Serum EBI-3 Protein Levels in Behçet's Disease
Serum Epstein-Barr Virus-induced Gene 3 Protein Levels in Patients With Behçet's Disease
This cross-sectional study aims to evaluate serum Epstein-Barr virus-induced gene 3 (EBI-3) protein levels in patients with Behçet's disease compared with healthy controls.
研究概览
地位
条件
详细说明
Behçet's disease is a chronic multisystem inflammatory disorder. Serum EBI-3 protein levels may reflect inflammatory activity.
This observational study will include adult patients diagnosed with Behçet's disease according to the International Criteria for Behçet's Disease and age-matched healthy controls. Serum EBI-3 protein levels will be measured by ELISA.
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Shrouk S Mohamed, Resident
- 电话号码：01004638754
- 邮箱：shrouk.18313202@med.aun.edu.eg
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
Adult patients with Behçet's disease attending the Physical Medicine, Rheumatology and Rehabilitation Department at Assiut University Hospitals, and healthy controls.
描述
Inclusion Criteria:
- - Age 18 years or older
- Diagnosis of Behçet's disease according to the International Criteria for Behçet's Disease (cases)
- Healthy individuals without autoimmune or inflammatory diseases (controls)
- Written informed consent
Exclusion Criteria:
- - Other autoimmune disorders (RA, SLE, psoriatic arthritis, ankylosing spondylitis)
- Acute or chronic infection
- Malignancy or history of malignancy
- Chronic liver disease or advanced chronic kidney disease
- Pregnancy or lactation
- Vasculitis caused by diseases other than Behçet's disease
学习计划
研究是如何设计的？
设计细节
- 观测模型：CASE_CONTROL
- 时间观点：CROSS_SECTIONAL
队列和干预
团体/队列 |
|---|
|
Behçet's Disease
Patients diagnosed with Behçet's disease according to the International Criteria for Behçet's Disease. |
|
Healthy Controls
Age-matched healthy individuals without autoimmune or inflammatory diseases. |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Mean serum EBI-3 protein level
大体时间：Baseline
|
Mean serum Epstein-Barr virus-induced gene 3 (EBI-3) protein concentration measured by ELISA in patients with Behçet's disease compared with healthy controls. |
Baseline
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Serum EBI-3 level according to disease activity
大体时间：Baseline
|
Mean serum EBI-3 protein concentration according to Behçet's Disease Current Activity Form (BDCAF) score. |
Baseline
|
|
Serum EBI-3 level in patients with vascular involvement
大体时间：Baseline
|
Mean serum EBI-3 protein concentration in patients with and without vascular involvement |
Baseline
|
|
Serum EBI-3 level in patients with ocular involvement
大体时间：Baseline
|
Mean serum EBI-3 protein concentration in patients with and without ocular involvement. |
Baseline
|
|
Serum EBI-3 level in patients with neurological involvement
大体时间：Baseline
|
Mean serum EBI-3 protein concentration in patients with and without neurological involvement. |
Baseline
|
合作者和调查者
调查人员
- 学习椅：Gehan I Abdelraziq, prof、Physical Medicine, Rheumatology and Rehabilitation Department, Assiut University Hospitals
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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