Predicting Risk of Progression of Early to Late AMD in the Aging Eye Through Imaging and Multimodal Evaluation (PRIME)
Predicting Risk of Progression of Early to Late AMD in the Aging Eye Through Imaging and Multimodal Evaluation - PRIME Study
研究概览
地位
条件
详细说明
An effective screening programme requires several key components to be successful. First, the natural history of the condition needs to be well understood. Next, a clear threshold for referral must be established and finally, effective intervention must be available to treat the condition in question. In ophthalmology, the most effective screening programme we have is for diabetic retinopathy (DR). Here, the natural history and thresholds are well established, and treatment in the form of pan-retinal photocoagulation is effective in preventing progression to visually threatening DR.
While there is consensus regarding features that predispose to late AMD, at an individual level, risk, rate and pattern of progression remain unpredictable therefore there is a need to develop effective AMD screening. This is in contrast to diabetic retinopathy because the natural history is well understood and the risk of vision loss increases sharply in those with referrable DR. In AMD, this threshold is not yet established.
As there is currently no standardized screening protocol for early AMD, especially in the community-based setting and community hospital settings, our study aims to understand the natural progression of AMD in the elderly and establish a referrable threshold before visually threatening AMD occurs. This will ultimately inform a comprehensive and standardized community-based screening approach for AMD.
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Gemmy Cheung Professor
- 电话号码：+6563224500
- 邮箱：gemmy.cheung.c.m@singhealth.com.sg
学习地点
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Singapore、新加坡
- 招聘中
- Singapore National Eye Centre/ Singapore Eye Research Institute
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接触：
- Gemmy Cheung Professor
- 电话号码：+6563227460
- 邮箱：gemmy.cheung.c.m@singhealth.com.sg
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Singapore、新加坡
- 招聘中
- Outram Community Hospital
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接触：
- Lian Leng Low Associate Professor
- 电话号码：+6563265872
- 邮箱：low.lian.leng@singhealth.com.sg
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参与标准
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
取样方法
研究人群
描述
Inclusion Criteria:
- Adults aged 55 years or older
- No severe systemic illnesses that prevent study participation
- Willing and able to undergo protocol-required procedures for both eyes
- Willing and able to provide written informed consent
Exclusion Criteria:
- Systemic disorders that preclude reliable clinical examination or multimodal imaging
- Poor compliance or severe mental illness that hinders participation
- Persons who are unable to give informed consent
学习计划
研究是如何设计的？
设计细节
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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To establish the natural history of AMD in Asian elderly and to identify clinical multimodal imaging, genetic, and metabolomic predictors of progression.
大体时间：3 years
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Progression is defined as the change from early signs of AMD to advanced AMD.
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3 years
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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