients with mobility limitations, and confirm the superiority of videos over static images.
The results could support the development of digital tools, such as serious games, to enhance patients' autonomy and address aging-related challenges.
研究类型
介入性
注册 (估计的)
80
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习联系方式
- 姓名：Céline BORD, MD
- 电话号码：+33 (0)4 77 82 88 82
- 邮箱：celine.borg@chu-st-etienne.fr
研究联系人备份
- 姓名：Céline LECLERCQ TRAUTVETTER, CDP
- 电话号码：+33 (0)4 77 82 94 27
- 邮箱：Celine.LECLERCQTRAUTVETTER@chu-stetienne.fr
学习地点
-
-
-
Grenoble、法国、38700
- 尚未招聘
- Chu Grenoble
-
首席研究员：
- Mathilde SAUVEE, MD
-
副研究员：
- Olivier MOREAUD, MD
-
Saint-Etienne、法国、42055
- 招聘中
- CHU de Saint Etienne
-
首席研究员：
- Céline BORG, MD
-
Villeurbanne、法国、69100
- 尚未招聘
- HLC, Hôpital des Charpennes
-
首席研究员：
- Isabelle ROUCH, MD
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
是的
描述
Inclusion Criteria:
Patient group: Diagnosis of Alzheimer's disease made by one of the consulting physicians-a neurologist and/or geriatrician (Dubois et al., 2014)-at the early stage, presenting with mild memory impairment of which the patient has been informed
- MMSE score of 21 or higher
Control group: individuals without a diagnosis of Alzheimer's disease, but meeting the other criteria listed below
- Enrollment in a social security program
- Age 60 or older
- French as a native language
- Consent to participate
Exclusion Criteria:
- Uncorrected visual or hearing impairments
- Language or motor impairments
- Delirium or psychosis.
- Medical treatment affecting vision, language, or motor skills (or participation in a study involving a drug or device that influences cognition).
- Refusal to participate.
- Inability to communicate
- Persons deprived of liberty by a judicial or administrative decision and adults subject to a legal protection measure or unable to express their consent
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：其他
- 分配：非随机化
- 介入模型：交叉作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：Control condition
|
Reading a sentence aloud and the participant is asked to freely recall, without delay and without cues, all the sentences presented in the block.
The number of correctly recalled sentences is recorded.
其他名称：
|
|
实验性的：Motor imagery intervention
|
Following the reading of each sentence, the participant is instructed to mentally simulate performing the action described in the sentence.
And the participant is asked to freely recall, without delay and without cues, all the sentences presented in the block.
The number of correctly recalled sentences is recorded.
其他名称：
|
|
实验性的：Real action
|
After reading the sentence, the participant pantomimes the action described and The participant is asked to freely recall, without delay and without cues, all the sentences presented in the block.
The number of correctly recalled sentences is recorded.
其他名称：
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Free recall score
大体时间：at 1 week
|
The free recall score corresponds to the number of sentences spontaneously retrieved by participants after learning, measuring free retrieval ability.
|
at 1 week
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2026年7月15日
初级完成 (估计的)
2028年3月1日
研究完成 (估计的)
2028年6月1日
研究注册日期
首次提交
2026年6月2日
首先提交符合 QC 标准的
2026年6月2日
首次发布 (实际的)
2026年6月8日
研究记录更新
最后更新发布 (实际的)
2026年7月31日
上次提交的符合 QC 标准的更新
2026年7月30日
最后验证
2026年7月1日
更多信息
与本研究相关的术语
其他研究编号
- 25CH313
- ANSM (其他标识符：2024-A02435-42)
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
不
IPD 计划说明
insitute decision
药物和器械信息、研究文件
研究美国 FDA 监管的药品
不
研究美国 FDA 监管的设备产品
不
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.