Diagnostic Performance of Serum Calprotectin in Acute Appendicitis (SCP-AA)
Diagnostic Performance of Serum Calprotectin in Acute Appendicitis: A Prospective Comparative Analysis Study
研究概览
详细说明
Acute appendicitis is one of the most common causes of acute abdominal pain requiring emergency surgical intervention. However, establishing an accurate diagnosis may be difficult, particularly in patients presenting with nonspecific abdominal pain or atypical clinical findings. Conventional inflammatory markers and clinical scoring systems are useful adjuncts, but their diagnostic accuracy remains limited.
This prospective single-center observational study evaluated the diagnostic performance of serum calprotectin in adult patients presenting with acute abdominal pain and suspected acute appendicitis. Patients with histopathologically confirmed acute appendicitis were compared with a control group consisting of patients diagnosed with nonspecific abdominal pain after clinical, laboratory, radiological evaluation, and follow-up.
Serum calprotectin concentrations were measured and compared with white blood cell count, C-reactive protein, ferritin, and the Alvarado score. The relationship between serum calprotectin levels and histopathological severity of appendicitis was also assessed.
The primary objective of the study was to determine the diagnostic accuracy of serum calprotectin in distinguishing acute appendicitis from nonspecific abdominal pain.
研究类型
注册 (实际的)
联系人和位置
学习地点
-
-
ATASEHIR
-
Istanbul、ATASEHIR、土耳其（türkiye）、34752
- Fatih Sultan Mehmet Training and Research Hospital
-
-
参与标准
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
取样方法
研究人群
描述
Inclusion Criteria:
- Age between 18 and 75 years
- Presentation to the emergency department with acute abdominal pain and suspected acute appendicitis
- Willingness to participate and provide informed consent
Exclusion Criteria:
- Previous abdominal surgery
- Chronic inflammatory or autoimmune disease
- Active infection other than suspected appendicitis
- Use of systemic anti-inflammatory or immunosuppressive therapy
- Pregnancy
- Incomplete clinical or laboratory data
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
Acute Appendicitis
Patients with histopathologically confirmed acute appendicitis who underwent appendectomy.
|
Measurement of serum calprotectin levels using ELISA for diagnostic evaluation of acute appendicitis.
|
|
Non-specific Abdominal Pain
Patients presenting with nonspecific abdominal pain without evidence of appendicitis during follow-up.
|
Measurement of serum calprotectin levels using ELISA for diagnostic evaluation of acute appendicitis.
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Diagnostic accuracy of serum calprotectin for acute appendicitis
大体时间：At admission to the emergency department
|
Comparison of serum calprotectin levels between patients with acute appendicitis and nonspecific abdominal pain.
|
At admission to the emergency department
|
合作者和调查者
调查人员
- 首席研究员：fatih kilic, MD、Fatih Sultan Mehmet Training and Research Hospital
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- FSMEAH-KAEK-2015-53
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
IPD 计划说明
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
Serum Calprotectin Measurement的临床试验
-
Harvard University Faculty of MedicineNational Institute of Allergy and Infectious Diseases (NIAID); Brigham and Women's Hospital; Harvard... 和其他合作者未知